TAB]

Glycolysis ATP + D-Glucose => ADP + D-Glucose 6-phosphate D-Glucose 6-phosphate <=> D-Fructose 6-phosphate D-Fructose 1,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate D-Fructose 1,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate

ATP + D-Fructose 6-phosphate => ADP + D-Fructose 1,6-bisphosphate ATP + D-Fructose 6-phosphate => ADP + D-Fructose 1,6-bisphosphate D-Fructose 1,6-bisphosphate <=> Glycerone phosphate + D-Glyceraldehyde 3-phosphate D-Glyceraldehyde 3-phosphate <=> Glycerone phosphate D-Glyceraldehyde 3-phosphate + Orthophosphate + NADP+ <= 3-Phospho-D-glyceroyl phosphat H+ D-Glyceraldehyde 3-phosphate + Orthophosphate + NAD+ => 3-Phospho-D-glyceroyl phosphate H+ + 3-Phospho-D-glycerate <=> ADP + 3-Phospho-D-glyceroyl phosphate ATP 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O

Pentose-Phosphate-Pathway and Calvin Cycle D-Sedoheptulose 1,7-bisphosphate <= Glycerone phosphate + D-Erythrose 4-phosphate D-Sedoheptulose 1,7-bisphosphate <= Glycerone phosphate + D-Erythrose 4-phosphate D-Sedoheptulose 1,7-bisphosphate + H2O => D-Sedoheptulose 7-phosphate + Orthophosphate D-Glucose 6-phosphate + NADP+ => D-Glucono-1,5-lactone 6-phosphate + NADPH + H+ D-Glucono-1,5-lactone 6-phosphate + H2O => 6-Phospho-D-gluconate 6-Phospho-D-gluconate + NADP+ => D-Ribulose 5-phosphate + CO2 + NADPH + H+ D-Ribose 5-phosphate <=> D-Ribulose 5-phosphate D-Ribose 5-phosphate <=> D-Ribulose 5-phosphate D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Ribose 5-phosphate + D phosphate D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + D-Xy phosphate D-Ribulose 5-phosphate <=> D-Xylulose 5-phosphate D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + 6-phosphate D-Ribulose 1,5-bisphosphate + CO2 + H2O => 2 3-Phospho-D-glycerate ATP + D-Ribulose 5-phosphate => ADP + D-Ribulose 1,5-bisphosphate ATP + D-Ribose 5-phosphate <=> AMP + 5-Phospho-alpha-D-ribose 1-diphosphate

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D-Ribulose 1,5-bisphosphate + O2 => 3-Phospho-D-glycerate + 2-Phosphoglycolate

Storage and Nucleotide Sugars D-Glucose 1-phosphate <=> D-Glucose 6-phosphate ATP + D-Glucose 1-phosphate => Pyrophosphate + ADP-Glucose ADP-Glucose => ADP + Amylose ADP-Glucose => ADP + Amylose Amylose => Glycogen Amylose + Orthophosphate => D-Glucose 1-phosphate Amylose + Orthophosphate => D-Glucose 1-phosphate Glycogen + Orthophosphate => D-Glucose 1-phosphate Glycogen + Orthophosphate => D-Glucose 1-phosphate Glycogen + H2O => D-Glucose ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate D-Mannose 6-phosphate <=> D-Fructose 6-phosphate D-Mannose 6-phosphate <=> D-Mannose 1-phosphate D-Mannose 6-phosphate <=> D-Mannose 1-phosphate GTP + D-Mannose 1-phosphate => Diphosphate + GDP-mannose GTP + D-Mannose 1-phosphate => Diphosphate + GDP-mannose GDP + D-Mannose 1-phosphate => Orthophosphate + GDP-mannose GDP + D-Mannose 1-phosphate => Orthophosphate + GDP-mannose dTTP + D-Glucose 1-phosphate => Diphosphate + dTDP-glucose CTP + D-Glucose 1-phosphate => Diphosphate + CDP-glucose dTTP + D-Glucose 1-phosphate <=> Diphosphate + dTDP-glucose dTDP-glucose <=> dTDP-galactose dTDP-glucose <=> dTDP-galactose dTDP-glucose <=> dTDP-galactose dTDP-glucose => 4,6-Dideoxy-4-oxo-dTDP-D-glucose + H2O dTDP-glucose => 4,6-Dideoxy-4-oxo-dTDP-D-glucose + H2O 4,6-Dideoxy-4-oxo-dTDP-D-glucose => dTDP-4-dehydro-6-deoxy-L-mannose 4,6-Dideoxy-4-oxo-dTDP-D-glucose => dTDP-4-dehydro-6-deoxy-L-mannose 4,6-Dideoxy-4-oxo-dTDP-D-glucose <=> GDP-4-dehydro-6-deoxy-L-mannose 4,6-Dideoxy-4-oxo-dTDP-D-glucose <=> GDP-4-dehydro-6-deoxy-L-mannose dTDP-6-deoxy-L-mannose + NADP+ <= dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+ GDP-6-deoxy-L-mannose + NADP+ <= GDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+ 1 L-Aspartate + 1 L-Arginine + 2 ATP => Cyanophycin + Diphosphate 1 L-Aspartate + 1 L-Arginine + 2 ATP => Cyanophycin + Diphosphate

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Cyanophycine + 1 H2O => 1 L-Aspartate + 1 L-Arginine UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose UDP-glucose <=> UDP-D-galactose Pyruvate Glycerone phosphate => Methylglyoxal + Orthophosphate (R)-S-Lactoylglutathione <=> Glutathione + Methylglyoxal (R)-S-Lactoylglutathione + H2O => Glutathione + (R)-Lactate ATP + Pyruvate <= ADP + Phosphoenolpyruvate ATP + Pyruvate <= ADP + Phosphoenolpyruvate Pyruvate + CoA + NAD+ => Acetyl-CoA + CO2 + NADH + H+ Pyruvate + CoA + NAD+ => Acetyl-CoA + CO2 + NADH + H+ Pyruvate + CoA + NAD+ => Acetyl-CoA + CO2 + NADH + H+ ATP + Acetate + CoA <=> AMP + Pyrophosphate + Acetyl-CoA Acetaldehyde + NAD+ + H2O <= Acetate + NADH + H+ Ethanol + NAD+ <= Acetaldehyde + NADH + H+ Ethanol + NADP+ <= Acetaldehyde + NADPH + H+ Orthophosphate + Oxaloacetate <= H2O + Phosphoenolpyruvate + CO2 ATP + Pyruvate + H2O => AMP + Phosphoenolpyruvate + Orthophosphate L-Alanine + NAD+ + H2O <= Pyruvate + NH3 + NADH + H+ (R)-Lactate + NAD+ <=> Pyruvate + NADH + H+ (S)-Malate + NAD+ => Pyruvate + CO2 + NADH + H+ (S)-Malate + NADP+ => Pyruvate + CO2 + NADPH + H+ Acetyl-CoA + Orthophosphate <=> CoA + Acetyl phosphate Reduced ferredoxin + Acetyl-CoA + CO2 <= Oxidized ferredoxin + Pyruvate + CoA

ATP + Acetate <=> ADP + Acetyl phosphate TCA-Cycle (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ Citrate <=> cis-Aconitate + H2O Isocitrate <=> cis-Aconitate + H2O Isocitrate + NADP+ => 2-Oxoglutarate + CO2 + NADPH + H+ ATP + Succinate + CoA <=> ADP + Orthophosphate + Succinyl-CoA

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(S)-Malate <=> Fumarate + H2O Succinate + FAD <=> FADH2 + Fumarate

Citrate + CoA <= Acetyl-CoA + H2O + Oxaloacetate

Histidine 1-(5-Phospho-D-ribosyl)-ATP + Pyrophosphate <= ATP + 5-Phospho-alpha-D-ribose 1-diphosphate

1-(5-Phospho-D-ribosyl)-ATP + H2O => Phosphoribosyl-AMP + Pyrophosphate Phosphoribosyl-AMP + H2O => 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)- im carboxamide 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)- imidazole-4-carboxamide => N-(5' 1'-ribulosylformimino)-5-amino-1-(5''-phospho-D- ribosyl)-4-imidazolecarboxamide N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D- ribosyl)-4-imidazolecarboxamid Glutamine => D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4imidazolecarboxamide + L-Glutamate N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D- ribosyl)-4-imidazolecarboxamid Glutamine => D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4imidazolecarboxamide + L-Glutamate D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate => 3-(Imidazol-4-yl)-2-oxopropyl phosphate + H2 L-Histidinol phosphate + 2-Oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + L-Glutam L-Histidinol phosphate + H2O => L-Histidinol + Orthophosphate L-Histidinol L-Histidinol L-Histidinal L-Histidinal + + + + NAD+ => L-Histidinal + NADH + H+ NAD+ => L-Histidinal + NADH + H+ H2O + NAD+ => L-Histidine + NADH + H+ H2O + NAD+ => L-Histidine + NADH + H+

Aromatic Amino Acids Phosphoenolpyruvate + D-Erythrose 4-phosphate + H2O => 2-Dehydro-3-deoxy-D-arabino-hepto phosphate + Orthophosphate 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate => 3-Dehydroquinate + Orthophosphate 3-Dehydroquinate <=> 3-Dehydroshikimate + H2O Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ ATP + Shikimate => ADP + Shikimate 3-phosphate Phosphoenolpyruvate + Shikimate 3-phosphate <=> Orthophosphate + 5-O-(1-Carboxyvinyl)-3phosphoshikimate 5-O-(1-Carboxyvinyl)-3-phosphoshikimate => Chorismate + Orthophosphate

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Chorismate + L-Glutamine => Anthranilate + Pyruvate + L-Glutamate Chorismate + NH3 => Anthranilate + Pyruvate + H2O

N-(5-Phospho-D-ribosyl)anthranilate + Pyrophosphate <= Anthranilate + 5-Phospho-alpha-D-ribo diphosphate N-(5-Phospho-D-ribosyl)anthranilate => 1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosph 1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate => Indoleglycerol phosphate + CO2 Indoleglycerol phosphate => Indole + D-Glyceraldehyde 3-phosphate L-Serine + Indoleglycerol phosphate => L-Tryptophan + D-Glyceraldehyde 3-phosphate + H2O L-Serine + Indole <=> L-Tryptophan + H2O Chorismate <=> Prephenate Prephenate => Phenylpyruvate + H2O + CO2 Prephenate + NAD+ => 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH + H+ L-Phenylalanine + 2-Oxoglutarate <= Phenylpyruvate + L-Glutamate L-Phenylalanine + 2-Oxoglutarate <= Phenylpyruvate + L-Glutamate L-Tyrosine + 2-Oxoglutarate <= 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate

Cysteine, Glycerate, Glycine, Glyoxylate and Serine 2-Phosphoglycolate + H2O => Glycolate + Orthophosphate 2-Phosphoglycolate + H2O => Glycolate + Orthophosphate 2-Phosphoglycolate + H2O => Glycolate + Orthophosphate Glycolate + NAD+ => Glyoxylate + NADH + H+ Glycolate + NAD+ => Glyoxylate + NADH + H+ L-Serine + Acetyl-CoA => O-Acetyl-L-serine + CoA O-Acetyl-L-serine + Hydrogen sulfide => L-Cysteine + Acetate O-Acetyl-L-serine + Hydrogen sulfide => L-Cysteine + Acetate L-Serine => Pyruvate + NH3 5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-Serine Glycine + Tetrahydrofolate + NAD+ => 5,10-Methylenetetrahydrofolate + NH3 + CO2 + NADH + D-Glycerate + NAD+ <=> Hydroxypyruvate + NADH + H+ D-Glycerate + NADP+ <=> Hydroxypyruvate + NADPH + H+

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L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine

ATP + D-Glycerate => ADP + 2-Phospho-D-glycerate

D-Glycerate + NAD+ <= Tartronate semialdehyde + NADH + H+ D-Glycerate + NADP+ <= Tartronate semialdehyde + NADPH + H+ 2 Glyoxylate => Tartronate semialdehyde + CO2 Glyoxylate + O2 + H2O => Oxalate + H2O2 Oxalate => Formate + CO2 Formate + 2 Ferricytochrome b1 => CO2 + 2 Ferrocytochrome b1 + 2 H+ L-Cysteine + [enzyme]-cysteine = L-Alanine + [enzyme]-S-sulfanylcysteine L-Cysteine + [enzyme]-cysteine = L-Alanine + [enzyme]-S-sulfanylcysteine L-Cysteine + [enzyme]-cysteine = L-Alanine + [enzyme]-S-sulfanylcysteine Glycine + 2-Oxoglutarate <=> Glyoxylate + L-Glutamate ATP + L-Glutamate + L-Cysteine => ADP + Orthophosphate + gamma-L-Glutamyl-L-cysteine ATP + gamma-L-Glutamyl-L-cysteine + Glycine => ADP + Orthophosphate + Glutathione Glutathione + H2O => Cys-Gly + L-Glutamate Cys-Gly + H2O => L-Cysteine + Glycine D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+ Glycerol + NADP+ <=> D-Glyceraldehyde + NADPH + H+ sn-Glycerol 3-phosphate + NAD+ <=> Glycerone phosphate + NADH + H+ sn-Glycerol 3-phosphate + FAD => Glycerone phosphate + FADH2 ATP + Glycerol => ADP + sn-Glycerol 3-phosphate Cys-Gly + H2O => L-Cysteine + Glycine

Methionine and Sulfate ATP + Sulfate => Pyrophosphate + Adenylyl sulfate ATP + Adenylyl sulfate => ADP + 3'-Phosphoadenylyl sulfate Thioredoxin + 3'-Phosphoadenylyl sulfate => Thioredoxin disulfide + Sulfite + Adenosine 3',5'-bi Adenosine 3',5'-bisphosphate + H2O => AMP + Orthophosphate Hydrogen sulfide + 3 Oxidized ferredoxin + 3 H2O <= Sulfite + 3 Reduced ferredoxin 5-Methyltetrahydrofolate + L-Homocysteine => Tetrahydrofolate + L-Methionine S-Adenosyl-L-homocysteine + H2O => Adenosine + L-Homocysteine

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S-Adenosyl-L-methionine + DNA => S-Adenosyl-L-homocysteine + DNA 5-methylcytosine Orthophosphate + Pyrophosphate + S-Adenosyl-L-methionine <= ATP + L-Methionine + H2O ATP + H2O + SulfateEx => ADP + Orthophosphate + Sulfate

Acetyl-CoA + L-Homoserine => CoA + O-Acetyl-L-homoserine O-Acetyl-L-homoserine + Hydrogen sulfide => L-Homocysteine + Acetate

Aspartate, Lysine, Nicotinamide and Threonine L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate O-Phospho-L-homoserine + H2O => L-Threonine + Orthophosphate O-Phospho-L-homoserine + H2O => L-Threonine + Orthophosphate ATP + L-Homoserine => ADP + O-Phospho-L-homoserine L-Homoserine + NADP+ <= L-Aspartate 4-semialdehyde + NADPH + H+ L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ <= 4-Phospho-L-aspartate + NADPH + ATP + L-Aspartate => ADP + 4-Phospho-L-aspartate L-Aspartate 4-semialdehyde + Pyruvate => L-2,3-Dihydrodipicolinate + 2 H2O 2,3,4,5-Tetrahydrodipicolinate + NADP+ <= L-2,3-Dihydrodipicolinate + NADPH + H+ LL-2,6-Diaminoheptanedioate + 2-Oxoglutarate <= 2,3,4,5-Tetrahydrodipicolinate + L-Glutamate LL-2,6-Diaminoheptanedioate <=> meso-2,6-Diaminoheptanedioate meso-2,6-Diaminoheptanedioate => L-Lysine + CO2 L-Asparagine + H2O => L-Aspartate + NH3 L-Asparagine + H2O => L-Aspartate + NH3 L-Aspartate + Oxygen => Iminoaspartate + H2O2 L-Aspartate + H2O + Oxygen => Oxaloacetate + NH3 + H2O2 Pyridine-2,3-dicarboxylate + 2 H2O + Orthophosphate <= Iminoaspartate + Glycerone phosphat Nicotinate D-ribonucleotide + Diphosphate + CO2 <= Pyridine-2,3-dicarboxylate + 5-Phospho-al 1-diphosphate ATP + Nicotinate D-ribonucleotide <=> Diphosphate + Deamino-NAD+ ATP + Nicotinate D-ribonucleotide <=> Diphosphate + Deamino-NAD+ ATP + Deamino-NAD+ + NH3 => AMP + Diphosphate + NAD+ ATP + NAD+ => ADP + NADP+ Folate

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5-Methyltetrahydrofolate + NADP+ <= 5,10-Methylenetetrahydrofolate + NADPH + H+

5-Methyltetrahydrofolate + NAD+ <= 5,10-Methylenetetrahydrofolate + NADH + H+

N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate GTP + H2O => 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphospha 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + H2O => Dihydroneopterin phosphate + Diphosphate

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine + Orthophosphate < Dihydroneopterin phosphate + H2O

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine => Glycolaldehyde hydroxy-6-hydroxymethyl-7,8-dihydropteridine Glycolaldehyde + NAD+ + H2O => Glycolate + NADH + H+ ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine => AMP + 2-Amino-7,8-dihydro(diphosphooxymethyl)pteridine 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-Aminobenzoate => Diphos Dihydropteroate 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoate => Dihydropteroa 4-Amino-4-deoxychorismate => 4-Aminobenzoate + Pyruvate Chorismate + L-Glutamine => 4-Amino-4-deoxychorismate + L-Glutamate ATP + Dihydropteroate + L-Glutamate => ADP + Orthophosphate + Dihydrofolate ATP + Dihydropteroate + L-Glutamate => ADP + Orthophosphate + Dihydrofolate Tetrahydrofolate + NADP+ <= Dihydrofolate + NADPH + H+ 10-Formyltetrahydrofolate + H2O => Formate + Tetrahydrofolate 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+ 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH Ammonia, Arginine, Glutamate, Glutamine and Proline N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate 2 L-Glutamate + NAD+ <= L-Glutamine + 2-Oxoglutarate + NADH + H+

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ATP + L-Glutamate + NH3 => ADP + Orthophosphate + L-Glutamine ATP + L-Glutamate + NH3 => ADP + Orthophosphate + L-Glutamine L-Glutamine + H2O => L-Glutamate + NH3 L-Glutamate + NADP+ + H2O <= 2-Oxoglutarate + NH3 + NADPH + H+ ATP + L-Glutamate => ADP + L-Glutamyl 5-phosphate L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ <= L-Glutamyl 5-phosphate + NADPH L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ <= L-Glutamyl 5-phosphate + NADPH L-Glutamate 5-semialdehyde + NAD+ + H2O => L-Glutamate + NADH + H+ (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O => L-Glutamate + NADH + H+ L-Proline + FAD => (S)-1-Pyrroline-5-carboxylate + FADH2 L-Proline + NAD+ <= (S)-1-Pyrroline-5-carboxylate + NADH + H+ L-Proline + NADP+ <= (S)-1-Pyrroline-5-carboxylate + NADPH + H+ Acetyl-CoA + L-Glutamate => CoA + N-Acetyl-L-glutamate N-Acetylornithine + L-Glutamate => L-Ornithine + N-Acetyl-L-glutamate (S)-1-Pyrroline-5-carboxylate + H2O <=> L-Glutamate 5-semialdehyde ATP + N-Acetyl-L-glutamate => ADP + N-Acetyl-L-glutamate 5-phosphate N-Acetyl-L-glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> N-Acetyl-L-glutamate 5NADPH + H+ Carbamoyl phosphate + L-Ornithine <=> Orthophosphate + L-Citrulline N-(L-Arginino)succinate => Fumarate + L-Arginine ATP + L-Citrulline + L-Aspartate => AMP + Pyrophosphate + N-(L-Arginino)succinate L-Glutamine + H2O => L-Glutamate + NH3 2 ATP + L-Glutamine + HCO3- + H2O => 2 ADP + Orthophosphate + L-Glutamate + Carbamoyl

ATP + NH3 + CO2 <=> ADP + Carbamoyl phosphate Nitrite + H2O + 2 Oxidized ferredoxin <= Nitrate + 2 Reduced ferredoxin NH3 + 2 H2O + 6 Oxidized ferredoxin <= Nitrite + 6 Reduced ferredoxin + 7 H+ 2 L-Glutamate + 2 Oxidized ferredoxin <= L-Glutamine + 2-Oxoglutarate + 2 Reduced ferredoxin L-Glutamate => 4-Aminobutanoate + CO2 Succinate semialdehyde + NADP+ + H2O => Succinate + NADPH + H+ 4-Aminobutanoate + 2-Oxoglutarate <=> Succinate semialdehyde + L-Glutamate L-Arginine + H2O => L-Citrulline + NH3 L-Ornithine + 2-Oxoglutarate <=> L-Glutamate 5-semialdehyde + L-Glutamate L-Arginine + FAD => 5-Guanidino-2-oxopentanoate + NH3 + FADH2 5-Guanidino-2-oxopentanoate => 4-Guanidinobutanoate + CO2

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4-Guanidinobutanoate + H2O => 4-Aminobutanoate + Urea ATP + H2O + UreaEx => ADP + Urea + Orthophosphate

Urea + H2O => CO2 + 2 NH3

L-Proline + 2-Oxoglutarate + Oxygen => trans-4-Hydroxy-L-proline + Succinate + CO2

trans-4-Hydroxy-L-proline + NAD+ => L-1-Pyrroline-3-hydroxy-5-carboxylate + NADH + H+ trans-4-Hydroxy-L-proline + NADP+ => L-1-Pyrroline-3-hydroxy-5-carboxylate + NADPH + H+ L-1-Pyrroline-3-hydroxy-5-carboxylate + NAD+ + 2 H2O => L-erythro-4-Hydroxyglutamate + NAD L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate <=> D-4-Hydroxy-2-oxoglutarate + L-Glutamat D-4-Hydroxy-2-oxoglutarate => Pyruvate + Glyoxylate D-4-Hydroxy-2-oxoglutarate => Pyruvate + Glyoxylate ATP + H2O + NitrateEx => ADP + Nitrate + Orthophosphate

Branched-Chain Amino Acids and CoA L-Threonine => 2-Oxobutanoate + NH3 Pyruvate + Thiamin diphosphate => 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2

2-Acetolactate + Thiamin diphosphate <= 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruva

2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate => (S)-2-Aceto-2-hydroxybutano Thiamin diphosphate

2-Acetolactate + NADPH + H+ => 2,3-Dihydroxy-3-methylbutanoate + NADP+ (S)-2-Aceto-2-hydroxybutanoate => (R)-3-Hydroxy-3-methyl-2-oxopentanoate (R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <= (R)-3-Hydroxy-3-methyl-2-oxopentanoate + 2,3-Dihydroxy-3-methylbutanoate => 3-Methyl-2-oxobutanoic acid + H2O

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(R)-2,3-Dihydroxy-3-methylpentanoate => (S)-3-Methyl-2-oxopentanoic acid + H2O L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate (2S)-2-Isopropylmalate + CoA <= Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O (2S)-2-Isopropylmalate + CoA <= Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O (2S)-2-Isopropylmalate => 2-Isopropylmaleate + H2O (2R,3S)-3-Isopropylmalate <= 2-Isopropylmaleate + H2O (2S)-2-Isopropyl-3-oxosuccinate => 4-Methyl-2-oxopentanoate (2R,3S)-3-Isopropylmalate + NAD+ => (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+ 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxobutanoic acid + H2O => Tetrahydrofolate + 2Dehydropantoate (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+

ATP + (R)-Pantoate + beta-Alanine => AMP + Diphosphate + Pantothenate ATP + Pantothenate => ADP + D-4'-Phosphopantothenate (R)-4'-Phosphopantothenoyl-L-cysteine => Pantetheine 4'-phosphate + CO2 ATP + D-4'-Phosphopantothenate + L-Cysteine => AMP + Diphosphate + (R)-4'-Phosphopantothe cysteine CTP + D-4'-Phosphopantothenate + L-Cysteine => CMP + Diphosphate + (R)-4'-Phosphopantothe cysteine ATP + Pantetheine 4'-phosphate => Diphosphate + Dephospho-CoA ATP + Dephospho-CoA => ADP + CoA L-Aspartate => beta-Alanine + CO2 L-Aspartate => beta-Alanine + CO2 Photophosphorylation and Respiratory Chain 2 Reduced ferredoxin + NADP+ <=> 2 Oxidized ferredoxin + NADPH + H+ 2 H2O + 2 NADP+ + 8 Photon => 12 Hextern + 2 NADPH + 2 H+ + O2

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NADH + H+ + Q => NAD+ + QH2 + 2 Hextern

FADH2 + Q => FAD + QH2 2 QH2 + O2 => 2 Q + 4 Hextern 14 Hextern + 3 ADP + 3 Orthophosphate => 3 ATP + 3 H2O

1 Photon => 2 Hextern 1 PhotonEx => 1 Photon

Purine and Riboflavin ATP + AMP <=> 2 ADP ATP + AMP <=> 2 ADP 5-Phosphoribosylamine + Diphosphate + L-Glutamate <= L-Glutamine + 5-Phospho-alpha-D-ribo diphosphate + H2O ATP + 5-Phosphoribosylamine + Glycine => ADP + Orthophosphate + 5'-Phosphoribosylglycinam 10-Formyltetrahydrofolate + 5'-Phosphoribosylglycinamide => Tetrahydrofolate + 5'-Phosphorib formylglycinamide

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5'-Phosphoribosylglycinamide + 5,10-Methenyltetrahydrofolate + H2O => 5'-Phosphoribosyl-Nformylglycinamide + Tetrahydrofolate 5'-Phosphoribosylglycinamide + Formate + ATP => 5'-Phosphoribosyl-N-formylglycinamide + AD Orthophsophate ATP + 5'-Phosphoribosyl-N-formylglycinamide + L-Glutamine + H2O => ADP + Orthophosphate + (Formamido)-N1-(5'-phosphoribosyl)acetamidine + L-Glutamate

ATP + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine => ADP + Orthophosphate + Aminoim ribotide 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate <=> Aminoimidazole ribotide + CO2

ATP + 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-Aspartate <=> ADP + Orthop 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole <=> Fumarate + 1-(5'-Phosp amino-4-imidazolecarboxamide 10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide => Tetrahy (5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide GTP + IMP + L-Aspartate => GDP + Orthophosphate + N6-(1,2-Dicarboxyethyl)-AMP N6-(1,2-Dicarboxyethyl)-AMP => Fumarate + AMP dADP + Thioredoxin disulfide + H2O <= Thioredoxin + ADP dCDP + Thioredoxin disulfide + H2O <= Thioredoxin + CDP dGDP + Thioredoxin disulfide + H2O <= GDP + Thioredoxin dUDP + Thioredoxin disulfide + H2O <= Thioredoxin + UDP

ATP + GDP <=> ADP + GTP ATP + dADP <=> ADP + dATP ATP + dGDP <=> ADP + dGTP ATP + dTDP <=> ADP + dTTP ATP + dCDP <=> ADP + dCTP ATP + dUDP <=> ADP + dUTP AMP + H2O <=> Adenosine + Orthophosphate AMP + H2O <=> Adenosine + Orthophosphate IMP + NAD+ + H2O => Xanthosine 5'-phosphate + NADH + H+ ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O <=> AMP + Diphosphate + GMP + L-Gluta GTP + H2O => GMP + Diphosphate ATP + GMP <=> ADP + GDP

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TAB]

GTP + 3 H2O => Formate + 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + Diphosp 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + H2O => 5-Amino-6-(5'-phosphoribosy + NH3 5-Amino-6-(5'-phosphoribitylamino)uracil + H2O <=> 5-Amino-6-(1-D-ribitylamino)uracil + Ortho

5-Amino-6-(5'-phosphoribitylamino)uracil + NADP+ <= 5-Amino-6-(5'-phosphoribosylamino)uraci H+ D-Ribulose 5-phosphate => 3,4-Dihydroxy-2-butanone 4-phosphate + Formate 5-Amino-6-(1-D-ribitylamino)uracil + 3,4-Dihydroxy-2-butanone 4-phosphate => 6,7-Dimethyl-8-( ribityl)lumazine + 2 H2O + Orthophosphate 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine => Riboflavin + 5-Amino-6-(1-D-ribitylamino)uracil ATP + Riboflavin => ADP + FMN ATP + FMN => Diphosphate + FAD

Pyrimidine UTP + H2O => UMP + Diphosphate Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate (S)-Dihydroorotate + H2O <=> N-Carbamoyl-L-aspartate (S)-Dihydroorotate + H2O <=> N-Carbamoyl-L-aspartate (S)-Dihydroorotate + Oxygen <=> Orotate + H2O2 Orotidine 5'-phosphate + Diphosphate <=> Orotate + 5-Phospho-alpha-D-ribose 1-diphosphate Orotidine 5'-phosphate => UMP + CO2 ATP + CMP <=> ADP + CDP ATP + UMP <=> ADP + UDP ATP + UMP <=> ADP + UDP ATP + UDP <=> ADP + UTP ATP + CDP <=> ADP + CTP ATP + UTP + NH3 => ADP + Orthophosphate + CTP ATP + UTP + L-Glutamine + H2O => ADP + Orthophosphate + CTP + L-Glutamate dCTP + H2O => dUTP + NH3 CTP + H2O => UTP + NH3 dCTP + H2O => dUTP + NH3 ATP + dTMP <=> ADP + dTDP ATP + dUMP <=> ADP + dUDP 5,10-Methylenetetrahydrofolate + dUMP + NADPH + H+ => Tetrahydrofolate + dTMP + NADP+ Others NADPH + H+ + NAD+ <=> NADP+ + H+ + NADH

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TAB]

1 ATP + H2O => 1 ADP + Orthophosphate Thioredoxin + NADP+ <= Thioredoxin disulfide + NADPH + H+ 2 H2O2 => Oxygen + 2 H2O Carbonic acid <=> CO2 + H2O Carbonic acid <=> CO2 + H2O 1 O2Ex <=> 1 O2 1 CO2 => 1 CO2Ex 1 HCO3-EX + 1 ATP => 1 HCO3- + 1 ADP

1 HCO3- + 1 H+ <=> 1 HC2CO3 Diphosphate + H2O => 2 Orthophosphate ATP + Orthophosphate <=> ADP + Diphosphate

Biomass Formation Protein 1 ATP + 2 GTP + 0.058 L-Isoleucine + 0.094 L-Leucine + 0.036 L-Lysine + 0.018 L-Methionine + 0 Phenylalanine + 0.054 L-Threonine + 0.009 L-Tryptophan + 0.076 L-Valine + 0.053 L-Arginine + 0 Histidine + 0.101 L-Alanine + 0.098 L-Aspartate + 0.132 L-Glutamate + 0.007 L-Cysteine + 0.086 0.038 L-Proline + 0.054 L-Serine + 0.033 L-Tyrosine + 2 H2O => 2 GDP + 1 AMP + Pyrophosphat Orthophosphate + 1 B1 DNA 0.222 dCTP + 0.279 dTTP + 0.222 dGTP + 0.279 dATP => 1 Diphosphate + 1 B2 RNA 0.322 GTP + 0.262 ATP + 0.2 CTP + 0.216 UTP => 1 Diphosphate + 1 B3 Carbohydrates 0.1379 UDP-glucose + 0.8143 dTDP-Rhamnose + 0.0478 Glycogen => 1 B4 + 0.8143 dTDP + 0.1 Lipids 1 sn-Glycerol 3-phosphate + 0.7153 UDP-D-galactose + 0.1807 UDP-glucose + 1.470 Acetyl-CoA + + 0.1807 Hydrogen-sulfide => 1 B5 + 1.470 CoA + 0.8960 UDP + 0.7350 Orthophosphate Total 0.8404 B1 + 0.0039 B2 + 0.013 B3 + 0.123 B4 + 0.0182 B5 => 1 Biomass

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TAB]

EC Number 2.7.1.2 5.3.1.9 3.1.3.11 3.1.3.11 2.7.1.11 2.7.1.11 4.1.2.13 5.3.1.1 1.2.1.59 1.2.1.12 2.7.2.3 5.4.2.1 5.4.2.1 4.2.1.11

Gene sll0593 slr1349 slr2094 slr0952 sll1196 sll0745 sll0018 slr0783 sll1342 slr0884 slr0394 slr1124 sll0395 slr0752

Evidence A A A A A A A A A A A A A A

4.1.2.13 4.1.2.13 3.1.3.37 1.1.1.49 3.1.1.31 1.1.1.44 5.3.1.6 5.3.1.6 2.2.1.1 2.2.1.1 5.1.3.1 2.2.1.2 4.1.1.39 2.7.1.19 2.7.6.1

sll0018 slr0943 slr2094 slr1843 sll1479 sll0329 slr0194 ssl2153 sll1070 sll1070 sll0807 slr1793 slr0009, slr0012 sll1525 sll0469

A A A A A A A A A A A A A A A

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TAB]

4.1.1.39

slr0009, slr0012

5.4.2.2 2.7.7.27 2.4.1.21 2.4.1.21 2.4.1.18 2.4.1.1 2.4.1.1 2.4.1.1 2.4.1.1 3.2.1.2.7.1.4 5.3.1.8 5.4.2.8 5.4.2.8 2.7.7.13 2.7.7.13 2.7.7.22 2.7.7.22 2.7.7.24 2.7.7.33 2.7.7.33 5.1.3.2 5.1.3.2 5.1.3.2 4.2.1.46 4.2.1.46 5.1.3.13 5.1.3.13 5.1.3.13 5.1.3.13 1.1.1.133 1.1.1.133 6.3.2.29 6.3.2.30

sll0726 slr1176 sll1393 sll0945 sll0158 sll1356 slr1367 sll1356 slr1367 slr1857 slr1448 slr0493 slr1334 sll1496 sll1558 sll1496 slr2074 sll1370 sll0207 slr0983 slr0983 sll0244 slr1067 slr1078 slr0836 slr0809 slr1933 slr0985 slr1933 slr0985 sll1395 sll1395 slr2002 slr2002

A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

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TAB]

3.4.15.6 2.7.7.9 5.1.3.2

slr2001 sll0244

A D A

4.2.3.3 4.4.1.5 3.1.2.6 2.7.1.40 2.7.1.40 2.3.1.12 1.8.1.4 1.2.4.1 6.2.1.1 1.2.1.3 1.1.1.1 1.1.1.2 4.1.1.31 2.7.9.2 1.4.1.1 1.1.1.28 1.1.1.38 1.1.1.38 2.3.1.8 1.2.7.1

sll0036 slr0381 sll1019 or slr1259 sll0587 sll1275 sll1841 slr1096 sll1721, slr1934 sll0542 slr0091 sll0990 slr0942 sll0920 slr0301 sll1682 slr1556 slr0721 slr0721 slr2132 sll0741

A A A A A A A A A A A A A A A A A A A C

2.7.2.1

sll1299

1.1.1.37 4.2.1.3 4.2.1.3 1.1.1.41 6.2.1.5

sll0891 slr0665 slr0665 slr1289 sll1023, sll1557

A A A A A

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TAB]

4.2.1.2 1.3.99.1

2.3.3.1

slr0018 sll0823, sll1625, slr1233 sll0401

A A

2.4.2.17 2.4.2.17 3.5.4.19 5.3.1.16 4.1.3.- HisF

sll0900, slr1560 sll0900 slr0608 slr0652 sll1893

A A A A A

2.4.2.-HisH

slr0084

4.2.1.19 2.6.1.9 3.1.3.15 1.1.1.23 1.1.1.23 1.1.1.23 1.1.1.23

slr0500 sll1958 sll0084 slr0682 slr1848 slr0682 slr1848

A A C A A A A

2.5.1.54 4.2.3.4 4.2.1.10 1.1.1.25 2.7.1.71 2.5.1.19 4.2.3.5

sll0934 slr2130 sll1112 slr1559 sll1669 slr0444 sll1747

A A A A A A A

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TAB]

4.1.3.27 4.1.3.27 2.4.2.18 5.3.1.24 4.1.1.48 4.2.1.20 4.2.1.20 4.2.1.20 5.4.99.5 4.2.1.51 1.3.1.12 2.6.1.9 2.6.1.1 2.6.1.1

slr0055, slr0738 slr0055, slr0738 slr1867 sll0356 slr0546 slr0543, slr0966 slr0543, slr0966 slr0543, slr0966 sll0109 sll1662 slr2081 sll1958 sll0402 sll0402

A A A A A A A A A A A A A A

3.1.3.18 3.1.3.18 3.1.3.18 1.1.99.14 1.1.99.14 2.3.1.30 2.5.1.47 2.5.1.47 4.3.1.19 2.1.2.1 2.1.2.10 1.1.1.81 1.1.1.81

sll1349 slr0458 slr1762 sll0404 slr0806 slr1348 slr1842 sll0712 slr2072 sll1931 sll0171 sll1908 sll1908

A A A B B A A A A A A B B

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TAB]

2.6.1.45

sll1559

2.7.1.31

slr1840

1.1.1.60 1.1.1.60 4.1.1.47 1.2.3.5 4.1.1.2 1.2.2.1 2.8.1.7 2.8.1.7 2.8.1.7 2.6.1.4 6.3.2.2 6.3.2.3 2.3.2.2 3.4.11.2 1.2.1.3 1.1.1.2 1.1.1.94 1.1.5.3 2.7.1.30 3.4.11.1

slr0229 slr0229 sll1981 sll1556 sll1358 sll1359 sll0704 slr0077 slr0387 sll0006 slr0990 slr1238 slr1269 sll1343 slr0091 slr0942 slr1755 sll1085 slr1672 sll2001

B B B B A B A A A B C A A A A A A A A A

2.7.7.4 2.7.1.25 1.8.4.8 3.1.3.7 1.8.7.1 2.1.1.13 3.3.1.1

slr1165 slr0676 slr1791 sll0895 slr0963 slr0212 sll1234

A A A B A A A

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TAB]

2.1.1.37 2.5.1.6 3.6.3.25

slr0214 sll0927 slr1452, slr1453, slr1454, slr1455

A A A

2.3.1.31 2.5.1.49

D D

2.6.1.1 4.2.3.1 4.2.3.1 2.7.1.39 1.1.1.3 1.2.1.11 2.7.2.4 4.2.1.52 1.3.1.26 2.6.1.83 5.1.1.7 4.1.1.20 3.5.1.1 3.5.1.1 1.4.3.16 1.4.3.16 2.5.1.72 2.4.2.19 2.7.7.18 2.7.7.1 6.3.1.5 2.7.1.23

sll0402 sll1172 sll1688 sll1760 sll0455 slr0549 slr0657 slr0550 sll1058 sll0480 slr1665 sll0504 sll0422 sll0585 sll0631 sll0631 sll0622 slr0936 sll1916 slr0787 slr1691 sll1415

A A A A A A A A A A A A A A A A A A A A A A A A

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TAB]

1.5.1.20

slr2141

1.5.1.20

slr2141

2.6.1.11 3.5.4.16 3.6.1.-

3.6.1.-

4.1.2.25 1.2.1.3 2.7.6.3 2.5.1.15 2.5.1.15 4.1.3.38 2.6.1.85 6.3.2.17 6.3.2.12 1.5.1.3 3.5.1.10 3.5.4.9 1.5.1.5

sll0938 slr0426 sll0672, sll1076, slr0787, slr0920 sll0672, sll1076, slr0787, slr0920 slr1626 slr0091 slr1093 slr2026 slr2026 slr0887 slr1979 sll1612 sll1612 slr2026 sll0070 sll0753 sll0753

A A A

A D A A A A C A A B A A A

2.6.1.11 1.4.1.14

slr1022 sll1027, sll1502

A A

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TAB]

6.3.1.2 6.3.1.2 3.5.1.2 1.4.1.4 2.7.2.11 1.2.1.41 1.2.1.41 1.5.1.12 1.5.1.12 1.5.99.8 1.5.1.2 1.5.1.2 2.3.1.1 2.3.1.35 spontaneous 2.7.2.8 1.2.1.38 2.1.3.3 4.3.2.1 6.3.4.5 6.3.5.5 6.3.5.5 2.7.2.2 1.7.7.2 1.7.7.1 1.4.7.1 4.1.1.15 1.2.1.16 2.6.1.19 3.5.3.6 2.6.1.13 spontaneous

slr0288 slr1756 slr2079 slr0710 slr2035 sll0461 sll0373 sll1561 sll1561 sll1561 slr0661 slr0661 sll1883 sll1883 spontaneous slr1898 sll0080 sll0902 slr1133 slr0585 sll0370, sll1498 sll0370, sll1498 sll0573 sll1454 slr0898 sll1499 sll1641 slr0370 slr1022 or sll0017 sll1336 slr1022 slr0782 spontaneous

A A A A A A A A A A A A A A A A A A A A A A A A A A A A B B B B B

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TAB]

3.5.3.7 -

3.5.1.5

1.14.11.2

sll1077 or sll0228 slr0447, slr1200, slr1201, sll0764, sll0374 sll0420, sll1750, slr1256 sll0428 or sll0191 slr0661 slr0661 sll1561 sll0402 sll0107 sll0107 sll1450, sll1451, sll1452, sll1453

B A

1.5.1.2 1.5.1.2 1.5.1.12 2.6.1.1 4.1.2.14 4.1.3.16 -

A A A A A A A

4.3.1.19 2.2.1.6

2.2.1.6

2.2.1.6

1.1.1.86 1.1.1.86 1.1.1.86 4.2.1.9

slr2072 sll0065, sll1981, slr2088 sll0065, sll1981, slr2088 sll0065, sll1981, slr2088 sll1363 sll1363 sll1363 slr0452

A A

A A A A

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TAB]

4.2.1.9 2.6.1.42 2.6.1.42 2.6.1.42 2.3.3.13 2.3.3.13 4.2.1.33 4.2.1.33 spontaneous 1.1.1.85 2.1.2.11 1.1.1.169 6.3.2.1 2.7.1.33 4.1.1.36 6.3.2.5 6.3.2.5 2.7.7.3 2.7.1.24 4.1.1.15 4.1.1.11

slr0452 slr0032 slr0032 slr0032 sll1564 slr0186 sll1444, sll1470 sll1444, sll1470 spontaneous slr1517 slr0526 sll1363 sll1249 slr0812 sll0250 sll0250 sll0250 slr0847 slr0553 sll1641 sll0892

A A A A A A A A A A A B A A A A A A A A A

1.18.1.2

slr1643

A B

Page PAGE]

TAB]

1.6.5.3

slr1281, sll1732, sll0520, sll0027, ssr1386, slr0844, sll0223, sll1733, sll0522, sll0519, slr1291, slr0331, sll0521, sll0026, slr1279, slr0261, slr1280, slr1623, sll1262 slr1380, slr1379 sll1327, sll1323, sll1322, ssl2615, sll1324, sll1325, sll1326

1.10.3.3.6.3.14

A A A

2.7.4.3 2.7.4.3 2.4.2.14 6.3.4.13 2.1.2.2

sll1815 sll1059 sll0757 slr1159 slr0477

A A A A A

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TAB]

2.1.2.2 2.1.2.2 6.3.5.3

slr0477 slr0861 sll1056, slr0519, slr0520 slr0838 sll0578, sll0901 slr1226 sll0421 slr0597 slr0597 sll1823 sll0421 slr0591, slr1164 slr0591, slr1164 slr0591, slr1164 slr0591, slr1164 sll1852 sll1852 sll1852 sll1852 sll1852 sll1852 sll1459 sll1108 slr1722 slr0213 sll1005 slr1123

A B A

6.3.3.1 4.1.1.21 6.3.2.6 4.3.2.2 2.1.2.3 2.1.2.3 6.3.4.4 4.3.2.2 1.17.4.1 1.17.4.1 1.17.4.1 1.17.4.1 2.7.4.6 2.7.4.6 2.7.4.6 2.7.4.6 2.7.4.6 2.7.4.6 3.1.3.5 3.1.3.5 1.1.1.205 6.3.5.2 3.6.1.19 2.7.4.8

A A A A A A A A A A A A A A A A A A A A A A A A

Page PAGE]

TAB]

3.5.4.25 3.5.4.26 3.1.3.1.1.1.193 RibB 2.5.1.2.5.1.9 2.7.1.26 2.7.7.2

sll1894 slr0066

A A D

slr0066 sll1894 sll1282 sll0300 slr1882 slr1882

A A B A A A

3.6.1.19 2.1.3.2 3.5.2.3 3.5.2.3 1.3.3.1 2.4.2.10 4.1.1.23 2.7.4.14 2.7.4.14 2.7.4.22 2.7.4.6 2.7.4.6 6.3.4.2 6.3.4.2 3.5.4.13 3.5.4.13 3.5.4.13 2.7.4.9 2.7.4.9 2.1.1.148

sll1005 slr1476 sll1018 slr0406 slr1418 slr0185 sll0838 sll1249 sll1249 sll0144 sll1852 sll1852 sll1443 sll1443 sll1258 sll1258 sll1258 slr0379 slr0379 sll1635

A A A A A A A A A A A A A A A A A A A A

1.6.1.2

slr1239, slr1434

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TAB]

1.8.1.9 1.11.1.6 4.2.1.1 4.2.1.1

slr0600 sll1987 slr1347 slr0051

A A A A A

cmpA-cmpD

spontaneous 3.6.1.1 2.7.4.1

slr0040, slr0041, slr0043, slr0044 spontaneous slr1622 sll0290

A A A

Page PAGE]

TAB]

Page PAGE]

TAB]

Page PAGE]

TAB]

No gene could be identified for UDP-glucose phosphorylase (2.7.7.9.)

Unclear if NADP or NAD serves as electron acceptor Unclear if NADP or NAD serves as electron acceptor Identified with BLAST Search: 77 % indentity, 1940 score and E-value 0 to pyruvate-flavodoxin oxidoreductase from Micorystis aeruginosa; flavodoxin replaced by ferredoxin

Page PAGE]

TAB]

Identified with BLAST Search: 56% indentity, 189 score and E-value e-49 to hisB from Cyanothece sp. ATCC 51142

Page PAGE]

TAB]

Identified by Eisenhut et al. 2008; NAD serves as electron acceptor Identified by Eisenhut et al. 2008; NAD serves as electron acceptor

Identified by Eisenhut et al. 2008; Unclear if NADP or NAD serves as electron acceptor Identified by Eisenhut et al. 2008; Unclear if NADP or NAD serves as electron acceptor

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TAB]

Identified by Eisenhut et al. 2008, BLAST Search: 70 % identity, 565 score and E-value e-162 to Serine-Glyoxylate transaminase from Trichodesmium erythraeum IMS101 Identified by Eisenhut et al. 2008, Bartsch et al. 2008; BLAST SEACRH: 41.9 % identity, 201 score and E-value 3e-53 to glyerate kinase from Synechococcus sp. JA3-3Ab Identified by Eisenhut et al. 2008; Unclear if NADP or NAD serves as electron acceptor Identified by Eisenhut et al. 2008; Unclear if NADP or NAD serves as electron acceptor Identified by Eisenhut et al. 2008 Identified by Eisenhut et al. 2008 Identified by Eisenhut et al. 2008

Identified by Eisenhut et al. 2008 Identified with BLAST Search: 68 % indentity, 540 score and E-value e-155 to glutamate-cysteine ligase from Cyanothece sp. PCC 8801

sll0895 is coding for CysQ, which is annotaed in many organisms for 3.1.3.7

Page PAGE]

TAB]

no pathway for the synthesis of methionine could been identified for Synechocystis sp. PCC6803; transferred pathyway from Microcystis aeruginosa for the synthesis of methionine could been identified for no pathway Synechocystis sp. PCC6803; transferred pathyway from Microcystis aeruginosa

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TAB]

Identified with BLAST Search: 75 % indentity, 450 Score and E-value e-128 to methylenetetrahydrofolate reductase from Cyanothece sp. PCC 8801 ; Unclear if NADP or NAD serves as electron acceptor Identified with BLAST Search: 75 % indentity, 450 Score and E-value e-128 to methylenetetrahydrofolate reductase from Cyanothece sp. PCC 8801 ; Unclear if NADP or NAD serves as electron acceptor

maybe catalyzed by the aldehyde dehyrogenase 1.2.1.21 (no evidence)

Identified with BLAST Search: 63.5 % indentity, 574 Score and E-value e-165 to para-aminobenzoate synthase component I from Cyanothece sp. PCC 8801

slr2026 is coding for FoIP (2.5.1.15 ) which also can act as a dihydropteroate reductase 1.5.1.3 (at least in H. pylori); Levin et al. 2007

Page PAGE]

TAB]

Final electron acceptor is likely to be Q (Rasmusson et al. 2007)

Transferred from Flores et al. 2005 Transferred from Flores et al. 2005

Identified by Schriek et al. 2007 Identified by Schriek et al. 2007 Identified by Schriek et al. 2007 Arginine dehydrogenase, Schriek et al. 2009 Identified by Schriek et al. 2007

Page PAGE]

TAB]

Identified by Schriek et al. 2007

Identified with BLAST Search: sll0428 57 % indentity, 257 score and E-value 8 e-70 and sll0191 48 % indentity, 197 score and E-value 8 e-52 prolyl 4hydroxylase from Trichodesmium erythraeum IMS101

Nitrate transporter; transferred from Flores et al. 2005

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sll1363 is coding for IlvC (1.1.1.86) which can also act as 2-dehydropantoate 2-reductase (at least in C. glutamicum); Merkmann et al. 2003

Net reaction of the noncyclic electron transport, Morgan et al. 2005

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Oxidative phosphorylation

Net reaction of the cyclic electron transport, Morgan et al. 2005 Photon absoprtion

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PurT reaction of GAR transformylase; Marolewski et al. 1997

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Correspondig gene not detectable in any cyanobacteria; essential for de novo FAD sythesis

ribH only in Cyanobase annotated

NADPH serves as final electrion acceptor; Agrawal et al. 2004

NAD(P) transhydrogenase

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ATP hydrolysis representing additional ATP usage of the cell / maintenance

Oxygene exchange reaction Carbon dioxide output Hydrogen carbonate transporter, transferred from Omata et al. 1999

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Evidence A: multiple sources (serveral supporting informations in databases like KEGG, Cyanobase, Biocyc literature) B: one or few refernece to literature or databases C: identified by means of sqeuence similarity, no reference to any publication or database D: no reference to any database or literature, no sequence similarity found, included into the netw complete essential pathways

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R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14 R15 R16 R17 R18 R19 R20 R21 R22 R23 R24 R25 R26 R27 R28 R29 R30 R31 R32 R33 R34 R35 R36 R37 R38 R39 R40 R41 R42 R43 R44

ATP + D-Glucose => ADP + D-Glucose 6-phosphate ATP + D-Glucose => ADP + D-Glucose 6-phosphate D-Glucose 6-phosphate <=> D-Fructose 6-phosphate D-Fructose 1,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate D-Fructose 1,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate ATP + D-Fructose 6-phosphate => ADP + D-Fructose 1,6-bisphosphate ATP + D-Fructose 6-phosphate => ADP + D-Fructose 1,6-bisphosphate D-Fructose 1,6-bisphosphate <=> Glycerone phosphate + D-Glyceraldehyde 3-phosphate D-Sedoheptulose 1,7-bisphosphate <= Glycerone phosphate + D-Erythrose 4-phosphate D-Sedoheptulose 1,7-bisphosphate <= Glycerone phosphate + D-Erythrose 4-phosphate D-Sedoheptulose 1,7-bisphosphate + H2O => D-Sedoheptulose 7-phosphate + Orthophospha D-Glyceraldehyde 3-phosphate <=> Glycerone phosphate D-Glyceraldehyde 3-phosphate + Orthophosphate + NADP+ <= 3-Phospho-D-glyceroyl phosp D-Glyceraldehyde 3-phosphate + Orthophosphate + NAD+ => 3-Phospho-D-glyceroyl phosph ATP + 3-Phospho-D-glycerate <=> ADP + 3-Phospho-D-glyceroyl phosphate 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate 2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O D-Glucose 1-phosphate <=> D-Glucose 6-phosphate ATP + D-Glucose 1-phosphate => Diphosphate + ADP-Glucose ADP-Glucose => ADP + Amylose ADP-Glucose => ADP + Amylose Amylose => Glycogen Amylose + Orthophosphate => D-Glucose 1-phosphate Amylose + Orthophosphate => D-Glucose 1-phosphate Glycogen + Orthophosphate => D-Glucose 1-phosphate Glycogen + Orthophosphate => D-Glucose 1-phosphate Glycogen + H2O => D-Glucose D-Glucose 6-phosphate + NADP+ => D-Glucono-1,5-lactone 6-phosphate + NADPH + H+ D-Glucono-1,5-lactone 6-phosphate + H2O => 6-Phospho-D-gluconate 6-Phospho-D-gluconate + NADP+ => D-Ribulose 5-phosphate + CO2 + NADPH + H+ D-Ribose 5-phosphate <=> D-Ribulose 5-phosphate D-Ribose 5-phosphate <=> D-Ribulose 5-phosphate D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Ribose 5-phosphate D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phosphate + D D-Ribulose 5-phosphate <=> D-Xylulose 5-phosphate D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate <=> D-Erythrose 4-phospha D-Ribulose 1,5-bisphosphate + CO2 + H2O => 2 3-Phospho-D-glycerate ATP + D-Ribulose 5-phosphate => ADP + D-Ribulose 1,5-bisphosphate ATP + D-Ribose 5-phosphate <=> AMP + 5-Phospho-alpha-D-ribose 1-diphosphate D-Ribulose 1,5-bisphosphate + Oxygen => 3-Phospho-D-glycerate + 2-Phosphoglycolate Glycerone phosphate => Methylglyoxal + Orthophosphate (R)-S-Lactoylglutathione <=> Glutathione + Methylglyoxal (R)-S-Lactoylglutathione + H2O => Glutathione + (R)-Lactate

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R45 R46 R47 R48 R49 R50 R51 R52 R53 R54 R55 R56 R57 R58 R59 R60 R61 R62 R63 R64 R65 R66 R67 R68 R69 R70 R71 R72 R73 R74 R75 R76 R77 R78 R79 R80 R81 R82 R83 R84 R85 R86 R87 R88

1-(5-Phospho-D-ribosyl)-ATP + Diphosphate <= ATP + 5-Phospho-alpha-D-ribose 1-diphospha 1-(5-Phospho-D-ribosyl)-ATP + H2O => Phosphoribosyl-AMP + Diphosphate Phosphoribosyl-AMP + H2O => 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl) 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)- imidazole-4-carboxamide => N N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D- ribosyl)-4-imidazolecarboxa N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D- ribosyl)-4-imidazolecarboxa D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate => 3-(Imidazol-4-yl)-2-oxopropyl phosphate + L-Histidinol phosphate + 2-Oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl phosphate + L-Gl L-Phenylalanine + 2-Oxoglutarate <= Phenylpyruvate + L-Glutamate L-Histidinol phosphate + H2O => L-Histidinol + Orthophosphate L-Histidinol + NAD+ => L-Histidinal + NADH + H+ L-Histidinol + NAD+ => L-Histidinal + NADH + H+ L-Histidinal + H2O + NAD+ => L-Histidine + NADH + H+ L-Histidinal + H2O + NAD+ => L-Histidine + NADH + H+ ATP + Pyruvate <= ADP + Phosphoenolpyruvate ATP + Pyruvate <= ADP + Phosphoenolpyruvate Pyruvate + CoA + NAD+ => Acetyl-CoA + CO2 + NADH + H+ Pyruvate + CoA + NAD+ => Acetyl-CoA + CO2 + NADH + H+ Pyruvate + CoA + NAD+ => Acetyl-CoA + CO2 + NADH + H+ ATP + Acetate + CoA <=> AMP + Diphosphate + Acetyl-CoA Acetaldehyde + NAD+ + H2O <= Acetate + NADH + H+ Ethanol + NAD+ <= Acetaldehyde + NADH + H+ Ethanol + NADP+ <= Acetaldehyde + NADPH + H+ Orthophosphate + Oxaloacetate <= H2O + Phosphoenolpyruvate + CO2 (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate L-Phenylalanine + 2-Oxoglutarate <= Phenylpyruvate + L-Glutamate L-Tyrosine + 2-Oxoglutarate <= 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate ATP + Pyruvate + H2O => AMP + Phosphoenolpyruvate + Orthophosphate L-Alanine + NAD+ + H2O <= Pyruvate + NH3 + NADH + H+ Citrate <=> cis-Aconitate + H2O Isocitrate <=> cis-Aconitate + H2O Isocitrate + NADP+ => 2-Oxoglutarate + CO2 + NADPH + H+ ATP + Succinate + CoA <=> ADP + Orthophosphate + Succinyl-CoA (S)-Malate <=> Fumarate + H2O Succinate + FAD <=> FADH2 + Fumarate Citrate + CoA <= Acetyl-CoA + H2O + Oxaloacetate (R)-Lactate + NAD+ <=> Pyruvate + NADH + H+ (S)-Malate + NAD+ => Pyruvate + CO2 + NADH + H+ (S)-Malate + NADP+ => Pyruvate + CO2 + NADPH + H+ Acetyl-CoA + Orthophosphate <=> CoA + Acetyl phosphate ATP + Acetate <=> ADP + Acetyl phosphate 2-Phosphoglycolate + H2O => Glycolate + Orthophosphate 2-Phosphoglycolate + H2O => Glycolate + Orthophosphate

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R89 R90 R91 R92 R93 R94 R95 R96 R97 R98 R99 R100 R101 R102 R103 R104 R105 R106 R107 R108 R109 R110 R111 R112 R113 R114 R115 R116 R117 R118 R119 R120 R121 R122 R123 R124 R125 R126 R127 R128 R129 R130 R131 R132

2-Phosphoglycolate + H2O => Glycolate + Orthophosphate L-Serine + Acetyl-CoA => O-Acetyl-L-serine + CoA O-Acetyl-L-serine + Hydrogen sulfide => L-Cysteine + Acetate O-Acetyl-L-serine + Hydrogen sulfide => L-Cysteine + Acetate ATP + Sulfate => Diphosphate + Adenylyl sulfate ATP + Adenylyl sulfate => ADP + 3'-Phosphoadenylyl sulfate Thioredoxin + 3'-Phosphoadenylyl sulfate => Thioredoxin disulfide + Sulfite + Adenosine 3',5 Adenosine 3',5'-bisphosphate + H2O => AMP + Orthophosphate Hydrogen sulfide + 3 Oxidized ferredoxin + 3 H2O <= Sulfite + 3 Reduced ferredoxin L-Serine => Pyruvate + NH3 L-Threonine => 2-Oxobutanoate + NH3 Reduced ferredoxin + Acetyl-CoA + CO2 <= Oxidized ferredoxin + Pyruvate + CoA 5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-Serine Glycine + Tetrahydrofolate + NAD+ => 5,10-Methylenetetrahydrofolate + NH3 + CO2 + NAD 5-Methyltetrahydrofolate + NADP+ <= 5,10-Methylenetetrahydrofolate + NADPH + H+ 5-Methyltetrahydrofolate + NAD+ <= 5,10-Methylenetetrahydrofolate + NADH + H+ 5-Methyltetrahydrofolate + L-Homocysteine => Tetrahydrofolate + L-Methionine S-Adenosyl-L-homocysteine + H2O => Adenosine + L-Homocysteine S-Adenosyl-L-methionine + DNA => S-Adenosyl-L-homocysteine + DNA 5-methylcytosine Orthophosphate + Diphosphate + S-Adenosyl-L-methionine <= ATP + L-Methionine + H2O D-Glycerate + NAD+ <=> Hydroxypyruvate + NADH + H+ D-Glycerate + NADP+ <=> Hydroxypyruvate + NADPH + H+ L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine Phosphoenolpyruvate + D-Erythrose 4-phosphate + H2O => 2-Dehydro-3-deoxy-D-arabino-h 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate => 3-Dehydroquinate + Orthophospha 3-Dehydroquinate <=> 3-Dehydroshikimate + H2O Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ ATP + Shikimate => ADP + Shikimate 3-phosphate Phosphoenolpyruvate + Shikimate 3-phosphate <=> Orthophosphate + 5-O-(1-Carboxyvinyl 5-O-(1-Carboxyvinyl)-3-phosphoshikimate => Chorismate + Orthophosphate Chorismate + L-Glutamine => Anthranilate + Pyruvate + L-Glutamate Chorismate + NH3 => Anthranilate + Pyruvate + H2O N-(5-Phospho-D-ribosyl)anthranilate + Diphosphate <= Anthranilate + 5-Phospho-alpha-D-rib N-(5-Phospho-D-ribosyl)anthranilate => 1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-ph 1-(2-Carboxyphenylamino)-1'-deoxy-D-ribulose 5'-phosphate => Indoleglycerol phosphate + Indoleglycerol phosphate => Indole + D-Glyceraldehyde 3-phosphate L-Serine + Indoleglycerol phosphate => L-Tryptophan + D-Glyceraldehyde 3-phosphate + H2 L-Serine + Indole <=> L-Tryptophan + H2O Chorismate <=> Prephenate Prephenate => Phenylpyruvate + H2O + CO2 Prephenate + NAD+ => 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH + H+ O-Phospho-L-homoserine + H2O => L-Threonine + Orthophosphate O-Phospho-L-homoserine + H2O => L-Threonine + Orthophosphate ATP + L-Homoserine => ADP + O-Phospho-L-homoserine

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R133 R134 R135 R136 R137 R138 R139 R140 R141 R142 R143 R144 R145 R146 R147 R148 R149 R150 R151 R152 R153 R154 R155 R156 R157 R158 R159 R160 R161 R162 R163 R164 R165 R166 R167 R168 R169 R170 R171 R172 R173 R174 R175 R176

L-Homoserine + NADP+ <= L-Aspartate 4-semialdehyde + NADPH + H+ L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ <= 4-Phospho-L-aspartate + NADP ATP + L-Aspartate => ADP + 4-Phospho-L-aspartate L-Aspartate 4-semialdehyde + Pyruvate => L-2,3-Dihydrodipicolinate + 2 H2O 2,3,4,5-Tetrahydrodipicolinate + NADP+ <= L-2,3-Dihydrodipicolinate + NADPH + H+ LL-2,6-Diaminoheptanedioate + 2-Oxoglutarate <= 2,3,4,5-Tetrahydrodipicolinate + L-Glutam LL-2,6-Diaminoheptanedioate <=> meso-2,6-Diaminoheptanedioate meso-2,6-Diaminoheptanedioate => L-Lysine + CO2 N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamat N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamat Pyruvate + Thiamin diphosphate => 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2 2-Acetolactate + Thiamin diphosphate <= 2-(alpha-Hydroxyethyl)thiamine diphosphate + Py 2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate => (S)-2-Aceto-2-hydroxybu 2-Acetolactate + NADPH + H+ => 2,3-Dihydroxy-3-methylbutanoate + NADP+ (S)-2-Aceto-2-hydroxybutanoate => (R)-3-Hydroxy-3-methyl-2-oxopentanoate (R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <= (R)-3-Hydroxy-3-methyl-2-oxopentanoat 2,3-Dihydroxy-3-methylbutanoate => 3-Methyl-2-oxobutanoic acid + H2O (R)-2,3-Dihydroxy-3-methylpentanoate => (S)-3-Methyl-2-oxopentanoic acid + H2O L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate (2S)-2-Isopropylmalate + CoA <= Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O (2S)-2-Isopropylmalate + CoA <= Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O (2S)-2-Isopropylmalate => 2-Isopropylmaleate + H2O (2R,3S)-3-Isopropylmalate <= 2-Isopropylmaleate + H2O (2S)-2-Isopropyl-3-oxosuccinate => 4-Methyl-2-oxopentanoate (2R,3S)-3-Isopropylmalate + NAD+ => (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+ 2 L-Glutamate + NAD+ <= L-Glutamine + 2-Oxoglutarate + NADH + H+ ATP + L-Glutamate + NH3 => ADP + Orthophosphate + L-Glutamine ATP + L-Glutamate + NH3 => ADP + Orthophosphate + L-Glutamine L-Glutamine + H2O => L-Glutamate + NH3 L-Glutamate + NADP+ + H2O <= 2-Oxoglutarate + NH3 + NADPH + H+ ATP + L-Glutamate => ADP + L-Glutamyl 5-phosphate L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ <= L-Glutamyl 5-phosphate + NAD L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ <= L-Glutamyl 5-phosphate + NAD L-Glutamate 5-semialdehyde + NAD+ + H2O => L-Glutamate + NADH + H+ (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O => L-Glutamate + NADH + H+ L-Proline + FAD => (S)-1-Pyrroline-5-carboxylate + FADH2 L-Proline + NAD+ <= (S)-1-Pyrroline-5-carboxylate + NADH + H+ L-Proline + NADP+ <= (S)-1-Pyrroline-5-carboxylate + NADPH + H+ Acetyl-CoA + L-Glutamate => CoA + N-Acetyl-L-glutamate N-Acetylornithine + L-Glutamate => L-Ornithine + N-Acetyl-L-glutamate (S)-1-Pyrroline-5-carboxylate + H2O <=> L-Glutamate 5-semialdehyde ATP + N-Acetyl-L-glutamate => ADP + N-Acetyl-L-glutamate 5-phosphate

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R177 R178 R179 R180 R181 R182 R183 R184 R185 R186 R187 R188 R189 R190 R191 R192 R193 R194 R195 R196 R197 R198 R199 R200 R201 R202 R203 R204 R205 R206 R207 R208 R209 R210 R211 R212 R213 R214 R215 R216 R217 R218 R219 R220

N-Acetyl-L-glutamate 5-semialdehyde + Orthophosphate + NADP+ <=> N-Acetyl-L-glutamat Carbamoyl phosphate + L-Ornithine <=> Orthophosphate + L-Citrulline N-(L-Arginino)succinate => Fumarate + L-Arginine ATP + L-Citrulline + L-Aspartate => AMP + Diphosphate + N-(L-Arginino)succinate L-Glutamine + H2O => L-Glutamate + NH3 2 ATP + L-Glutamine + HCO3- + H2O => 2 ADP + Orthophosphate + L-Glutamate + Carbam ATP + NH3 + CO2 <=> ADP + Carbamoyl phosphate Nitrite + H2O + 2 Oxidized ferredoxin <= Nitrate + 2 Reduced ferredoxin NH3 + 2 H2O + 6 Oxidized ferredoxin <= Nitrite + 6 Reduced ferredoxin + 7 H+ 2 L-Glutamate + 2 Oxidized ferredoxin <= L-Glutamine + 2-Oxoglutarate + 2 Reduced ferred L-Asparagine + H2O => L-Aspartate + NH3 L-Asparagine + H2O => L-Aspartate + NH3 ATP + D-Glycerate => ADP + 2-Phospho-D-glycerate 2 Reduced ferredoxin + NADP+ <=> 2 Oxidized ferredoxin + NADPH + H+ D-Glycerate + NAD+ <= Tartronate semialdehyde + NADH + H+ D-Glycerate + NADP+ <= Tartronate semialdehyde + NADPH + H+ 2 Glyoxylate => Tartronate semialdehyde + CO2 Glyoxylate + Oxygen + H2O => Oxalate + H2O2 Oxalate => Formate + CO2 Formate + 2 Ferricytochrome b1 => CO2 + 2 Ferrocytochrome b1 + 2 H+ 2 H2O + 2 NADP+ + 8 Photon => 12 Hextern + 2 NADPH + 2 H+ + Oxygen NADH + H+ + Q => NAD+ + QH2 + 2 Hextern FADH2 + Q => FAD + QH2 2 QH2 + Oxygen => 2 Q + 4 Hextern 14 Hextern + 3 ADP + 3 Orthophosphate => 3 ATP + 3 H2O 1 Photon => 2 Hextern 1 PhotonEx => 1 Photon NADPH + H+ + NAD+ <=> NADP+ + H+ + NADH 1 ATP + H2O => 1 ADP + Orthophosphate ATP + AMP <=> 2 ADP ATP + AMP <=> 2 ADP L-Cysteine + [enzyme]-cysteine = L-Alanine + [enzyme]-S-sulfanylcysteine L-Cysteine + [enzyme]-cysteine = L-Alanine + [enzyme]-S-sulfanylcysteine L-Cysteine + [enzyme]-cysteine = L-Alanine + [enzyme]-S-sulfanylcysteine ATP + H2O + SulfateEx => ADP + Orthophosphate + Sulfate ATP + H2O + NitrateEx => ADP + Nitrate + Orthophosphate Glycine + 2-Oxoglutarate <=> Glyoxylate + L-Glutamate 5-Phosphoribosylamine + Diphosphate + L-Glutamate <= L-Glutamine + 5-Phospho-alpha-DATP + 5-Phosphoribosylamine + Glycine => ADP + Orthophosphate + 5'-Phosphoribosylglyci 10-Formyltetrahydrofolate + 5'-Phosphoribosylglycinamide => Tetrahydrofolate + 5'-Phosph 5'-Phosphoribosylglycinamide + 5,10-Methenyltetrahydrofolate + H2O => 5'-PhosphoribosylATP + 5'-Phosphoribosyl-N-formylglycinamide + L-Glutamine + H2O => ADP + Orthophospha ATP + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine => ADP + Orthophosphate + Amin 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate <=> Aminoimidazole ribotide + CO2

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R221 R222 R223 R224 R225 R226 R227 R228 R229 R230 R231 R232 R233 R234 R235 R236 R237 R238 R239 R240 R241 R242 R243 R244 R245 R246 R247 R248 R249 R250 R251 R252 R253 R254 R255 R256 R257 R258 R259 R260 R261 R262 R263 R264

ATP + 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-Aspartate <=> ADP + Or 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole <=> Fumarate + 1-(5'-Ph 10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide => Tetr IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide GTP + IMP + L-Aspartate => GDP + Orthophosphate + N6-(1,2-Dicarboxyethyl)-AMP N6-(1,2-Dicarboxyethyl)-AMP => Fumarate + AMP dADP + Thioredoxin disulfide + H2O <= Thioredoxin + ADP dCDP + Thioredoxin disulfide + H2O <= Thioredoxin + CDP dGDP + Thioredoxin disulfide + H2O <= GDP + Thioredoxin dUDP + Thioredoxin disulfide + H2O <= Thioredoxin + UDP Thioredoxin + NADP+ <= Thioredoxin disulfide + NADPH + H+ GTP + H2O => GMP + Diphosphate UTP + H2O => UMP + Diphosphate ATP + GDP <=> ADP + GTP ATP + dADP <=> ADP + dATP ATP + dGDP <=> ADP + dGTP ATP + dTDP <=> ADP + dTTP ATP + dCDP <=> ADP + dCTP ATP + dUDP <=> ADP + dUTP AMP + H2O <=> Adenosine + Orthophosphate AMP + H2O <=> Adenosine + Orthophosphate IMP + NAD+ + H2O => Xanthosine 5'-phosphate + NADH + H+ ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O <=> AMP + Diphosphate + GMP + L-G ATP + GMP <=> ADP + GDP Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate (S)-Dihydroorotate + H2O <=> N-Carbamoyl-L-aspartate (S)-Dihydroorotate + H2O <=> N-Carbamoyl-L-aspartate (S)-Dihydroorotate + Oxygen <=> Orotate + H2O2 Orotidine 5'-phosphate + Diphosphate <=> Orotate + 5-Phospho-alpha-D-ribose 1-diphospha Orotidine 5'-phosphate => UMP + CO2 ATP + CMP <=> ADP + CDP ATP + UMP <=> ADP + UDP ATP + UMP <=> ADP + UDP ATP + UDP <=> ADP + UTP ATP + CDP <=> ADP + CTP ATP + UTP + NH3 => ADP + Orthophosphate + CTP ATP + UTP + L-Glutamine + H2O => ADP + Orthophosphate + CTP + L-Glutamate dCTP + H2O => dUTP + NH3 CTP + H2O => UTP + NH3 ATP + dTMP <=> ADP + dTDP ATP + dUMP <=> ADP + dUDP 5,10-Methylenetetrahydrofolate + dUMP + NADPH + H+ => Tetrahydrofolate + dTMP + NAD L-Aspartate + Oxygen => Iminoaspartate + H2O2 L-Aspartate + H2O + Oxygen => Oxaloacetate + NH3 + H2O2

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R265 R266 R267 R268 R269 R270 R271 R272 R273 R274 R275 R276 R277 R278 R279 R280 R281 R282 R283 R284 R285 R286 R287 R288 R289 R290 R291 R292 R293 R294 R295 R296 R297 R298 R299 R300 R301 R302 R303 R304 R305 R306 R307 R308

Pyridine-2,3-dicarboxylate + 2 H2O + Orthophosphate <= Iminoaspartate + Glycerone phosp Nicotinate D-ribonucleotide + Diphosphate + CO2 <= Pyridine-2,3-dicarboxylate + 5-Phosph ATP + Nicotinate D-ribonucleotide <=> Diphosphate + Deamino-NAD+ ATP + Nicotinate D-ribonucleotide <=> Diphosphate + Deamino-NAD+ ATP + Deamino-NAD+ + NH3 => AMP + Diphosphate + NAD+ ATP + NAD+ => ADP + NADP+ L-Glutamate => 4-Aminobutanoate + CO2 L-Aspartate => beta-Alanine + CO2 L-Aspartate => beta-Alanine + CO2 Succinate semialdehyde + NADP+ + H2O => Succinate + NADPH + H+ 4-Aminobutanoate + 2-Oxoglutarate <=> Succinate semialdehyde + L-Glutamate 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxobutanoic acid + H2O => Tetrahydrofolate + (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+ ATP + (R)-Pantoate + beta-Alanine => AMP + Diphosphate + Pantothenate ATP + Pantothenate => ADP + D-4'-Phosphopantothenate (R)-4'-Phosphopantothenoyl-L-cysteine => Pantetheine 4'-phosphate + CO2 ATP + D-4'-Phosphopantothenate + L-Cysteine => AMP + Diphosphate + (R)-4'-Phosphopant CTP + D-4'-Phosphopantothenate + L-Cysteine => CMP + Diphosphate + (R)-4'-Phosphopant ATP + Pantetheine 4'-phosphate => Diphosphate + Dephospho-CoA ATP + Dephospho-CoA => ADP + CoA 2 H2O2 => Oxygen + 2 H2O ATP + L-Glutamate + L-Cysteine => ADP + Orthophosphate + gamma-L-Glutamyl-L-cysteine ATP + gamma-L-Glutamyl-L-cysteine + Glycine => ADP + Orthophosphate + Glutathione Glutathione + H2O => Cys-Gly + L-Glutamate Cys-Gly + H2O => L-Cysteine + Glycine Cys-Gly + H2O => L-Cysteine + Glycine GTP + 3 H2O => Formate + 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + Diph 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + H2O => 5-Amino-6-(5'-phosphori 5-Amino-6-(5'-phosphoribitylamino)uracil + H2O <=> 5-Amino-6-(1-D-ribitylamino)uracil + O 5-Amino-6-(5'-phosphoribitylamino)uracil + NADP+ <= 5-Amino-6-(5'-phosphoribosylamino)u D-Ribulose 5-phosphate => 3,4-Dihydroxy-2-butanone 4-phosphate + Formate 5-Amino-6-(1-D-ribitylamino)uracil + 3,4-Dihydroxy-2-butanone 4-phosphate => 6,7-Dimethy 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine => Riboflavin + 5-Amino-6-(1-D-ribitylamino)uracil ATP + Riboflavin => ADP + FMN ATP + FMN => Diphosphate + FAD GTP + H2O => 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphos 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate + H2O = 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine + Orthophospha 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine => Glycolaldeh Glycolaldehyde + NAD+ + H2O => Glycolate + NADH + H+ ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine => AMP + 2-Amino-7,8-dihy 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-Aminobenzoate => Dip 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoate => Dihydropte 4-Amino-4-deoxychorismate => 4-Aminobenzoate + Pyruvate

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R309 R310 R311 R312 R313 R314 R315 R316 R317 R318 R319 R320 R321 R322 R323 R324 R325 R326 R327 R328 R329 R330 R331 R332 R333 R334 R335 R336 R337 R338 R339 R340 R341 R342 R343 R344 R345 R346 R347 R348 R349 R350 R351 R352

Chorismate + L-Glutamine => 4-Amino-4-deoxychorismate + L-Glutamate ATP + Dihydropteroate + L-Glutamate => ADP + Orthophosphate + Dihydrofolate ATP + Dihydropteroate + L-Glutamate => ADP + Orthophosphate + Dihydrofolate Tetrahydrofolate + NADP+ <= Dihydrofolate + NADPH + H+ 10-Formyltetrahydrofolate + H2O => Formate + Tetrahydrofolate 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+ 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH Acetyl-CoA + L-Homoserine => CoA + O-Acetyl-L-homoserine O-Acetyl-L-homoserine + Hydrogen sulfide => L-Homocysteine + Acetate H2CO3 <=> CO2 + H2O H2CO3 <=> CO2 + H2O ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate D-Mannose 6-phosphate <=> D-Fructose 6-phosphate D-Mannose 6-phosphate <=> D-Mannose 1-phosphate D-Mannose 6-phosphate <=> D-Mannose 1-phosphate GTP + D-Mannose 1-phosphate => Diphosphate + GDP-mannose GTP + D-Mannose 1-phosphate => Diphosphate + GDP-mannose GDP + D-Mannose 1-phosphate => Orthophosphate + GDP-mannose GDP + D-Mannose 1-phosphate => Orthophosphate + GDP-mannose dTTP + D-Glucose 1-phosphate => Diphosphate + dTDP-glucose CTP + D-Glucose 1-phosphate => Diphosphate + CDP-glucose dTTP + D-Glucose 1-phosphate <=> Diphosphate + dTDP-glucose dTDP-glucose <=> dTDP-galactose dTDP-glucose <=> dTDP-galactose dTDP-glucose <=> dTDP-galactose dTDP-glucose => 4,6-Dideoxy-4-oxo-dTDP-D-glucose + H2O dTDP-glucose => 4,6-Dideoxy-4-oxo-dTDP-D-glucose + H2O 4,6-Dideoxy-4-oxo-dTDP-D-glucose => dTDP-4-dehydro-6-deoxy-L-mannose 4,6-Dideoxy-4-oxo-dTDP-D-glucose => dTDP-4-dehydro-6-deoxy-L-mannose 4,6-Dideoxy-4-oxo-dTDP-D-glucose <=> GDP-4-dehydro-6-deoxy-L-mannose 4,6-Dideoxy-4-oxo-dTDP-D-glucose <=> GDP-4-dehydro-6-deoxy-L-mannose dTDP-6-deoxy-L-mannose + NADP+ <= dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+ GDP-6-deoxy-L-mannose + NADP+ <= GDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+ 1 O2Ex <=> 1 Oxygen 1 CO2 => 1 CO2Ex 1 HCO3-EX + 1 ATP => 1 HCO3- + 1 ADP 1 HCO3- + 1 H+ <=> 1 H2CO3 1 ATP + 2 GTP + 0.058 L-Isoleucine + 0.094 L-Leucine + 0.036 L-Lysine + 0.018 L-Methionine 0.222 dCTP + 0.279 dTTP + 0.222 dGTP + 0.279 dATP => 1 Diphosphate + 1 B2 0.322 GTP + 0.262 ATP + 0.2 CTP + 0.216 UTP => 1 Diphosphate + 1 B3 0.1379 UDP-glucose + 0.8143 dTDP-Rhamnose + 0.0478 Glycogen => 1 B4 + 0.8143 dTDP + 1 sn-Glycerol 3-phosphate + 0.7153 UDP-D-galactose + 0.1807 UDP-glucose + 1.470 Acetyl-C 0.8404 B1 + 0.0039 B2 + 0.013 B3 + 0.123 B4 + 0.0182 B5 => 1 E1 1 L-Aspartate + 1 L-Arginine + 2 ATP => Cyanophycin + Diphosphate

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R353 R354 R355 R356 R357 R358 R359 R360 R361 R362 R363 R364 R365 R366 R367 R368 R369 R370 R371 R372 R373 R374 R375 R376 R377 R378 R379 R380

1 L-Aspartate + 1 L-Arginine + 2 ATP => Cyanophycin + Diphosphate Cyanophycine + 1 H2O => 1 L-Aspartate + 1 L-Arginine Diphosphate + H2O => 2 Orthophosphate ATP + Orthophosphate <=> ADP + Diphosphate UTP + D-Glucose 1-phosphate <=> Diphosphate + UDP-glucose UDP-glucose <=> UDP-D-galactose D-Glyceraldehyde + NAD+ + H2O <=> D-Glycerate + NADH + H+ Glycerol + NADP+ <=> D-Glyceraldehyde + NADPH + H+ ATP + Glycerol => ADP + sn-Glycerol 3-phosphate sn-Glycerol 3-phosphate + NAD+ <=> Glycerone phosphate + NADH + H+ sn-Glycerol 3-phosphate + FAD => Glycerone phosphate + FADH2 Glycolate + NAD+ => Glyoxylate + NADH + H+ Glycolate + NAD+ => Glyoxylate + NADH + H+ 5'-Phosphoribosylglycinamide + Formate + ATP => 5'-Phosphoribosyl-N-formylglycinamide + L-Arginine + H2O => L-Citrulline + NH3 L-Ornithine + 2-Oxoglutarate <=> L-Glutamate 5-semialdehyde + L-Glutamate L-Arginine + FAD => 5-Guanidino-2-oxopentanoate + NH3 + FADH2 5-Guanidino-2-oxopentanoate => 4-Guanidinobutanoate + CO2 4-Guanidinobutanoate + H2O => 4-Aminobutanoate + Urea ATP + H2O + UreaEx => ADP + Urea + Orthophosphate Urea + H2O => CO2 + 2 NH3 L-Proline + 2-Oxoglutarate + Oxygen => trans-4-Hydroxy-L-proline + Succinate + CO2 trans-4-Hydroxy-L-proline + NAD+ => L-1-Pyrroline-3-hydroxy-5-carboxylate + NADH + H+ trans-4-Hydroxy-L-proline + NADP+ => L-1-Pyrroline-3-hydroxy-5-carboxylate + NADPH + H+ L-1-Pyrroline-3-hydroxy-5-carboxylate + NAD+ + 2 H2O => L-erythro-4-Hydroxyglutamate + L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate <=> D-4-Hydroxy-2-oxoglutarate + L-Glutam D-4-Hydroxy-2-oxoglutarate => Pyruvate + Glyoxylate D-4-Hydroxy-2-oxoglutarate => Pyruvate + Glyoxylate

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-phosphate + Orthophosphate -phosphate + Orthophosphate 1,6-bisphosphate 1,6-bisphosphate ate + D-Glyceraldehyde 3-phosphate osphate + D-Erythrose 4-phosphate osphate + D-Erythrose 4-phosphate oheptulose 7-phosphate + Orthophosphate

NADP+ <= 3-Phospho-D-glyceroyl phosphate + NADPH + H+ NAD+ => 3-Phospho-D-glyceroyl phosphate + NADH + H+ -D-glyceroyl phosphate

actone 6-phosphate + NADPH + H+ spho-D-gluconate hosphate + CO2 + NADPH + H+

phosphate <=> D-Ribose 5-phosphate + D-Xylulose 5-phosphate hate <=> D-Erythrose 4-phosphate + D-Xylulose 5-phosphate

phosphate <=> D-Erythrose 4-phosphate + D-Fructose 6-phosphate hospho-D-glycerate 1,5-bisphosphate alpha-D-ribose 1-diphosphate o-D-glycerate + 2-Phosphoglycolate

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+ 5-Phospho-alpha-D-ribose 1-diphosphate yl-AMP + Diphosphate ylaminoformimino)-1-(5-phosphoribosyl)- imidazole-4-carboxamide ribosyl)- imidazole-4-carboxamide => N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D- ribosyl)-4-imidazo -phospho-D- ribosyl)-4-imidazolecarboxamide + L-Glutamine => D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-P -phospho-D- ribosyl)-4-imidazolecarboxamide + L-Glutamine => D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate + 1-(5'-P -(Imidazol-4-yl)-2-oxopropyl phosphate + H2O azol-4-yl)-2-oxopropyl phosphate + L-Glutamate e + L-Glutamate

enolpyruvate + CO2

e + L-Glutamate pyruvate + L-Glutamate ate + Orthophosphate

+ Succinyl-CoA

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oxin disulfide + Sulfite + Adenosine 3',5'-bisphosphate

= Sulfite + 3 Reduced ferredoxin

d ferredoxin + Pyruvate + CoA > Tetrahydrofolate + L-Serine netetrahydrofolate + NH3 + CO2 + NADH + H+ netetrahydrofolate + NADPH + H+ etetrahydrofolate + NADH + H+ hydrofolate + L-Methionine L-Homocysteine mocysteine + DNA 5-methylcytosine ionine <= ATP + L-Methionine + H2O

H2O => 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + Orthophosphate => 3-Dehydroquinate + Orthophosphate

Orthophosphate + 5-O-(1-Carboxyvinyl)-3-phosphoshikimate mate + Orthophosphate te + L-Glutamate

= Anthranilate + 5-Phospho-alpha-D-ribose 1-diphosphate phenylamino)-1'-deoxy-D-ribulose 5'-phosphate sphate => Indoleglycerol phosphate + CO2 + H2O yde 3-phosphate n + D-Glyceraldehyde 3-phosphate + H2O

e + CO2 + NADH + H+

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yde + NADPH + H+ DP+ <= 4-Phospho-L-aspartate + NADPH + H+

ydrodipicolinate + 2 H2O hydrodipicolinate + NADPH + H+ ,3,4,5-Tetrahydrodipicolinate + L-Glutamate + H2O oheptanedioate

lutamate 5-semialdehyde + L-Glutamate lutamate 5-semialdehyde + L-Glutamate yethyl)thiamine diphosphate + CO2 ydroxyethyl)thiamine diphosphate + Pyruvate phosphate => (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate methylbutanoate + NADP+ methyl-2-oxopentanoate (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+ butanoic acid + H2O yl-2-oxopentanoic acid + H2O anoate + L-Glutamate oic acid + L-Glutamate opentanoic acid + L-Glutamate hyl-2-oxobutanoic acid + H2O hyl-2-oxobutanoic acid + H2O

yl-3-oxosuccinate + NADH + H+ arate + NADH + H+ e + L-Glutamine e + L-Glutamine

NH3 + NADPH + H+

DP+ <= L-Glutamyl 5-phosphate + NADPH + H+ DP+ <= L-Glutamyl 5-phosphate + NADPH + H+ utamate + NADH + H+ Glutamate + NADH + H+

+ NADPH + H+

Acetyl-L-glutamate e 5-semialdehyde tamate 5-phosphate

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ate + NADP+ <=> N-Acetyl-L-glutamate 5-phosphate + NADPH + H+ phate + L-Citrulline

ate + N-(L-Arginino)succinate

thophosphate + L-Glutamate + Carbamoyl phosphate

Reduced ferredoxin Reduced ferredoxin + 7 H+ ne + 2-Oxoglutarate + 2 Reduced ferredoxin

edoxin + NADPH + H+

+ NADPH + H+

ytochrome b1 + 2 H+ DPH + 2 H+ + Oxygen

me]-S-sulfanylcysteine me]-S-sulfanylcysteine me]-S-sulfanylcysteine

e <= L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O rthophosphate + 5'-Phosphoribosylglycinamide amide => Tetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide ydrofolate + H2O => 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate tamine + H2O => ADP + Orthophosphate + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine + L-Glutamate dine => ADP + Orthophosphate + Aminoimidazole ribotide ate <=> Aminoimidazole ribotide + CO2

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rboxylate + L-Aspartate <=> ADP + Orthophosphate + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazo de)-imidazole <=> Fumarate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide amino-4-imidazolecarboxamide => Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide -imidazolecarboxamide + N6-(1,2-Dicarboxyethyl)-AMP

O <=> AMP + Diphosphate + GMP + L-Glutamate

phate + N-Carbamoyl-L-aspartate

+ 5-Phospho-alpha-D-ribose 1-diphosphate

osphate + CTP + L-Glutamate

H+ => Tetrahydrofolate + dTMP + NADP+

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e <= Iminoaspartate + Glycerone phosphate = Pyridine-2,3-dicarboxylate + 5-Phospho-alpha-D-ribose 1-diphosphate + Deamino-NAD+ + Deamino-NAD+

ate + NADPH + H+ semialdehyde + L-Glutamate anoic acid + H2O => Tetrahydrofolate + 2-Dehydropantoate

phate + Pantothenate

ne 4'-phosphate + CO2 MP + Diphosphate + (R)-4'-Phosphopantothenoyl-L-cysteine MP + Diphosphate + (R)-4'-Phosphopantothenoyl-L-cysteine Dephospho-CoA

sphate + gamma-L-Glutamyl-L-cysteine DP + Orthophosphate + Glutathione

horibosylamino)-4-pyrimidineone + Diphosphate one + H2O => 5-Amino-6-(5'-phosphoribosylamino)uracil + NH3 5-Amino-6-(1-D-ribitylamino)uracil + Orthophosphate = 5-Amino-6-(5'-phosphoribosylamino)uracil + NADPH + H+ e 4-phosphate + Formate butanone 4-phosphate => 6,7-Dimethyl-8-(1-D-ribityl)lumazine + 2 H2O + Orthophosphate + 5-Amino-6-(1-D-ribitylamino)uracil

ihydroxypropyl)dihydropteridine triphosphate + Formate dihydropteridine triphosphate + H2O => Dihydroneopterin phosphate + Diphosphate yl)-7,8-dihydropteridine + Orthophosphate <= Dihydroneopterin phosphate + H2O yl)-7,8-dihydropteridine => Glycolaldehyde + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine

ropteridine => AMP + 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine yl)pteridine + 4-Aminobenzoate => Diphosphate + Dihydropteroate dine + 4-Aminobenzoate => Dihydropteroate + H2O

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smate + L-Glutamate hophosphate + Dihydrofolate hophosphate + Dihydrofolate

ltetrahydrofolate + H+ Methenyltetrahydrofolate + NADPH

ocysteine + Acetate

+ GDP-mannose + GDP-mannose

ro-6-deoxy-L-mannose ro-6-deoxy-L-mannose dro-6-deoxy-L-mannose dro-6-deoxy-L-mannose dro-6-deoxy-L-mannose + NADPH + H+ o-6-deoxy-L-mannose + NADPH + H+

e + 0.036 L-Lysine + 0.018 L-Methionine + 0.039 L-Phenylalanine + 0.054 L-Threonine + 0.009 L-Tryptophan + 0.076 L-Va P => 1 Diphosphate + 1 B2 Diphosphate + 1 B3 478 Glycogen => 1 B4 + 0.8143 dTDP + 0.1379 UDP + 0.1807 UDP-glucose + 1.470 Acetyl-CoA + 0.7350 H2O + 0.1807 Hydrogen-sulfide => 1 B5 + 1.470 CoA + 0.8960 UDP 182 B5 => 1 E1 in + Diphosphate

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in + Diphosphate

osphate + NADH + H+

'-Phosphoribosyl-N-formylglycinamide + ADP + Orthophsophate

mialdehyde + L-Glutamate NH3 + FADH2

roxy-L-proline + Succinate + CO2 -hydroxy-5-carboxylate + NADH + H+ 3-hydroxy-5-carboxylate + NADPH + H+ 2O => L-erythro-4-Hydroxyglutamate + NADH + H+ > D-4-Hydroxy-2-oxoglutarate + L-Glutamate

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''-phospho-D- ribosyl)-4-imidazolecarboxamide )glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + L-Glutamate )glycerol 3-phosphate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + L-Glutamate

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idine + L-Glutamate

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N-succinocarboxamide)-imidazole

4-imidazolecarboxamide

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.009 L-Tryptophan + 0.076 L-Valine + 0.053 L-Arginine + 0.014 L-Histidine + 0.101 L-Alanine + 0.098 L-Aspartate + 0.132

1 B5 + 1.470 CoA + 0.8960 UDP + 0.7350 Orthophosphate

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ne + 0.098 L-Aspartate + 0.132 L-Glutamate + 0.007 L-Cysteine + 0.086 Glycine + 0.038 L-Proline + 0.054 L-Serine + 0.0

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L-Proline + 0.054 L-Serine + 0.033 L-Tyrosine + 2 H2O => 2 GDP + 1 AMP + Diphosphate + 2 Orthophosphate + 1 B1

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+ 2 Orthophosphate + 1 B1

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