Scribd Logo
Upload

Welcome to Scribd!

  • An Dan Nilai Ic50

    Uploaded by

    Gian Primahana
    59 views3 pages
    1. The document describes the antioxidant properties and IC50 values of various hydroxychalcone derivatives tested against DPPH radicals. Compounds were tested for their ability to inhibit the DPPH electron spin resonance signal. 2. Compounds with additional hydroxyl and methoxy groups showed increased antioxidant effects, with lower IC50 values ranging from 2.7 to 13 μM. Compounds with only one hydroxyl group had weaker antioxidant effects, with IC50 values around 100 μM or higher. 3. A series of substituted chalcones were also evaluated, finding IC50 values between 86-107 μg/mL, with halogen and methoxy substitutions on the aromatic rings. Overall, the data suggests hydroxylation and additional functional

    Original Description:

    Original Title

    an Dan Nilai Ic50

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    1. The document describes the antioxidant properties and IC50 values of various hydroxychalcone derivatives tested against DPPH radicals. Compounds were tested for their ability to inhibit the DPPH electron spin resonance signal. 2. Compounds with additional hydroxyl and methoxy groups showed increased antioxidant effects, with lower IC50 values ranging from 2.7 to 13 μM. Compounds with only one hydroxyl group had weaker antioxidant effects, with IC50 values around 100 μM or higher. 3. A series of substituted chalcones were also evaluated, finding IC50 values between 86-107 μg/mL, with halogen and methoxy substitutions on the aromatic rings. Overall, the data suggests hydroxylation and additional functional

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    59 views3 pages

    An Dan Nilai Ic50

    Uploaded by

    Gian Primahana
    1. The document describes the antioxidant properties and IC50 values of various hydroxychalcone derivatives tested against DPPH radicals. Compounds were tested for their ability to inhibit the DPPH electron spin resonance signal. 2. Compounds with additional hydroxyl and methoxy groups showed increased antioxidant effects, with lower IC50 values ranging from 2.7 to 13 μM. Compounds with only one hydroxyl group had weaker antioxidant effects, with IC50 values around 100 μM or higher. 3. A series of substituted chalcones were also evaluated, finding IC50 values between 86-107 μg/mL, with halogen and methoxy substitutions on the aromatic rings. Overall, the data suggests hydroxylation and additional functional

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 3

    ANTIOKSIDAN DAN NILAI IC50 DARI BERBAGAI TURUNAN HIDROKSIKALKON Struktur Senyawa IC50 (1x10-5 M) Metode

    No

    9% (5x10-3 M) (2) 100,08 ppm


    OH

    DPPH

    1a

    Mr = 224 g/mol
    OH O

    500 (1) 1120 ppm

    DPPH

    2a

    Mr = 224 g/mol
    O

    1% (5x10-3 M) (2) 11,2 ppm


    HO

    DPPH

    3a

    Mr = 224 g/mol
    OH O

    7% (5x10-3 M) (2) 84 ppm


    OH

    DPPH

    4a

    Mr = 240 g/mol
    OH HO HO O

    5.0 (1) 12,8 ppm Mr = 256 g/mol


    OH O

    DPPH

    5a

    11% (5x10-3 M) (2) 28,16 ppm


    HO OH

    DPPH

    6a

    Mr = 256 g/mol
    OH O OH HO OH

    2.7 (1) 7,34 ppm

    DPPH

    7a

    Mr = 272 g/mol
    OH O

    100.0 (1) 272 ppm


    HO OH OH

    DPPH

    8a

    Mr = 272 g/mol

    OH

    O OH

    3.1 (1) 8,93 ppm

    DPPH

    9a

    HO

    OH

    OH

    Mr = 288 g/mol
    OH O OCH3 HO OH

    13.0 (1) 37,18 ppm

    DPPH

    10a

    Mr = 286 g/mol
    a) David Kozlowski, Patrick Trouillas, Claude Calliste, Philippe Marsal, Roberto Lazzaroni, and JeanLuc Duroux, Density Functional Theory Study of the Conformational, Electronic, and Antioxidant Properties of Natural Chalcones J. Phys. Chem. A 2007, 111, 1138-1145 IC50 represents the chalcone concentration required to reduce the DPPH electron spin resonance (ESR) signal by 50%. Standard deviations are <10%. Values given in brackets represent the inhibition percentage at 5x10-3 M for compounds with IC50 >500.0 x 10-5

    1. 2.

    OH

    96.38(g/mL)
    OCH3

    DPPH

    11b

    OH

    107(g/mL)
    Cl

    DPPH

    12b

    OH

    Cl

    88.41(g/mL)

    DPPH

    13b

    OH

    Br

    86.70(g/mL)

    DPPH

    14b

    OH

    O OCH3

    96.24(g/mL)
    OCH3 OCH3
    a)

    DPPH

    15b

    Belsare D .P., Pal S.C.,Kazi A .A., Kankate R.S.,Vanjari S.S, Evaluation of Antioxidant Activity of Chalcones and Flavonoids, International Journal of ChemTech Research, 2010, Vol.2, No.2, pp 1080-1089

    OH

    O OH

    OH

    You might also like