Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class Responsibility

Generic Name Antipsychotic Unclear. Schizophrenia  Hypersensitivit CNS: ♦Monitor WBC

agent Thought to in patients y to drug Sedation, count weekly for 6
CLOZAPINE interfere unresponsive  Uncontrolled drowsiness, months of therapy,
with to therapies. seizures dizziness, If its normal, WBC
Brand Name dopamine  Severe CNS headache, testing can be
 Clozaril binding in depression or tremor, reduced to every
 Denazapine limbic coma insomnia, other week. Notify
 Zaponex system of  Concurrent use slurred speech, prescriber
CNS, with of drugs that restlessness, immediately if
high can cause tardive WBC counts
affinity for agranulocytosi dyskenisia, decreases.
dopamine4 s or bone akathisia, ♦Monitor ECG and
receptors. marrow seizures. liver function test.
May depression. CV: ♦If drug must be
antagonize Hypotension, withdrawn
adrenergic , tachycardia, abruptly monitor
cholinergic chest pain. for patient for
, myocarditis. psychosis and
histaminerg EENT: cholinergic
-ic and Blurred vision, rebound.
serotonergi dry eyes, nasal ♦Continue to
-c receptor. congestion, and monitor WBC
sinusitis. count weekly for 4
GU: weeks, after
Urinary therapy ands.
retention, ♦Tell patient to
incontinence, allow orally
frequency, disintegrating
urgency and tablet to dissolve in
inhibited mouth.
ejaculation. ♦Advice patient to
Musculoskelet immediately report
al: new onset of
Muscle spasm, lethargy,
rigidity,back Weakness, fever,
and muscle sore throat,
pain. malaise, mucus
Hematlogic: membrane ulcers,
Agranulocytosis flulike symptoms
, leucopenia, of infection.
hemolytic
anemia,
neutropenia,
eosinphilia.
Respiratory:
Dyspnea,
respiratory
arrest.
Skin:
Rash, sweating,
Steven_johnson
Syndrome.
Other:
Weigth gain,
Fever.
 Drug Name Therapeutic Action Indication Contraindication Adverse Nursing
Class Effect Responsibility

Generic Name Antipsychotic Unknown. ♦Symptomati  Hypersensitivity CNS: ♦Monitor CNS

Thought to c treatment of to drugs, Confusion, status closely,
HALO- block psychotic tartrazine, sesame drowsiness, especially for
PERIDOL postsynaptic disorder or oil, o benzyl EPR, seizures and
dopamine Tourrete alcohol. sedation, neuroleptic
Brand Name receptor in syndrome.  Severe CNS insomnia, malignant
 Haldol brain and ♦Schizophren depression. tardive syndrome.
 Peridol increase ia in patients dyskinesia, ♦Monitor
 Serenace dopamine who need seizure, cardiovascular
turnover prolonged lethargy. status, particular
rate, parenteral CV: for ECG changes,
inhibiting antipsychotic Hypotension, blood pressure
signs and therapy. hypertension, changes, torsades
symptoms of ♦Psychotic tachycardia, de pointes, and
psychosis. disorder torsades de atypical rapid
♦Nonpsychoti pointes. ventricular
c behavior EENT: tachycardia, w/c
disorder; Blurred may progress to
Tourrete vision, dry ventricular
Syndrome. eyes. tachycardia.
GU: ♦Asses respiration
Urinary ♦Monitor liver
retention, function test
menstrual results and CBC
irregularities, with white cell
gyecomastia. deferential.
GI: ♦Tell patient to
Constipation, dilute oral
 ileus, dry concentrate with
mouth, water, cola, juice
anorexia. immediately before
Hematologic: taking.
Anemia, ♦Instruct patient to
leukocytosis, immediately report
leukopenia. serious adverse
Hepatic: reaction.
Jaundice, ♦Advise patient to
drug-induced- minimize GI upset
hepatitis. by eating frequent,
Metabolic: small serving of
Galactorrea food and drinking
Respiratory: adequate fluids.
Bronchospas-
m, dyspnea,
respiratort
depression.
Skin:
Diaphoresis,
photosensitivi
ty, rash.
Other:
Hyperpyrexia,
hypersensitivi
ty reaction.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

 Class Rsponsibility

Generic Name Antipsychotic Unknown. ●Psychotic ● Hypersensitivity to CNS: ♦Measure blood

Thought to disorders drugs or other Drowsiness, pressure before
LOXAPINE block dibenzoxapines. Insomia, and periodically
neurotrans ●Coma or severe shuffling gait, during therapy.
Brand Name mission of depression from any Staggering, ♦Monitor
 Loxitane postsynapti cause. slurred speech, hematologic
 Loxapac c dopamine tardive studies and liver
receptors dyskinesia, function test.
in brain, confusion, ♦Stay alert for
alleviating parkinsonism, evidence of
psychotic seizures. neuroleptic
symptoms. CV: malignant
Orthostatic syndrome.
hypotension, ♦Asses for tardive
hypertension, dyskinesia,
ECG changes. especially in
EENT: elderly woman.
Blurred vision, ♦Tel patient to take
ptosis, and nasal with or without
congestion. food.
GI: ♦Inform patient
N/V, that drug may
constipation, dry cause tardive
mouth, paralytic dyskinesia.
ileus. ♦Avoid activities
GU: requiring mental
Urinary concentration until
retention. drug effect are
Hematologic: known.
Leukopenia, ♦Teach patient to
agranulocytosis, immediately report
thrombocytopeni sore throat, fever,
a. rash, impaired
Hepatic: vision, tremors,
Hepatocellular involuntary muscle
injury with twitching or
hepatic enzyme yellowing of eyes
elevations. or skin.
Meatbolic: ♦Instruct patient to
Polydipsia. move slowly when
Musculoskeletal: sitting up or
Muscle standing, to avoid
twitching. dizziness from
Skin: sudden blood
Rash, pruritus, pressure decrease.
sobrrhea,
photosensitivity,
alopecia.
Other:
Weight gain or
loss,
hyperpyrexia,
facial edema,
hypersensitivity
reaction.
 Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing
Class Responsibility

Generic Name Antipsychotic Unknown. ●Schizophrenia ●Hypersensitivit CNS: ♦Assess mental

Though y to drugs. Dizziness, patient during
OLANZIPINE antagonize headache, therapy.
dopamine and weakness, ♦Monitor vital
Brand Name serotonin type fatigue, mood signs during
 Zyprexa 2 in CNS. changes, tremor, dosage
 Olanzapro Also tardive adjustment.
antagonizes dyskinesia, ♦Make sure that
muscarinic dystonia, extra- the patient takes
receptors in pyramidal effect, drug and doesn’t
respiratory neurologic hoard it.
tract, causing malignant ♦Watch for sign
cholinergic syndrome, coma. and symptoms
activation. CV: of neuroleptic
Orthostatic malignant
hypotension, syndrome.
chest pain, ♦Watch for
tachycardia. signs of
EENT: decreasing
Amblyopia, depression.
rhinitis, ♦Monitor blood
pharyngitis. glucose level
GI: closely
Nausea, especially with
constipation, DM.
abdominal pain, ♦Watch for
increased orthostatic
salivation, dry hypotension.
mouth. Before I.M.
injection.
GU: Tell patient he
Urinary take without
incontinence, regard to meal.
UTI. ♦Advise patient
Hematologic: to avoid
Leukopenia. smoking,
Metabolic: alcohol, and
Goiter, increased other can
thirst, severe depress CNS .
hyperglycemia. ♦Tell patient to
Musculoskeletal: slowly sitting up
Hypertonia, joint and standing to
pain. avoid dizziness.
Respiratory: ♦Tell patient
Cough dyspnea. that drug may
Skin: cause extra
Ecchymosis, pyramidal
photosensitivity. symptoms.
Other: akathisia,
Increase tardive
appetite, weight dyskinesia etc.
gain or loss,
fever.
 Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing
Class Responsibility

Generic Name Antipsychotic Exerts ●Nausea ●Hypersensitivit CNS: ♦Monitor

Antiemetic anticholinergic, Nausea and y to Sedation, tardive patient closely
Prochlorperazine Anxiolytic CNS depressant vomiting phenothiazines, dyskinesia, if he’s receiving
and related to comatose states, neuroleptic drug for nausea
Brand Name antihistaminic surgery. ●Do not use in malignant and vomiting
 Compazine effects. ●Schizophrenia children for syndrome, associated with
 Compro Depresses ●Anxiety conditions for CV: chemotherapy.
 Stemil release of which dosage has Orthostatic ♦Instruct patient
hypothalamic not been hypertension, to dilute oral
and established. tachycardia. solution with
hypophyseal EENT: tomato or fruit
hormones, Blurred vision, juice, milk,
decrease lens opacities, coffee, soda, or
sensitivity of dry eyes. tea.
middle-ear GI: ♦Monitor
labyrinth, and Constipation, neurologic
reduces ileus, dry mouth, status,
conduction in anorexia. especially for
vestibular GU: signs and
cerebelar Pink & reddish- symptoms of
pathways. brown urine, neuroleptic
Urinary malignant
retention syndrome.
galactorrhea.
Hematologic:
Agranulocytosis,
leucopenia.
Hepatic:
Cholestatic
jaundice,
 hepatitis.
Metabolic:
Hyperthermia.
Skin:
Photosensitivity,
pigmentation
changes, rashes.
Other:
Allergic.
Reactions.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class responsibility

Generic Name Antipsychotic Uses may ●Mania ●Promazine ●Side-effects

is ♦Monitor blood
include the ●Agitation contra-indicated in
include pressure daily in
Promazine treatment of organic brain comatose patients
drowsiness, a supine position
obsessive- syndrome (particularly those
dryness of ♦Anticipate the
Brand Name compulsive ●Alcoholic under the influence
mouth, pallor of development of
 Sparine disorder and ●Hallucinosis of alcohol,
the skin, postural postural
 Prozine severe ●Drug induced barbiturates, hypotension, hypotension.
behavioral emesis narcotics or otherweakness, ♦Monitor
disorders in ●Radiation central nervous
lowering of body cardiovascular
autism sickness system depressants)
temperature status, particular
●Intractable an in patients with
(occasionally for ECG
hiccough bone marrow
pyrexia), changes, blood
depression. tachycardia, pressure
arrhythmias, changes,
●Promazine should agitation, torsades de
not be given to insomnia, pointes, and
patients being depression, atypical rapid
 treated with drugs photosensitivity ventricular
that might cause and skin rashes. tachycardia, w/c
leucopenia. Women may progress to
who may become ventricular
pregnant. tachycardia.
♦Asses
respiration
♦Monitor liver
function test
results and CBC
with white cell
deferential.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class responsibility

Generic Name Anti psychotic Blocks ●Schizophrenia ●Hypersensitivity to ●Akathisia ♦monitor the
dopamine drugs, its ●Tardive neurologic status
Thioridazine HCl receptors in component, or other dyskinesia of the patient.
CNS. Exerts phenothiazine. ●Rabbit ♦Assess for
BrandName strong alpha- ●Severe CNS syndrome urinary retention,
 Mellaril adregenic and depression ●Sialadenitis constipation and
 Novo- an ●Severe ●Impotence blurred vision.
Ridazine ticholinergic hypotension and ●Anorgasmia ♦Closely
 Apo-Thiori blocking hypertension ●Sedation monitor
dazine activity; also ●History of ●Urinary depressed patient
depress arrhythimias retention for suicidal
ceredral ● Neuroleptic attack.
cortex, malignant ♦Monitor
hypothalamus syndrome bilirubin level,
and limbic ●Agranulocytosis CBC, liver
system. function test and
vision exams.
 Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing
Class Responsibility

Generic Name Antipsychotic Unknown. ●Schizophrenia ●Hypersensityvit ●Drowsiness, ♦Monitor

Though to act on ●Nonpsychotic y to drug, other dizziness, neurologic
Trifluoperazine subcortical level anxiety phenothiazines or skin reactions, status,
HCl of hypothalamic bisufites  rash,  especially for
and limbic ●Severe hepatic dry mouth,  indication of
Brand Name system by disease insomnia,  neuroleptic
 Solazine producing ●Bone marrow amenorrhea, malignant
 stelazine antidopaminergi depression fatigue, syndrome
 Terfluzine c effects. Also ●Blood dyscasias muscular (unstable blood
lower seizure ●Coma weakness, pressure, high
threshold and ●Concomitant use anorexia, fever, sweating,
exibit some of other CNS lactation, stupor, muscle
adrenergic , depressants in blurred vision  rigidity and
muscaranic, and high school and autonomic
anticholnergic neuromuscular  dysfunction.)
activity. (extrapyramidal) ♦Monitor for
reactions. ECG and blood
pressure.
♦Instruct
patient taking
oral solution to
add solution to
60ml or more
of liquid.
♦Tell patient to
avoid alcohol
and certain
herbs.
 ♦Instruct
patient to move
slowly when
sitting up or
standing, to
avoid dizziness.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class Responsibility

Generic Name Antipsychotic Used in the ●Management ●Use for ●Skin rash, ♦Monitor vital
treatment of of psychoses. psychoses in itching, sign
Triflupromazine disorganized Also used to children less than or hives ♦Asses
and psychotic control nausea 2.5 years of age. ●Trouble neurologic status
Brand Name thinking and vomiting breathing of the patient.
 Vesperin Fast or ♦Tell patient to
irregular slowly sitting up
heartbeat and standing to
●Unexplained avoid dizziness.
high fever, ♦If drug must be
muscle stiffness withdrawn
●Uncontrollable abruptly monitor
movements of for patient for
the face, neck, psychosis and
or tongue cholinergic
rebound.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

 Class Responsibility

Generic Name Antipsychotic An ●Effective in ●Hypersensitivity ●Tachycardia,  ♦Monitor

antipsychotic of the to drug, ●hypotension, neurologic
Thiothixene the thioxanthene management of circulatory  ●lightheadedness status,
series. Navane schizophrenia. collapse, , and syncope, especially for
Brand Name possesses certain Navane has not comatose states, ●Drowsiness, indication of
 Novane chemical and been evaluated central depressio ●Restlessness, neuroleptic
pharmacological in the n due to any ●Agitation malignant
similarities to management of cause, and blood and insomnia  syndrome
the piperazine behavioral dyscrasias (unstable blood
phenothiazines complications pressure, high
and differences in patients with fever, sweating,
from the mental stupor, muscle
aliphatic group retardation. rigidity and
of autonomic
phenothiazines. dysfunction.)
Tell patient to
avoid alcohol
and certain
herbs.
♦Instruct patient
to move slowly
when sitting up
or standing, to
avoid dizziness.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class Responsibility
Generic Name: Antipsychotic Has ●Schizophrenia ●Hypersensitivit ●Aggressive ♦Instruct patient
antipsychotic y to drug. behavior, to take
Risperidone effect, ●Bipolar Mania dizziness, prescribed dose
apparently headache, once or twice
Brand Name: caused by ●Irritability fatigue, anxiety, daily as
 Risperdal, dopamine- and symptoms of transient prescribed,
 Risperdal serotonin- aggression ischemic attack, without regard
 Consta receptor toward others, cerebrovascular to meals. Advise
blocking in deliberate self- accident, patient to take
CNS. injury, and neuroleptic with food if GI
temper tantrums syndrome, upset occurs.
associated with Tachycardia, ♦Instruct patient
autistic disorder chest pain, using oral
bradycardia, solution to use
orthostatic calibrated
hypotension, pipette to
arrhythmia, measure each
Rash, skin dose. Advise
discoloration, patient that
skin ulceration, solution may be
acne, dry skin, mixed with 3 to
seborrhea, 4 oz of water,
pruritus, coffee, orange
Rhinitis, juice, or low-fat
abnormal milk (but not
vision, with cola or tea)
pharyngitis, prior to
conjunctivitis, administration.
otitis media, ♦Caution patient
blurred vision, using orally
earache. disintegrating
Vomiting tablet not to
 increased open the blister
salivation, until ready to
constipation, take the dose.
abdominal pain. ♦Advise patient
Dyspepsia, that dose will be
nausea, dry started low and
mouth, then increased
anorexia. until max
benefit is
obtained.
♦Instruct patient
not to stop
taking
risperidone
when feeling
better.
Tell patient to
immediately
report altered
mental status,
high fever,
irregular pulse,
muscle rigidity,
rash, seizures, or
sweating to
health care
provider.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

 Class Responsibility

Generic Name Antipsychotic Unknown. ●For the ●Do not use in Cardiovascular ♦Assess mental
Antiemetic May block treatment patients with Hypotensive Eff status prior to
Chlorpromazine Anxiolytic postsynaptic of schizophreni known ects, EKG and periodically
HCl dopamine a. hypersensitivity Changes during therapy.
receptors in ●To to phenothiazines. ♦Monitor BP
Brand Name brain and control nausea a ●Do not use in CNS Reactions and pulse prior
 Thorazine depressareas nd vomiting. comatose states or Neuromuscular  to and
 Largactil involved in ●For relief of in the presence of (Extrapyramidal frequently
Chlorpro- wakefulness restlessness and large amounts of ) Reactions during the
manyl and emesis. apprehension central nervous Dystonias, period of dosage
Also possesses before surgery. system Motor adjustment.
anticholinergic ●For acute  depressants Restlessness, May cause QT
, antihistamine, intermittent  (alcohol, Pseudo- interval changes
and adrenergic porphyria. barbiturates, parkinsonism, on ECG.
blocking ●As an adjunct narcotics, etc.). Tardive Dyskin ♦Observe
properties. in the treatment esia patient carefully
of tetanus. when
●To control the administering
manifestations medication, to
of ensure that
the manic type medication is
of manic- actually taken
depressive and not
illness. hoarded.
●For relief ♦Monitor I&O
of intractable  ratios and daily
hiccups. eight. Assess
patient for signs
and symptoms
of dehydration.
♦ Monitor for
development of
neuroleptic
malignant
syndrome
(fever,
respiratory
distress,
tachycardia,
seizures,
diaphoresis,
hypertension or
hypotension,
pallor, tiredness,
severe muscle
stiffness, loss of
bladder control.
Report
symptoms
immediately.
May also cause
leukocytosis,
elevated liver
function tests,
elevated CPK.
♦ Advise patient
to take
medication as
directed. Take
missed doses as
soon as
remembered,
with remaining
doses evenly
 spaced
throughout the
day. May
require several
weeks to obtain
desired effects.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class Responsibility

Generic Name Antipsychotic Unknown. ●PROLIXIN is ●Phenothiazines Central

Though indicated in the are Nervous ♦Use exactly as
Fluphenazine antagonize management of contraindicated in System directed; do not
hydrochloride dopamine and manifestations patients with  pseudoparkinso increase dose or
serotonin type of psychotic suspected or nism,  frequency.
Brand Name 2 in CNS. Also disorders. established dystonia, 
 Prolixin antagonizes subcortical brain dyskinesia,akat ♦Do not
 Permitil muscarinic ●PROLIXIN damage, in hisia, discontinue
receptors in has not been patients receiving oculogyric without
respiratory shown effective large doses of crises,  consulting
tract, causing in the hypnotics, and in opisthotonos, prescriber.
cholinergic management of comatose or and
activation. behavioral severely hyperreflexia.  ♦Dilute with
complications depressed states. Autonomic water, milk,
in patients The presence Nervous orange or
with mental of blood System grapefruit juice;
retardation. dyscrasia or liver Hypertension an do not dilute
damage precludes d with beverages
the use of fluctuation in containing
fluphenazine  blood pressure  caffeine, tannin,
hydrochloride. have been
●PROLIXIN reported with or pectinate (eg,
(fluphenazine fluphenazine coffee, colas,
hydrochloride) is hydrochloride. tea, or apple
contraindicated in Metabolic and juice). ♦Do not
patients who have Endocrine take within 2
shown Weight change, hours of any
hypersensitivity peripheral antacid. ♦Avoid
to fluphenazine; edema, alcohol or
cross-sensitivity abnormal caffeine and
to phenothiazine  lactation,  other
derivatives may gynecomastia, prescription or
occur. menstrual OTC
irregularities, medications not
false results on  approved by
pregnancy tests, prescriber.
impotency in
men ♦Avoid skin
and contact with
increasedlibido medication; may
 in women have cause contact
all dermatitis (wash
been known to immediately
occur in some with warm,
patients on soapy water).
phenothiazine
therapy. ♦Maintain
Allergic adequate
Reactions hydration unless
Skin disorders instructed to
such restrict fluid
as itching, eryth intake. You may
ema,  experience
urticaria, seborr
hea,  excess
photosensitivity drowsiness,
,eczema and lightheadedness,
even dizziness, or
exfoliative derm blurred vision
atitis have been (use caution
reported with driving or when
phenothiazine engaging in
derivatives. tasks requiring
alertness until
response to drug
is known); dry
mouth, upset
stomach,
nausea,
vomiting (small
frequent meals,
frequent mouth
care, chewing
gum, or sucking
lozenges may
help);
constipation
(increased
exercise, fluids,
fruits, or fiber
may help);
postural
hypotension
(use caution
climbing stairs
or when
changing
position from
lying or sitting
to standing);
urinary
retention (void
before taking
medication);
ejaculatory
dysfunction
(reversible);
decreased
perspiration
(avoid strenuous
exercise in hot
environments);
or
photosensitivity
(use sunscreen,
wear protective
clothing and
eyewear, and
avoid direct
sunlight).
 Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing
Class Responsibility

Generic Name Antipsychotic Unknown. ●Perphenazine ●Perphenazine CNS Effects ♦Monitor

Thought to is indicated for products are Extrapyramidal neurologic
Perphenazine block use in the contraindicated in Reactions status,
neurotransmiss treatment comatose or opisthotonus,  especially for
Generic Name ion of of schizophreni greatly obtunded trismus,  indication of
 Trilafon postsynaptic a and for the patients and in torticollis, neuroleptic
dopamine control of patients receiving retrocollis, malignant
receptors in severe nausea a large doses aching and syndrome
brain, nd vomiting in of central nervous numbness (unstable blood
alleviating adults. systemdepressant of the limbs, pressure, high
psychotic s (barbiturates, motor fever, sweating,
symptoms. ●Perphenazine alcohol, narcotics, restlessness, stupor, muscle
has not been analgesics, oculogyric rigidity and
shown effective or antihistamines) crisis, autonomic
for the ; in the presence hyperreflexia, dysfunction.)
management of of existing blood  dystonia, ♦Monitor for
behavioral dyscrasias, bone including ECG and blood
complications marrow protrusion, pressure.
in patients depression, or discoloration, ♦Instruct patient
with mental liver damage; and aching taking oral
retardation. in patients who and rounding of solution to add
have shown the solution to 60ml
hypersensitivity  tongue, tonic or more of
to perphenazine spasm liquid.
tablets, their of the ♦Tell patient to
components, or masticatory avoid alcohol
related muscles, and certain
compounds. tight feeling in herbs.
the throat,
slurred speech, 
●Perphenazine dysphagia,akath
products are also isia, 
contraindicated in dyskinesia, 
patients with parkinsonism,
suspected or and ataxia.
established Persistent
subcortical brain Tardive
damage, with or Dyskinesia
without Other CNS
hypothalamic Effects
damage, since a include cerebral
hyperthermic edema;
reaction with abnormality of
temperatures in cerebrospinal
excess of 104°F fluid
may occur in such proteins;
patients, convulsive
sometimes not seizures,
until 14 to 16 particularly
hours after drug in patients with
administration. EEG
Total body ice- abnormalities
packing is or a history of
recommended for such disorders;
such a reaction; and headaches.
antipyretics may Autonomic
also be useful. Effects
dry mouth or
salivation,
 nausea,
vomiting, diarrh
ea, 
anorexia, consti
 pation,
obstipation,
fecal
impaction,
urinary
retention,
frequency
or incontinence
,
bladder
paralysis,
 polyuria, nasal
congestion,
pallor,
myosis, mydria
sis,
blurred
vision,glaucoma
, 
perspiration, hy
pertension, 
hypotension,
and change in
pulse rate
occasionally
may occur

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

 Class Responsibility

Generic Name Anticonvulsant The mechanism The control of Ethosuximide Gastrointestin

of action of the should not be ♦When initiating
Ethosuximide succinimides is absence (petit used in patients al:
unknown. mal) epilepsy. with a history of Gastrointestinal therapy or
Brand name hypersensitivity changing a dose,
symptoms
to succinimides. monitor the drug
 Zarontin occur
frequently and serum level to
include determine
anorexia, vague whether a
gastric upset, therapeutic
nausea and range has been
vomiting, obtained
cramps,
♦Assess
epigastric and
complete blood
abdominal pain,
counts regularly
weight loss, and
to determine
diarrhea.
whether any low
Hemopoietic: blood cell
Leukopenia, counts are
agranulocytosis present
, pancytopenia,
♦Notify
aplastic anemia,
physician if
eosinophilia.
there are
presence of skin
Nervous rashes, joint
system: pain,
drowsiness, unexplained
headache, fever, sore
dizziness, throat, unusual
euphoria, bleeding or
hiccups, bruising, severe
irritability, drowsiness,
hyperactivity, severe dizziness,
lethargy, blurred vision or
fatigue, and pregnancy.
ataxia.
Psychiatric or
psychological
aberrations
associated with
ethosuximide
administration
have included
disturbances of
sleep, night
terrors, inability
to concentrate,
and
aggressiveness.

Integumentar
y:
Dermatologic
manifestations
which have
occurred with
the
administration
of ethosuximide
have included
urticaria,
Stevens-
Johnson
syndrome,
systemic lupus
erythematosus,
and pruritic
erythematous
rashes.

Genitourinary
:
Microscopic
 hematuria.

Miscellaneous:
Myopia,
vaginal
bleeding,
swelling of the
tongue, gum
hypertrophy.

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class Responsibility

Generic Name Anticonvulsant The mechanism ● Methsuximide ●Nausea ♦Encourage

of action of ●Celontin is should not be ●Vomiting maintenance of
Methsuximide succinimides is indicated for the used in patients ●Indigestion a regular
unknown. control of with a history of ●Sedation lifestyle and
Brand Name absence (petit hypersensitivity ●Drowsiness moderate
 Celontin mal) seizures to succinimides. ●Dizziness activity.
that ●Fatigue ♦Avoid
arerefractory to ●Lethargy excessive
other drugs. exercise that
would lead to
excessive
fatigue.
♦Avoid
excessive use of
stimulants.
Seizures are also
known to follow
the significant
intake of
alcoholic
beverages;
therefore
ingestion should
be avoided or
restricted.
♦Monitor vital
signs and
neurologic
status.
♦Administer
oxygen; have
suction and
resuscitation
equipment
available.
 Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing
Class Responsibility

Generic Name Anticonvulsant Thought limit ●Status ●Hypersentivity ●Head ache ♦Asses blood
seizures epilipticus to drug Fatigue, coma, pressure, ECG,
Pheytoin activity by ●Generalized ●Sinus confusion, and heart rate,
promoting tonic – clonic bradycardia, agitation, CNs especially
Brand Name sodium efflux ( grand mal) sinoatrial block, depression. during I.V.
 Dilantin from neurons and complex second or third ●Edema, loading dose.
 Phenytek in motor cortex partial 9 degree vasodilation, ♦Monitor
 Epanutin and reducing psychomotor, antrioventricular chest pain, phenytoin blood
activity in temporal lobe) block. Adams tachycardia, level therapeutic
brainstem seizures. stokes syndrome. hypotension. range is 10-
centers ●To prevent ●Dipophia, 20mcg/ml.
responsible for seizure during sinusitis, ♦Evaluate CBC
tonic phase of neurosurgery. amblyopia, and kidney and
tonic clonic visual field liver function
defect. tests.
●N/V, diarrhea, ♦Closely
constipation, lip monitor
enlargement. prothrombin
●Pink, red, or time.
reddish-brown ♦Monitor drug
urine. efficacy.
●hypocalcemia, ♦Avidest patient
diabetes to avoid alcohol.
insipidus, ♦Inform patient
hyperglycemia, that drug may
●back pain, discolor urine.
Pelvic pain,
osteomalacia.
 ●dyspnea, apnea

Drug Name Therapeutic Action Indication Contraindication Adverse Effect Nursing

Class responsibility

Brand Name Antipsychotic Unknown. Schizophrenia  ●Contraindicated CNS Effects ●Evaluate

Through the and for the inn comatose or respiratory status
Perphenazine antagonize control of greatly obtunded ●Extrapyramid especially for
dopamine and severe nausea a patients and in al Reactions dyspnea and
Generic Name serotonin type 2 nd vomiting in patients receiving opisthotonus, tri airway spasm.
 Phenazine in CNS. Also adults. large doses smus, torticollis ●Monitor CBC,
 Fentazin antagonize of central nervous , retrocollis, glucose, level
muscarinic Management systemdepressant aching and and liver
receptors in of behavioral s (barbiturates, numbness of the function test.
respiratory complications alcohol, narcotics, limbs, motor watch for
tract, causing in patients analgesics, restlessness, evidence of
cholinergic with mental or antihistamines) oculogyric blood dyscrasias.
activation. retardation ; in the presence crisis,
of existing blood hyperreflexia, d
dyscrasias, bone ystonia,
marrow including
depression, or protrusion,
liver damage; and discoloration,
in patients who aching and
have shown rounding of
hypersensitivity the tongue,
to perphenazine tonic spasm of
tablets, their the masticatory
components, or muscles, tight
related feeling in the
compounds throat, slurred
 speech, dysphag
●Contraindicated ia,akathisia, dys
in patients with kinesia, parkins
suspected or onism,
established and ataxia.
subcortical brain
damage, with or ●Persistent
without Tardive
hypothalamic Dyskinesia
damage, since a Other CNS
hyperthermic Effects
reaction with ●Include cerebr
temperatures in al edema;
excess of 104°F abnormality of
may occur in such cerebrospinal
patients, fluid proteins;
sometimes not convulsive
until 14 to 16 seizures,
hours after drug particularly in
administration. patients with
Total body ice- EEG
packing is abnormalities or
recommended for a history of
such a reaction; such disorders;
antipyretics may and headaches.
also be useful
●Autonomic
Effects
●Dry mouth or
salivation, naus
ea,
vomiting, diarrh
ea, anorexia, co
nstipation,
obstipation,
fecal impaction,
urinary
retention,
frequency
or incontinence,
bladder
paralysis, polyu
ria, nasal
congestion,
pallor,
myosis, mydrias
is, blurred
vision,glaucoma
, perspiration, h
ypertension, hy
potension, and
change in pulse
rate
occasionally
may occur