University of Pangasinan PHINMA Education Network College of Nursing

DRUG STUDY
DRUG Generic Name: omeprazole INDICATION Short-term treatment of activeduodenal ulcer; Firstlinetherapy in treatment of heartburn or symptoms of gastroesophageal refluxdisease (GERD); Shorttermtreatment of active benigngastric ulcer; GERD, severeerosive esophagitis, poorlyresponsive symptomatic GERD;Long-term therapy: Treatmentof pathologic hypersecretorycondi tions (ZollingerEllisonsyndrome, multiple adenomas,systemic mastocytosis);Eradic ation of H. pylori With amoxicillin or metronidazole. ACTION Gastric acidpump inhibitor: Suppresses gastric acid secretion by specific inhibition of the hydrogenpotassium ATP as enzyme system at the secretory surface of the gastric parietal cells; blocks the final step of acid production. DRUG INTERACTION Omeprazole potentially can increase the concentrations in blood of diazepam (Valium), w arfarin (Coumadin), andphenytoin (Dilantin) by decreasing the elimination of these drugs by the liver. The absorption of certain drugs may be affected by stomach acidity. Therefore, omeprazole as well as other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may reduce the effectiveness of ketoconazole or increase digoxin toxicity CONTRAINDICATION Contraindicated with hypersensitivity to omeprazoleor its components;Use cautiously with pregnancy,lactation. ADVERSE EFFECT Diarrhea, nausea, fatigue, constipation, vomiting, flatulence, acid regurgitation, taste perversion, arthralgia, myalgia, urticaria, dry mouth, dizziness, headache, paraesthesia, abdominal pain, skin rashes, weakness, back pain, upper respiratory infection, cough. NURSING CONSIDERATION

Brand Name: Prilosec

Drug Classification: proton pump inhibitors (PPI)

Caution patient to swallow capsules wholenot to open, chew, or crush them. Arrange for further evaluation of patient after 8 weeks of therapy for gastro reflux disorders; not intended for maintenance therapy. Administer antacids with omeprazole, if needed. Teaching points: Take the drug before meals. Swallow the capsules whole; do not chew, open, or crush them. This drug Potentially will need to be Fatal: Anaphylaxis. taken for up to 8wk (short-term therapy) or for a prolonged period(> 5 yr in some cases).Have regular medical follow-up visits.

Submitted by: JANINE KRISTINE D. MANAOIS, UPCN-SN

Submitted to:

University of Pangasinan PHINMA Education Network College of Nursing

DRUG STUDY

Submitted by: JANINE KRISTINE D. MANAOIS, UPCN-SN

Submitted to: