Professional Documents
Culture Documents
Co p e e ts Complements
Co p e e ts Complements
Thecomplementisahighlyconservedinnate immunecascadeofabout30proteinsthat interacttorecognizeandeliminatepathogens. i t tt i d li i t th
Complement
Agroupofplasmaproteinsproducedbytheliver (~30). Theyareproducedasproenzymeswhichare p p activatedaspartofanimmuneresponse Pathways for activation Pathwaysforactivation Classicalpathway Alternativepathway MBLpathway
Complement
Activationtakesplacebyproteolytic cleavage. Eachcomplementmoleculeiscleavedintotwo p fragmenta andb Usuallybisthelargefragmentwhichisinvolvedin thepathway. the pathway
Complement
Complement
Theclassicalpathway isactivatedprimarilyby q theinteractionofC1qwithimmune complexesofantibodywithantigen. CanalsobeactivatedbyinteractionofC1q withnonimmunemolecules.
Complement
Thealternativepathway doesnotdependupon thepresenceofimmunecomplexesandleadsto thedepositionofC3fragmentsonthetarget the deposition of C3 fragments on the target cells.
Complement
Thelectin pathway sharesseveralmoleculeswith theclassicalpathwayandisactivatedbybinding ofMBLtocarbohydratesexpressedon of MBL to carbohydrates expressed on pathogens.
Complement
Theendresultofallthreepathwaysiseitherthe opsonisation orthedestruction(through formationofthelytic moleculeC5b9)ofnonself formation of the lytic molecule C5b9) of nonself cellsandtargetorganisms.
Complement