Properties Well conserved; 90% recycled 75 % thyroid gland
25% lactating mammary gland 3-5 g; 100 – 150 g 20-30 g 2.5 mg 30 % TOTAL IRON BINDING CAPACITY Absorption 1. HEME iron porphyrin complex 1. assoc. w/ METALLOTHIONEIN 2. NON-HEME Fe2+ (by gastric juice) Transport 1. Mucosal Tf + Apf = FERRITIN 1. bounded to ALBUMIN (intes’l lumen to mucosal cells) 2. Serum Tf – carries Fe3+ (mucosal cells to tissues) Storage 1. FERRITIN – readily mobilized 1. bound to CERULOPLASMIN 2. HEMOSIDERIN – not mobilized BRAIN, HEART, LIVER and LIVER, BM, SPLEEN and MXs Kidneys Excretion 1. Bleeding 1. Bile 2. Feces, sweat 3. Exfoliation Function 1. O2 transport – Hb and Mb 1. Coenzyme 1. integral part of TH 1. resistance to dental caries 2. Oxidative Prod. of ATP via a. cyt c oxidase 2. FLUORAPATITE REDOX (Fe2+ Fe3+) – b. SOD – replaced OH group in Ca2+ P04- cytochromes c. tyrosinase salts 3. P450 system – H20 insol. sol. d. lysyl oxidase - less absorbed < hydroxyapatite 4. Immune system 2. O2 of Fe2+ before transport a. neutrophils, WBC 3. Collagen Cross-linking b. Tf and Lacto Tf 4. mito ENERGY production 5. Cognitive Performance 5. ANTI-OXIDANT 6. synth. of Melanin and Catecholamine