Q.No.

1 Write True or False

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1) The first cancer causing virus, avian virus leukemia virus was discovered by Ellermann and Bang in 1908. 2) Blue tongue virus is composed of 12 discrete segments of double stranded RNA genome. 3) In bovine leukemia viruses there is no vertical transmission but the transmission in utero take place. 4) Rotaviruses are main cause of widespread and common type of milk scours. 5) In equine infectious anemia vertical transmission occurs but not all foals from affected mares acquire the disease. 6) Immunosuppression induced by IBDV is most pronounced in chicken more than 3 weeks of age. 7) Swine pox is transmitted most commonly between swine by bite of pig louse Hematopinus suis. 8) Bluetongue viruses are sub groped in 1-25 sub group. 9) Proteolytic enzymes decrease the infectivity of orthoreovirus and rotavirus. 10) There are present 9 HA and 15 NA subtypes of influenza A virus isolated from poultry. 11) The most prevalent serotype of FMD is Asia 1 in northwest India. 12) Both antigenic drift and antigenic shift occurs in avian influenza. 13) Swine influenza is an acute febrile respiratory disease of swine with low morbidity and high mortality. 14) NDV is easily destroyed by 1/1000 potassium permanganate. 15) Equine encephalomyelitis virus is of zoonotic importance. 16) NDV is classified into 6 distinct pathotypes based on disease produced in chicken under laboratory conditions. 17) Swine influenza virus is deposited on the surface of low respiratory tract. 18) Isolation of Herpes virus is not practical. 19) The differential diagnosis of equine viral artheritis should be done from equine rhino pneumonitis and African horse sickness. 20) Mortality due to avian influenza is strain dependent. 21) Most alpha herpes virus grows rapidly and establishes latency in secretary gland 22) Low sensitivity is the biggest limitation of electron microscope 23) Equine encephalomyelitis can be transmitted by biological vectors. 24) Vaccination against Mareks disease can prevent or regress the tumor formation but does not prevent active replication. 25) The primary target of IBD virus is intestine. 26) Rabies virus infection induces immunity.

27) Malberry appearance of pox virus is due to presence of long filaments. 28) All pox viruses share a common antigen. 29) Virion associated with transcriptase is found in family Toga viridae 30) Equine arteritis virus persists for long periods in accessory sexual glands of fertile stallions.

Q.No. 2 Fill in the blanks. 1) Bovine malignant catarrhal fever is caused by______________.

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2) ______________and ______________ viruses are orthomyxovirus that are transmitted by ticks. 3) Strand displacement mechanism of replication occurs in ______________ 4) Smallest vertebrate virus ______________ 5) Joest Degen bodies are pathognomonic of ______________ disease. 6) Laboratory test for equine infectious anemia is ______________ 7) Infectious canine hepatitis was first recognized by ______________ and the disease is also called --______________. 8) Goat pox and sheep pox viruses share a common ______________ . 9) During 1957 outbreak of avian influenza H1N1 serotype was suddenly replaced by ______________ and during the year ______________ H1N1 reappeared. 10) In fixed stained cells infected with ______________ virus, inclusion bodies appear as Owls eye 11) Viruria is prolonged and common in ______________ infection and lifelong in ______________ infection. 12) Dogs infected with infectious canine hepatitis shed virus in urine for ______________ months. 13) Mareks disease virus causes a ______________ disease in domestic chicken. 14) ______________ or ______________is the simplest reliable laboratory diagnostic method for Mareks disease. 15) Contagious pustular dermatitis infection can be misdiagnosed as ______________, ______________ or ______________ in early stages of disease. 16) The syndrome produce in chickens by avian retero viruses are ______________, ______________and ______________. 17) Avian leucosis viruses are highly conducive to ______________. 18) Bovine leukaemia virus is inactivated at______________ temperature. 19) In Swamp fever, anaemia is due to destruction of RBC by ______________. 20) Avian influenza is distinguished from fowl paste caused by ______________. 21) The genome of avian influenza A virus is consists of ______________. 22) In swine influenza ______________ are the bases for dividing the virus into subtypes. 23) NDV genome is ______________. 24) ______________ first reported viral nature of canine distemper.

25) In cerebral form of canine distemper ______________ is observed. 26) Rinderpest is very ______________ and gets inactivated even by ______________. 27) Intracellular inclusion bodies are common in ______________ in carnivorous and ______________ in herbivorous in case of rabies. 28) Negri bodies are best demonstrated in impression smears of brain tissue with ______________ stain. 29) Virus adsorption to a host cell does not require ______________. 30) Cow pox grows well on ______________ of 7 to 15 days old embroynated eggs.

Q.No. 3 Encircle the correct answer in this multiple choice question. 1) Which of the following virus do not carry their own transcriptase in the virion a) Pox virus b) Asfarvirus c) Irido virus d) Herpes virus 2) Pseudo T60 symmetry is found in a) Pox virus b) Herpes virus c) Adeno virus d) Calcivirus 3) Th 1 cells are defined as except

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a) Secreting IL2 b) Secreting IL4 c) mediating delayed type of hypersensitivity d) promoting IgG2a production. 4) The order of genes in Rhabdoviruses is a) 3N-NS-M-G-L-5 b) 5N-NS-M-G-L-3 c) 3N-NS- G - M L-5 d) none of above 5) Rabies is also known as (a) (a) (a) photophobia (b) Hydrophobia (c) hydrophilia (d) all. Toga virus (b) Myxo virus (c) Pox virus (d) Influenza virus. Papova viridae (b) Adeno viridae (c) Pox viridae (d) pramyxoviridae. 6) Allantoic membrane is used for the cultivation of 7) Which of the following does not belong to DNA Virus 8) Infectious agent that lacks nucleic acid is a) Virus b) Prions c) Viroids d) Bacteria 9) Single stranded virus belongs to (a) (a) (a) Irido viridae (b) Pox viridae (c) Parvo viridae (d) Herpes viridae Irido viridae (b) Pox viridae (c) Parvo viridae (d) Herpes viridae. Ortho pox (b) Capri pox (c) para pox (d) hepori pox virus. 10) Virus multiply in the cytoplasm belongs to 11) Milkers nodule is caused by 12) Malberry appearance of pox virus is due to presence of (a) long filaments (b) inclusion bodies (c) both (d) none. 13) Monoclonal antibodies at epitope level and sequencing of nucleic acid have wide applications in the study FMDV to

a)

Subtype starins b) Analyze antigenic sites c) Evaluate the virulence of the strains d)Evaluate the immunogenicity f the strain (a) (a) Toga viridae (b) Rhabdo viridae (c) Picorna viridae (d) Calci viridae. Pox viruses (b) Adeno viruses (c) Influenza (d) All

14) Virion associated with transcriptase is found in family 15) Recombination by genetic resentments occurs in 16) Attenuation of virulent live virus is the natural process of genomic alteration during adaptation in heterologous host due to (a) host induced (b) virus induced (c) evolutionary (d) selective. 17) Viruses associated with development of syncytia in cell culture are (a) (a) Aptho virus (b) Rinder pest virus (c) Hog cholera virus (d) Buffalo pox virus tongue (b) fore feet (c) thigh (d)planter pad in hind feet 18) For the propagation of F.M.D. virus in guinea pig ,the virus inoculum is injected in the 19) Most useful diagnosis test for canine distemper is (a) demonstration of antigen by FAT (b) Antibody detection by ELISA (c)Clinical symptoms (d) All 20) In malignant catarrhal fever primarily affected cells are (a) Lymphoid cells (b) Epithelial (c)Both a and b(d) none 21) New castle disease virus is transmitted to man and cause (a) Conjunctivitis (b) Diarrhoea (c ) Fatality(d) all 22) Most of the DNA viruses are oncogenic, except a) Hepadna virus b) Parvo virus c) Pox virus d) Herpes virus 23) Rota virus is adapted to grow in cell culture by (a) Co- culture technique (b)Fusion Technique(c) Repeated passage in presence of low concentration of trypsin (d) None 24) Blue tongue virus is transmitted through a)Semen (b)Arthropod bite (c)Congenital mode (d)All 25) The most serious disease from following in horse is Eastern equine encephalitis b) western equine encephalitis c) Venezuelan equine encephalitis d) all Which of the following virus comes under BSL-4 category a) Rinderpest virus b) Ebola virus c) Blue tounge d) Mareks Disease virus Antiviral drug, which is preferred for herpes virus infection is a) Amantadine hydrochloride b) 5-iodo-2-deoxyuridine c) Thiosemicarbazones d) Acyclovir Overlapping subgenomic nested set of RNA transcripts with same termination points are formed during the replication of a) Coronavirus b) Toroviridae c) Arteriviridae d) All of the above Genetic reassortment is seen between viruses having a) Double stranded DNA b) Circular nucleic acid c) Positive stranded nucleic acid d)Segmented nucleic acid Virus coded proteins that influence the host response to infection is called a) Virokines b) Capsid proteins c) Cytokines d) None of the above a)

26) 27) 28) 29) 30)

Q.No4. Match the following 1. 2. 3. 4. 5. 6. 7. 8. 9. Prusiner Max Theiler Jerne and Burnet Fenner Encephalitis Pseudo lumpy skin disease Cattle plague Hard pad disease in dogs Mad itch a) Rinder pest b) Ectromelia model in mouse c) pseudorabies d) Bovine Herpes virus 2 e) Bovine Herpes virus 5 f) Rotavirus g)Canine distemper h) Prions i) Clonal selection j) Yellow fever vaccine

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10. White scours

Q. No 5. Define or Explain the following terms: 1. 2. 3. 4. 5.

(5x3=15)

Zone phenomenon Multiplicity reactivation Star activity Infection from African swine fever virus do not produce neutralizing antibodies. Why? RNA editing/ stuttering (3x10=30)

Q. No 6. Short notes 1. 2. 3.

Write in brief the etiology, pathogenesis, disease, prevention and control of Hog Cholera Replication and properties of prions Write the pathogenesis and replication of FMD virus