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Reg. No. : ....................................

Name : .........................................

M.Pharm. (Part – I) Degree Examination, May 2009

Branch D : Pharmaceutics
MPH 19 : BIOPHARMACEUTICS AND PHARMACOKINETICS
(Paper – II)

Time : 3 Hours Max. Marks : 100

Instructions : 1) Answer five questions.

2) Question no. 1 is compulsory.
3) All questions carry equal marks.

I. Give brief answers :

a) What is plateau principle ? 2
b) How is attainment of therapeutic objective possible by use of conventional
formulations ? 2
c) What is the major mechanism of absorption of most drugs ? What is the
driving force for such a process ? 2
d) Can a drug have two or more Vd values ? Explain why. 2
e) Why are drugs referred to as Xenobiotics ? 2
f) What are the various non-renal routes of drug excretion ? 2
g) Define pharmacokinetics. 2
h) What is the major mechanism of distribution of drugs and what is its driving
force ? 2
i) What are the rate-limiting steps in the hepatic clearance of drugs ? 2
j) What is flip-flop phenomenon and when is it observed ? 2

II. a) Discuss physico-chemical properties of drugs affecting GI absorption, with

suitable examples. 12

b) Explain the characteristics of passive diffusion and active transport. 8

P.T.O.
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III. a) Deduce expressions for calculating pharmacokinetic parameters of a drug

exhibiting one compartment disposition when given extravascularly. 15

b) Explain the applications of pharmacokinetics in the designing of controlled /

sustained release formulations. 5

IV. a) Mention the objectives of bioavailability studies and describe the pharmacokinetic
method of estimating bioavailability using plasma samples. 12

b) Write a note on invitro-in vivo correlation. 8

V. a) Define excretion and describe the renal excretion of drugs. 10

b) “Phase II biotransformation is true detoxification reaction”. Justify the statement

with suitable examples. 10

VI. a) Explain volume of distribution and derive the equation indicating the relationship
between tissue-drug binding and volume of distribution. 10

b) Explain the causes of non-linearity in pharmacokinetics. 5

c) What are the uses of pharmacokinetic models ? 5

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