Central Nervous System

Michelle Y. So, M.D.

 Case 1
A 52 – year old hypertensive
male complained of headache
and became unconscious. He
was admitted and eventually
expired after one month .
Autopsy was done with the
following findings.
Case 1
 Case 1
1. Given the previous autopsy
findings, give your diagnosis .
2. Give the gross and
microscopic findings.
3. Give the etiology .
 Case 1
4. Also discuss the etiology of
subarachnoid hemorrhage and
combined intracerebral &
subarachnoid bleed.
 Case 2
A 5 – year old boy complained of
headache with high grade fever.
When he was admitted, he was
noted to already have decreased
sensorium. Physical examination
showed the presence of nuchal
rigidity. Patient expired after two
weeks.
Case 2
 Case 2
1. Given the previous autopsy
findings , what is your
diagnosis.
2. Give the gross and
microscopic findings.
3. If CSF examination were
done, what are the expected
findings.
 Case 2
4. Given the age of the patient ,
what is the most likely
etiologic agent ? Give the most
likely etiologic agents for
newborns, adolescents and
young adults , for the elderly
age group.
 Case 3
• A 60 year old male complained of
headache and right-sided body
weakness. He has been previously
diagnosed with bronchogenic
carcinoma.
He was admitted to the hospital
and eventually expired after one
month. Autopsy was performed.
Case 3 - A
Case 3 - A
Case 3 - B
Case 3 - B
 Case 3
1. Given the clinical history ,
which of the two cases is the
more likely diagnosis ?
2. What is the diagnosis of the
other case.
3. Classify the two tumors
whether primary or
secondary.
 Case 3
4. Give the gross and
microscopic findings for both
cases.
5. What are the most common
primary sites of metastatic
tumors to the CNS ?