Pathophysiology of acute Glomerulonephritis

Post streptococcal infection

(group-a beta hemolytic
#elease of material from the
organism, into the circulation
(Antigen)

ormation of antibody
Immune complex reaction in the
glomerular capillary
Inflammatory response
Proliferation of epithelial cell
lining Glomerulus and cells
between endothelium & epithelium
of capillary membrane
Swelling capillary membrane & infiltration
with leukocytes
Increase permeability of base membrane
Occlusion of the capillaries of the
glomeruli vasospasm of afferent
ventrioles

Acute Glumerulonephritis
ecrease glomerular filtration rate
ecrease ability to form filtrate form
glomeruli plasma flow
#etention of H2O & Na;
hypovolemia; circulatory congestion
Edema
Hypertension
ec. urinary output
Urine dark in color
Anorexia
Irritability lethargy