1 Drug Study of Allopurinol

Generic & Brand Name Mode of Action Mechanism of Action Indication & Contraindication Indication: Treatment of primary or secondary gout, hyperuricemia resulting from chemotherapy for malignancies, recurrent calcium oxalate renal calculi. Recurrent tophaceous deposits or uric acid stones. Contraindication: Severe renal impairment, and children except those with hyperuricemia secondary to malignancy, idiopathic hemochromatosis, acute gouty attack. Hypersensitivity. Lactation. Dosage & Adverse Reactions Dosage: 100 mg Nursing Responsibilities

Generic: Allopurinol Brand: Elavil

Uricosurics

Inhibits xanthine oxidase, an enzyme involved in the synthesis of uric acid without disrupting the biosynthesis of essential purine. Results in decreased uric acid level.

 Assess patients history, gout may be secondary to diseases such as acute or chronic leukemia, Adverse Reactions: CNS: headache, drowsiness, polycythemia vera, multiple myeloma or peripheral neuropathy, psoriasis neuritis  Assess for pain including Dermatologic: rashes location, characteristics, GI: nausea, vomiting, onset/duration, frequency, diarrhea, abdominal pain, quality, intensity or gastritis, hepatomegaly. severity of pain, precipitating factors Hyperbilirubinemia,  Monitor uric acid levels cholestatic jaundice every 2 weeks GU: exacerbation of gout  Monitor renal function and renal calculi, renal  Monitor CBC and hepatic failure function at the start of Hematologic: anemia, therapy and periodically leucopenia, agranulocytosis, thereafter  Monitor nutritional status thrombocytopenia  Be alert for adverse reaction and drug interaction  Tell patient to increase fluid intake to 2L/day and to maintain a neutral of alkaline urine  Tell patient to stop drug and report if skin rash, stomatitis, malaise and fever occur