predisposing factors: * age * immunocompromised *systemic infection inhale

Airways Lymph system

alveoli Other parts of body Other areas of lungs (upper lobe)

multiply

precipitating factors: * environment * recurrence of infection

Bodys immune system responds

Initiate inflammatory reaction

bloodstream

inhale

airways

alveoli

Lymph systems

Other parts of body Other areas of lungs (upper lobe)

Blood strea,m

predisposing factors: * age * immunocompromised *systemic infection

alveoli inhale inflammatory response other parts of body, other areas of lungs

phagocytes (neutrophils, macrophages)

exudate accumulation in alveoli

bronchopneu monia fibrous tissue (necrotoic) collagenous scar bacteria dormant

TB specific lymphocytes granuloma

cheesy mass

precipitating factors: * environment * recurrence of infection

ghon tubercle

ulcerates

cheesy material release in bronchi

bacteria become airborne bronchopneu monia, tubercle formation

scar tissue

lungs more inflammed

other lung lobes