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Fact: Many are not aware of proper way & drug dosages for nebulization!
Why Nebulization?
Oral medications donot achieve the required bronchodilation in children esp. infants
Side effects of oral bronchodilators may be unbearable e.g. insomnia, tremors, etc.
Convenient, although it may not work for the 12 hours. [required because in clinic settings it is difficult to nebulize more than twice in a day] May be more easy than inhaler for some older children Good in case of severe bronchospasm or acute severe asthma.
Inhalation therapy is always better than oral medication!
Drug is delivered directly to the target organ (lung), with minimal systemic exposure
Systemic side effects are less frequent and severe with inhalation compared to systemic delivery (injection, oral); e.g., less muscle tremor, tachycardia with 2-agonists; lower HPA suppression with corticosteroids Inhaled drug therapy is less painful and relatively comfortable
Nebulizers / Nebulisers
A device used to administer medication in the form of a mist inhaled into the lungs Use oxygen, compressed air or ultrasonic power to break up medical solutions/suspensions into small aerosol droplets that can be directly inhaled from the mouthpiece of the device. The definition of an aerosol is a "mixture of gas and liquid particles," [like mist] A wide variety of nebulizer are available. Nebulizers can be driven by compressed gas (jet nebulizer) or by an ultrasonically vibrating crystal (ultrasonic nebuliser). Conventional jet Nebulizers waste a great deal of the drug during expiration and ultrasonic Nebulizers are becoming more common
Nebulizers / Nebulisers
The efficiency of drug delivery depends on the type & volume of nebuliser chamber and the flow rate at which it is driven. Some chambers have reservoir and valve systems to increase efficiency of particle delivery during inspiration and reduce environmental losses during expiration. Breath-assisted open vent systems improve drug delivery but are dependent on the patient having an adequate expiratory flow. Facemasks & mouthpieces are equally effective, but breathless patients may prefer facemasks. Facemasks should be avoided or sealed very tightly when Anticholinergic drugs are administered to patients with glaucoma. Facemasks should ideally also be avoided for delivery of nebulized corticosteroids, to prevent contact with the surrounding facial skin & eyes.
Nebulizers: Development
The first powered or pressurized inhaler was invented in France by SalesGirons in 1858 In 1864 the first steam driven nebulizer was invented in Germany known as: Siegles steam spray inhaler
The first electrical nebulizer was invented in the 1930s and called a Pneumostat
In 1956 pressurized MDI was launched by Riker Laboratories (3M), with isoprenaline & adrenaline as 1st two products In 1964 Ultrasonic wave nebulizers introduced
Nebulizers
Advantages
Use of passive breathing: Any age Easy to teach & use Patient coordination not required High drug doses possible, Many drugs Can be used with supplemental O2 Mixtures (>1 drug), if drugs are compatible
Disadvantages
Time intensive
Paraphernalia
Ultrasonic Nebulizers
Advantages
Little patient coordination required
Small dead volume Quiet Aerosol accumulates during exhalation High doses possible
Disadvantages
Expensive
Contamination possible Prone to electrical and mechanical breakdown Not all drug formulations available Drug preparation required
No chlorofluorocarbon release
Fast drug delivery
The fate of an inhaled drug. The total amount of drug in the systemic circulation is the sum of the systemic absorption via the lungs and via the GI tract
DPI
MDI
5 10%
5 10%
10 15%
~15% >30%
Ultrasonic nebulizer: same efficacy as jet nebulizer. Breath actuated nebulizers may have better drug deposition in airways. Newer devices (DPI/MDI) have better deposition.
Asthma Training Module, 2011, Asthma By Consensus, IAP
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy. 2008 Jan;63(1):5-34
Bitolterol
Epinephrine Formoterol Ipratropium Isoetharine Isoproterenol Levalbuterol Metaproterenol Pirbuterol
Ciclesonide
Cromolyn Flunisolide Fluticasone Dexamethasone Fluticasone Mometasone Nedocromil Triamcinolone
Glutathione
Insulin Methacholine Nicotine Sodium chloride Mucolytics Ambroxol N-acetyl cysteine
Procaterol
Racepinephrine (racemic epinephrine) Salbutamol Salmeterol
Antimicrobials
Pentamidine Ribavirin Tobramycin Zanamivir
Terbutaline
Tiotropium
* It is strongly recommended that Mucinac respules when admixed with Ipravent, Asthalin, Levolin, Budecort or Flohale respules, should be used immediately. Any unused mixture should be discarded. # Foratec respules when admixed with Budecort, Flohale, Ipravent, Inhalex or Mucinac respules should be used within 30 minutes. Flohale respules when admixed with Ipravent, Asthalin, or Levolin respules should be used within 2 hours Budecort respules when admixed with Asthalin, Levolin or Ipravent respules should be used within 2 hours
Note : If the equipment is not likely to be used again for a few days, it should be placed in a plastic bag with a twist tie and stored in a clean area. *Acetic acid solution is made by mixing one part white vinegar and three parts water and should be freshly prepared every day. Poor maintenance may lead to contamination of the wet parts of a nebulizer and cause bacterial respiratory tract infections
Practical Points
Prerequisites: Optimal volume of solution in nebulizer chamber is 2 to 4 ml Particle size is 2-5 microns Driven by O2 or air
Flow is 4 to 8 L/ min
Electric (220V AC) or battery powered Respules do not need addition of NS for nebulization Saline should be used as the diluent and not distilled water. This is because hypoosmolar solutions can lead to reflex bronchospasm
Flunisolide MDI
Triamcinolone MDI Beclomethasone MDI Fluticasone MDI Fluticasone/Salmeterol DPI
Fluticasone DPI
Budesonide Nebulization
10 11 12 13 14 15 16+
Classes of b2-agonists
Speed of onset
RESCUE MEDICATION
fast onset, long duration
fast
inhaled formoterol
slow
M A I N T E N A N C E
short
long
Duration of action
=1 full respule
=1 respule =2 respules
K+ Rich Diet
Common Preparations
Drug Salbutamol
Asthalin
Availability
Nebulizer soln 5 mg/mL, Respule 2.5 mg/2.5 mL 0.31 mg, 0.63 mg, 1.25 mg/2.5 mL Respules
Dose
0.15 mg/kg (Min 2.5 mg) as often as 20 min 3, then 0.15-0.3 mg/kg up to 10 mg q1-4h PRN, or up to 0.5 mg/kg/hr by continuous nebulization 0.075 mg/kg (Min 1.25 mg) q20 min 3, then 0.075 0.15 mg/kg up to 5 mg q1-4 h PRN, or 0.25 mg/kg/hr continuous nebulization. 0.63 mg = 1.25 mg salbutamol for both efficacy & SE Initiating dose 0.5-1 mg BD, Maintenance 0.250.5 mg BD 1 mg BD
Levosalbuta mol
Levolin
Budesonide
Budecort, Pulmicort
Fluticasone
Flohale
Ipratropium
Ipravent Formeterol Foratec Respules
0.5 ml < 1 year, 1 ml >1 year every 20 mins for 3 doses, then every 6-8 hours solution. Limit use to 24 hrs to prevent atropine like effects. Adults: 1 respule two times a day
Common Preparations
Drug Ambroxol
Inhalex Respule
Availability
Respule 2 mL = 15 mg Acetylcysteine 20% w/v [200 mg/mL] Mucolytic (free sulfhydryl group opens up disulfide bonds in mucoproteins, lowering viscosity) Bricanyl Respule 1 mg/mL
Dose
< 5 yrs: respule BD, > 5 yrs/adults: 1 respule BD Dose: based on 10% sol or diluted 20% sol (1:1) for inhalation. Infants: 24 mL tidqid. Children: 610 mL tidqid. Adolescents: 10 mL tidqid Caution: Give a bronchodilator 1015 min before it to avoid bronchospasm. Follow treatment with chest percussion and suction to manage increased secretions. For acute asthma, rescue. <2 yrs: 0.5 mg/2.5 mL NS q4-6h PRN. 2-9 yrs: 1 mg/2.5 mL NS q4-6h PRN, >9 yrs: 1.5-2.5 mg/2.5 mL NS q4-6hr PRN Some role in Acute Bronchiolitis.
N-Acetyl Cysteine
Mucinac 2 & 5 mL
Terbutaline
Hypertonic Saline (3%7%) & Racemic Epinephrine
Tobramycin
Tobramist Respules
Available Combinations
Availability Drugs Dose
Children >1 yr: 1 respule (0.5 mg) 3-4 times a day or 1-2 respules 2 times a day Adults: 2-4 respules (1-2 for 1 mg respule/dose) Children >12 yrs & adults: 1 respule 3 times a day. Esp. for acute severe asthma Budesonide Budesal 0.5 or 1 mg + Respule Levoalbuterol 0.5 & 1 mg
1.25 mg
Duolin Respule
Ipratropium + Levosalbutam ol
Right plan, route, drug & right method of administration are integral part of management of wheezy child
Thanks