athophys|o|ogy

PepaLocyLes undergo paLhologlc

changes
kupffer cells lncrease ln slze and number
Llver funcLlons alLered
PepaLocellular damage
lmpalred funcLlon
lnflammaLlon of Lhe llver wlLh areas of necrosls
CellmedlaLed response ulrecL acLlon of Lhe vlrus
PAv
Peallng 3 Lo 4 weeks
Llver fallure
CompllcaLlons
vascular and ducLular Llssues undergo
lnflammaLory changes

Llver lnflammaLlon Llver necrosls Llver flbrosls and scarrlng
aln lever
nausea vomlLlng
anorexla
laLlgue
uecreased blllrubln meLabollsm
Hyperbilirubinemia
Jaundice

uecreased blle ln
gasLrolnLesLlnal LracL
Light colored stools

uecrease vlLamln k absorpLlon
Bleeding tendency

lncreased uroblllnogen
Dark Urine
orLal hyperLenslon
AsclLes
Ldema
Splenomegaly
Anemia
Thrombocytopenia
Leukopenia
varlces
Esophageal varices
Hemorrhoids
Suprficial
abdominal veins

uecreased hormone meLabollsm

lncreased androgens and esLrogens
Gynecomastia
Loss of body hair
Enstrual dysfunction
Spider angiomas
Palamar erythea

lncrease AuP and aldosLerone
Ldema
uecrease meLabollsm of
proLelns carbohydraLes and
faLs
Hypoglycemia

uecreased plasma proLelns
Ascites and edema
8lochemlcal alLeraLlons
LlevaLed AS1 and AL1 levels
LlevaLed blllrubln
Low serum albumln
rolonged proLhrombln Llme
LlevaLed alkallne phosphaLe
Llver fallure
PepaLlc encephalopaLhy
PepaLorenal fallure
PepaLlc Coma
uLA1P