SULFUR CONTAINING AMINO ACID

Mr. V. Kuzhandai velu Tutor Department of Biochemistry MGMCRI

Sulfur contain AA

Metabolism
Activation of methionine and transmethylation Conversion of methionine to cysteine Degradation of cysteine

TRANSMETHYLATION REACTION
Methyl acceptor Guanido acetic acid Nicotinamide Norepinephrine Epinephrine Ethanolamine Carnosine Acetyl serotonin Serine Histidine Lysine tRNA Methylated product Creatine N-methyl nicotinamide Epinephrine Metanephrine Choline Anserine Melatonin Choline Methyl histidine Methyl lysine Methylated tRNA

FATE OF ATOMS OF MET

CH3 p methyl transfer  S p CYS  CH2  CH2  CH NH3  COOp NH4+
converted to propionyl CoA p succinyl CoA p glucose

pCO2

 Metabolic function of Cysteine 1. 2. 3. 4. 5. 6. 7. 8. Formation of Glutathione Amino Acid Transport Co-enzyme Role RBC Membrane Integrity Met-hemoglobin Conjugation for Detoxification Activation of enzymes Formation of Taurine

 Formation of Glutathione and amino acid transport

FORMATION OF TAURINE

Cysteine

Cysteic Acid

Taurine

CYSTINE
(I) dimer of CYS (ii) formed through oxidation mediated by O2,
Cu2+, Mn2+ or Fe2+

(iii) little free in cells (iv) important in disulfide bond formation in intact proteins to provide bridges and stabilize conformation of proteins.