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PATHOPHSIOLOGY OF MALIGNANT PLEURAL EFFUSION Predisposing Factors: Age Late Adulthood Lifestyle Smoker for 20 years 3 sticks/day Precipitating

ng Factor: HISTORY OF BREAST CANCER CANCER CELLS METASTIZ E

Enters lymphatic system

Enters bloodstream

Settles @ parietal lymphatic vessel of pleura


CANCER CELLS ACCUMULAT E AND PROLIFERAT E

Travels along internal mammary arteries that branches to parietal circulatory system of pleura and settles in

Occlusion of stoma on the parietal pleura increases oncotic pressure

capillary permeability or vascular disruption

MALIGNANT PLEURAL EFFUSION

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