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Fluid compartments are separated by membranes that are freely permeable to water. Movement of fluids due to: hydrostatic pressure osmotic pressure\ Capillary filtration (hydrostatic) pressure Capillary colloid osmotic pressure Interstitial hydrostatic pressure Tissue colloid osmotic pressure
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Balance
Fluid and electrolyte homeostasis is maintained in the body Neutral balance: input = output Positive balance: input > output Negative balance: input < output
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Non-electrolytes - Uncharged
Proteins, urea, glucose, O2, CO2
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Body fluids are: Electrically neutral Osmotically maintained Specific number of particles per volume of fluid
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MW (Molecular Weight) = sum of the weights of atoms in a molecule mEq (milliequivalents) = MW (in mg)/ valence mOsm (milliosmoles) = number of particles in a solution
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Movement of body fluids Where sodium goes, water follows. Diffusion movement of particles down a concentration gradient. Osmosis diffusion of water across a selectively permeable membrane Active transport movement of particles up a concentration gradient ; requires energy
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IVF ISF IVF happens constantly due to changes in fluid pressures and osmotic forces at the arterial and venous ends of capillaries
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Stimulate osmoreceptors in hypothalamus ADH released from posterior pituitary Increased thirst
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Result: increased water consumption increased water conservation Increased water in body, increased volume and decreased Na+ concentration
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Dysfunction or trauma can cause: Decreased amount of water in body Increased amount of Na+ in the body Increased blood osmolality Decreased circulating blood volume
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Edema is the accumulation of fluid within the interstitial spaces. Causes: increased hydrostatic pressure lowered plasma osmotic pressure increased capillary membrane permeability lymphatic channel obstruction
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Hydrostatic pressure increases due to: Venous obstruction: thrombophlebitis (inflammation of veins) hepatic obstruction tight clothing on extremities prolonged standing Salt or water retention congestive heart failure renal failure
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Decreased plasma osmotic pressure: plasma albumin (liver disease or protein malnutrition) plasma proteins lost in : glomerular diseases of kidney hemorrhage, burns, open wounds and cirrhosis of liver
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Fluid accumulation: increases distance for diffusion may impair blood flow = slower healing increased risk of infection pressure sores over bony prominences Psychological effects
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Water is trapped, unavailable for metabolic processes. Can result in dehydration and shock. (severe burns)
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Electrolyte balance
Na + (Sodium)
90 % of total ECF cations 136 -145 mEq / L Pairs with Cl- , HCO3- to neutralize charge Low in ICF Most important ion in regulating water balance Important in nerve and muscle function
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Regulation of Sodium
Renal tubule reabsorption affected by hormones: Aldosterone Renin/angiotensin Atrial Natriuretic Peptide (ANP)
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Potassium
Major intracellular cation ICF conc. = 150- 160 mEq/ L Resting membrane potential Regulates fluid, ion balance inside cell pH balance
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Regulation of Potassium
Through kidney Aldosterone Insulin
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Hypernatremia Due to: Hypertonic IV soln. Oversecretion of aldosterone Loss of pure water Long term sweating with chronic fever Respiratory infection water vapor loss Diabetes polyuria Insufficient intake of water (hypodipsia)
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Treatment of Hypernatremia
Lower serum Na+ Isotonic salt-free IV fluid Oral solutions preferable
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Hyponatremia
Overall decrease in Na+ in ECF Two types: depletional and dilutional Depletional Hyponatremia
Na+ loss: diuretics, chronic vomiting Chronic diarrhea Decreased aldosterone Decreased Na+ intake
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Dilutional Hyponatremia:
Renal dysfunction with intake of hypotonic fluids Excessive sweating increased thirst intake of excessive amounts of pure water Syndrome of Inappropriate ADH (SIADH) or oliguric renal failure, severe congestive heart failure, cirrhosis all lead to: Impaired renal excretion of water
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Muscle symptoms
Cramps, weakness, fatigue
Gastrointestinal symptoms
Nausea, vomiting, abdominal cramps, and diarrhea
Hypokalemia
Serum K+ < 3.5 mEq /L Beware if diabetic Insulin gets K+ into cell Ketoacidosis H+ replaces K+, which is lost in urine
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Causes of Hypokalemia
Decreased intake of K+ Increased K+ loss Chronic diuretics Acid/base imbalance Trauma and stress Increased aldosterone Redistribution between ICF and ECF
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Hyperkalemia
Serum K+ > 5.5 mEq / L Check for renal disease Massive cellular trauma Insulin deficiency Addisons disease Potassium sparing diuretics Decreased blood pH Exercise causes K+ to move out of cells
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Treatment of Hyperkalemia
If time, decrease intake and increase renal excretion Insulin + glucose Bicarbonate Ca++ counters effect on heart
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Calcium Imbalances
Most in ECF Regulated by: Parathyroid hormone Blood Ca++ by stimulating osteoclasts GI absorption and renal retention Calcitonin from the thyroid gland Promotes bone formation renal excretion
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Hypercalcemia
Results from:
Hyperparathyroidism Hypothyroid states Renal disease Excessive intake of vitamin D Milk-alkali syndrome Certain drugs Malignant tumors hypercalcemia of malignancy Tumor products promote bone breakdown Tumor growth in bone causing Ca++ release
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Hypercalcemia
Usually also see hypophosphatemia Effects:
Many nonspecific fatigue, weakness, lethargy Increases formation of kidney stones and pancreatic stones Muscle cramps Bradycardia, cardiac arrest Pain GI activity also common
Nausea, abdominal cramps Diarrhea / constipation
Metastatic calcification
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Hypocalcemia
Hyperactive neuromuscular reflexes and tetany differentiate it from hypercalcemia Convulsions in severe cases Caused by:
Renal failure Lack of vitamin D Suppression of parathyroid function Hypersecretion of calcitonin Malabsorption states Abnormal intestinal acidity and acid/ base bal. Widespread infection or peritoneal inflammation 56
Hypocalcemia
Diagnosis:
Chvosteks sign Trousseaus sign
Treatment
IV calcium for acute Oral calcium and vitamin D for chronic
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