Marc Imhotep Cray, M.D.

Drugs Acting on the Respiratory System Review Test

Directions: Each of the numbered items or incomplete statements in this section is followed by answers or by completions of the statement. Select the ONE lettered answer or completion that is BEST in each case. 1. A 17-year-old patient is brought to your allergy practice complaining of chronic cough that gets quite severe at times. The condition occurs about twice a week and is beginning to interfere with his studies. Which of the following would be most appropriate treatment for this patient? A. Oral prednisone B. Omalizumab C. Diphenhydramine D. Inhaled budesonide E. Theophylline

2. An asthmatic female patient recovering from a myocardial infarction is on several medications including a baby aspirin a day. She complains of large bruises on her arms and legs and some fatigue. A standard blood panel reveals markedly elevated ALT. Which of the following is most likely responsible for the increase in liver enzymes? A. Heparin B. Zileuton C. Zafirlukast D. Albuterol E. Aspirin

3. A 20-year-old college student participates in several intramural athletic programs but is complaining that his asthma, which you have been treating for 5 years, is getting worse. In the last month, he has used his albuterol inhaler at least 20 times following baseball practice, but he has not been waking much at night. You elect to change his treatment regimen. Which of the following would be the best change in treatments for this patient? A. Oral triamcinolone B. Zileuton C. Salmeterol D. Nedocromil

1 Drugs Acting on the Respiratory System Review Test

Marc Imhotep Cray, M.D.

4. Which of the following statements regarding the pharmacokinetics of theophylline is correct? A. It is primarily metabolized by the kidney B. Its metabolism depends on age C. It is poorly absorbed after oral administration D. It has a wide therapeutic index A. It stimulates cyclic AMP phosphodiesterase B. It is an adenosine-receptor antagonist C. It does not cross the bloodbrain barrier D. It blocks the release of ACh in the bronchial tree 6. Which of the following statements regarding opiate action is correct? A. It triggers a vagal reflex to suppress cough B. It can cause diarrhea C. Its expectorant action is caused by stimulation of mucus production D. It acts centrally to suppress the medullary cough center 7. Which of the following statements about the mechanism of action of ipratropium is correct? A. It acts centrally to decrease vagal ACh release B. It inhibits pulmonary ACh receptors C. It decreases mast cell release of histamine D. It blocks the action of histamine at H1 receptors 8. Zileuton is useful in the treatment of asthma because it A. Inhibits prostaglandin biosynthesis B. Inhibits leukotriene synthesis C. Inhibits leukotriene receptors D. Inhibits 12-lipoxygenase

2 Drugs Acting on the Respiratory System Review Test