T111 - Dispensing Pharmacy (Theory) (3 hrs/ week) Section I TOPICS Pharmacy Practice Hrs.

1) Pharmacist: A Health Care Provider, Concept of pharmaceutical health care, Growth of 03 2) Compounding & Dispensing of medication: Definition of dispensing & compounding.
Good dispensing & compounding practices, fundamental operations in compounding. Containers & closures for dispensed products, labeling & storage of compounded products. Dispensing of prefabricated dosage forms, patient counseling, and documentation of compounding & dispensing records. 3) Prescription: Its parts, types of prescription, prescription pricing & documentation. 4) Incompatibilities: Definition types o fprescription, prescription pricing & documentation 5) Pharmaceutical Calculations: - % Calculations, Allegation method, isotonicity, proof spirit. Posology: factors affecting & Calculations of doses. Weight & measures. Section II TOPICS 6) Compounding & Dispensing Aspects of i) Formulation & procedure for compounding & dispensing of oral & external use liquids.,gargles, nasal drops, sprays, enemas. ii) Suspensions: - Thickening agents, Diffusible & in diffusible type, oral suspensions & lotions. iii) Emulsions: - Emulgents, choice of emulgents, HLB values, two phase emulsion, methods of preparation (Dry & wet gum & soap emulsions.), determination of type, physical stability & causes for instability.. iv) Semisolids: - Ointments, Creams, Pastes, jellies, Poultices & Plasters. v) Suppositories: - Formulation, displacement value, compounding & evaluation. vi) Solid Dosage Forms: - Divided & bulk (oral & external) powders, effervescent granules. Filling of Hard gelatin Capsules, dispensing of prefabricated Tablets, Capsules, Pastilles, Lozenges, Pills & tablet triturates. 7) Surgical Aids including Ligatures & Sutures: Surgical dressing, medicated bandages, Ligatures & Sutures processing and manufacturing, packing & Q.C. test of catgut Hrs. 04 04 04 07 02 07 03 07 05 10 04

TOTAL Hrs: - 45 Books Recommended: 1. AH. Gennaro Remington's Pharmaceutical Science-(Mack Publishing) 2. Collett & Aulton Pharmaceutical Practice 3. Hoover Dispensing of Medications (Mack Publishing) 4. Sprowls Prescription Pharmacy Lippincott) 5. Stocklos Pharmaceutical Calculations 6. IP, BP, USP-NF, NFI and the Pharmaceutical Codex, Martindale Extra Pharmacopoeia 8. Winfield and Richard Pharmaceutical Practice

P111- Dispensing Pharmacy (Practicals) (3 hrs/ week) Notes: (i) (ii) (iii) (iv) 1. 2. All the prescriptions shall be in metric system except a few for practice which shall be in the imperial system. Latest editions of books wherever applicable shall be used. Special attention to be paid to the cleanliness and precise working (including documentation) of the candidate in the laboratory. Minimum thirty exercises should be conducted Dispensing Vs Compounding Weighing technique for the dispensing-balance sensitivity - Weight box calibration and - accuracy. Precision of weighing and error evaluation. Measuring techniques - Precision and accuracy of measuring and error evaluation Devices for accurate dosage measurement Handling of prescription - Reading, checking, labeling and dispensing with detailing. General Dispensing procedure - Different containers for dispensing, labeling of dispensed medicines Documentation. 3. Posology and calculations Weights and measures Reducing and enlarging formulae Percentage calculations Dilutions and concentration (Stock solutions) H.L.B. System Isotonic solutions 4. Compounding and dispensing with precision of the following preparations: (I) Powders and Granules Compound Magnesium Trisilicate oral powder* Siedlitz powder* Isapgol granules** Effervescent granules of sodium sulphate** Zinc, starch and Talc Dusting powder* Eutectic powder containing Menthol with camphor* (ii) Solutions Salicylic acid colloid* Paediatric ferrous sulphate oral solution* Zinc Sulphate and Zinc chloride mouth wash* Mouth wash containing Thymol, Menthol, Peppermint oil and a suitable antiseptic.** (iii) Suspensions Paediatric kaolin mixture** Magnesium Trisilicate mixture** Paediatric chalk mixture** Inhalation containing menthol and eucalyptus* (iv) Emulsions Emulsion for internal use containing acacia White liniment* Oily calamine lotion** Benzyl Benzoate application*

(v) Ointment Sulphur ointment** Whitfields ointment** Methyl salicylate ointment** Lubricating jelly** (vi) Suppositories Use of displacement value** Suppository with fatty base** Suppository with PEG base vii) 5. 6. Preparation of Lozenges (2)*, pastilles (2)*, pills (including Ayurvedic Pills) (3)*, tablet triturates (2)*, capsules (1)*. Pre-packaging and bulk compounding of any one dosage forms* Drug information - Source - An exercise on drug information.* ** Indicate Major experiments

* Indicate minar experiments Books Recommended: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10 Sprowls - Prescription Pharmacy

Cooper & Gunn - Dispensing for Pharmacy students - - 12th edition Collett & Aulton -Pharmaceutical Practice Hoover- Dispensing of Medication Martindale -The Extra Pharmacopoeia Merck Index Remingtons Pharmaceutical Sciences Bradley -- Pharmaceutical calculations Joel L. Zatz -Pharmaceutical calculations Stocklos - Pharmaceutical Calculations Scheme for practical Examination

Sr.No. 1 2 3 4 5

Head Synopsis Major experiment Minor experiment Viva Journal & Attendance Total Duration

Sessional 05 07 04 04 10 30 03 Hrs

Annual 10 35 15 10 70 4 Hrs

T112 PHARMACEUTICAL INORGANIC CHEMISTRY-I (4 Hrs/Week) SEMESTER- I Sr.No. 1 Topics Section I Acids, Bases, Buffers Types & Mechanism, Pharmaceutical buffers, Buffer equation and buffer capacity in general, buffers in pharmaceutical systems, Preparation, stability, buffered isotonic solutions, measurement of tonicity and calculation and methods of adjusting isotonicity. Major Intra & Extra cellular Electrolytes Physiological ions, Electrolytes used for replacement therapy Acid base balance, Combination therapy Limit tests: for arsenic , heavy metals , lead , iron , chloride and sulphate and Pharmacopoeial standards Section II Limit tests: Chlorides and sulphates according ot pharmacopoeial standards Gastrointestinal Agents Acidifying agents, Antacids, protective Adsorbents Cathartics Essential & Trace elements Transition elements & their compounds of Pharmaceutical importance, Iron & Haematinics, Minerals supplements. Total no.of hours Hours 10

08

3a

04

3b 4

04 12

07

45

Books Recommended: 1. Vogels Textbooks of qualitative Inorganic Analysis By Denny, Jeffery. 2. Practical Pharmaceutical inorganic chemistry, By Beckett & Stenlake. 3. Inorganic Medicinal & Pharmaceutical Chemistry By Block & Roche. 4. Text book of Pharmaceutical Chemistry, By Chatten L.G.(Dekker series) 5. Textbook of Pharmaceutical analysis By Connors K.A. 6. Text book of Pharmaceutical Analysis By Dr. H. N. More 7. Indian Pharmacopoeia 8. British Pharmacopoeia 9. Remingtons Pharmaceutical Sciences.

P112 PHARMACEUTICAL INORGANIC CHEMISTRY-I Duration: 3Hrs/week Sr.No. Topic 1 Systematic qualitative analysis of inorganic mixtures containing two anions and two cations. (Minimum five practical) ** 2 Limit test for following as per the procedure given in Indian pharmacopoeia (1996-including the latest addendum )* chloride Sulphate Heavy metals Iron Arsenic 3 Preparation of inorganic compounds* (Minimum five practical) * Indicate minar experiments Books Recommended: 1. Vogels Textbooks of qualitative Inorganic Analysis By Denny, Jeffery. 2. Practical Pharmaceutical inorganic chemistry, By Beckett & Stenlake. 3. Inorganic Medicinal & Pharmaceutical Chemistry By Block & Roche. 4. Text book of Pharmaceutical Chemistry, By Chatten L.G.(Dekkerseries) 5. Textbook of Pharmaceutical analysis By Connors K.A. 6. Text book of Pharmaceutical Analysis By Dr.H.N.More 7. Indian Pharmacopoeia 8. British pharmacopoeia 9. Remingtons Pharmaceutical Sciences. Scheme for practical Examination Sr.No. 1 2 3 4 6 Head Synopsis Major experiment Minor experiment Viva Journal & Attendance Total Duration Sessional 05 07 04 04 10 30 03 Hrs Annual 10 35 15 10 70 4 Hrs ** Indicate Major experiments

T113 Biochemistry: Theory (4 hr/week) Sr.No. 1 TOPIC Section-I Animal cell Structure and function of different organells, nucleus, cytoskeleton, mitochondria plasma membrane, ribosome, endoplasmic reticulum, lysozome, Golgi apparatus, Biochemistry of specialized tissue. Nerve, kidney, liver and muscle. Bio-membranes: Structure of membrane, transportation, membrane receptors, membrane potential, membrane bound Adenyl cyclase, protein kinase and phosphodiesterase, Na+ k + pump, Ca++ ATPasae, and diffusion. 06 Proteins and amino acids: Functions of proteins and their classification physicochemical properties of proteins, study of amino acid, classification, acid base property. Isoelectric point, Essential and nonessential amino acids, peptides. Different methods for separation and purification of proteins and amino acids, ion-exchange chromatography, centrifugation and affinity chromatography (Explain elementary idea and outline the method of separation) Protein structure at various level primary, secondary, teriary and quaternary. Aplication of protein structure database in drug design. Enzymes: Classification, mechanism of enzyme action factors affecting rate of enzymatic reaction. Activators and inhibitors of enzymes. Competitive and non- competitive, allosteric types of nzymes inhibition with respect to drug action. Enzyme induction and Isozymes. Pharmaceutical application of enzymes, mutienzymecomplex. Vitamins and coenzymes : Structure and functions and biochemical role of coenzyme from water soluble vitamins folic acid thiamin, pyridoxine, cyanocobalamine,Folic acid, riboflavin,Pantothenic acid , Niacin,vitamin C , Fat soluble vitamins A, D, E ,K. Lipids: Defination, and classification , structure, and significance of phospholipids essencial and non essencial fatty acids, biological value of lipids, analysis of fat, acid value, saponification value,Iodine value,types of lipoproteins, changes in LP profile in various disease condition, Phospholipids , Sphingolipids, Cholesterol, Cardiolipin, Rancidity, Antioxidants Carbohydrate metabolism: Glycolysis (aerobic and anaerobic) , TCA cycle, gluconeogenesis, glycogenolysis, glycogenesis, pentose phosphate pathway, insulin, structure of insulin, biosynthesis of insulin, mechanism of action of insulin, study of insulin receptor Section II Boienergetics: energy flow in biological system, ATP cycle, Biological oxidation: ETC, oxidative phosphorylation, mechanism of oxidative phosphorylation viz. chemical coupling conformational coupling Chemoiosmotic coupling hypothrsis, Inhibitors of oxidative phosphorylation including uncoupling in brown adipose tissue,High energy compounds.ATP synthesis, and ATP synthetase complex. Protein metabolism: Integration of protein metabolism with glycolysis transamination, oxidative deamination,non oxidative deaminatin, urea cycle , glucogenic amino acids,ketogenic amino acids, catabolism of individual amino acids, Synthesis of physiologically important substances from amino acids (neurotransmitters, hormones) Lipid Metabolism: B- oxidation, oxidation of fatty acids, biosynthesis of fatty acids, study of lipoproteins, and their role in lipid metabolism, Different types of lipopriteins , changes in lipoproteins profile in various disease conditation, Cholesterol biosynthesis,Formation of keton bodies,Lipases,Biosynthesis of unsaturated fatty acids,Prostaglandins their biochemical role and biosynthesis. Genetics: Structure of DNA and its role as a genetic material, experimental evidences indicating DNA as a genetic material, Watson and Crick model for DNA structure, physiochemical properties of DNA , flow of informationreplication, reverse transcription, translation, (Drugs acting at various levels) Mutation and DNA repair , Control of gene expression , Lac operon. 02 Hours

02

04

06

06

08

08

8 9

02 02

10

08

11

08

12

04

Total no of lectures

60

P113 Biochemistry (Practical) Sr.No. 1 2 TOPIC Qualitative tests for carbohydrates. ** Qualitative tests for proteins. ** A. precipitation reaction. B .color reactions. Quantitative estimation of carbohydrate by follin Wu method ** Quantitative estimation of glucose in urine by Benedict method ** Standardization of glass ware, study of biological variation, sources of errors. * Expression of concentration such as normality, molality, morality, percent, gms/litre etc. * Preparation of normal (N) solution, percent solution v/v and w/v. * Titration to find out acidity of gastric juice by titrating it against potassium hydroxide or sodium hydroxide. * Identification of unknown substance of biomedical importance. * Identification of given fat sample. * A study of activity of enzyme salivary amylase. * Determination of ascorbic acid using dye 2, 6 dichlorophenol indophenol. * Determination of acid value of given fat sample. * Electrophoresis, paper electrophoresis of serum protein. (demonstration) * Care and use of pH meter constrict titration curve for amino acid alanine. * Separation of amino acid by paper chromatography.(Demonstration) * Separation of lipids by thin layer chromatography.(Demonstration) * Isolation of DNA * ** Indicate major experiments

3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

* Indicate minor experiments Books Recommended: 1. Harpers review of biochemistry Martin

2. Text book of biochemistry D. Satyanarayan 3. Tex book of Clinical Chemistry Alex Kaplan & Laverve L. Szabo 4. Principles of biochemistry Lehninger 5. Text book of biochemistry Ramarao 6. Practical Biochemistry David T. Plummer 7. Practical Biochemistry Pattabhiraman Scheme for practical Examination Sr.No. 1 2 3 4 6 Head Synopsis Major experiment Minor experiment Viva Journal & Attendance Total Duration Sessional 05 07 04 04 10 30 03 Hrs Annual 10 35 15 10 70 4 Hrs

Sr. No.

T114 Human Anatomy & Physiology (3hrs/Week) Chapter The topics which were covered up to 10 + 2 should be covered with more details as given in books recommended to increase the depth. Section-I Scope of Anatomy and Physiology, basic terminologies used in this subject (Description of the body using planes and terminologies) Structure of cell-Its components and their functions (details). Process of cell division and protein synthesis Elementary tissues of the human body :epithelial, connective, muscular and nervous tissuestheir sub-types and characteristics Homeostasis Various mechanisms to maintain homeostasis a)Osseous system - structure, composition and functions of the skeleton b)Classification of joints, Types of movements of joints and c)disorders of joints (definitions only) (a) :To be done in practical classes-6 hrs Haemopoietic System a) Composition and functions of blood and Blood components b) Haemopoiesis c) Blood groups d) Haemostasis-Clotting factors and mechanism Lymph a) Lymph and lymphatic system composition, Formation, and circulation b) Spleen : Physiology and Function Endocrine System ( introduction) a) Pituitary gland b) Adrenal gland c) Thyroid and parathyroid glands d) Pancreas and gonads Section-II Nervous System Neuron, Histology and Physiology, Neuronal Circuits. a) Definition and classification of nervous system b) Functional areas and functions of cerebrum c) Cerebellum d) Pons and medulla e) Thalamus and Hypothalamus f) Basal ganglion g) Spinal cord: Structure and functions- reflexes- Mono-Poly-Plantar h) Cranial Nerves- Names and functions, CSF formation and functions Blood Brain Barrier. ANS-Anatomy and functions of sympathetic and parasympathetic N.S. Cardio vascular system a) Anatomy of heart a) Blood vessels and circulation b) Pulmonary, coronary & systemic circulation c) Conduction and ECG d) Cardiac cycle and Heart Sounds f) Blood Pressure , maintenance and regulation

No of Hrs

1 2 3 4 5

01 02 02 02 01

02 01 01 02 02 01 01 01 01 01 02

02 01 02 01 01 02 01 02 02 01 02

10

01 02 01 01 01 01

Books Recommended: 1) Guyton & Hall. Textbook of medical physiology, Elsevier. New Delhi, 2000 10th edition. 2) Vander, Sherman, Luciano. Human Physiology. Mc-Graw Hill Publication New Delhi 1998 7th edition. 3) Tortora G.J. Principles of anatomy & physiology. Harper Collins College Publishers, New York 1996 8th edition. 4) Chatterjee C.C. Human Physiology. Medical allied agency. Kolkata 2003 11th Edition. 5) Ross and Wilson. Anatomy and Physiology in health and illness. Churchill Livingstone 2001. 9th edition. 6) AB Mc Naught and Callander R., Illustrated Physiology, B.I. Churchill Living Stone, New Delhi, 987. 1st edition. 7) Chaudhry Sujit K., Consise Medical Physiology, New Cenrtal Book Agency, Calcutta, 1993. 2nd edition 8) Douglas E., Kelly, Richard Wood and Allen C. Enders, Bailey`s TextBook of Microscopic Anatomy, Williams and Wilkins publishers, London, 1984. 18th Edition

09) Elaine N. Marieb, Human Anatomy and Physiology, Addison Wesley, New York, 1997 4th edition. 10) Inderbir Singh, Text Book of Human Histology with Colour Atlas, Jaypee Brothers, New Delhi, 2002. 4th edition.

P114 Human Anatomy & Physiology (Practical) 1. Study of Microscope# 2. Determination of ESR* 3. Determination of R.B.C. content of blood* 4. Determination of W.B.C. content of blood* 5. Determination of differential count of blood* 6. Determination of hemoglobin content of blood ** 7. Determination of blood groups** 8. Determination of blood pressure** 9. Determination of bleeding time and clotting time** 10. Study of various systems using Charts/ Models# 11. Study of histology using permanent slides # 12. Study of skeletal system# #-Experiments for preliminary knowledge and may be examined in form of identification/spotting * Indicate Minor Experiment ** Indicate Major Experiment

Books Recommended Books1. Ranade V.G., Pradhan S, Joshi P.N. Text Book of Practical Physiology. Pune Vidyapith Griha Prakashan, Pune, 1997 2. Mukherjee K.L. Medical Laboratory Technology. Tata McGraw Hill. New Delhi,1999 4th edition (Vol.I,II,III) 3. Bharihoke V. Text book of Histology .A.I.T.B.S Publication. 2005, 2nd edition Scheme for practical Examination Sessional 04 04 07 03 02 10 30 03 Hrs

SR.NO 1 2 3 4 5 6

Head Spotting / identification Synopsis Major experiment Minor experiment Viva Journal & Attendance Total Duration

Annual 10 10 30 15 10 70 4 Hrs

10

T115 Hospital and Community Pharmacy Duration: 3Hrs/week Section -I TOPICS 1) Hospitals- Classification, functions, Organization administration governing body and management, medical staff, clinical departments, support service, dietetic service, nursing service, medical records department, pathology service, Blood bank, radiology, medical social service departments, anesthesia service, Central service department, Hospital contractual relations, contract management, Health maintenance Organization. 2) Hospital Pharmacy: History and Development 3) Duties and Responsibilities of Hospital Pharmacist 4) Pharmacy and Therapeutic Committee: Purpose of committee, committee name, membership, frequency of meeting, the committee agenda, functions of the committee, Generic vs. brand named drugs, Evaluation of drugs, Recommended reference materials, recommendations, committees role in the adverse drug reaction program, Drug experience reporting, Automatic stop order for dangerous drugs, committees role in developing emergency drug list. 5) Hospital Formulary: Format and appearance of the formulary, distribution of the formulary, keeping the formulary current, use of non-formulary drugs, (PPI),the legal basis of the formulary system, Anti substitution laws and the formulary, preparation of the formulary, formulary vs. Drug catalogue or list, selection of guiding for admission or deletion of drug , conteins , prescription writing ,format, size , loose leaf vs. bound , publication , formulary drug listing service formulary drug listing service preparation , categorizing and indexing , sample pharmacologic index , text, specialty formularies. 6) Organization and Personnel: Pharmacy specialist , drug information specialists, pharmacy education, job Descriptions, Determining the departmental staffsprofessional , departmental staffs-lay personal, ofessional service s Rendered, Charting of pharmacy organization, personal in organized health care setting , control of personnel , Hiring of pharmacists , women in pharmacy, Salaries, Section II 7) Purchasing procedure and Inventory control: Procurement: Drug selection , purchasing authority, responsibility and control , role of purchasing agent in drug procurement , role of pharmacist in drug procurement, purchasing procedure , control on purchases, quality of drug , Discounts , central storage vs. pharmacy storage , storeroom arrangement , shelf stripping and floor- marking , marking of merchandise, control of dated or perishable inventory , taking of physical inventory , the perpetual inventory , material management. 8) Dispensing of Controlled Substances: Comprehensive Drug abuse prevention and control Act of 1970, authority of control , schedules for controlled substances, Registration Requirements , registration Exemption for hospital house staff, separate registration for independent activities, separate registrations for separate location , exemption of agent and employees, Times for application for registration , expiration of registration , application forms , modification in registration , inventory requirements, perceptions ,offenses and penalties, labeling and packaging requirements, model sets of hospital controlled sustenances regulations, Miscellaneous regulations , control of narcotics by nurses , narcotics delivery to nursing station , protocol for reporting drug abuse or diversion , other systems, specials uses. 9) Techniques in radio pharmacy and clinical applications of radiopharmaceuticals: Introduction to particulate radiation, half life, therapeutic and diagnostic radiopharmaceuticals, facilities required, protection of operators, preparation of radiopharmaceuticals kits. 10) Use of Computers in Hospital: Terminology, program criteria, managing computers systems development ASHP technical assistant bulletin on hospital Drug Distrubition and control, Impact of the computer on dispensing time, model computer regulations. 11) Pharmacist and community pharmacy 12) Community health care concepts, levels and systems. Health policy, health team, health promotion, education and rehabilation, public health. 13) Health program in India:- National health programs- AIDS, Tuberculosis and child health. 14) Practice of patient education and counseling:- Objectives, methods, qualities for successful counseling, barriers and outcome of patient counseling, barriers and outcome of patient counseling, medical compliance and patient information leafletscontent, design and layouts, advisory labels. Total no. of lectures otal Hrs: Books Recommended: Merchant & Qadry , Text book of Hospital Pharmacy - (B.S. Shah Prakashan) Hassan , Hospital Pharmacy (Lea and Febiger)

Hrs. 04

01 02 05

05

05

03

04

02

02 01 03 03 04

22 45

11

Parmar N S, Health education and Community Pharmacy WHO consultative group report Robin J Harman, Hand book of Pharmacy (The Pharmaceutical Press) Winfield, Richards-- Pharmaceutical Practice

12

T121-Pharmaceutics-I (Theory) (3Hrs/week) Section- I TOPICS 1) Introduction to pharmaceutics and its scope: 2) History of pharmacy: Historical background and development of profession of pharmacy and pharmaceutical industry in India. Introduction to pharmacopoeias (IP, BP,USP,BPC and NF of India , Extra Pharmacopoeia and European Pharmacopoeia. 3) Definition of drug and development of new drug 4) Pharmaceutical Excipients: Organoleptic additives, Preservatives, Antioxidants. 5) Introduction to Pharmaceutical Equipments used for solid dosage forms 6) Introduction to Routes of Administration, dosage forms and their classification :a) Reasons to develop dosage forms, preformulation and formulation development: Physicochemical properties of drugs substances, Formulation development based on different aspects including physicochemical studies, therapeutic, biopharmaceutical and technical aspect, patient acceptance 7) Powders and granules: Formulation, preparation and evaluation of various powders and granules. Products like dusting powder, oral dehydration powder, dry syrup formulation, talcum powder, tooth powder. 8) Solutions: Factors affecting rate of solution, Formulation, Manufacturing process and equipments, Packaging (Glass and plastic containers), Quality control standards (Viscosity determination, weight per ml and specific gravity. Formulation aspects of syrups, elixirs, linctuses, aromatic waters, ENT Preparations and paints, mouthwashes. Equipment used in the production of powders and granules. Section-II 9) Filtration and clarification: Factors affecting rate of filtration, filter media, filter aid : Nutsch filter, plate and frame filter, sparkle, leaf filter, rotary vacuums filter. Equipment used for manufacturing and packaging of liquids: bottle washing and machine filling equipment, belt conveyer cartooning and batch numbering, hydroextractors (basket centrifuge) 10) Size reduction: Importance in pharmacy, factors influencing size reduction grinding mills of various types like hammer mill, multimill, conico cylindrical, ball mill, edge and end runner mill, fluid energy mill. 11) Size separation : Sieves, sifting, size gradation, size distribution- methods of determining size distribution 12) Powder mixing: Mechanism of mixing, various types of trough mixers, sigma and ribbon blenders, paddle mixers, tumblers like cube and double cone. Planetary mixer 13) Unit processes and equipment used for manufacturing of non sterile monophasic liquids, mechanism of liquid mixing, impellers, propeller type mexers, tanks baffles, pravantion of aeration and foam Total Hours: Books Recommended: 1. Lachmann- Libermann & Kanig- Industrial pharmacy (Lea & Febiger) 2. Ansel- Popovich & Allen-(Willams and Wilkins) Pharmaceutical dosage and drug delivery systems3. Dittert , American pharmacy- (J.B. Lipincott) 4. Alfonso R. Gennaro ,Remington: The science and practice of pharmacy- (Mack publishing Co.) 5. Rawlins , Bentleys Text Book of Pharmaceutics- (ELBS) 6. Banker and Rhodes- Modern pharmaceutics-(Dekker) 7. Groves- Parental products-(William Heinemann Medical Books Ltd.) 8. Hanlon- Hand Book of Package Engg.(McGraw Hill) 9. David Gaderton- Unit processes in pharmacy(William Heinemann) 10. Cooper and Gunn. Tutorial Pharmacy- 5th edition 11. Leon Shargel- Pharmacy review (John Wiley and sons) 12. Swarbrick and Boylon: Encyclopedia of pharmaceutical technology (Dekker) Vol 1-3. 13. James J. Wells- Pharmaceutical preformulation (Ellis Horwood Ltd.) Hrs. 01 03 01 03 03 04

03

05

07

04 04 04 03

45

13

P121-Pharmaceutics-I (Practicals) (3hrs/week) A) Solutions: 1. Aqueous iodine solution (Lugol I.P.) * 2. Tincture of iodine I.P. * 3. Magnesium citrate solution N.F.* * 4. Cresol with soap I.P. * 5. Surgical chlorinated soda solution B.P.C* 6. Paracetamol pediatrics solubilized drops** B) Aromatic waters: 1. Conc. Dill water B.P*. 2. Dill water* 3. Conc. Anise water B.P.C* 4. Chloroform water* 5. Gripe water** C) Glycerites: * 1. Glycerine of Boric acid I.P. 2. Tannic acid Glycerine I.P. 3. Glycerine of starch I.P. D) Syrups: * 1. Simple syrups I.P. 2. Artificial syrup 3. Cough syrup 4. Flavoured syrup E) Elixir: ** 1. Piperazine citrate elixir B.P.C F) Linctus: * 1. Simple linctus B.P.C G) Ear and nose preparation** 1. Chloramphenicol ear drop OR Gentamycin ear drop 2. Nasal drop Paint** 1. Mandles paint B.P.C H) Powders: 1. Oral rehydration powder * 4. Dry syrup* 2. Talcum powder * 5. Effervescent granules** 3. Tooth power * Indicate minar experiments Books Recommended: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Ansel, Introduction to pharmaceutical dosage forms (Lea and Febiger) Dittert, Sprouls American Pharmacy (J.B.Lipincott) Martin, Remington's Pharmaceutical Sciences. (Mack) Harkishan Singh, Pharmacopeias and Formularies, Vallabh Prakashan Delhi) M.L. Shroff General Pharmacy Series Mittal, Pharmaceutical Formulations Lachman, Industrial Pharmacy (Lea & Febiger) I.P., B.P., B.P.C., U.S.P. Aulton, Pharmaceutics Winfield, Richards, Pharmaceutical Practice Scheme for practical Examination Sr.No. 1 2 3 4 6 Head Synopsis Major experiment Minor experiment Viva Journal & Attendance Total Duration Sessional 05 07 04 04 10 30 03 Hrs Annual 10 35 15 10 70 4 Hrs ** Indicate Major experiments

14

T122 Pharmacognosy-I Theory (3 Hrs / Weekly) Section I

Sr.No. 1. Topic General Pharmacognosy: Definition, History and Scope of Pharmacognosy Indian & International trade in Medicinal & Aromatic plants. 2. Drugs of Natural Origin Sources of drugs:Vegetable, animal, marine, mineral & plant tissue Scheme for Pharmacognostic study of crude drugs. Systems of Classification of crude drugs. Alphabetical, morphological, pharmacological, chemical, taxonomical and geographical 3. Study of plant cell and tissue structure. A) Study of cells, tissues, cell wall, & cell inclusions. B) General morphological & microscopical characteristics of plant parts with examples. a. b. c. d. e. f. g. h. Leaves Barks Woods Stems Flowers Fruits Seeds Substerian drugs 8 6 Hrs. 3

4.

Quality Control of crude drugs: WHO guidelines for quality control of crude drugs.

Section II 5 Detailed study of Cultivation, collection, processing and storage of crude drugs. Detailed study of methods of cultivation, Merits and demerits of cultivation. Exogenous and endogenous factors affecting cultivation , quality of crude drugs & Collection and processing (Garbling, drying, preservation & storage, sterilization & preparation for market) Study of following drugs with respect to cultivation, collection, & preparation aspects Turmeric, Isapghula. 6

4 7 Study of Mineral Drugs (Source, Chemistry, Uses, & Pharmacology): Bentonite, Kaolin, Shilajit, fullers earth, Calamine , Talc, coral . 3 8 Adulteration: Definition, Types, determination of adulterants by Organoleptic, Microscopic, Physical, Chemical, & Instrumental

15

P122 Pharmacognosy-I Practical (3 Hrs / Week) 1. Study of simple microscope, compound microscope, Camera Lucida, microtome and digital photographic microscope. 2. Morphological and histological study of different parts of plant mentioned under: Chapter three**(Minimum 4 practicals) 3. Quantitative microscopy: **(Minimum 4 practicals) 4. Measurement of starch grains*, calcium oxalate crystals *and phloem fibers* in powdered crude drugs. 5. Determination of stomatal number and stomatal index of leaf drugs. ** 6. Determination of vein islet and veinlet termination number of leaf drugs. ** 7. Determination of palisade cell ratio of leaf drugs. ** 8. Determination of moisture content*, ash value*, extractive value*, foreign organic matter and swelling index of crude drugs. (Minimum 2 practical) * Indicate minar experiments ** Indicate Major experiments

Books Recommended:
1. Kokate C. K. Purohit A. P. and Gokhale S. B. , Pharmacognosy (degree ) Nirali Prakashan 2. Kokate C. K. Practical Pharmacognosy, Vallabh Prakashan, Delhi. 3. Atal C. K. and Kapur B. M. Cultivation and utilization of Medicinal plants, RRL, Jammu. 4. Brain K. R. and Turner T. D., The practical Evaluation of phytopharmaceuticals 5. Khandelwal KR, Practical Pharmacognosy, Nirali Prakashan Pune. 6. Chandha K.L. and Gupta R. Advances in Horticulture Vol II- medicinal and aromatic plants, 7. Chopra R. N., Nayar S. L. and Chopra I. C., Glossary of Indian Medicinal plants CSIR, New Delhi. 8. Fahn A, Plant anatomy, 3rd Ed. Pergamon press, Oxford. 9. Iyengar M.A., Study of Crude Drugs, Manipal Power Press, Manipal. 10. Iyengar M.A. , Pharmacognosy Lab Manual. Manipal Power Press, Manipal. 11. Medicinal Plants of India, Zafar R., C.B.S. Publisher, New Delhi. 12. Swain T., Chemical Plant Taxonomy, Academic Press London. 13. Swain T., Comparative Phytochemistry, Academic Press London. 14. The Wealth of India, Raw Marerials (All Volumes), Council of Scientific and Industrial Research, 15. Trease, G.E. and Evans, W.C. Pharmacognosy, 12th Edition, Bailliere Tindall, Eastbourne, U.K. 16. Wallis, T.E. Analytical Microscopy, J.A. Churchill Limited, London. 17. Wallis, T.E. Textbook of Pharmacognosy, J.A. Churchill Limited, London. 18. Whistler R.L., Industrial Gums, Polysaccharides and their derivatives, 2nd Edition,Academic Press, 19. Tyler, V.E., Brady, R., Pharmacognosy 20. Wagner, S.B., Zgainsky, Plant drug Analysis. 21. A.C.Dutta, A Class Book of Botany. 22. V.D.Rangari, Pharmacognosy and Phytochemistry, Volume I & II Scheme of practial examination Sr.No. 1 2 3 4 5 6 Head Spotting / identification Synopsis Major experiment Minor experiment Viva Journal & Attendance Total Marks Duration Sessional 04 04 07 03 02 10 30 03 Hrs Annual 10 10 30 10 10 70 4 Hrs

16

Sr.No. 1

Hours Introduction: Significance of quantitative analysis in quality control, different techniques of analysis, 04 preliminaries and definitions, types of errors, Selection of sample, precision and accuracy. Fundamentals of volumetric analysis, methods of expressing concentrations, primary and secondary standards. Calculation of equivalent weight and Stochiometry. Aqueous Acid-Base titrations: 05 Law of mass action, hydrolysis of salts, neutralization curves, Theory of indicators, choice of indicators, mixed indicator. Applications in assay of Benzoic acid, Boric acid, Aspirin. Non-Aqueous titrations: 03 Types of solvents, end point detection, Application in assay of Sodium acetate, Sodium benzoate, Norfloxacin tablet. Oxidation-Reduction titrations: Theory of redox titration, measurement of electrode potential. Oxidation-reduction curves, redox Indicators. Titrations involving potassium permanganate, potassium dichromate, potassium bromate, potassium iodate, cerium (IV) sulfate, Iodine (Iodimetry and Iodometry), titanous chloride. Applications in assay of Ferrous sulfate, Ascorbic acid, Isoniazide, Hydrogen peroxide. Total no. of lectures Complexometric titrations: Theory, formation of complex and its stability, titration curves, Metallochrome indicators (no structures), types of EDTA titrations. Application in assay of Magnesium sulfate, Lead nitrate and calcium gluconate. Argentometric titrations: Theory, factors affecting solubility of a precipitate, titration methods Mohrs, Volhards, Gay lussac, and Fajans method, indicators. Applications in assay of Potassium chloride, Sodium chloride and Ammonium chloride. Miscellaneous methods of analysis: Diazotization titrations, Kjeldahls method of nitrogen determination And Oxygen flask combustion method.

T123 PHARMACEUTICAL ANALYSIS I Duration: 3hrs/week SECTION I Topic

07

20 05

04

03

Gravimetric analysis: 06 Precipitation techniques, solubility products, colloidal state, supersaturation, coprecipitation, post precipitation, digestion, filtration, ignition, weighing and calculation. Application in assay of Alum by oximereagent, Calcium as calcium oxalate and magnesium as magnesium pyrophosphate. Total no. of lectures 18

17

P123 Pharmaceutical Analysis I (Practical) Duration: 3hrs /week Sr.No. Practical InstructionThe students should have a clear understanding of the principal and working of a typical analytical balance, the precautions to be taken during handaling of analytical balance, methods of weighing and erroe of weighing. The students should also be acquainted with use of appropriate apparatus for various analytical procedures. Calibration of analytical weights and of volumetric apparatus like volumetric falsk , pipette, burette etc.* Acid Base Titrations: Preparation and standardization of acids (HCl, H2SO4) Bases ( NaOH) . Assays involving Direct and Back titrations. Benzoic acid, Boric acid, Aspirin.** Non aqueous Titrations: Preparation and standardization of perchloric acid and sodium/ potassium/ lithium methoxide solutions* Assays of amines or amine hydrochlorides, sodium acetate, norfloxacin tablet. ** Oxidation reduction Titrations: Preparation and standardization of redox titrants such as potassium permanganate, Ceric ammonium sulphate , potassium dichromate , iodine , sodium thiosulfate etc.* Assays of oxalic acis/ hydrogen peroxide, Ferrous ammonium gluconate, Ascorbic acid/ Analgin ** Precipitation Titration: Preparation and standardization of tityrants like Silver nitrate, ammonium thiocyanate.* Assay of Sodium chloride, potassium chloride, Ammonium chloride. ** Complexometric Titrations: Preparation and standardization of EDTA solution.* Assay of magnesium sulfate, lead nitrate, calcium gluconate, Hardness of water** Gravimetric Analysis: Determination of Alum by oxime reagent, Sulphate as abrium sulphate/ Ni as Ni DMG complex. ** Miscellaneous methods : Nitrogen determination by Kjeldahl method Sodium nitrite titration. (Demonstration) ** Indicate Major experiments

1. 2. 3.

4.

6. 7. 8.

*Indicate Minor experiments Books Recommended: 1. IP, USP,BP, European Pharmacopoeia, International pharmacopoeia 2. Pharmaceutical analysis-Higuchi and brochmann 3. The quantitative analysis of drugs- Garrat 4. Analytical chemistry- MEITES H.B. 5. Analytical chemistry- garry Chrisian 6. Principles of instrumental analysis- Skoog 7. Vogel textbook of quantitative chemical analysis 8. Textbook of Pharmaceutical analysis- K.A. Connors 9. Guide for safety in chemical laboratory- Van Nostrand Reinhold co. 10. Practical Pharmaceutical Chemistry Part-I - Beckett and Stenlake Scheme for practical Examination Sr.No. 1 2 3 4 5 Head Synopsis Major experiment Minor experiment Viva Journal & Attendance Total Duration

Sessional 05 07 04 04 10 30 03 Hrs

Annual 10 35 15 10 70 4 Hrs

18

Sr. No. 1

T124 Pharmaceutical Organic ChemistryI (Theory) 4 h/week SECTION I Name of the Chapter Introduction to Organic Chemistry: Importance and properties of carbon. Hybridization of elements Concepts of structural theory; types of bonding(ionic, covalent, co-ordinate, non-bonded electrons); Hydrogen bonding; Van der Waals forces; Bond length; Bond strengths; Dipole moment and polarity Fundamentals as Molecular formula, Molecular weight, Empirical formula Introduction, Classification, Structure and Nomenclature (general and IUPAC) of Organic Compounds of the Following Classes: Hydrocarbons (Aliphatic; saturated and unsaturated, Aromatic), Alkyl and Aryl halides, Alcohols, Aldehydes and Ketones, Ethers and Epoxides, Carboxylic acids and their functional derivatives, Amines, Phenols, Conjugated dienes, Heterocyclics: a) One Hetero atom Five membered: Pyrrole, Furan and Thiophene, b) One Hetero atom Six memberd: Pyridine, Pyrimidine, Pyran, c) Two Hetero atoms Five membered: Imidazole, Oxazole, Thiazole, Isoxazole, Isothiazole, d) Two Hetero atoms Six membered: Pyrazine, Oxazine e) Benzo-fused Heterocyclics- Indole, Benzoxazole, Carbazole, Benzimidazole, Benzopyran, Benzodiazepine, Quinoline, Isoquinoline, Polynuclear Aromatic Hydrocarbons: Naphthalene, Anthracene, Indanone, Phenanthrene and Dibenzocycloheptene, Biomolecules I: Carbohydrates, Fats & Lipids, Amino acids, Proteins, Steroids (Estrones, Androstanes, Pregnanes and Sterols) SECTION II Correlation of physical properties like physical states, physical constants, solubility etc. with respective structures of above mentioned classes compounds Introduction to Stereochemistry: Isomerism, Stereoisomerism, Geometric isomerism, Saw-Horse, Fischers and Newmanns projections of molecules, Optical activity, Specific rotation, Enantiomers, Diastereomers, Racemic modifications, Conformational isomerism, Meso-compounds, elements of symmetry, chirality, chiral centres, Nomenclature in stereoisomerism(configurations: R & S, Z & E, D & L), Sequence Rules Total on. Of Lectures

Allotted number of Lectures 3

2a

12

2b

06

08

16

45

Books Recommended 1. Organic Chemistry by I.L. Finar vol. I and II ELBS / Longman, London 2. Organic synthesis by Gilman and Blatt Collective vol 3 3. Stereochemistry of carbon compounds by E.L. Eliel Mc. Graw Hill Book Co, Inc. New York. 4. Advanced organic chemistry by Bahl and Bahl 5. Organic chemistry by T.R. Morrison and R. Boyd, Prentice Hall of India Pvt. Ltd. New Delhi 6. Organic chemistry by Hendrickson, Cram and Hammond. 7. Frontier orbitals and organic chemistry by lan Flaming. 8. Principles of organics synthesis by R.O.C. Norman 9. Introduction to organic chemistry By Streitweiser and Health Cook 10. Reaction mechanisms in organic chemistry by Mukherjee and Singh.

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P124 Pharmaceutical Organic Chemistry I (Practical) 3 h/Week 1) Introduction to the laboratory chemicals and apparatus, commonly used in chemistry laboratories.* 2) Preparation, transfer & storage of chromic acid mixture.* 3) Determination of physical constants of few organic compounds (both solid and liquid) and calibration of thermometer.** 4) Study of physical properties of organic compounds in correlation with their structures. Compounds containing following functional classes to be considered** Aliphatic & aromatic carboxylic acid. Aliphatic & aromatic amines. Aliphatic & aromatic aldehydes & ketones Aliphatic & aromatic amides. Phenols Aromatic hydrocarbons Carbohydrates 2) Introduction to the use of stereomodels with following examples** Lactic acid Tartaric acid cis alkene Ephedrine Trans alkene Mesotartaric acid Inversion of configuration *Indicate Minor experiments ** Indicate Major experiments NOTE: Minimum 14 experiments should be covered I) Books Recommended 1. Elementary practical organic chemistry A.I.Vogel, ELBS and Longman Group Ltd. London. 2. Practical organic chemistry Mann and Sounders, ELBS and Longman Group Ltd. London. 3. Introduction to organic laboratory techniques D.L. Pavia G. Lampman and G.D. kriz. Examination Scheme: Sr.No. 1 2 3 Type of questions Synopsis Viva-voce Experiment : Major Minor : Journal marks Total marks Sessional 5 5 10 10 30 University examination 10 10 30 20 -----70

20

T125

PHARMACEUTICAL INORGANIC CHEMISTRY-II (4 Hrs/Week)

1 2

4 5 6 6

Section II Topical Agents Protective, astringents, Anti-infective Gases & Vapors Oxygen, Anesthetics Respiratory stimulants. Dental Products Dentifrices Anticarries agent Theoretical Principals of Qualitative analysis Section II Complexing & Chelating agents other antidotes Radiopharmaceuticals and contrast media: Radiopharmaceuticals, Radiopharmaceutical preparation, Radiopaque contrast media Miscellaneous : Environmental Sciences Water, Types Use of water in Pharmaceuticals as solvents, Water pollution & Purification techniques Industrial water wastes & pollutants Sclerosing agents, Expectorants, Emetics, Antioxidants. Total no. of lectures

08 04

04

07 04 08 10

45

Books Recommended: 1. Vogels Textbooks of qualitative Inorganic Analysis By Denny, Jeffery. 2. Practical Pharmaceutical inorganic chemistry, By Beckett & Stenlake. 3. Inorganic Medicinal & Pharmaceutical Chemistry By Block & Roche. 4. Text book of Pharmaceutical Chemistry, By Chatten L.G.(Dekker series) 5. Textbook of Pharmaceutical analysis By Connors K.A. 6. Text book of Pharmaceutical Analysis By Dr. H. N. More 7. Indian Pharmacopoeia 8. British Pharmacopoeia 9. Remingtons Pharmaceutical Sciences.

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T126 Human Anatomy, Physiology and Health Education 45 Hours (3hrs/Week) Sr. No. Chapter The topics which were covered up to 10+2 shuld be covered with more dtails as given in books recommended to increase the depth. Section-I Urinary System a) Parts of the Urinary System and Gross structure of the kidney b) Structure of Nephron c) Physiology of Urine Formation and Micturition d) Renin Angiotensin System Juxtra- Glomerular apparatuse) Maintenance of Acid-Base balance Respiratory System a) Anatomy of respiratory organs and functions b) Mechanism and regulation of respiration c) Physiology of respiration: Transport of respiratory gases d) Respiratory volumes and vital capacity e) Neural and chemical regulation of respiration O2 and CO2 carriage and hypoxia f) Definitions of Hypoxia, Asphyxia , Dysbarism, Oxygen Therapy and resuscitation Digestive System a) Anatomy of Gastro intestinal Tract(GIT) b) Anatomy, Secretions and functions of-Salivary glands, Stomach, Liver, Pancreas, Intestine c) Digestion and absorption Section-II Reproductive System a) Male and female reproductive systems b) Their hormones- Physiological role c) Physiology of menstruation, ovarian cycle d) Spermatogenesis e) Sex determination(genetic basis) f) Pregnancy and its maintenance and parturition g) Contraception and Contraceptive devices Sense Organs a) Eye b) Ear-Hearing and Equillibrium c) Skin d) Taste and smell Skeletal muscles a) Histology b) Physiology of muscle contraction c) Physiological properties of skeletal muscle Fluid & electrolyte balance Health Education- Health Programme in India, Demography and Family Planning, Nutrition and Health, Occupational Health, Mental Health, Health Education, Health Planning and Management, communicable and non communicable diseases. No of Hrs

07

08

07

07

05

03 03 05

7 8

Books Recommended: 1) Guyton & Hall. Textbook of medical physiology, Elsevier. New Delhi, 2000 10th edition. 2) Vander, Sherman, Luciano. Human Physiology. Mc-Graw Hill Publication New Delhi 1998 7th edition. 3) Tortora G.J. Principles of anatomy & physiology. Harper Collins College Publishers, New York 1996 8th edition. 4) Chatterjee C.C. Human Physiology. Medical allied agency. Kolkata 2003 11th Edition. 5) Ross and Wilson. Anatomy and Physiology in health and illness. Churchill Livingstone 2001. 9th edition. 6) AB Mc Naught and Callander R., Illustrated Physiology, B.I. Churchill Living Stone, New Delhi, 987. 1st edition. 7) Chaudhry Sujit K., Consise Medical Physiology, New Cenrtal Book Agency, Calcutta, 1993. 2nd edition 8) Douglas E., Kelly, Richard Wood and Allen C. Enders, Bailey`s TextBook of Microscopic Anatomy, Williams and Wilkins publishers, London, 1984. 18th Edition 9) Elaine N. Marieb, Human Anatomy and Physiology, Addison Wesley, New York, 1997 4th edition. 10) Inderbir Singh, Text Book of Human Histology with Colour Atlas, Jaypee Brothers, New Delhi, , 2002. 4th edition. 11) Park J.E. and Park K., Preventive and Social Medicine, Banarasidas Bhanot, India, 1991. 13th edition

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