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CHEM 002: G1
performed
10/26/06
Logan Hill
submitted
10/17/06
Hill 2
Introduction
This purpose of this lab is to test and compare the ability of a few common commercial
antacids to neutralize hydrochloric acid (stomach acid). The benefits of knowing this
information are multifold. Manufacturers interests are obvious: to sell a product, one must
always work to increase its effectiveness to the consumer. Regulating agencies like the FDA
look into the legitimacy and safety of commercially sold products like antacids. Finally, any
good consumer would like to be informed of the “bang for the buck” of the product they are
purchasing.
Using basic knowledge of chemical equations and stoichiometry, one can determine the
strength of a strong base (in this case, one of the antacids) by calculating the amount of strong
acid that the base neutralizes. In this lab, both forward (direct) and back (indirect) titration
methods are used to ascertain the strength of the antacid. Forward titration titrates the acid
directly into an aqueous solution of the antacid, using an indicator to signify the end point. Back
titration adds the antacid to an excess of acid then titrates a strong base into the acidic solution
until it is neutralized. The amount of acid neutralized by the antacid can then be determined by
subtracting the amount neutralized by the titrated base from the total amount of acid neutralized.
Safety is a substantial issue in this lab. Strong acids (hydrochloric acid) and bases
(sodium hydroxide) are very toxic if ingested and can cause severe burns upon contact with skin.
Proper attire (approved lab goggles, appropriate clothing, closed-toed shoes) should be worn at
all times. Products of the experimental reactions could be harmful to the environment, and thus
In addition to the dose effectiveness of each antacid in the study, the cost effectiveness
was also determined. This data is very important to the consumer sector. If an equivalent result
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can be safely achieved between a higher dosage of one antacid at an overall lower price than
another more powerful and expensive antacid, it is obviously more advantageous to the
consumer to purchase the cheaper product. Considering this, the cost effectiveness of the antacid
is more important than the per dose effectiveness, at least as far as the consumer is concerned.
Hill 4
Experimental Methods
Three different antacids were chosen for this experiment: Maalox, Rolaids, and Tums.
The neutralization capabilities of all three were evaluated using back titration. The Tums was
then analyzed again, this time using forward titration. The recommended dosage (1 tablet) for
each antacid was obtained and added to approximately 25 ml of hydrochloric acid in separate
Erlenmeyer flasks (the acid was added prior using a buret and the exact amount in each flask was
measured to .01 ml). The antacids were then dissolved in the acid with a combination of stirring
and heating. Upon complete reaction of the antacids, three drops of phenolphthalein were then
added to each flask. Each solution was individually titrated with sodium hydroxide until the first
sign of a slightly pink color change. The volume of sodium hydroxide added was recorded as the
For the forward titration of the Tums, a Tums tablet was first added to approximately 50
ml of water in an Erlenmeyer flask, then dissolved with the help of heat and stirring. Fifteen to
twenty drops of bromcresol green indicator were added to the solution. The solution was then
titrated with hydrochloric acid until the indicator produced a distinctive green color. Upon
reaching the end point, the volume of hydrochloric acid titrated was recorded.
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Chemical Equations:
HCl (l) + NaOH (l) → NaCl (aq) + H2O (l) (1)
2HCl (l) + CaCO3 (s) → CaCl2 (aq) + H2O (l) + CO2 (g) (2)
300 276.7
200
100
0
d)
ds
x
ck
lo
ar
ai
a
aa
w
(b
ol
r
M
(fo
s
m
s
Tu
m
Tu
Antacid
Theoretical Actual
114%
120% 104%
90%
Pe rce ntage Yie ld
100%
76%
80%
60%
40%
20%
0%
Maalox Rolaids Tums Tums
(back) (forward)
Antacid
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37.5
Cost Effectiveness (mg per
40 34.3
35
30
22.9
25
dollar)
20
15 11.7
10
5
0
Maalox Rolaids Tums Tums
(back) (forward)
Antacid
500
415.5
Weight HCl Neutralized (mg)
400
276.7
300
200
100
0
Forward Back
Titration Method
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Data Tables:
Table 4. Results
Conclusion
It can be seen from Figure 1 above that there were some discrepancies between the
calculated theoretical weight and the actual experimental weight of acid neutralized. The error
exhibited is not overly large, and is not consistent over the entire experiment. These signs point
to random error on the part of the experimenters. Random error could consist of continuing past
the end point of titration, misreading the buret, or error in calculation. The percent yield
obviously exhibits these same symptoms, as seen in Figure 2. Because the error seems to be
more random than systematic, a comparison between the effectiveness of the antacids may be
In addition to these, a large difference can be seen between the yields from the forward
and back titrations. This is shown in Figure 4. It is interesting to point out that the larger error
seems to be exhibited in the back titration, though the forward titration is often more difficult to
perform accurately.
Overall, the experiment went well in terms of procedure. The students were prepared and
knowledgeable as to what was required and how they were to go about the lab. Although some
error was exhibited, in only one case was it substantially large. This leads the students to believe
their results to be acceptable, with most of the theoretical yields within of 15% of the actual
yield.
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Works Consulted
“Antacid Analysis.” Chem 2. Laboratory Packet. Rolla, MO: UMR Chemistry Department,
2006. 6.1-6.6.
<http://web.umr.edu/~tbone/>