Annual Publication Report 2009

2 9 19 24 31 46 63 67 TABLE OF CONTENTS GRONINGEN INSTITUTE FOR KIDNEY DISEASES CARDIOVASCULAR CENTER GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD CENTER FOR LIVER, DIGESTIVE AND METABOLIC DISEASES INSTITUTE FOR TRANSPLANTATION, IMMUNITY AND INFLAMMATION NORTHERN NETHERLANDS ONCOLOGY CENTER INSTITUTE FOR BIOPHARMACEUTICALS: DISCOVERY, DESIGN AND DELIVERY CENTER FOR SYNTHESIS AND ANALYSIS
GIKD

CVC GRIAC CLDS TRIO NNOC BDDD S&A

GRONINGEN INSTITUTE FOR KIDNEY DISEASES - GIKD

Dissertations
Boersma, C. Health Economics of cardiovascular & renal disease prevention. (2009) Damman, K. Cardiorenal interaction in heart failure. (2009) Hillege, H. L., Veldhuisen, D. J., Navis, G. J., and Voors, A. A. de Vries, R. Lipid transfer proteins: consequences for cellular cholesterol efflux and cardiovascular risk in diabetes mellitus. (2009) Wolfenbuttel, B. H. R., Dullaart, R. P. F., and van Tol, A. Koudstaal, L. G. The impact of cerebral injury in donation and transplantation : a central role of the intestine. (2009) Ploeg, R. J., van Goor, H., and Leuvenink, H. G. D. Loef, B. G. Acute kidney injury after cardiac surgery : impact on long-term outcome and target for intervention. (2009) Ebels, T., Navis, G. J., Epema, A. H., and Stegeman, C. A. Meijering, B. D. M. Ultrasound and microbubble targeted delivery : exploring the mechanism and its therapeutic potential. (2009) Henning, R. H., van Gilst, W. H., and Deelman, L. E.

Melenhorst, W. B. W. H. The biology of ADAMs in renal disease. (2009) van Goor, H. and Visser, L. Rook, M. Living kidney donor safety : insights & outcome. (2009) Navis, G. J., Ploeg, R. J., van Goor, H., van Son, W. J., and Homan van der Heide, J. J. Sanders, J. S. F. Disease-activity in ANCA-associated vasculitis. (2009) Kallenberg, C. G. M. and Stegeman, C. A. Ulu, N. Vascular function in chronic end-organ damage : pharmacological characterization of vasomotor function in systemic vasculature. (2009) Henning, R. H., van Gilst, W. H., Buikema, H., and Schoemaker, R. G. van der Toorn, M. Cigarette smoke-induced mitochondrial dysfunction and oxidative stress in. (2009) Kauffman, H. F., Gans, R. O. B., Koter, G. H., Slebos, D. J., and Bakker, S. J. L. van Ree, R. M. Chronic low-grade inflammation in renal transplantation. (2009) Gans, R. O. B., Bakker, S. J. L., van Son, W. J., and Homan van der Heide, J. J. vom Hagen, F. M. Experimental models of retinal angiogenesis : the effect of angiopoietin-2 and TNFa modulation. (2009) Molema, G., Hammes, H.-P., and Gans, R. O. B.

Journal articles
Alkhalaf, A., Kleefstra, N., Groenier, K. H., Bakker, S. J. L., Navis, G. J., Bilo, H. J. G. Thiamine in diabetic nephropathy: a novel treatment modality? Diabetologia 52(6): 1212-1213, 2009. Bakker, S. J. L., Gansevoort, R. T., de Zeeuw, D. Albuminuria: What can we expect from the determination of nonimmunoreactive albumin? Current Hypertension Reports 11(2): 111-117, 2009. Bakker, W. W., Henning, R. H., van Son, W. J., van Pampus, M. G., Aarnoudse, J. G., Niezen-Koning, K. E., Borghuis, T., Jongman, R. M., van Goor, H., Poelstra, K., Navis, G., Faas, M. M. Vascular Contraction and Preeclampsia Downregulation of the Angiotensin Receptor 1 by Hemopexin In Vitro. Hypertension 53(6): 959-U127, 2009. Boersema, M., Rienstra, H., van den Heuvel, M., van Goor, H., van Luyn, M. J. A., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Contribution to Transplant Vasculopathy in Chronic Renal Transplant Dysfunction. Transplantation 88(12): 13861392, 2009. Boersema, M., Rienstra, H., van den Heuvel, M., van Goor, H., van Luyn, M. J. A., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Contribution to Transplant Vasculopathy in Chronic Renal Transplant Dysfunction. Transplantation 88(12): 13861392, 2009. Bos, E. M., Leuvenink, H. G. D., Snijder, P. M., Kloosterhuis, N. J., Hillebrands, J. L., Leemans, J. C., Florquin, S., van Goor, H. Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury. Journal of the American Society of Nephrology 20(9): 1901-1905, 2009. Broekema, M., Harmsen, M. C., Koerts, J. A., van Kooten, T. G., Uges, D. R. A., Petersen, A. H., van Luyn, M. J. A., Navis, G., Popa, E. R. Ciclosporin Does Not Influence Bone Marrow-Derived Cell Differentiation to Myofibroblasts Early after Renal Ischemia/Reperfusion. American Journal of Nephrology 30(1): 73-83, 2009. Celie, J. W. A. M., Beelen, R. H. J., van den Born, J. Heparan sulfate proteoglycans in extravasation: assisting leukocyte guidance. Frontiers in Bioscience 14: 4932-4949, 2009.

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Chen, C., Liang, W., Jia, J. Y., van Goor, H., Singhal, P. C., Ding, G. H. Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3K/Akt and p38MAPK Signaling Pathways. Nephron Experimental Nephrology 113(1): E26-E34, 2009. Corpeleijn, E., Bakker, S. J. L., Stolk, R. P. Obesity and impaired renal function: potential for lifestyle intervention? European Journal of Epidemiology 24(6): 275-280, 2009. Damman, K., Jaarsma, T., Voors, A. A., Navis, G., Hillege, H. L., van Veldhuisen, D. J. Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: results from the Coordinating Study Evaluating Outcome of Advising and Counseling in Heart Failure (COACH). European Journal of Heart Failure 11(9): 847-854, 2009. Damman, K., van Deursen, V. M., Navis, G., Voors, A. A., van Veldhuisen, D. J., Hillege, H. L. Increased Central Venous Pressure Is Associated With Impaired Renal Function and Mortality in a Broad Spectrum of Patients With Cardiovascular Disease. Journal of the American College of Cardiology 53(7): 582-588, 2009. Dasselaar, J. J., Slart, R. H. J. A., Knip, M., Pruim, J., Tio, R. A., McIntyre, C. W., de Jong, P. E., Franssen, C. F. M. Haemodialysis is associated with a pronounced fall in myocardial perfusion. Nephrology Dialysis Transplantation 24(2): 604-610, 2009. de Borst, M. H., Prakash, J., Sandovici, M., Klok, P. A., Hamming, I., Kok, R. J., Navis, G., van Goor, H. c-Jun NH2-Terminal Kinase Is Crucially Involved in Renal Tubulo-Interstitial Inflammation. Journal of Pharmacology and Experimental Therapeutics 331(3): 896-905, 2009. de Jong, P. E., Gansevoort, R. T. Focus on Microalbuminuria to Improve Cardiac and Renal Protection. Nephron Clinical Practice 111(3): C204-C210, 2009. de Leeuw, K., Smit, A. J., de Groot, E., van Roon, A. M., Kallenberg, C. G., Bijl, M. Longitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus. Atherosclerosis 206(2): 546-550, 2009. de Zeeuw, D., Lambers-Heerspink, H. Drug Dosing for Renoprotection: Maybe It's Time for a Drug Efficacy-Safety Score? Journal of the American Society of Nephrology 20(4): 688-689, 2009. Dobre, D., Nimade, S., de Zeeuw, D. Albuminuria in heart failure: what do we really know? Current Opinion in Cardiology 24(2): 148-154, 2009. Dobre, D., Heerspink, H. J. L., de Zeeuw, D. Reducing cardiovascular risk: protecting the kidney. European Heart Journal Supplements 11(F): F39-F46, 2009. Doorenbos, C. R. C., van den Born, J., Navis, G., de Borst, M. H. Possible renoprotection by vitamin D in chronic renal disease: GUIDE Annual Publication Report 2009 3

beyond mineral metabolism. Nature Reviews Nephrology 5(12): 691-700, 2009. Dullaart, R. P. F. Comment on high HDL-cholesterol in women with rheumatoid arthritis on low-dose glucocorticoid therapy. European Journal of Clinical Investigation 39(6): 533, 2009. Dullaart, R. P. F., de Vries, R., Sluiter, W. J., Voorbij, H. A. M. High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus. Clinical Endocrinology 70(2): 221226, 2009. Dullaart, R. P. F., Plomgaard, P., de Vries, R., Dahlback, B., Nielsen, L. B. Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness. Clinica Chimica Acta 406(1-2): 129-133, 2009. Dullaart, R. P. F., de Vries, R., Voorbij, H. A. M., Sluiter, W. J., van Tol, A. Serum paraoxonase-I activity is unaffected by short-term administration of simvastatin, bezafibrate, and their combination in type 2 diabetes mellitus. European Journal of Clinical Investigation 39(3): 200-203, 2009. Fabbrini, P., Schilte, M. N., Zareie, M., ter Wee, P. M., Keuning, E. D., Beelen, R. H. J., van den Born, J. Celecoxib treatment reduces peritoneal fibrosis and angiogenesis and prevents ultrafiltration failure in experimental peritoneal dialysis. Nephrology Dialysis Transplantation 24(12): 3669-3676, 2009. Gansevoort, R. T., Ritz, E. Hermann Senator and albuminuria025EFforgotten pioneering work in the 19th century. Nephrology Dialysis Transplantation 24(3): 1057-1062, 2009. Gansevoort, R. T., de Jong, P. E. The Case for Using Albuminuria in Staging Chronic Kidney Disease. Journal of the American Society of Nephrology 20(3): 465-468, 2009. Gerrits, E. G., Smit, A. J., Bilo, H. J. G. AGEs, autofluorescence and renal function. Nephrology Dialysis Transplantation 24(3): 710713, 2009. Halbesma, N., Bakker, S. J. L., Jansen, D. F., Stolk, R. P., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. High Protein Intake Associates with Cardiovascular Events but not with Loss of Renal Function. Journal of the American Society of Nephrology 20(8): 1797-1804, 2009. Heerspink, H. J. L., Nauta, F. L., van der Zee, C. P., Brinkman, J. W., Gansevoort, R. T., de Zeeuw, D., Bakker, S. J. L. Alkalinization of urine samples preserves albumin concentrations during prolonged frozen storage in patients with diabetes mellitus. Diabetic Medicine 26(5): 556-559, 2009. Heerspink, H. J. L., Perkovic, V., de Zeeuw, D. Renal and cardioprotective effects of direct renin inhibition: a systematic literature review. Journal of Hypertension 27(12): 2321-2331, 2009.

Heerspink, H. J. L., Agarwal, R., Coyne, D. W., Parving, H. H., Ritz, E., Remuzzi, G., Audhya, P., Amdahl, M. J., Andress, D. L., Zeeuw, D. The Selective Vitamin D Receptor Activator for Albuminuria Lowering (VITAL) Study: Study Design and Baseline Characteristics. American Journal of Nephrology 30(3): 280286, 2009. Heerspink, H. L., Ninomiya, T., Zoungas, S., de Zeeuw, D., Grobbee, D. E., Jardine, M. J., Gallagher, M., Roberts, M. A., Cass, A., Neal, B., Perkovic, V. Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta-analysis of randomised controlled trials. Lancet 373(9668): 1009-1015, 2009. Herman, W. H., Dungan, K. M., Wolffenbuttel, B. H. R., Buse, J. B., Fahrbach, J. L., Jiang, H. H., Martin, S. Racial and Ethnic Differences in Mean Plasma Glucose, Hemoglobin A(1c), and 1,5-Anhydroglucitol in Over 2000 Patients with Type 2 Diabetes. Journal of Clinical Endocrinology & Metabolism 94(5): 1689-1694, 2009. Hettema, M. E., Zhang, D., Stienstra, Y., Smit, A. J., Bootsma, H., Kallenberg, C. G. M. No effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis. Clinical Rheumatology 28(7): 825-833, 2009. Jochemsen, B. M., Mulder, D. J., van Doormaal, J. J., Mulder, G., Volmer, M., Graaff, R., Smit, A. J. Relation between food and drinking habits, and skin autofluorescence and intima media thickness in subjects at high cardiovascular risk. Journal of Food and Nutrition Research 48(1): 51-58, 2009. Kamilic, J., Lely, A. T., van Goor, H., Buikema, H., Tent, H., Navis, G. J., Korstanje, R. Differential ACE expression among tissues in allele-specific Wistar rat lines. Mammalian Genome 20(3): 170179, 2009. Kappelle, P. J. W. H., Zwang, L., Huisman, M. V., Banga, J. D., Sluiter, W. J., linga-Thie, G. M., Dullaart, R. P. F. Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus: modification by triglycerides and cholesteryl ester transfer protein. Expert Opinion on Therapeutic Targets 13(7): 743-751, 2009. Koetsier, M., Lutgers, H. L., Smit, A. J., Links, T. P., de Vries, R., Gans, R. O. B., Rakhorst, G., Graaff, R. Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient. Optics Express 17(2): 509519, 2009. Koudstaal, L. G., Ottens, P. J., Uges, D. R. A., Ploeg, R. J., van Goor, H., Leuvenink, H. G. D. Increased Intestinal Permeability in Deceased Brain Dead Rats. Transplantation 88(3): 444-446, 2009. Kramer, A. B., van Timmeren, M. M., Schuurs, T. A., Vaidya, V. S., Bonventre, J. V., van Goor, H., Navis, G. Reduction of proteinuria

in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time. American Journal of Physiology-Renal Physiology 296(5): F1136-F1145, 2009. Krikken, J. A., Waanders, F., linga-Thie, G. M., Dikkeschei, L. D., Vogt, L., Navis, G. J., Dullaart, R. P. F. Antiproteinuric therapy decreases LDL-cholesterol as well as HDL-cholesterol in nondiabetic proteinuric patients: relationships with cholesteryl ester transfer protein mass and adiponectin. Expert Opinion on Therapeutic Targets 13(5): 497-504, 2009. Krikken, J. A., Laverman, G. D., Navis, G. Benefits of dietary sodium restriction in the management of chronic kidney disease. Current Opinion in Nephrology and Hypertension 18(6): 531-538, 2009. Krikken, J. A., Bakker, S. J. L., Navis, G. J. Role of renal haemodynamics in the renal risks of overweight. Nephrology Dialysis Transplantation 24(6): 1708-1711, 2009. Kurth, T., de Jong, P. E., Cook, N. R., Buring, J. E., Ridker, P. M. Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study. British Medical Journal 339 AR b2392 DI 10.1136/bmj.b2392 2009. Lambers Heerspink, H. J., Dobre, D., de Zeeuw, D. Does the European clinical trials directive really improve clinical trial approval time? Pharmaceutisch Weekblad 144(38): 152-155, 2009. Laverman, G. D., Bakker, S. J. L., Navis, G. J. Optimal dosing of reninangiotensin-aldosterone system blockers for renal protection: a solved issue? Diabetologia 52(6): 1217-1218, 2009. linga-Thie, G. M., van Tol, A., Dullaart, R. P. F. Plasma pre beta-HDL formation is decreased by atorvastatin treatment in type 2 diabetes mellitus: Role of phospholipid transfer protein. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1791(8): 714-718, 2009. Linssen, G. C. M., Damman, K., Hillege, H. L., Navis, G., van Veldhuisen, D. J., Voors, A. A. Urinary N-Terminal Prohormone Brain Natriuretic Peptide Excretion in Patients With Chronic Heart Failure. Circulation 120(1): 35-41, 2009. Loef, B. G., Epema, A. H., Navis, G., Ebels, T., Stegeman, C. A. Postoperative renal dysfunction and preoperative left ventricular dysfunction predispose patients to increased long-term mortality after coronary artery bypass graft surgery. British Journal of Anaesthesia 102(6): 749-755, 2009. Logtenberg, S. J., Kleefstra, N., Houweling, S. T., Groenier, K. H., Gans, R. O., van Ballegooie, E., Bilo, H. J. Improved Glycemic Control With Intraperitoneal Versus Subcutaneous Insulin in Type 1 Diabetes A randomized controlled trial. Diabetes Care 32(8): 1372-1377, 2009.

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Logtenberg, S. J. J., Kleefstra, N., Groenier, K. H., Gans, R. O. B., Bilo, H. J. G. Use of Short-Term Real-Time Continuous Glucose Monitoring in Type 1 Diabetes Patients on Continuous Intraperitoneal Insulin Infusion: A Feasibility Study. Diabetes Technology & Therapeutics 11(5): 293-299, 2009. Lutgers, H. L., Gerrits, E. G., Sluiter, W. J., Ubink-Veltmaat, L. J., Landman, G. W. D., Links, T. P., Gans, R. O. B., Smit, A. J., Bilo, H. J. G. Life Expectancy in a Large Cohort of Type 2 Diabetes Patients Treated in Primary Care (ZODIAC-10). PLoS ONE 4(8 AR e6817 DI 10.1371/journal.pone.0006817) 2009. Lutgers, H. L., Gerrits, E. G., Graaff, R., Links, T. P., Sluiter, W. J., Gans, R. O., Bilo, H. J., Smit, A. J. Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus. Diabetologia 52(5): 789797, 2009. Mahmoodi, B. K., Gansevoort, R. T., Kluin-Nelemans, H. C. Antiphospholipid Syndrome, Microalbuminuria, and Risk of Venous Thromboembolism Reply. JAMA - Journal of the American Medical Association 302(9): 945-946, 2009. Mahmoodi, B. K., Gansevoort, R. T., Veeger, N. J. G. M., Matthews, A. G., Navis, G., Hillege, H. L., van der Meer, J. Microalbuminuria and Risk of Venous Thromboembolism. JAMA - Journal of the American Medical Association 301(17): 1790-1797, 2009. Martens, D. H. J., Rake, J. P., Navis, G., Fidler, V., van Dael, C. M. L., Smit, G. P. A. Renal Function in Glycogen Storage Disease Type I, Natural Course, and Renopreservative Effects of ACE Inhibition. Clinical Journal of the American Society of Nephrology 4(11): 1741-1746, 2009. Martens, H. A., Zuurman, M. W., de Lange, A. H. M., Nolte, I. M., van der Steege, G., Navis, G. J., Kallenberg, C. G. M., Seelen, M. A., Bijl, M. Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity. Annals of the Rheumatic Diseases 68(5): 715-720, 2009. Meerwaldt, R., Zeebregts, C. J., Navis, G., Hillebrands, J. L., Lefrandt, J. D., Smit, A. J. Accumulation of Advanced Glycation End Products and Chronic Complications in ESRD Treated by Dialysis. American Journal of Kidney Diseases 53(1): 138-150, 2009. Meijer, E., Bakker, S. J. L., de Jong, P. E., van der Heide, J. J. H., van Son, W. J., Struck, J., Lems, S. P. M., Gansevoort, R. T. Copeptin, a Surrogate Marker of Vasopressin, Is Associated With Accelerated Renal Function Decline in Renal Transplant Recipients. Transplantation 88(4): 561-567, 2009. Meijer, E., de Jong, P. E., van der Jagt, E. J., Peters, D. J., Breuning, M. H., Gansevoort, R. T. Hereditary cystinuria: New insights and possible treatments. Nederlands Tijdschrift voor Geneeskunde 153(20): 968-974, 2009.

Meijering, B. D. M., van der Wouden, E. A., Pelgrom, V., Henning, R. H., Sharma, K., Deelman, L. E. TGF-beta Inhibits Ang II-Induced MAPK p44/42 Signaling in Vascular Smooth Muscle Cells by Ang II Type 1 Receptor Downregulation. Journal of Vascular Research 46(5): 459-468, 2009. Meijering, B. D. M., Juffermans, L. J. M., van Wamel, A., Henning, R. H., Zuhorn, I. S., Emmer, M., Versteilen, A. M. G., Paulus, W. J., van Gilst, W. H., Kooiman, K., de Jong, N., Musters, R. J. P., Deelman, L. E., Kamp, O. Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation. Circulation Research 104(5): 679-U226, 2009. Melenhorst, W. B., Visser, L., Timmer, A., van den Heuvel, M. C., Stegeman, C. A., van Goor, H. ADAM17 upregulation in human renal disease: a role in modulating TGF-alpha availability? American Journal of Physiology-Renal Physiology 297(3): F781F790, 2009. Muntinghe, F. L. H., Verduijn, M., Zuurman, M. W., Grootendorst, D. C., Carrero, J. J., Qureshi, A. R., Luttropp, K., Nordfors, L., Lindholm, B., Brandenburg, V., Schalling, M., Stenvinkel, P., Boeschoten, E. W., Krediet, R. T., Navis, G., Dekker, F. W. CCR5 Deletion Protects Against Inflammation-Associated Mortality in Dialysis Patients. Journal of the American Society of Nephrology 20(7): 1641-1649, 2009. Muntinghe, F. L. H., Gross, S., Bakker, S. J. L., Landman, G. W. D., van der Harst, P., Bilo, H. J. G., Navis, G., Zuurman, M. W. CCR5 Delta 32 genotype is associated with outcome in type 2 diabetes mellitus. Diabetes Research and Clinical Practice 86(2): 140-145, 2009. Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S., Zhao, J. H., Heath, S. C., Eyheramendy, S., Papadakis, K., Voight, B. F., Scott, L. J., Zhang, F., Farrall, M., Tanaka, T., Wallace, C., Chambers, J. C., Khaw, K. T., Nilsson, P., van der Harst, P., Polidoro, S., Grobbee, D. E., Onland-Moret, N. C., Bots, M. L., Wain, L. V., Elliott, K. S., Teumer, A., Luan, J., Lucas, G., Kuusisto, J., Burton, P. R., Hadley, D., McArdle, W. L., Brown, M., Dominiczak, A., Newhouse, S. J., Samani, N. J., Webster, J., Zeggini, E., Beckmann, J. S., Bergmann, S., Lim, N., Song, K., Vollenweider, P., Waeber, G., Waterworth, D. M., Yuan, X., Groop, L., Orho-Melander, M., Allione, A., Di Gregorio, A., Guarrera, S., Panico, S., Ricceri, F., Romanazzi, V., Sacerdote, C., Vineis, P., Barroso, I., Sandhu, M. S., Luben, R. N., Crawford, G. J., Jousilahti, P., Perola, M., Boehnke, M., Bonnycastle, L. L., Collins, F. S., Jackson, A. U., Mohlke, K. L., Stringham, H. M., Valle, T. T., Willer, C. J., Bergman, R. N., Morken, M. A., Doring, A., Gieger, C., Illig, T., Meitinger, T., Org, E., Pfeufer, A., Wichmann, H. E., Kathiresan, S., Marrugat, J., O'Donnell, C. J., Schwartz, S. M., Siscovick, D. S., Subirana, I., Freimer, N. B., Hartikainen, A. L., McCarthy, M. I., O'Reilly, P. F., Peltonen, L., Pouta, A., de Jong, P. E., Snieder, H., van Gilst, W. H., Clarke, R., Goel, A., Hamsten, A., Peden, J. F., Seedorf, U., Syvanen, A. C., Tognoni, G., Lakatta, E. G., Sanna, S., Scheet, P., Schlessinger, D., Scuteri, A., Dorr, M., Ernst, F., Felix, S. B., Homuth, G., Lorbeer, R., Reffelmann, T., Rettig, R.,

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Volker, U., Galan, P., Gut, I. G., Hercberg, S., Lathrop, G. M., Zelenika, D., Deloukas, P., Soranzo, N., Williams, F. M., Zhai, G., Salomaa, V., Laakso, M., Elosua, R., Forouhi, N. G., Volzke, H., Uiterwaal, C. S., van der Schouw, Y. T., Numans, M. E., Matullo, G., Navis, G., Berglund, G., Bingham, S. A., Kooner, J. S., Connell, J. M., Bandinelli, S., Ferrucci, L., Watkins, H., Spector, T. D., Tuomilehto, J., Altshuler, D., Strachan, D. P., Laan, M., Meneton, P., Wareham, N. J., Uda, M., Jarvelin, M. R., Mooser, V., Melander, O., Loos, R. J. F., Elliott, P., Abecasis, G. R., Caulfield, M., Munroe, P. B. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 41(6): 666-676, 2009. Nienhuis, H. L. A., Westra, J., Smit, A. J., Limburg, P. C., Kallenberg, C. G. M., Bijl, M. AGE and their receptor RAGE in systemic autoimmune diseases: An inflammation propagating factor contributing to accelerated atherosclerosis. Autoimmunity 42(4): 302-304, 2009. Nijboer, W. N., Schuurs, T. A., Damman, J., van Goor, H., Vaidya, V. S., van der Heide, J. J. H., Leuvenink, H. G. D., Bonventre, J. V., Ploeg, R. J. Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation. American Journal of Transplantation 9(8): 1752-1759, 2009. Ochodnicky, P., Henning, R. H., Buikema, H., Kluppel, A. C. A., van Wattum, M., de Zeeuw, D., van Dokkum, R. P. E. Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage. Nephrology Dialysis Transplantation 24(2): 413-420, 2009. Oeseburg, H., Iusuf, D., van der Harst, P., van Gilst, W. H., Henning, R. H., Roks, A. J. M. Bradykinin Protects Against Oxidative Stress-Induced Endothelial Cell Senescence. Hypertension 53(2): 417-422, 2009. Oterdoom, L. H., de Vries, A. P. J., Gansevoort, R. T., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. Fasting insulin is a stronger cardiovascular risk factor in women than in men. Atherosclerosis 203(2): 640-646, 2009. Oterdoom, L. H., de Vries, A. P. J., van Ree, R. M., Gansevoort, R. T., van Son, W. J., van der Heide, J. J. H., Navis, G., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. N-Terminal Pro-B-Type Natriuretic Peptide and Mortality in Renal Transplant Recipients Versus the General Population. Transplantation 87(10): 1562-1570, 2009. Oterdoom, L. H., Gansevoort, R. T., Schouten, J. P., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population. Atherosclerosis 207(2): 534-540, 2009. Parving, H. H., Brenner, B. M., McMurray, J. J. V., de Zeeuw, D., Haffner, S. M., Solomon, S. D., Chaturvedi, N., Ghadanfar, M., Weissbach, N., Xiang, Z. H., Armbrecht, J., Pfeffer, M. A. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints

(ALTITUDE): rationale and study design. Nephrology Dialysis Transplantation 24(5): 1663-1671, 2009. Perkovic, V., Heerspink, H. L., Ninomiya, T., Cass, A., Neal, B. Blood pressure in dialysis patients-look before we leap reply. Lancet 373(9679): 1945-1946, 6-6-2009. Pfeffer, M. A., Burdmann, E. A., Chen, C. Y., Cooper, M. E., de Zeeuw, D., Eckardt, K. U., Feyzi, J. M., Ivanovich, P., Kewalramani, R., Levey, A. S., Lewis, E. F., Mcgill, J. B., McMurray, J. J. V., Parfrey, P., Parving, H. H., Remuzzi, G., Singh, A. K., Solomon, S. D., Toto, R. A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease. New England Journal of Medicine 361(21): 20192032, 2009. Pfeffer, M. A., Burdmann, E. A., Chen, C. Y., Cooper, M. E., de Zeeuw, D., Eckardt, K. U., Ivanovich, P., Kewalramani, R., Levey, A. S., Lewis, E. F., McGill, J., McMurray, J. J. V., Parfrey, P., Parving, H. H., Remuzzi, G., Singh, A. K., Solomon, S. D., Toto, R., Uno, H. Baseline Characteristics in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). American Journal of Kidney Diseases 54(1): 59-69, 2009. Piers, L. H., Touw, H. R. W., Gansevoort, R., Franssen, C. F. M., Oudkerk, M., Zijlstra, F., Tio, R. A. Relation of Aortic Valve and Coronary Artery Calcium in Patients With Chronic Kidney Disease to the Stage and Etiology of the Renal Disease. American Journal of Cardiology 103(10): 1473-1477, 2009. Plomgaard, P., Dullaart, R. P. F., de Vries, R., Groen, A. K., Dahlback, B., Nielsen, L. B. Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects. Journal of Internal Medicine 266(3): 258-267, 2009. Postma, M. J., de Zeeuw, D. The economic benefits of preventing end-stage renal disease in patients with type 2 diabetes mellitus. Nephrology Dialysis Transplantation 24(10): 2975-2983, 2009. Rienstra, H., Boersema, M., Onuta, G., Boer, M. W., Zandvoort, A., van Riezen, M., Rozing, J., van Goor, H., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Origin of Mesenchymal and Endothelial Cells in Chronic Renal Allograft Remodeling. American Journal of Transplantation 9(3): 463-472, 2009. Samarska, I. V., van Meurs, M., Buikema, H., Houwertjes, M. C., Wulfert, F. M., Molema, G., Epema, A. H., Henning, R. H. Adjunct Nitrous Oxide Normalizes Vascular Reactivity Changes after Hemorrhagic Shock in Mice under Isoflurane Anesthesia. Anesthesiology 111(3): 600-608, 2009. Smilde, T. D. J., Damman, K., van der Harst, P., Navis, G., Westenbrink, B. D., Voors, A. A., Boomsma, F., van Veldhuisen, D. J., Hillege, H. L. Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure. Clinical Research in Cardiology 98(2): 121-129, 2009. Tak, L. M., Bakker, S. J. L., Slaets, J. P. J., Rosmalen, J. G. M. Is highsensitive C-reactive protein a biomarker for functional somatic

GUIDE Annual Publication Report 2009 6

symptoms? A population-based study. Brain Behavior and Immunity 23(7): 1014-1019, 2009. ter Bogt, N. C. W., Bemelmans, W. J. E., Beltman, F. W., Broer, J., Smit, A. J., van der Meer, K. Preventing Weight Gain One-Year Results of a Randomized Lifestyle Intervention. American Journal of Preventive Medicine 37(4): 270-277, 2009. Ulu, N., Henning, R. H., Goris, M., Schoeinaker, R. G., van Gilst, W. H. Effects of Ivabradine and Metoprolol on Cardiac Angiogenesis and Endothelial Dysfunction in Rats With Heart Failure. Journal of Cardiovascular Pharmacology 53(1): 9-17, 2009. Ulu, N., Schoemaker, R. G., Henning, R. H., Buikema, H., Teerlink, T., Zijlstra, F. J., Bakker, S. J. L., van Gilst, W. H., Navis, G. Proteinuria-Associated Endothelial Dysfunction Is Strain Dependent. American Journal of Nephrology 30(3): 209-217, 2009. van den Hoven, M. J., Waanders, F., Rops, A. L., Kramer, A. B., van Goor, H., Berden, J. H., Navis, G., van der Vlag, J. Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species. Nephrology Dialysis Transplantation 24(9): 2637-2645, 2009. van der Velde, M., Halbesma, N., de Charro, F. T., Bakker, S. J. L., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. Screening for Albuminuria Identifies Individuals at Increased Renal Risk. Journal of the American Society of Nephrology 20(4): 852-862, 2009. van Dokkum, R. P. E., Buikema, H. Possible new druggable targets for the treatment of nephrosis Perhaps we should find them in caveolea? Current Opinion in Pharmacology 9(2): 132-138, 2009. van Goor, H., Melenhorst, W. B. W. H., Turner, A. J., Holgate, S. T. Adamalysins in biology and disease. Journal of Pathology 219(3): 277-286, 2009. van Goor, H., Leuvenink, H. G. D. The goddess of the waters. Kidney International 75(8): 767-769, 2009. van Timmeren, M. M., Lems, S. P. M., Hepkema, B. G., Bakker, S. J. L. Anti-Human Leukocyte Antigen Antibodies and Development of Graft Failure After Renal Transplantation. Transplantation 88(12): 1399-1400, 2009. van Timmeren, M. M., Lems, S. P. M., Hepkema, B. G., Bakker, S. J. L. Anti-Human Leukocyte Antigen Antibodies and Development of Graft Failure After Renal Transplantation. Transplantation 88(12): 1399-1400, 2009. Vegter, S., Perna, A., Hiddema, W., Ruggenenti, P., Remuzzi, G., Navis, G., Postma, M. J. Cost-effectiveness of ACE inhibitor therapy to prevent dialysis in nondiabetic nephropathy:

influence of the ACE insertion/deletion polymorphism. Pharmacogenetics and Genomics 19(9): 695-703, 2009. Visser, A., Dijkstra, G. J., Kuiper, D., de Jong, P. E., Franssen, C. F. M., Gansevoort, R. T., Izaks, G. J., Jager, K. J., Reineveld, S. A. Accepting or declining dialysis: Considerations taken into account by elderly patients with end-stage renal disease. Journal of Nephrology 22(6): 794-799, 2009. Visser, A., Dijkstra, G. J., Kuiper, D., de Jong, P. E., Franssen, C. F. M., Gansevoort, R. T., Izaks, G. J., Jager, K. J., Reijneveld, S. A. Accepting or declining dialysis: considerations taken into account by elderly patients with end-stage renal disease. Journal of Nephrology 22(6): 794-799, 2009. Visser, F. W., Krikken, J. A., Muntinga, J. H. J., Dierckx, R. A., Navis, G. J. Rise in Extracellular Fluid Volume During High Sodium Depends on BMI in Healthy Men. Obesity 17(9): 1684-1688, 2009. Vogt, L., de Zeeuw, D., Woittiez, A. J. J., Navis, G. Selective cyclooxygenase-2 (COX-2) inhibition reduces proteinuria in renal patients. Nephrology Dialysis Transplantation 24(4): 11821189, 2009. Waanders, F., Vaidya, V. S., van Goor, H., Leuvenink, H., Damman, K., Hamming, I., Bonventre, J. V., Vogt, L., Navis, G. Effect of Renin-Angiotensin-Aidosterone System Inhibition, Dietary Sodium Restriction, and/or Diuretics on Urinary Kidney Injury Molecule 1 Excretion in Nondiabetic Proteinuric Kidney Disease: A Post Hoc Analysis of a Randomized Controlled Trial. American Journal of Kidney Diseases 53(1): 16-25, 2009. Waanders, F., Rienstra, H., Boer, M. W., Zandvoort, A., Rozing, J., Navis, G., van Goor, H., Hillebrands, J. L. Spironolactone ameliorates transplant vasculopathy in renal chronic transplant dysfunction in rats. American Journal of Physiology-Renal Physiology 296(5): F1072-F1079, 2009. Westendorp, B., Hamming, I., Szymanski, M. K., Navis, G., van Goor, H., Buikema, H., van Gilst, W. H., Schoemaker, R. G. Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor. European Journal of Pharmacology 602(2-3): 373-379, 2009. Witte, E. C., Heerspink, H. J. L., de Zeeuw, D., Bakker, S. J. L., de Jong, P. E., Gansevoort, R. First Morning Voids Are More Reliable Than Spot Urine Samples to Assess Microalbuminuria. Journal of the American Society of Nephrology 20(2): 436-443, 2009. Wolffenbuttel, B. H. R., Klaff, L. J., Bhushan, R., Fahrbach, J. L., Jiang, H., Martin, S. Initiating insulin therapy in elderly patients with Type 2 diabetes: efficacy and safety of lispro mix 25 vs. basal insulin combined with oral glucose-lowering agents. Diabetic Medicine 26(11): 1147-1155, 2009. Wong, L. S., Windt, W. A., Roks, A. J., van Dokkum, R. P., Schoemaker, R. G., de Zeeuw, D., Henning, R. H. Renal failure

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induces telomere shortening in the rat heart. Netherlands Heart Journal 17(5): 190-194, 2009. Xu, Y., Henning, R. H., Sandovici, M., van der Want, J. J., van Gilst, W. H., Buikema, H. Enhanced myogenic constriction of mesenteric artery in heart failure relates to decreased smooth

muscle cell caveolae numbers and altered AT(1)- and epidermal growth factor-receptor function. European Journal of Heart Failure 11(3): 246-255, 2009.

GUIDE Annual Publication Report 2009 8

CARDIOVASCULAR CENTER -CVC

Dissertations
Broers, C. J. M. De nurse practitioner: verpleegkundig specialist tussen care en cure. (2009) Veldhuisen, D. J., Jaarsma, T., and Umans, V. A. W. M. Damman, K. Cardiorenal interaction in heart failure. (2009) Hillege, H. L., Veldhuisen, D. J., Navis, G. J., and Voors, A. A. Meijering, B. D. M. Ultrasound and microbubble targeted delivery : exploring the mechanism and its therapeutic potential. (2009) Henning, R. H., van Gilst, W. H., and Deelman, L. E. Piers, L. H. Computed tomography for the evaluation of the aortic valve and coronary arteries. (2009) Zijlstra, F. and Tio, R. Ulu, N. Vascular function in chronic end-organ damage : pharmacological characterization of vasomotor function in systemic vasculature. (2009) Henning, R. H., van Gilst, W. H., Buikema, H., and Schoemaker, R. G. van der Vleuten, P. A. Left ventricular function after STEMI : developments in diagnostics and cell therapy. (2009) Zijlstra, F. and Tio, R. A.

Journal articles
Buck, S. Optimization of cardiac resynchronization therapy in atrial fibrillation and sinus rhythm. edited by I. C. van Gelder, D. J. Veldhuisen, and A. H. Maass, 2009, Aalberts, J. J. J., Boonstra, P. W., van den Berg, M. P., Waterbolk, T. W. In-hospital mortality and three-year survival after repaired acute type A aortic dissection. Netherlands Heart Journal 17(6): 226-231, 2009. Ahmed, S., Crijns, H. J. G. M., van Gelder, I. C. Treatment With Amiodarone to Prevent Atrial Fibrillation Reply. JAMA - Journal of the American Medical Association 301(10): 1020, 2009. Al-Ansari, S., Zeebregts, C. J., Slart, R. H. J. A., Peppelenbosch, M., Tio, R. A. Galectins in Atherosclerotic Disease. Trends in Cardiovascular Medicine 19(5): 164-169, 2009. Al Ansari, S., Zeebregts, C. J., Slart, R. H. J. A., Peppelenbosch, M., Tio, R. A. Galectins in Atherosclerotic Disease. Trends in Cardiovascular Medicine 19(5): 164-169, 2009. Altena, R., Perik, P. J., van Veldhuisen, D. J., de Vries, E. G. E., Gietema, J. A. Cardiovascular toxicity caused by cancer treatment: strategies for early detection. Lancet Oncology 10(4): 391-399, 2009. Anker, S. D., Voors, A., Okonko, D., Clark, A. L., James, M. K., von Haehling, S., Kjekshus, J., Ponikowski, P., Dickstein, K. Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: data from the OPTIMAAL trial. European Heart Journal 30(11): 1331-1339, 2009. Annema, C., Luttik, M. L., Jaarsma, T. Do Patients With Heart Failure Need a Case Manager? Journal of Cardiovascular Nursing 24(2): 127-131, 2009. Annema, C., Luttik, M. L., Jaarsma, T. Reasons for readmission in heart failure: Perspectives of patients, caregivers, cardiologists, and heart failure nurses. Heart & Lung 38(5): 427-434, 2009. Backlund, M., Paukku, K., Daviet, L., de Boer, R. A., Valo, E., Hautaniemi, S., Kalkkinen, N., Ehsan, A., Kontula, K. K., Lehtonen, J. Y. A. Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase. Nucleic Acids Research 37(7): 2346-2358, 2009. Bartels, A. L., Zeebregts, C. J., Bijl, M., Tio, R. A., Slart, R. H. J. A. Fused FDG-PET and MRI imaging of Takayasu arteritis in vertebral arteries. Annals of Nuclear Medicine 23(8): 753-756, 2009. Beghetti, M., Haworth, S. G., Bonnet, D., Barst, R. J., Acar, P., Fraisse, A., Ivy, D. D., Jais, X., Schulze-Neick, I., Galie, N., Morganti, A., Dingemanse, J., Kusic-Pajic, A., Berger, R. M. F. Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study. British Journal of Clinical Pharmacology 68(6): 948-955, 2009. Belonje, A. M. S., Westenbrink, B. D., Voors, A. A., von Haehling, S., Ponikowski, P., Anker, S. D., van Veldhuisen, D. J., Dickstein, K. Erythropoietin levels in heart failure after an acute myocardial infarction: Determinants, prognostic value, and the effects of captopril versus losartan. American Heart Journal 157(1): 91-96, 2009. Bhuiyan, Z. A., Jongbloed, J. D. H., van der Smagt, J., Lombardi, P. M., Wiesfeld, A. C. P., Nelen, M., Schouten, M., Jongbloed, R., Cox, M. G. P. J., van Wolferen, M., Rodriguez, L. M., van Gelder, I. C., Bikker, H., Suurmeijer, A. J. H., van den Berg, M. P., Mannens,

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M. M. A. M., Hauer, R. N. W., Wilde, A. A. M., van Tintelen, J. P. Desmoglein-2 and Desmocollin-2 Mutations in Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomypathy Patients Results From a Multicenter Study. CirculationCardiovascular Genetics 2(5): 418-U22, 2009. Bhuiyan, Z. A., Jongbloed, J. D. H., van der Smagt, J., Lombardi, P. M., Wiesfeld, A. C. P., Nelen, M., Schouten, M., Jongbloed, R., Cox, M. G. P. J., van Wolferen, M., Rodriguez, L. M., van Gelder, I. C., Bikker, H., Suurmeijer, A. J. H., van den Berg, M. P., Mannens, M. M. A. M., Hauer, R. N. W., Wilde, A. A. M., van Tintelen, J. P. Desmoglein-2 and Desmocollin-2 Mutations in Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomypathy Patients Results From a Multicenter Study. Circulation-Cardiovascular Genetics 2(5): 418-U22, 2009. Broers, C. J. M., Sinclair, N., van der Ploeg, T. J., Jaarsma, T., van Veldhuisen, D. J., Umans, V. A. W. M. The post-infarction nurse practitioner project A prospective study comparing nurse intervention with conventional care in a non-high-risk myocardial infarction population. Netherlands Heart Journal 17(2): 61-67, 2009. Brugemann, J., van der Bij, W., Verschuuren, E. A. M., Klungel, A. A., van der Horst, I. C. C., Erasmus, M. E., Kerstjens, H. A. M., van Veldhuisen, D. J., Zijlstra, F. Experience with combined heartlung transplant at the University Medical Center Groningen. Nederlands Tijdschrift voor Geneeskunde 153(27): 1314-1319, 2009. Buck, S., Maass, A. H., van Veldhuisen, D. J., van Gelder, I. C. Cardiac resynchronisation therapy and the role of optimal device utilisation. Netherlands Heart Journal 17(9): 354-357, 2009. Burzotta, F., De Vita, M., Gu, Y. L. L., Isshiki, T., Lefevre, T., Kaltoft, A., Dudek, D., Sardella, G., Orrego, P. S., Antoniucci, D., De Luca, L., Biondi-Zoccai, G. G. L., Crea, F., Zijlstra, F. Clinical impact of thrombectomy in acute ST-elevation myocardial infarction: an individual patient-data pooled analysis of 11 trials. European Heart Journal 30(18): 2193-2203, 2009. Carballo, S., Robinson, P., Otway, R., Fatkin, D., Jongbloed, J. D. H., de Jonge, N., Blair, E., van Tintelen, J. P., Redwood, C., Watkins, H. Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy. Circulation Research 105(4): 375U116, 2009. Cleland, J. G. F., McMurray, J. J. V., Kjekshus, J., Cornel, J. H., Dunselman, P., Fonseca, C., Hjalmarson, A., Korewicki, J., Lindberg, M., Ranjith, N., van Veldhuisen, D. J., Waagstein, F., Wedel, H., Wikstrand, J. Plasma Concentration of AminoTerminal Pro-Brain Natriuretic Peptide in Chronic Heart Failure: Prediction of Cardiovascular Events and Interaction With the Effects of Rosuvastatin A Report From CORONA (Controlled

Rosuvastatin Multinational Trial in Heart Failure). Journal of the American College of Cardiology 54(20): 1850-1859, 2009. Cohen-Solal, A., Kotecha, D., van Veldhuisen, D. J., Babalis, D., Bohm, M., Coats, A. J., Roughton, M., Poole-Wilson, P., Tavazzi, L., Flather, M. Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial. European Journal of Heart Failure 11(9): 872-880, 2009. Cox, M. G. P. J., van der Smagt, J. J., Wilde, A. A. M., Wiesfeld, A. C. P., Atsma, D. E., Nelen, M. R., Rodriguez, L. M., Loh, P., Cramer, M. J., Doevendans, P. A., van Tintelen, J. P., De Bakker, J. M. T., Hauer, R. N. W. New ECG Criteria in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Circulation-Arrhythmia and Electrophysiology 2(5): 524-530, 2009. Damman, K., Hillege, H. L., van Veldhuisen, D. J. Albuminuria in heart failure: a CHARMing new risk factor? Lancet 374(9689): 506-508, 2009. Damman, K., Jaarsma, T., Voors, A. A., Navis, G., Hillege, H. L., van Veldhuisen, D. J. Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: results from the Coordinating Study Evaluating Outcome of Advising and Counseling in Heart Failure (COACH). European Journal of Heart Failure 11(9): 847-854, 2009. Damman, K., van Veldhuisen, D. J., Hillege, H. L. Cardiac Resynchronization Therapy Improves Renal Function: Importance of Forward and Backward Failure. Journal of Cardiac Failure 15(1): 78-79, 2009. Damman, K., van Deursen, V. M., Navis, G., Voors, A. A., van Veldhuisen, D. J., Hillege, H. L. Increased Central Venous Pressure Is Associated With Impaired Renal Function and Mortality in a Broad Spectrum of Patients With Cardiovascular Disease. Journal of the American College of Cardiology 53(7): 582-588, 2009. Dasselaar, J. J., Slart, R. H. J. A., Knip, M., Pruim, J., Tio, R. A., McIntyre, C. W., de Jong, P. E., Franssen, C. F. M. Haemodialysis is associated with a pronounced fall in myocardial perfusion. Nephrology Dialysis Transplantation 24(2): 604-610, 2009. de Boer, R. A., Voors, A. A., Muntendam, P., van Gilst, W. H., van Veldhuisen, D. J. Galectin-3: a novel mediator of heart failure development and progression. European Journal of Heart Failure 11(9): 811-817, 2009. de Boer, R. A., van der Harst, P., van Veldhuisen, D. J., van den Berg, M. P. Pharmacogenetics in heart failure: promises and challenges. Expert Opinion on Pharmacotherapy 10(11): 1713-1725, 2009. de Jong, R. M., Tio, R. A., van der Harst, P., Voors, A. A., Koning, P. M., Zeebregts, C. J. A. M., van Veldhuisen, D. J., Dierckx, R. A. J. O., Slart, R. H. J. A. Ischemic patterns assessed by positron emission tomography predict adverse outcome in patients with

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idiopathic dilated cardiomyopathy. Journal of Nuclear Cardiology 16(5): 769-774, 2009. De Smedt, R. H. E., Denig, P., Haaijer-Ruskamp, F. M., Jaarsma, T. Perceived medication adverse effects and coping strategies reported by chronic heart failure patients. International Journal of Clinical Practice 63(2): 233-242, 2009. de Vries, B. M. W., Hillebrands, J. L., van Dam, G. M., Tio, R. A., de Jong, J. S., Slart, R. H. J. A., Zeebregts, C. J. Multispectral NearInfrared Fluorescence Molecular Imaging of Matrix Metalloproteinases in a Human Carotid Plaque Using a MatrixDegrading Metalloproteinase-Sensitive Activatable Fluorescent Probe. Circulation 119(20): E534-E536, 2009. Deuling, J. H. H., Smit, M. D., Maass, A. H., van den Heuvel, A. F. M., Nieuwland, W., Zijlstra, F., van Gelder, I. C. The value and limitations of a wound inspection clinic after cardiac device implantation. European Journal of Cardiovascular Nursing 8(4): 288-292, 2009. Dickinson, M. G., Scholvinck, E. H., Boonstra, A., VonkNoordegraaf, A., Snijder, R. J., Berger, R. M. F. Low Complication Rates With Totally Implantable Access Port Use in Epoprostenol Treatment of Pulmonary Hypertension. Journal of Heart and Lung Transplantation 28(3): 273-279, 2009. Dickstein, K., Bogale, N., Priori, S., Auricchio, A., Cleland, J. G., Gitt, A., Limbourg, T., Linde, C., van Veldhuisen, D. J., Brugada, J. The European cardiac resynchronization therapy survey. European Heart Journal 30(20): 2450-2460, 2009. Dieperink, W., Weelink, E. E. M., van der Horst, I. C. C., De Vos, R., Jaarsma, T., Aarts, L. P. H. J., Zijlstra, F., Nijsten, M. W. N. Treatment of presumed acute cardiogenic pulmonary oedema in an ambulance system by nurses using Boussignac continuous positive airway pressure. Emergency Medicine Journal 26(2): 141-144, 2009. Duffels, M. G. J., van der Plas, M. N., Surie, S., Winter, M. M., Bouma, B. J., Groenink, M., van Dijk, A. P. J., Hoendermis, E. S., Berger, R. M. F., Bresser, P., Mulder, B. J. M. Bosentan in pulmonary arterial hypertension: a comparison between congenital heart disease and chronic pulmonary embolism. Netherlands Heart Journal 17(9): 334-+, 2009. Duffels, M. G. J., Vis, J. C., van Loon, R. L. E., Berger, R. M. F., Hoendermis, E. S., van Dijk, A. P. J., Bouma, B. J., Mulder, B. J. M. Down patients with Eisenmenger syndrome: Is bosentan treatment an option? International Journal of Cardiology 134(3): 378-383, 2009. Duffels, M. G. J., Hardziyenka, M., Surie, S., de Bruin-Bon, R. H. A. C., Hoendermis, E. S., van Dijk, A. P. J., Bouma, B. J., Tan, H. L., Berger, R. M. F., Bresser, P., Mulder, B. J. M. Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension. European Journal of Echocardiography 10(3): 433-438, 2009.

Duffels, M. G. J., Vis, J. C., van Loon, R. L. E., Nieuwkerk, P. T., van Dijk, A. P. J., Hoendermis, E. S., de Bruin-Bon, R. H. A. C., Bouma, B. J., Bresser, P., Berger, R. M. F., Mulder, B. J. M. Effect of Bosentan on Exercise Capacity and Quality of Life in Adults With Pulmonary Arterial Hypertension Associated With Congenital Heart Disease With and Without Down's Syndrome. American Journal of Cardiology 103(9): 1309-1315, 2009. Fokkema, M. L., Vlaar, P. J., Vogelzang, M., Gu, Y. L., Kampinga, M. A., de Smet, B. J., Jessurun, G. A., Anthonio, R. L., van den Heuvel, A. F., Tan, E. S., Zijlstra, F. Effect of high-dose intracoronary adenosine administration during primary percutaneous coronary intervention in acute myocardial infarction a randomized controlled trial. Circulation: Cardiovascular Interventions 2(4): 323-329, 2009. Fokkema, M. L., Vlaar, P. J., Svilaas, T., Vogelzang, M., Amo, D., Diercks, G. F. H., Suurmeijer, A. J. H., Zijlstra, F. Incidence and clinical consequences of distal embolization on the coronary angiogram after percutaneous coronary intervention for STelevation myocardial infarction. European Heart Journal 30(8): 908-915, 2009. Fokkema, M. L., van der Vleuten, R., Vlaar, P. J., Svilaas, T., Zijlstra, F. Incidence, Predictors, and Outcome of Reinfarction and Stent Thrombosis Within One Year After Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction. Catheterization and Cardiovascular Interventions 73(5): 627-634, 2009. Fokkema, M. L., Vlaar, P. J., Zijlstra, F. Response to letter regarding article "effect of high-dose intracoronary adenosine administration during primary percutaneous coronary intervention in acute myocardial infarction: A randomized controlled trial". Circulation: Cardiovascular Interventions 2(6): e6, 2009. Fokkema, M. L., Vlaar, P. J., Vogelzang, M., Gu, Y. L., Kampinga, M. A., de Smet, B. J., Jessurun, G. A., Anthonio, R. L., van den Heuvel, A. F., Tan, E. S., Zijlstra, F. Effect of High-Dose Intracoronary Adenosine Administration During Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction A Randomized Controlled Trial. Circulation-Cardiovascular Interventions 2(4): 323-329, 2009. Fokkema, M. L., Vlaar, P. J., Zijlstra, F. Response to Letter Regarding Article "Effect of High-Dose Intracoronary Adenosine Administration During Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction: A Randomized Controlled Trial". Circulation-Cardiovascular Interventions 2(6): E6, 2009. Ge, D. L., Su, S. Y., Zhu, H. D., Dong, Y. B., Wang, X. L., Harshfield, G. A., Treiber, F. A., Snieder, H. Stress-Induced Sodium Excretion A New Intermediate Phenotype to Study the Early Genetic Etiology of Hypertension? Hypertension 53(2): 262-269, 2009.

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Geiger, R., Sharma, H. S., Mooi, W. J., Berger, R. M. F. Pulmonary vascular remodeling in congenital heart disease: Enhanced expression of heat shock proteins. Indian Journal of Biochemistry & Biophysics 46(6): 482-490, 2009. Ghali, J. K., Wikstrand, J., van Veldhuisen, D. J., Fagerberg, B., Goldstein, S., Hjalmarson, A., Johansson, P., Kjekshus, J., Ohlsson, L., Samuelsson, O., Waagstein, F., Wedel, H. The Influence of Renal Function on Clinical Outcome and Response to beta-Blockade in Systolic Heart Failure: Insights From Metoprolol CR/XL Randomized Intervention Trial in Chronic HF (MERIT-HF). Journal of Cardiac Failure 15(4): 310-318, 2009. Glaudemans, A. W. J. M., Slart, R. H. J. A., Zeebregts, C. J., Veltman, N. C., Tio, R. A., Hazenberg, B. P. C., Dierckx, R. A. J. O. Nuclear imaging in cardiac amyloidosis. European Journal of Nuclear Medicine and Molecular Imaging 36(4): 702-714, 2009. Groen, J. M., van der Vleuten, P. A., Greuter, M. J. W., Zijlstra, F., Oudkerk, M. Comparison of MRI, 64-slice MDCT and DSCT in assessing functional cardiac parameters of a moving heart phantom. European Radiology 19(3): 577-583, 2009. Groenveld, H. F., Crijns, H. J. G. M., Rienstra, M., van den Berg, M. P., van Veldhuisen, D. J., van Gelder, I. C. Does intensity of rate control influence outcome in persistent atrial fibrillation?: Data of the RACE study. American Heart Journal 158(5): 785-791, 2009. Gu, Y. L., Fokkema, M. L., Kampinga, M. A., de Smet, B. J. G. L., Tan, E. S., van den Heuvel, A. F. M., Zijlstra, F. Intracoronary versus intravenous abciximab in ST-segment elevation myocardial infarction: rationale and design of the CICERO trial in patients undergoing primary percutaneous coronary intervention with thrombus aspiration. Trials 10 AR 90 DI 10.1186/1745-6215-10-90 2009. Halbersma, W. B., Arrigoni, S. C., Mecozzi, G., Grandjean, J. G., Kappetein, A. P., van der Palen, J., Zijlstra, F., Mariani, M. A. FourYear Outcome of OPCAB No-Touch With Total Arterial YGraft: Making the Best Treatment a Daily Practice. Annals of Thoracic Surgery 88(3): 796-801, 2009. Hartog, J. W. L., Willemsen, S., Voors, A. A. Letter by Hartog et al Regarding Article, "Advanced Glycation End Products Accumulate in Vascular Smooth Muscle and Modify Vascular but Not Ventricular Properties in Elderly Hypertensive Canines". Circulation 119(10): E233, 2009. Hartong, D. T., Mcgee, T. L., Sandberg, M. A., Berson, E. L., Asselbergs, F. W., van der Harst, P., De Vivo, I., Dryja, T. P. Search for a correlation between telomere length and severity of retinitis pigmentosa due to the dominant rhodopsin Pro23His mutation. Molecular Vision 15(60-62): 592-597, 2009. Hassan, M. O., Bayoumi, R. A., Lopez-Alvarenga, J. C., Snieder, H., Jaju, D., Al-Yahyaee, S., Al-Hadabi, S., Comuzzie, A. G., Albarwani, S. Heritability of Hemodynamic Reactivity to

Laboratory Stressors in a Homogenous Arab Population: 'Oman Family Study'. Twin Research and Human Genetics 12(6): 541548, 2009. Hassan, M. O., Bayoumi, R. A., Lopez-Alvarenga, J. C., Snieder, H., Jaju, D., Al Yahyaee, S., Al Hadabi, S., Comuzzie, A. G., Albarwani, S. Heritability of Hemodynamic Reactivity to Laboratory Stressors in a Homogenous Arab Population: 'Oman Family Study'. Twin Research and Human Genetics 12(6): 541-548, 2009. Hoekstra, M., Vogelzang, M., Verbitskiy, E., Nijsten, M. W. N. Health technology assessment review: Computerized glucose regulation in the intensive care unit - how to create artificial control. Critical Care 13(5 AR 223 DI 10.1186/cc8023) 2009. Holm, P. W., Slart, R. H. J. A., Zeebregts, C. J., Hillebrands, J. L., Tio, R. A. Atherosclerotic plaque development and instability: A dual role for VEGF. Annals of Medicine 41(4): 257-264, 2009. Huijskes, R. V. H. P., Hoogenberg, K., Wiesfeld, A. C. P., Pijl, M. E. J., van Gelder, I. C. Phlebotomies as a treatment of serious heart failure due to haemochromatosis: a case report. Netherlands Heart Journal 17(11): 438-441, 2009. Jaarsma, T., Beattie, J. M., Ryder, M., Rutten, F. H., McDonagh, T., Mohacsi, P., Murray, S. A., Grodzicki, T., Bergh, I., Metra, M., Ekman, I., Angermann, C., Leventhal, M., Pitsis, A., Anker, S. D., Gavazzi, A., Ponikowski, P., Dickstein, K., Delacretaz, E., Blue, L., Strasser, F., McMurray, J. Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure 11(5): 433-443, 2009. Jaarsma, T., Arestedt, K. F., Martensson, J., Dracup, K., Stromberg, A. The European Heart Failure Self-care Behaviour scale revised into a nine-item scale (EHFScB-9): a reliable and valid international instrument. European Journal of Heart Failure 11(1): 99-105, 2009. Kampinga, M. A., Vlaar, P. J., Fokkema, M. L., Gu, Y. L., Zijlstra, F. Thrombus Aspiration during Percutaneous coronary intervention in Acute non-ST-elevation myocardial infarction Study (TAPAS II)-Study design. Netherlands Heart Journal 17(11): 409-413, 2009. Klapholz, M., Abraham, W. T., Ghali, J. K., Ponikowski, P., Anker, S. D., Knusel, B., Sun, Y., Wasserman, S. M., van Veldhuisen, D. J. The safety and tolerability of darbepoetin alfa in patients with anaemia and symptomatic heart failure. European Journal of Heart Failure 11(11): 1071-1077, 2009. Klinkenberg, T. J., Ahmed, S., Ten Hagen, A., Wiesfeld, A. C. P., Tan, E. S., Zijlstra, F., van Gelder, I. C. Feasibility and outcome of epicardial pulmonary vein isolation for lone atrial fibrillation using minimal invasive surgery and high intensity focused ultrasound. Europace 11(12): 1624-1631, 2009.

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Lazarenko, S. V., van der Vleuten, P. A., Tio, R. A., Willemsen, A. T. M., Paans, A. M. J., Douma, J. E., Zeebregts, C. J., Dierckx, R. A., Zijlstra, F., Slart, R. H. J. A. Left ventricular volume assessment by planar radionuclide ventriculography evaluated by MRI. Nuclear Medicine Communications 30(9): 727-735, 2009. Lesman-Leegte, I., van Veldhuisen, D. J., Hillege, H. L., Moser, D., Sanderman, R., Jaarsma, T. Depressive symptoms and outcomes in patients with heart failure: data from the COACH study dagger. European Journal of Heart Failure 11(12): 1202-1207, 2009. Lesman-Leegte, I., Jaarsma, T., Coyne, J. C., Hillege, H. L., van Veldhuisen, D. J., Sanderman, R. Quality of Life and Depressive Symptoms in the Elderly: A Comparison Between Patients With Heart Failure and Age- and Gender-Matched Community Controls. Journal of Cardiac Failure 15(1): 17-23, 2009. Lexis, C. P. H., Rahel, B. M., Meeder, J. G., Zijlstra, F., van derHorst, I. C. C. The role of glucose lowering agents on restenosis after percutaneous coronary intervention in patients with diabetes mellitus. Cardiovascular Diabetology 8 AR 41 DI 10.1186/14752840-8-41 2009. Li, Z. B., Snieder, H., Harshfield, G. A., Treiber, F. A., Wang, X. L. A 15-year longitudinal study on ambulatory blood pressure tracking from childhood to early adulthood. Hypertension Research 32(5): 404-410, 2009. Li, Z. B., Snieder, H., Su, S. Y., Ding, X. H., Thayer, J. F., Treiber, F. A., Wang, X. L. A longitudinal study in youth of heart rate variability at rest and in response to stress. International Journal of Psychophysiology 73(3): 212-217, 2009. Liem, A., van de Woestijne, A. P., Bruijns, E., van Lennep, H. W. O. R., de Boo, J. A. J., van Halteren, H. K., van Es, T. P., Jukema, J. W., van der Laarse, A., Zwinderman, A. H., van Veldhuisen, D. J. Effect of EPO administration on myocardial infarct size in patients with non-STE acute coronary syndromes; results from a pilot study. International Journal of Cardiology 131(2): 285-287, 2009. Linssen, G. C. M., Damman, K., Hillege, H. L., Navis, G., van Veldhuisen, D. J., Voors, A. A. Urinary N-Terminal Prohormone Brain Natriuretic Peptide Excretion in Patients With Chronic Heart Failure. Circulation 120(1): 35-41, 2009. Liu, G. F., Riese, H., Spector, T. D., Mangino, M., O'Dell, S. D., Stolk, R. P., Snieder, H. Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach. Diabetologia 52(6): 10481055, 2009. Luttik, M. L., Lesman-Leegte, I., Jaarsma, T. Quality of Life and Depressive Symptoms in Heart Failure Patients and Their Partners: The Impact of Role and Gender. Journal of Cardiac Failure 15(7): 580-585, 2009.

Luttik, M. L., Jaarsma, T., Lesman, I., Sanderman, R., Hagedoorn, M. Quality of life in partners of people with congestive heart failure: gender and involvement in care. Journal of Advanced Nursing 65(7): 1442-1451, 2009. Maass, A. H., Buck, S., Nieuwland, W., Brugemann, J., van Veldhuisen, D. J., van Gelder, I. C. Importance of Heart Rate During Exercise for Response to Cardiac Resynchronization Therapy. Journal of Cardiovascular Electrophysiology 20(7): 773780, 2009. Maass, A. H., Waterbolk, T. W., van Gelder, I. C. Pitfalls of internal cardioverter defibrillator implantation: Part I. Europace 11(2): 237-238, 2009. Maass, A. H., Waterbolk, T. W., van Gelder, I. C. Pitfalls of internal cardioverter defibrillator implantation: Part II. Europace 11(2): 268-270, 2009. Mahmoodi, B. K., Gansevoort, R. T., Veeger, N. J. G. M., Matthews, A. G., Navis, G., Hillege, H. L., van der Meer, J. Microalbuminuria and Risk of Venous Thromboembolism. JAMA - Journal of the American Medical Association 301(17): 1790-1797, 2009. McMurray, J. J. V., Anand, I. S., Diaz, R., Maggioni, A. P., O'Connor, C., Pfeffer, M. A., Polu, K. R., Solomon, S. D., Sun, Y., Swedberg, K., Tendera, M., van Veldhuisen, D. J., Wasserman, S. M., Young, J. B. Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbiditymortality trial. European Journal of Heart Failure 11(8): 795-801, 2009. Medeiros-Domingo, A., Bhuiyan, Z. A., Tester, D. J., Hofman, N., Bikker, H., van Tintelen, J. P., Mannens, M. M. A. M., Wilde, A. A. M., Ackerman, M. J. The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome A Comprehensive Open Reading Frame Mutational Analysis. Journal of the American College of Cardiology 54(22): 2065-2074, 2009. Meijering, B. D. M., Juffermans, L. J. M., van Wamel, A., Henning, R. H., Zuhorn, I. S., Emmer, M., Versteilen, A. M. G., Paulus, W. J., van Gilst, W. H., Kooiman, K., de Jong, N., Musters, R. J. P., Deelman, L. E., Kamp, O. Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation. Circulation Research 104(5): 679-U226, 2009. Metra, M., Teerlink, J. R., Voors, A. A., Felker, G. M., Milo-Cotter, O., Weatherley, B., Dittrich, H., Cotter, G. Vasodilators in the treatment of acute heart failure: what we know, what we don't. Heart Failure Reviews 14(4): 299-307, 2009. Moons, P., Fleck, D., Jaarsma, T., Norekval, T. M., Smith, K., Stromberg, A., Thompson, D. R., Budts, W. What do cardiovascular nurses know about the hematological

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management of patients with Eisenmenger syndrome? European Journal of Cardiovascular Nursing 8(4): 246-250, 2009. Mulder, D. J., van Haelst, P. L., Graaff, R., Gans, R. O., Zijlstra, F., Smit, A. J. Skin autofluorescence is elevated in acute myocardial infarction and is associated with the one-year incidence of major adverse cardiac events. Netherlands Heart Journal 17(4): 162-168, 2009. Muntinghe, F. L. H., Gross, S., Bakker, S. J. L., Landman, G. W. D., van der Harst, P., Bilo, H. J. G., Navis, G., Zuurman, M. W. CCR5 Delta 32 genotype is associated with outcome in type 2 diabetes mellitus. Diabetes Research and Clinical Practice 86(2): 140-145, 2009. Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S., Zhao, J. H., Heath, S. C., Eyheramendy, S., Papadakis, K., Voight, B. F., Scott, L. J., Zhang, F., Farrall, M., Tanaka, T., Wallace, C., Chambers, J. C., Khaw, K. T., Nilsson, P., van der Harst, P., Polidoro, S., Grobbee, D. E., Onland-Moret, N. C., Bots, M. L., Wain, L. V., Elliott, K. S., Teumer, A., Luan, J., Lucas, G., Kuusisto, J., Burton, P. R., Hadley, D., McArdle, W. L., Brown, M., Dominiczak, A., Newhouse, S. J., Samani, N. J., Webster, J., Zeggini, E., Beckmann, J. S., Bergmann, S., Lim, N., Song, K., Vollenweider, P., Waeber, G., Waterworth, D. M., Yuan, X., Groop, L., Orho-Melander, M., Allione, A., Di Gregorio, A., Guarrera, S., Panico, S., Ricceri, F., Romanazzi, V., Sacerdote, C., Vineis, P., Barroso, I., Sandhu, M. S., Luben, R. N., Crawford, G. J., Jousilahti, P., Perola, M., Boehnke, M., Bonnycastle, L. L., Collins, F. S., Jackson, A. U., Mohlke, K. L., Stringham, H. M., Valle, T. T., Willer, C. J., Bergman, R. N., Morken, M. A., Doring, A., Gieger, C., Illig, T., Meitinger, T., Org, E., Pfeufer, A., Wichmann, H. E., Kathiresan, S., Marrugat, J., O'Donnell, C. J., Schwartz, S. M., Siscovick, D. S., Subirana, I., Freimer, N. B., Hartikainen, A. L., McCarthy, M. I., O'Reilly, P. F., Peltonen, L., Pouta, A., de Jong, P. E., Snieder, H., van Gilst, W. H., Clarke, R., Goel, A., Hamsten, A., Peden, J. F., Seedorf, U., Syvanen, A. C., Tognoni, G., Lakatta, E. G., Sanna, S., Scheet, P., Schlessinger, D., Scuteri, A., Dorr, M., Ernst, F., Felix, S. B., Homuth, G., Lorbeer, R., Reffelmann, T., Rettig, R., Volker, U., Galan, P., Gut, I. G., Hercberg, S., Lathrop, G. M., Zelenika, D., Deloukas, P., Soranzo, N., Williams, F. M., Zhai, G., Salomaa, V., Laakso, M., Elosua, R., Forouhi, N. G., Volzke, H., Uiterwaal, C. S., van der Schouw, Y. T., Numans, M. E., Matullo, G., Navis, G., Berglund, G., Bingham, S. A., Kooner, J. S., Connell, J. M., Bandinelli, S., Ferrucci, L., Watkins, H., Spector, T. D., Tuomilehto, J., Altshuler, D., Strachan, D. P., Laan, M., Meneton, P., Wareham, N. J., Uda, M., Jarvelin, M. R., Mooser, V., Melander, O., Loos, R. J. F., Elliott, P., Abecasis, G. R., Caulfield, M., Munroe, P. B. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 41(6): 666-676, 2009. Nijveldt, R., van der Vleuten, P. A., Hirsch, A., Beek, A. M., Tio, R. A., Tijssen, J. G. P., Piek, J. J., van Rossum, A. C., Zijlstra, F. Early Electrocardiographic Findings and MR Imaging-Verified Microvascular Injury and Myocardial Infarct Size 33. JACC: Cardiovascular Imaging 2(10): 1187-1194, 2009. GUIDE Annual Publication Report 2009 14

Nolte, I. M., Wallace, C., Newhouse, S. J., Waggott, D., Fu, J. Y., Soranzo, N., Gwilliam, R., Deloukas, P., Savelieva, I., Zheng, D. L., Dalageorgou, C., Farrall, M., Samani, N. J., Connell, J., Brown, M., Dominiczak, A., Lathrop, M., Zeggini, E., Wain, L. V., NewtonCheh, C., Eijgelsheim, M., Rice, K., de Bakker, P. I. W., Pfeufer, A., Sanna, S., Arking, D. E., Asselbergs, F. W., Spector, T. D., Carter, N. D., Jeffery, S., Tobin, M., Caulfield, M., Snieder, H., Paterson, A. D., Munroe, P. B., Jamshidi, Y. Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies. PLoS ONE 4(7 AR e6138 DI 10.1371/journal.pone.0006138) 2009. Nolte, I. M., Wallace, C., Newhouse, S. J., Waggott, D., Fu, J. Y., Soranzo, N., Gwilliam, R., Deloukas, P., Savelieva, I., Zheng, D. L., Dalageorgou, C., Farrall, M., Samani, N. J., Connell, J., Brown, M., Dominiczak, A., Lathrop, M., Zeggini, E., Wain, L. V., NewtonCheh, C., Eijgelsheim, M., Rice, K., de Bakker, P. I. W., Pfeufer, A., Sanna, S., Arking, D. E., Asselbergs, F. W., Spector, T. D., Carter, N. D., Jeffery, S., Tobin, M., Caulfield, M., Snieder, H., Paterson, A. D., Munroe, P. B., Jamshidi, Y. Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies. PLoS ONE 4(7 AR e6138 DI 10.1371/journal.pone.0006138) 2009. Oeseburg, H., Iusuf, D., van der Harst, P., van Gilst, W. H., Henning, R. H., Roks, A. J. M. Bradykinin Protects Against Oxidative StressInduced Endothelial Cell Senescence. Hypertension 53(2): 417422, 2009. Otterman, M. L., Nijboer, J. M., van der Horst, I. C. C., van Meurs, M., ten Duis, H. J., Nijsten, M. W. N. Reticulocyte Counts and Their Relation to Hemoglobin Levels in Trauma Patients. Journal of Trauma-Injury Infection and Critical Care 67(1): 121-124, 2009. Peels, J. O. J., Hautvast, R. W. M., de Swart, J. B. R. M., Huybregts, M. A. J. M., Umans, V. A. W. M., Arnold, A. E. R., Jessurun, G. A. J., Zijlstra, F. Percutaneous coronary intervention without on site surgical back-up; two-years registry of a large Dutch community hospital. International Journal of Cardiology 132(1): 59-65, 2009. Petrie, C. J., Voors, A. A., van Veldhuisen, D. J. Low pulse pressure is an independent predictor of mortality and morbidity in non ischaemic, but not in ischaemic advanced heart failure patients. International Journal of Cardiology 131(3): 336-344, 2009. Piers, L. H., Touw, H. R. W., Gansevoort, R., Franssen, C. F. M., Oudkerk, M., Zijlstra, F., Tio, R. A. Relation of Aortic Valve and Coronary Artery Calcium in Patients With Chronic Kidney Disease to the Stage and Etiology of the Renal Disease. American Journal of Cardiology 103(10): 1473-1477, 2009. Pons, D., Monraats, P. S., Zwinderman, A. H., de Maat, M. P. M., Doevendans, P. A. F. M., de Winter, R. J., Tio, R. A., Waltenberger, J., Jukema, J. W. Metabolic background determines the importance of NOS3 polymorphisms in restenosis after

percutaneous coronary intervention: A study in patients with and without the metabolic syndrome. Disease Markers 26(2): 75-83, 2009. Postema, P. G., van den Berg, M. P., van Tintelen, J. P., van den Heuvel, F., Grundeken, M., Hofman, N., van der Roest, W. P., Nannenberg, E. A., Krapels, I. P. C., Bezzina, C. R., Wilde, A. A. M. Founder mutations in the Netherlands SCN5a 1795insD, the first described arrhythmia overlap syndrome and one of the largest and best characterised families worldwide. Netherlands Heart Journal 17(11): 422-428, 2009. Qian, C., Schoemaker, R. G., van Gilst, W. H., Roks, A. J. M. The role of the renin-angiotensin-aldosterone system in cardiovascular progenitor cell function. Clinical Science 116(34): 301-314, 2009. Rasoul, S., Ottervanger, J. P., de Boer, M. J., Dambrink, J. H. E., Hoorntje, J. C. A., Gosselink, A. T. M., Zijlstra, F., Suryapranata, H., van't Hof, A. W. J. Predictors of 30-day and 1-year mortality after primary percutaneous coronary intervention for STelevation myocardial infarction. Coronary Artery Disease 20(6): 415-421, 2009. Rasoul, S., Ottervanger, J. P., de Boer, M. J., Dambrink, J. H. E., Hoorntje, J. C. A., Gosselink, A. T. M., Zijlstra, F., Suryapranata, H., van 't Hof, A. W. J. Primary percutaneous coronary intervention for ST-elevation myocardial infarction: From clinical trial to clinical practice. International Journal of Cardiology 134(1): 104-109, 2009. Ruifrok, W. P. T., de Boer, R. A., Iwakura, A., Silver, M., Kusano, K., Tio, R. A., Losordo, D. W. Estradiol-induced, endothelial progenitor cell-mediated neovascularization in male mice with hind-limb ischemia. Vascular Medicine 14(1): 29-36, 2009. Savva, J., Maqbool, A., White, H. L., Galloway, S. L., Yuldasheva, N. Y., Ball, S. G., West, R. M., de Boer, R. A., van Veldhuisen, D. J., Balmforth, A. J. Polymorphisms of Adrenoceptors are Not Associated With an Increased Risk of Adverse Event in Heart Failure: A MERIT-HF Substudy. Journal of Cardiac Failure 15(5): 435-441, 2009. Slart, R. H. J. A., Tio, R. A., Zijlstra, F., Dierckx, R. A. Diagnostic pathway of integrated SPECT/CT for coronary artery disease. European Journal of Nuclear Medicine and Molecular Imaging 36(11): 1829-1834, 2009. Smilde, T. D. J., Damman, K., van der Harst, P., Navis, G., Westenbrink, B. D., Voors, A. A., Boomsma, F., van Veldhuisen, D. J., Hillege, H. L. Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure. Clinical Research in Cardiology 98(2): 121-129, 2009. Smilde, T. D. J., van Veldhuisen, D. J., van den Berg, M. P. Prognostic value of heart rate variability and ventricular arrhythmias during 13-year follow-up in patients with mild to

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possible tool for online decision making in the catheterization laboratory. Journal of Cardiovascular Medicine 10(5): 415-419, 2009. Tan, E. S., Mulder, B. A., Rienstra, M., Wiesfeld, A. C. P., Ahmed, S., Zijlstra, F., van Gelder, I. C. Pulmonary vein isolation of symptomatic refractory paroxysmal and persistent atrial fibrillation A single centre and single operator experience in the Netherlands. Netherlands Heart Journal 17(10): 366-372, 2009. Teerlink, J. R., Metra, M., Felker, G. M., Ponikowski, P., Voors, A. A., Weatherley, B. D., Marmor, A., Katz, A., Grzybowski, J., Unemori, E., Teichman, S. L., Cotter, G. Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet 373(9673): 1429-1439, 2009. Teichman, S. L., Unemori, E., Dschietzig, T., Conrad, K., Voors, A. A., Teerlink, J. R., Felker, G. M., Metra, M., Cotter, G. Relaxin, a pleiotropic vasodilator for the treatment of heart failure. Heart Failure Reviews 14(4): 321-329, 2009. Tio, R. A., Dabeshlim, A., Siebelink, H. M. J., de Sutter, J., Hillege, H. L., Zeebregts, C. J., Dierckx, R. A. J. O., van Veldhuisen, D. J., Zijlstra, F., Slart, R. H. J. A. Comparison Between the Prognostic Value of Left Ventricular Function and Myocardial Perfusion Reserve in Patients with Ischemic Heart Disease. Journal of Nuclear Medicine 50(2): 214-219, 2009. Tio, R. A., Slart, R. H. J. A., de Boer, R. A., van der Vleuten, P. A., de Jong, R. M., van Wijk, L. M., Willems, T., Lubbers, D. D., Voors, A. A., van Veldhuisen, D. J. Reduced regional myocardial perfusion reserve is associated with impaired contractile performance in idiopathic dilated cardiomyopathy. Netherlands Heart Journal 17(12): 470-474, 2009. Ulu, N., Henning, R. H., Goris, M., Schoeinaker, R. G., van Gilst, W. H. Effects of Ivabradine and Metoprolol on Cardiac Angiogenesis and Endothelial Dysfunction in Rats With Heart Failure. Journal of Cardiovascular Pharmacology 53(1): 9-17, 2009. Ulu, N., Schoemaker, R. G., Henning, R. H., Buikema, H., Teerlink, T., Zijlstra, F. J., Bakker, S. J. L., van Gilst, W. H., Navis, G. Proteinuria-Associated Endothelial Dysfunction Is Strain Dependent. American Journal of Nephrology 30(3): 209-217, 2009. van den Berg, M. P., de Boer, R. A., van Tintelen, J. P. Brugada Syndrome or Brugada Electrocardiogram? Journal of the American College of Cardiology 53(17): 1569, 2009. van der Meer, P., van Veldhuisen, D. J. Anaemia and renal dysfunction in chronic heart failure. Heart 95(21): 1808-1812, 2009.

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Kuks, J. B. M., Van Spaendonck-Zwarts, K. Y., Notermans, N., Boven, L., van den Heuvel, F., Veenstra-Knol, H. E., Saffitz, J. E., Hofstra, R. M. W., van den Berg, M. P. Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene. Heart Rhythm 6(11): 1574-1583, 2009. van Veldhuisen, D. J., Cohen-Solal, A., Bohm, M., Anker, S. D., Babalis, D., Roughton, M., Coats, A. J. S., Poole-Wilson, P. A., Flather, M. D. Beta-Blockade With Nebivolol in Elderly Heart Failure Patients With Impaired and Preserved Left Ventricular Ejection Fraction Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure). Journal of the American College of Cardiology 53(23): 2150-2158, 2009. van Veldhuisen, D. J., Maass, A. H., Priori, S. G., Stolt, P., van Gelder, I. C., Dickstein, K., Swedberg, K. Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008. European Journal of Heart Failure 11(12): 1143-1151, 2009. van Veldhuisen, D. J., de Boer, R. A. Low-dose digoxin in heart failure. International Journal of Cardiology 136(1): 90-91, 2009. Vis, J. C., Thoonsen, H., Duffels, M. G., de Bruin-Bon, R. A., Huisman, S. A., van Dijk, A. P., Hoendermis, E. S., Berger, R. M., Bouma, B. J., Mulder, B. J. Six-Minute Walk Test in Patients With Down Syndrome: Validity and Reproducibility. Archives of Physical Medicine and Rehabilitation 90(8): 1423-1427, 2009. Vlaar, P. J., Zijlstra, F. Angiographic Restenosis and Clinical Recurrence After Sirolimus- and Paclitaxel-Eluting Stent Implantation. JACC: Cardiovascular Interventions 2(8): 776-778, 2009. Vlaar, P. J., Svilaas, T., Damman, K., de Smet, B. J. G. L., Hillege, H. L., Zijlstra, F., Tijssen, J. G. P. Response to Letter Regarding Article, "Impact of Pretreatment With Clopidogrel on Initial Patency and Outcome in Patients Treated With Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Systematic Review. Circulation 120(4): E27, 2009. Vlaar, P. J., Zijlstra, F. Angiographic Restenosis and Clinical Recurrence After Sirolimus- and Paclitaxel-Eluting Stent Implantation. JACC: Cardiovascular Interventions 2(8): 776-778, 2009. Vogelzang, M., Vlaar, P. J., Svilaas, T., Amo, D., Nijsten, M. W. N., Zijlstra, F. Computer-assisted myocardial blush quantification after percutaneous coronary angioplasty for acute myocardial infarction: a substudy from the TAPAS trial. European Heart Journal 30(5): 594-599, 2009. Voors, A. A., von Haehling, S., Anker, S. D., Hillege, H. L., Struck, J., Hartmann, O., Bergmann, A., Squire, I., van Veldhuisen, D. J.,

Dickstein, K. C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. European Heart Journal 30(10): 1187-1194, 2009. Wang, X., Ding, X., Su, S., Spector, T. D., Mangino, M., Iliadou, A., Snieder, H. Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene-obesity interaction. Diabetologia 52(12): 2578-2584, 2009. Wang, X. L., Ding, X. H., Su, S. Y., Yan, W. L., Harshfield, G., Treiber, F., Snieder, H. Genetic influences on daytime and night-time blood pressure: similarities and differences. Journal of Hypertension 27(12): 2358-2364, 2009. Wang, X. L., Ding, X. H., Su, S. Y., Li, Z. B., Riese, H., Thayer, J. F., Treiber, F., Snieder, H. Genetic influences on heart rate variability at rest and during stress. Psychophysiology 46(3): 458-465, 2009. Westendorp, B., Hamming, I., Szymanski, M. K., Navis, G., van Goor, H., Buikema, H., van Gilst, W. H., Schoemaker, R. G. Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor. European Journal of Pharmacology 602(2-3): 373-379, 2009. Willemsen, H. M., de Jong, G., Tio, R. A., Nieuwland, W., Kema, I. P., van der Horst, I. C. C., Oudkerk, M., Zijlstra, F. Quick identification of acute chest pain patients study (QICS). BMC Cardiovascular Disorders 9 AR 24 DI 10.1186/1471-2261-9-24 2009. Willemsen, H. M., van der Horst, I. C. C., Nieuwland, W., Slart, R. J. H. A., Zeebregts, C. J., de Boef, E., Schuitemaker, J. H. N., Zijlstra, F., Tio, R. A. The diagnostic value of soluble CD163 in patients presenting with chest pain. Clinical Biochemistry 42(16-17): 1662-1666, 2009. Winter, M. M., Bouma, B. J., Groenink, M., Konings, T. C., Tijssen, J. G. P., van Veldhuisen, D. J., Mulder, B. J. M. Latest insights in therapeutic options for systemic right ventricular failure: a comparison with left ventricular failure. Heart 95(12): 960-963, 2009. Wong, L. S., Windt, W. A., Roks, A. J., van Dokkum, R. P., Schoemaker, R. G., de Zeeuw, D., Henning, R. H. Renal failure induces telomere shortening in the rat heart. Netherlands Heart Journal 17(5): 190-194, 2009. Wong, L. S. M., van der Harst, P., de Boer, R. A., Codd, V., Huzen, J., Samani, N. J., Hillege, H. L., Voors, A. A., van Gilst, W. H., Jaarsma, T., van Veldhuisen, D. J. Renal dysfunction is associated with shorter telomere length in heart failure. Clinical Research in Cardiology 98(10): 629-634, 2009. Wong, L. S. M., Oeseburg, H., de Boer, R. A., van Gilst, W. H., van Veldhuisen, D. J., van der Harst, P. Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing. Cardiovascular Research 81(2): 244-252, 2009.

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Xu, Y., Henning, R. H., Sandovici, M., van der Want, J. J., van Gilst, W. H., Buikema, H. Enhanced myogenic constriction of mesenteric artery in heart failure relates to decreased smooth muscle cell caveolae numbers and altered AT(1)- and epidermal growth factor-receptor function. European Journal of Heart Failure 11(3): 246-255, 2009.

Yap, S. C., Drenthen, W., Meijboom, F. J., Moons, P., Mulder, B. J. M., Vliegen, H. W., van Dijk, A. P. J., Jaddoe, V. W. V., Steegers, E. A. P., Roos-Hesselink, J. W., Pieper, P. G. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect. Bjog - an International Journal of Obstetrics and Gynaecology 116(12): 1593-1601, 2009.

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GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD - GRIAC

Dissertaties
Abello, N. J-R. Chemical labeling for the analysis of proteins, peptides and metabolites by mass spectroscopy. (2009) Bischoff, R. P. H. and Postma, D. S. Brusse-Keizer, M. G. J. COPD excacerbations. Treatment and outcome. (2009) van der Palen, J. and Kerstjens, H. A. M. Dijkstra, A. Lung function impairment in asthma : contributing risk factors and gene polymorphisms. (2009) Postma, D. S., Timens, W., ten Hacken, N. H. T., and Vonk, J. M. Flokstra-de Blok, B. M. J. Development, valdidation and outcome of health-related quality of life questionnairies for food allergic patients. (2009) Dubois, A. E. J., Duiverman, E. J., and VliegBoerstra, B. J.

Oude Elberink, H. Quality of Life in Insect venom allergy. (2009) Dubois, A. E. J. and de Monchy, J. G. R. Reijmerink, N. E. A Search for missing pieces of the puzzle; the development of asthma and atopy. (2009) Postma, D. S., Brunekreef, B., Koppelman, G. H., Kerkhof, M., and Gerritsen, J. Siedlinski, M. I. Genetic and environmental determinants of lung function in the general population. (2009) Boezen, H. M., Postma, D. S., and Smit, H. A. van der Toorn, M. Cigarette smoke-induced mitochondrial dysfunction and oxidative stress in. (2009) Kauffman, H. F., Gans, R. O. B., Koter, G. H., Slebos, D. J., and Bakker, S. J. L.

Journal articles
Barton, S. J., Koppelman, G. H., Vonk, J. M., Browning, C. A., Nolte, I. M., Stewart, C. E., Bainbridge, S., Mutch, S., Rose-Zerilli, M. J., Postma, D. S., Maniatis, N., Henry, A. P., Hall, I. P., Holgate, S. T., Tighe, P., Holloway, J. W., Sayers, I. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. Journal of Allergy and Clinical Immunology 123(6): 1391-1400, 2009. Bateman, E. D., Rennard, S., Barnes, P. J., Dicpinigaitis, P. V., Gosens, R., Gross, N. J., Nadel, J. A., Pfeifer, M., Racke, K., Rabe, K. F., Rubin, B. K., Welte, T., Wessler, I. Alternative mechanisms for tiotropium. Pulmonary Pharmacology & Therapeutics 22(6): 533-542, 2009. Bathoorn, E., Liesker, J. J. W., Postma, D. S., Koeter, G. H., van der Toorn, M., van der Heide, S., Ross, H. A., van Oosterhout, A. J. M., Kerstjens, H. A. M. Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation. International Journal of COPD 4(1): 101-109, 2009. Blacquiere, M. J., Timens, W., Melgert, B. N., Geerlings, M., Postma, D. S., Hylkema, M. N. Maternal smoking during pregnancy induces airway remodelling in mice offspring. European Respiratory Journal 33(5): 1133-1140, 2009. Boelens, M. C., van den Berg, A., Fehrmann, R. S. N., Geerlings, M., de Jong, W. K., Meerman, G. J. T., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M. Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. Journal of Pathology 218(2): 182-191, 2009. Boelens, M. C., Kok, K., van der Vlies, P., van der Vries, G., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M., van den Berg, A. Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. Lung Cancer 66(3): 372-378, 2009. Boezen, H. M. Genome-wide association studies: What do they teach us about asthma and chronic obstructive pulmonary disease? Proceedings of the American Thoracic Society 6(8): 701703, 2009. Bossenbrock, L., ten Thicken, N. H. T., van der Bij, W., Verschuuren, E. A. M., Koeter, G. H., de Greef, M. H. G. Cross-sectional Assessment of Daily Physical Activity in Chronic Obstructive Pulmonary Disease Lung Transplant Patients. Journal of Heart and Lung Transplantation 28(2): 149-155, 2009. Brandsma, C. A., Hylkema, M. N., Geerlings, M., van Geffen, W. H., Postma, D. S., Timens, W., Kerstjens, H. A. M. Increased levels of (class switched) memory B cells in peripheral blood of current smokers. Respiratory Research 10 AR 108 DI 10.1186/14659921-10-108 2009. Broekema, M., ten Hacken, N. H. T., Volbeda, F., Lodewijk, M. E., Hylkema, M. N., Postma, D. S., Timens, W. Airway Epithelial Changes in Smokers but Not in Ex-Smokers with Asthma. American Journal of Respiratory and Critical Care Medicine 180(12): 1170-1178, 2009. Broekema, M., ten Hacken, N. H. T., Volbeda, F., Lodewijk, M. E., Hylkema, M. N., Postma, D. S., Timens, W. Airway Epithelial Changes in Smokers but Not in Ex-Smokers with Asthma.

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American Journal of Respiratory and Critical Care Medicine 180(12): 1170-1178, 2009. Brugemann, J., van der Bij, W., Verschuuren, E. A. M., Klungel, A. A., van der Horst, I. C. C., Erasmus, M. E., Kerstjens, H. A. M., van Veldhuisen, D. J., Zijlstra, F. Experience with combined heartlung transplant at the University Medical Center Groningen. Nederlands Tijdschrift voor Geneeskunde 153(27): 1314-1319, 2009. Brusselle, G. G., Demoor, T., Bracke, K. R., Brandsma, C. A., Timens, W. Lymphoid follicles in (very) severe COPD: beneficial or harmful? European Respiratory Journal 34(1): 219-230, 2009. Camp, P. G., O'Donnell, D. E., Postma, D. S. Chronic obstructive pulmonary disease in men and women: Myths and reality. Proceedings of the American Thoracic Society 6(6): 535-538, 2009. Caudri, D., Wijga, A., Scholtens, S., Kerkhof, M., Gerritsen, J., Ruskamp, J. M., Brunekreef, B., Smit, H. A., de Jongste, J. C. Early Daycare Is Associated with an Increase in Airway Symptoms in Early Childhood but Is No Protection against Asthma or Atopy at 8 Years. American Journal of Respiratory and Critical Care Medicine 180(6): 491-498, 2009. Caudri, D., Wijga, A., Schipper, C. M. A., Hoekstra, M., Postma, D. S., Koppelman, G. H., Brunekreef, B., Smit, H. A., de Jongste, J. C. Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age. Journal of Allergy and Clinical Immunology 124(5): 903-910, 2009. Cerveri, I., Corsico, A. G., Accordini, S., Cervio, G., Ansaldo, E., Grosso, A., Niniano, R., Tegomo, E. T., Anto, J. M., Kunzli, N., Janson, C., Sunyer, J., Svanes, C., Heinrich, J., Schouten, J. P., Wjst, M., Pozzi, E., de Marco, R. What defines airflow obstruction in asthma? European Respiratory Journal 34(3): 568-573, 2009. Dekkers, B. G. J., Schaafsma, D., Tran, T., Zaagsma, J., Meurs, H. Insulin-Induced Laminin Expression Promotes a Hypercontractile Airway Smooth Muscle Phenotype. American Journal of Respiratory Cell and Molecular Biology 41(4): 494504, 2009. Dijkstra, A., Postma, D. S., Noordhoek, J. A., Lodewijk, M. E., Kauffman, H. F., ten Hacken, N. H. T., Timens, W. Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung. Virchows Archiv 454(4): 441-449, 2009. Duiverman, M. L., de Boer, E. W. J., van Eykern, L. A., de Greef, M. H. G., Jansen, D. F., Wempe, J. B., Kerstjens, H. A. M., Wijkstra, P. J. Respiratory muscle activity and dyspnea during exercise in chronic obstructive pulmonary disease. Respiratory Physiology & Neurobiology 167(2): 195-200, 2009. DunnGalvin, A., Chang, W. C., Laubach, S., Steele, P. H., Dubois, A. E. J., Burks, A. W., Hourihane, J. O. Profiling Families Enrolled in GUIDE Annual Publication Report 2009 20

Food Allergy Immunotherapy Studies. Pediatrics 124(3): E503E509, 2009. Effing, T., Kerstjens, H., van der Valk, P., Zielhuis, G., van der Palen, J. (Cost)-effectiveness of self-treatment of exacerbations on the severity of exacerbations in patients with COPD: the COPE II study. Thorax 64(11): 956-962, 2009. Effing, T. W., Kerstjens, H. A. M., Monninkhof, E. M., van der Valk, P. D. L. P., Wouters, E. F. M., Postma, D. S., Zielhuis, G. A., van der Palen, J. Definitions of Exacerbations Does It Really Matter in Clinical Trials on COPD? Chest 136(3): 918-923, 2009. Flokstra-de Blok, B. M. J., van der Meulen, G. N., DunnGalvin, A., Vlieg-Boerstra, B. J., Elberink, J. N. G. O., Duiverman, E. J., Hourihane, J. O., Dubois, A. E. J. Development and validation of the Food Allergy Quality of Life Questionnaire - Adult Form. Allergy 64(8): 1209-1217, 2009. Flokstra-de Blok, B. M. J., DunnGalvin, A., Vlieg-Boerstra, B. J., Oude Elberink, J. N. G., Duiverman, E. J., Hourihane, J. O., Dubois, A. E. J. Development and validation of a self-administered Food Allergy Quality of Life Questionnaire for children. Clinical and Experimental Allergy 39(1): 127-137, 2009. Flokstra-de Blok, B. M. J., Oude Elberink, J. N. G., Vlieg-Boerstra, B. J., Duiverman, E. J., Dubois, A. E. J. Measuring health-related quality of life: Fundamental methodological issues. Clinical and Experimental Allergy 39(11): 1774, 2009. Flokstra-de Blok, B. M. J., Dubois, A. E. J. Quality of life in food allergy: valid scales for children and adults. Current Opinion in Allergy and Clinical Immunology 9(3): 214-221, 2009. Gehring, U., Oldenwening, M., Brunekreef, B., Wieringa, M. H., Kerkhof, M., Smit, H. A., van der Ent, C. K., de Jongste, J. C. The impact of ambient NO on online measurements of exhaled and nasal NO: The PIAMA study. Pediatric Allergy and Immunology 20(7): 665-672, 2009. Gerritsen, J. The Brussels Declaration. European Respiratory Journal 34(1): 290, 2009. Gkoumassi, E., Dekkers, B. G. J., Droge, M. J., Elzinga, C. R. S., Hasenbosch, R. E., Meurs, H., Nelemans, S. A., Schmidt, M., Zaagsma, J. (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells. NaunynSchmiedebergs Archives of Pharmacology 380(1): 67-77, 2009. Goossens, L. M. A., Riemersma, R. A., Postma, D. S., van der Molen, T., Rutten-van Molken, M. P. M. H. An Economic Evaluation of Budesonide/Formoterol for Maintenance and Reliever Treatment in Asthma in General Practice. Advances in Therapy 26(9): 872-885, 2009. Gosens, R., Rieks, D., Meurs, H., Ninaber, D. K., Rabe, K. F., Nanninga, J., Kolahian, S., Halayko, A. J., Hiemstra, P. S., Zuyderduyn, S. Muscarinic M3 receptor stimulation increases

cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells. European Respiratory Journal 34(6): 14361443, 2009. Greven, F., Kerstjens, H. A. M., Duijm, F., Eppinga, P., de Meer, G., Heederik, D. Respiratory effects in the aftermath of a major fire in a chemical waste depot. Scandinavian Journal of Work Environment & Health 35(5): 368-375, 2009. Grimshaw, K. E. C., Allen, K., Edwards, C. A., Beyer, K., Boulay, A., van der Aa, L. B., Sprikkelman, A., Belohlavkova, S., Clausen, M., Dubakiene, R., Duggan, E., Reche, M., Marino, L. V., Norhede, P., Ogorodova, L., Schoemaker, A., Stanczyk-Przyluska, A., Szepfalusi, Z., Vassilopoulou, E., Veehof, S. H. E., Vlieg-Boerstra, B. J., Wjst, M., Dubois, A. E. J. Infant feeding and allergy prevention: a review of current knowledge and recommendations. A EuroPrevall state of the art paper. Allergy 64(10): 1407-1416, 2009. Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., Thorleifsson, G., Helgadottir, H., Steinthorsdottir, V., Stefansson, H., Williams, C., Hui, J., Beilby, J., Warrington, N. M., James, A., Palmer, L. J., Koppelman, G. H., Heinzmann, A., Krueger, M., Boezen, H. M., Wheatley, A., Altmuller, J., Shin, H. D., Uh, S. T., Cheong, H. S., Jonsdottir, B., Gislason, D., Park, C. S., Rasmussen, L. M., Porsbjerg, C., Hansen, J. W., Backer, V., Werge, T., Janson, C., Jonsson, U. B., Ng, M. C. Y., Chan, J., So, W. Y., Ma, R., Shah, S. H., Granger, C. B., Quyyumi, A. A., Levey, A. I., Vaccarino, V., Reilly, M. P., Rader, D. J., Williams, M. J. A., van Rij, A. M., Jones, G. T., Trabetti, E., Malerba, G., Pignatti, P. F., Boner, A., Pescollderungg, L., Girelli, D., Olivieri, O., Martinelli, N., Ludviksson, B. R., Ludviksdottir, D., Eyjolfsson, G. I., Arnar, D., Thorgeirsson, G., Deichmann, K., Thompson, P. J., Wjst, M., Hall, I. P., Postma, D. S., Gislason, T., Gulcher, J., Kong, A., Jonsdottir, I., Thorsteinsdottir, U., Stefansson, K. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics 41(3): 342-347, 2009. Hogg, J. C., Timens, W. The Pathology of Chronic Obstructive Pulmonary Disease. Annual Review of Pathology - Mechanisms of Disease 4: 435-459, 2009. Hospes, G., Bossenbroek, L., ten Hacken, N. H. T., van Hengel, P., de Greef, M. H. G. Enhancement of daily physical activity increases physical fitness of outclinic COPD patients: Results of an exercise counseling program. Patient Education and Counseling 75(2): 274-278, 2009. Hylkema, M. N., Blacquiere, M. J. Intrauterine effects of maternal smoking on sensitization, asthma, and chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society 6(8): 660-662, 2009. Kerkhof, M., Wijga, A. H., Brunekreef, B., Smit, H. A., de Jongste, J. C., Aalberse, R. C., Hoekstra, M. O., Gerritsen, J., Postma, D. S. Effects of pets on asthma development up to 8 years of age: the PIAMA study. Allergy 64(8): 1202-1208, 2009.

Koppelman, G. H., Meyers, D. A., Howard, T. D., Zheng, S. L., Hawkins, G. A., Ampleford, E. J., Xu, J. F., Koning, H., Bruinenberg, M., Nolte, I. M., van Diemen, C. C., Boezen, H. M., Timens, W., Whittaker, P. A., Stine, O. C., Bartons, S. J., Holloway, J. W., Holgate, S. T., Graves, P. E., Martinez, F. D., van Oosterhout, A. J., Bleecker, E. R., Postma, D. S. Identification of PCDH1 as a Novel Susceptibility Gene for Bronchial Hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 180(10): 929-935, 2009. Koster, E. S., Raaijmakers, J. A. M., Koppelman, G. H., Postma, D. S., van der Ent, C. K., Koenderman, L., Bracke, M., Maitland-van der Zee, A. H. Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort. Pharmacogenomics 10(8): 1351-1361, 2009. Lapperre, T. S., Snoeck-Stroband, J. B., Gosman, M. M. E., Jansen, D. F., van Schadewijk, A., Thiadens, H. A., Vonk, J. M., Boezen, H. M., ten Hacken, N. H. T., Sont, J. K., Rabe, K. F., Kerstjens, H. A. M., Hiemstra, P. S., Timens, W., Postma, D. S., Sterk, P. J. Effect of Fluticasone With and Without Salmeterol on Pulmonary Outcomes in Chronic Obstructive Pulmonary Disease A Randomized Trial. Annals of Internal Medicine 151(8): 517-U20, 2009. Liesker, J. J. W., ten Hacken, N. H., Zeinstra-Smith, M., Rutgers, S. R., Postma, D. S., Timens, W. Reticular basement membrane in asthma and COPD: Similar thickness, yet different composition. International Journal of COPD 4(1): 127-135, 2009. Maarsingh, H., Zaagsma, J., Meurs, H. Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. British Journal of Pharmacology 158(3): 652-664, 2009. Maarsingh, H., Bossenga, B. E., Bos, I. S. T., Volders, H. H., Zaagsma, J., Meurs, H. L-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction. European Respiratory Journal 34(1): 191-199, 2009. Melgert, B. N., Postma, D. S. All men are created equal? New leads in explaining sex differences in adult asthma. Proceedings of the American Thoracic Society 6(8): 724-727, 2009. Motta, A. C., Vissers, J. L. M., Gras, R., van Esch, B. C. A. M., van Oosterhout, A. J. M., Nawijn, M. C. GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma. Respiratory Research 10 AR 93 DI 10.1186/1465-9921-10-93 2009. Niedoszytko, M., de Monchy, J., van Doormaal, J. J., Jassem, E., Elberink, J. N. G. O. Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy. Allergy 64(9): 1237-1245, 2009. Oude Elberink, J. N. G., van der Heide, S., Guyatt, G. H., Dubois, A. E. J. Immunotherapy improves health-related quality of life of

GUIDE Annual Publication Report 2009 21

adult patients with dermal reactions following yellow jacket stings. Clinical and Experimental Allergy 39(6): 883-889, 2009. Pinelli, E., Willers, S. M., Hoek, D., Smit, H. A., Kortbeek, L. M., Hoekstra, M., de Jongste, J., van Knapen, F., Postma, D., Kerkhof, M., Aalberse, R., van der Giessen, J. W. B., Brunekreef, B. Prevalence of antibodies against Ascaris suum and its association with allergic manifestations in 4-year-old children in the Netherlands: the PIAMA birth cohort study. European Journal of Clinical Microbiology & Infectious Diseases 28(11): 1327-1334, 2009. Porsbjerg, C., Backer, V., Joos, G., Kerstjens, H. A. M., RodriguezRoisin, R. Current and future use of the mannitol bronchial challenge in everyday clinical practice. Clinical Respiratory Journal 3(4): 189-197, 2009. Postma, D. S., Koppelman, G. H. Genetics of asthma: Where are we and where do we go? Proceedings of the American Thoracic Society 6(3): 283-287, 2009. Postma, D. S., Calverley, P. Inhaled corticosteroids in COPD: a case in favour. European Respiratory Journal 34(1): 10-12, 2009. Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L. P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., de Jongste, J. C., Kerstjens, H. A. M., Lazarus, S. C., Levy, M. L., O'Byrne, P. M., Partridge, M. R., Pavord, I. D., Sears, M. R., Sterk, P. J., Stoloff, S. W., Sullivan, S. D., Szefler, S. J., Thomas, M. D., Wenzel, S. E. An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations Standardising Endpoints for Clinical Asthma Trials and Clinical Practice. American Journal of Respiratory and Critical Care Medicine 180(1): 59-99, 2009. Reijmerink, N. E., Kerkhof, M., Koppelman, G. H., Gerritsen, J., de Jongste, J. C., Smit, H. A., Brunekreef, B., Postma, D. S. Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness. Allergy 64(6): 898-904, 2009. Riemersma, R., Postma, D., Kerstjens, H., Buijssen, K., Boezen, M., Aalbers, R., Veldhuizen, W., Strijbos, J., van der Molen, T. Development of a questionnaire for the assessment of bronchial hyperresponsiveness. Primary Care Respiratory Journal 18(4): 287-293, 2009. Roduit, C., Scholtens, S., de Jongste, J. C., Wijga, A. H., Gerritsen, J., Postma, D. S., Brunekreef, B., Hoekstra, M. O., Aalberse, R., Smit, H. A. Asthma at 8 years of age in children born by caesarean section. Thorax 64(2): 107-113, 2009. Roscioni, S. S., Kistemaker, L. E. M., Menzen, M. H., Elzinga, C. R. S., Gosens, R., Halayko, A. J., Meurs, H., Schmidt, M. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respiratory Research 10 2009.

Rottier, B. L., Duiverman, E. J. Anti-inflammatory drug therapy in asthma. Paediatric Respiratory Reviews 10(4): 214-219, 2009. Ruskamp, J. M., Hoekstra, M. O., Postma, D. S., Kerkhof, M., Bottema, R. W., Koppelman, G. H., Rovers, M. M., Wijga, A. H., de Jongste, J. C., Brunekreef, B., Sanders, E. A. M. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. Clinical and Experimental Immunology 155(3): 433440, 2009. Scholtens, S., Wijga, A. H., Brunekreef, B., Kerkhof, M., Hoekstra, M. O., Gerritsen, J., Aalberse, R., de Jongste, J. C., Smit, H. A. Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study. Thorax 64(7): 604-609, 2009. Scholtens, S., Wijga, A. H., Smit, H. A., Brunekreef, B., de Jongste, J. C., Gerritsen, J., Seidell, J. C. Long-chain polyunsaturated fatty acids in breast milk and early weight gain in breast-fed infants. British Journal of Nutrition 101(1): 116-121, 2009. Scholtens, S., Wijga, A. H., Seidell, J. C., Brunekreef, B., de Jongste, J. C., Gehring, U., Postma, D. S., Kerkhof, M., Smit, H. A. Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age. Journal of Allergy and Clinical Immunology 123(6): 1312-1318, 2009. Schuttelaar, M. L. A., Kerkhof, M., Jonkman, M. F., Koppelman, G. H., Brunekreef, B., de Jongste, J. C., Wijga, A., Mclean, W. H. I., Postma, D. S. Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure. Allergy 64(12): 1758-1765, 2009. Siedlinski, M., Boezen, H. M., Boer, J. M. A., Smit, H. A., Postma, D. S. ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts. Pharmacogenetics and Genomics 19(9): 675-684, 2009. Siedlinski, M., Postma, D. S., Boer, J. M. A., van der Steege, G., Schouten, J. P., Smit, H. A., Boezen, H. M. Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population. Respiratory Research 10 AR 73 DI 10.1186/1465-9921-10-73 2009. Siedlinski, M., Postma, D. S., Smit, H. A., Boezen, H. M. No effects of EPHX1 polymorphisms on the level or change of FEV1 in the general population. European Respiratory Journal 33(2): 446-449, 2009. Siedlinski, M., van Diemen, C. C., Postma, D. S., Vonk, J. M., Boezen, H. M. Superoxide dismutases, lung function and bronchial responsiveness in a general population. European Respiratory Journal 33(5): 986-992, 2009. Smolonska, J., Wijmenga, C., Postma, D. S., Boezen, H. M. Metaanalyses on Suspected Chronic Obstructive Pulmonary Disease Genes A Summary of 20 Years' Research. American Journal of Respiratory and Critical Care Medicine 180(7): 618-631, 2009.

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Snijders, B. E. P., Stelma, F. F., Reijmerink, N. E., Thijs, C., van der Steege, G., Damoiseaux, J. G. M. C., van den Brandt, P. A., van Ree, R., Postma, D. S., Koppelman, G. H. CD14 polymorphisms in mother and infant, soluble CD14 in breast milk and atopy development in the infant (KOALA Study). Pediatric Allergy and Immunology 21(3): 541-549, 2009. Song, H., Bergstrasser, C., Rafat, N., Hoger, S., Schmidt, M., Endres, N., Goebeler, M., Hillebrands, J. L., Brigelius-Flohe, R., Banning, A., Beck, G., Loesel, R., Yard, B. A. The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression. British Journal of Pharmacology 157(5): 769-780, 2009. ten Hacken, N. H. T. Physical inactivity and obesity: Relation to asthma and chronic obstructive pulmonary disease? Proceedings of the American Thoracic Society 6(8): 663-667, 2009. van den Berge, M., ten Hacken, N. H., Kerstjens, H. A. M., Postma, D. S. Maintenance and Reliever Inhalation therapy in asthma. Different treatment strategies. Clinical Medicine: Therapeutics 2009. van den Berge, M., Arshad, S. H., Ind, P. W., Magnussen, H., Hamelmann, E., Kanniess, F., Postma, D. S. Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering. Respiratory Medicine 103(8): 1216-1223, 2009.

van den Berge, M., Heijink, H. I., van Oosterhout, A. J. M., Postma, D. S. The role of female sex hormones in the development and severity of allergic and non-allergic asthma. Clinical and Experimental Allergy 39(10): 1477-1481, 2009. van der Toorn, M., Rezayat, D., Kauffman, H. F., Bakker, S. J. L., Gans, R. O. B., Koeter, G. H., Choi, A. M. K., van Oosterhout, A. J. M., Slebos, D. J. Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 297(1): L109-L114, 2009. van der Velde, J. L., Flokstra-de Blok, B. M. J., Vlieg-Boerstra, B. J., Elberink, J. N. G., Schouten, J., DunnGalvin, A., Hourihane, J. O., Duiverman, E. J., Dubois, A. E. J. Test-retest reliability of the Food Allergy Quality of Life Questionnaires (FAQLQ) for children, adolescents and adults. Quality of Life Research 18(2): 245-251, 2009. van Hemelen, D., van Oosterhout, A. J. M. Adjuvants for immunotherapy: lost in translation? Clinical and Experimental Allergy 39(12): 1783-1785, 2009. Versluis, M., ten Hacken, N., Postma, D., Barroso, B., Rutgers, B., Geerlings, M., Willemse, B., Timens, W., Hylkema, M. Adenosine receptors in COPD and asymptomatic smokers: effects of smoking cessation. Virchows Archiv 454(3): 273-281, 2009. Zuurmond-Tromp, K. A., Klinkenberg, T. J., Dikkers, F. G., Koppelman, G. H., de Weerd, W. Severe dyspnea in children after a fall. Nederlands Tijdschrift voor Geneeskunde 153(44): 2162-2165, 2009.

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CENTER FOR LIVER, DIGESTIVE AND METABOLIC DISEASES CLDS

Research line Transport, Metabolism and Target Identification
Dissertations
Mulder, J. Towards treatment of cholestatic liver disease in children via interference with transcriptional regulation of hepatic transport systems. (2009) Kuipers, F. and Sauer, P. J. J. Oosterveer, M. H. Control of metabolic flux by nutrient sensors. (2009) Kuipers, F. and Reijngoud, D.-J. Schreurs, M. Regulatory enzymes of mitochondrial B-oxidation as targets for treatment of the metabolic syndrome. (2009) Kuipers, F. and Reijngoud, D.-J. van Straten, E. M. E. Programming of lipid metabolism. (2009) Kuipers, F., Verkade, H. J., and Plsch, T. Woudenberg, J. Novel aspects of peroxisome composition and function in the liver. (2009) Moshage, A. J. and Faber, K. N.

Journal Articles
Bahr, M. J., Boeker, K. H. W., Manns, M. P., Tietge, U. J. F. Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis. Clinical Endocrinology 70(1): 60-65, 2009. Beulens, J. W. J., Patel, A., Vingerling, J. R., Cruickshank, J. K., Hughes, A. D., Stanton, A., Lu, J., Thom, S. A. M., Grobbee, D. E., Stolk, R. P. Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial. Diabetologia 52(10): 2027-2036, 2009. Buis, C. L., Geuken, E., Visser, D. S., Kuipers, F., Haagsma, E. B., Verkade, H. J., Porte, R. J. Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures. Journal of Hepatology 50(1): 69-79, 2009. Corpeleijn, E., Bakker, S. J. L., Stolk, R. P. Obesity and impaired renal function: potential for lifestyle intervention? European Journal of Epidemiology 24(6): 275-280, 2009. Cuperus, F. J. C., Hafkamp, A. M., Havinga, R., Vitek, L., Zelenka, J., Tiribelli, C., Ostrow, J. D., Verkade, H. J. Effective Treatment of Unconjugated Hyperbilirubinemia With Oral Bile Salts in Gunn Rats. Gastroenterology 136(2): 673-682, 2009. Cuperus, F. J. C., Hafkamp, A. M., Hulzebos, C. V., Verkade, H. J. Pharmacological Therapies for Unconjugated Hyperbilirubinemia. Current Pharmaceutical Design 15(25): 2927-2938, 2009. de Boer, J. F., Bahr, M. J., Boker, K. H. W., Manns, M. P., Tietge, U. J. F. Plasma levels of PBEF/Nampt/visfatin are decreased in patients with liver cirrhosis. American Journal of PhysiologyGastrointestinal and Liver Physiology 296(2): G196-G201, 2009. Dunning, S., Hannivoort, R. A., de Boer, J. F., Buist-Homan, M., Faber, K. N., Moshage, H. Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death. Liver International 29(6): 922-932, 2009. Edens, M. A., Kuipers, F., Stolk, R. P. Non-alcoholic fatty liver disease is associated with cardiovascular disease risk markers. Obesity Reviews 10(4): 412-419, 2009. Edens, M. A., van Ooijen, P. M. A., Post, W. J., Haagmans, M. J. F., Kristanto, W., Sijens, P. E., van der Jagt, E. J., Stolk, R. P. Ultrasonography to Quantify Hepatic Fat Content: Validation by H-1 Magnetic Resonance Spectroscopy. Obesity 17(12): 22392244, 2009. El Harchaoui, K., Franssen, R., Hovingh, G. K., Bisoendial, R. J., Stellaard, F., Kuipers, F., Kastelein, J. J. P., Kuivenhoven, J. A., Stroes, E. S. G., Groen, A. K. Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia. Atherosclerosis 207(2): 614-616, 2009. El Harchaoui, K., Franssen, R., Hovingh, G. K., Bisoendial, R. J., Stellaard, F., Kuipers, F., Kastelein, J. J. P., Kuivenhoven, J. A., Stroes, E. S. G., Groen, A. K. Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia. Atherosclerosis 207(2): 614-616, 2009. Foltz, M., Maljaars, J., Schuring, E. A. H., van der Wal, R. J. P., Boer, T., Duchateau, G. S. M., Peters, H. P. F., Stellaard, F., Masclee, A. A. Intragastric layering of lipids delays lipid absorption and increases plasma CCK but has minor effects on gastric emptying and

GUIDE Annual Publication Report 2009 24

appetite. American Journal of Physiology-Gastrointestinal and Liver Physiology 296(5): G982-G991, 2009. Giepmans, B. N. G., van IJzendoorn, S. C. D. Epithelial cell-cell junctions and plasma membrane domains. Biochimica et Biophysica Acta-Biomembranes 1788(4): 820-831, 2009. Hoeke, M. O., Plass, J. R. M., Heegsma, J., Geuken, M., van Rijsbergen, D., Baller, J. F. W., Kuipers, F., Moshage, H., Jansen, P. L. M., Faber, K. N. Low Retinol Levels Differentially Modulate Bile Salt-Induced Expression of Human and Mouse Hepatic Bile Salt Transporters. Hepatology 49(1): 151-159, 2009. Hoekstra, H., Buis, C. I., Verdonk, R. C., van der Hilst, C. S., van der Jagt, E. J., Haagsma, E. B., Porte, R. J. Is Roux-en-Y Choledochojejunostomy an Independent Risk Factor for Nonanastomotic Biliary Strictures After Liver Transplantation? Liver Transplantation 15(8): 924-930, 2009. Hofker, M., Wijmenga, C. A supersized list of obesity genes. Nature Genetics 41(2): 139-140, 2009. Jansen, H., Postma, A., Stolk, R., Kamps, W. Acute lymphoblastic leukemia and obesity: increased energy intake or decreased physical activity? Supportive Care in Cancer 17(1): 103-106, 2009. Jansen, H., Wijga, A. H., Smit, H. A., Scholtens, S., Kerkhof, M., Koppelman, G. H., de Jongste, J. C., Stolk, R. P. HbA(1c) levels in non-diabetic Dutch children aged 8-9 years: the PIAMA birth cohort study. Diabetic Medicine 26(2): 122-127, 2009. Janssen, P., Gorter, K., Stolk, R., Rutten, G. Population screening on diabetes mellitus type 2 delivers little results. Report of the ADDITION research. Huisarts en Wetenschap 52(5): 225-230, 2009. Janssen, P. G. H., Gorter, K. J., Stolk, R. P., Rutten, G. E. H. M. Randomised controlled trial of intensive multifactorial treatment for cardiovascular risk in patients with screendetected type 2 diabetes: 1-year data from the ADDITION Netherlands study. British Journal of General Practice 59(558): 43-48, 2009. Klappe, K., Hummel, I., Hoekstra, D., Kok, J. W. Lipid dependence of ABC transporter localization and function. Chemistry and Physics of Lipids 161(2): 57-64, 2009. Koolman, A. H., Bloks, V. W., Oosterveer, M. H., Jonas, I., Kuipers, F., Sauer, P. J. J., van Dijk, G. Metabolic responses to long-term pharmacological inhibition of CB1-receptor activity in mice in relation to dietary fat composition. International Journal of Obesity 2009. Le May, C., Kourimate, S., Langhi, C., Chetiveaux, M., Jarry, A., Comera, C., Collet, X., Kuipers, F., Krempf, M., Cariou, B., Costet, P. Proprotein Convertase Subtilisin Kexin Type 9 Null Mice Are Protected From Postprandial Triglyceridemia. GUIDE Annual Publication Report 2009 25

Arteriosclerosis Thrombosis and Vascular Biology 29(5): 684U157, 2009. Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., Staels, B. Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation. Physiological Reviews 89(1): 147-191, 2009. Liem, E. T., Rolfe, E. D., L'Abee, C., Sauer, P. J. J., Ong, K. K., Stolk, R. P. Measuring abdominal adiposity in 6 to 7-year-old children. European Journal of Clinical Nutrition 63(7): 835-841, 2009. Liu, G. F., Riese, H., Spector, T. D., Mangino, M., O'Dell, S. D., Stolk, R. P., Snieder, H. Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach. Diabetologia 52(6): 1048-1055, 2009. Lukovac, S., Los, E. L., Stellaard, F., Rings, E. H. H. M., Verkade, H. J. Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice. American Journal of PhysiologyGastrointestinal and Liver Physiology 297(3): G520-G531, 2009. Luttikhuis, H. O., Baur, L., Jansen, H., Shrewsbury, V. A., O'Malley, C., Stolk, R. P., Summerbell, C. D. Interventions for treating obesity in children. Cochrane Database of Systematic Reviews (1 AR CD001872 DI 10.1002/14651858.CD001872.pub2) 2009. Martens, D. H. J., Rake, J. P., Navis, G., Fidler, V., van Dael, C. M. L., Smit, G. P. A. Renal Function in Glycogen Storage Disease Type I, Natural Course, and Renopreservative Effects of ACE Inhibition. Clinical Journal of the American Society of Nephrology 4(11): 1741-1746, 2009. Mee, C. J., Harris, H. J., Farquhar, M. J., Wilson, G., Reynolds, G., Davis, C., van IJzendoorn, S. C. D., Balfe, P., McKeating, J. A. Polarization Restricts Hepatitis C Virus Entry into HepG2 Hepatoma Cells. Journal of Virology 83(12): 6211-6221, 2009. Meex, S. J. R., Weissglas-Volkov, D., van der Kallen, C. J. H., Thuerauf, D. J., van Greevenbroek, M. M. J., Schalkwijk, C. G., Stehouwer, C. D. A., Feskens, E. J. M., Heldens, L., Ayoubi, T. A., Hofker, M. H., Wouters, B. G., Vlietinck, R., Sinsheimer, J. S., Taskinen, M. R., Kuusisto, J., Laakso, M., de Bruin, T. W. A., Pajukanta, P., Glembotski, C. C. The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels. Arteriosclerosis Thrombosis and Vascular Biology 29(9): 1322-1327, 2009. Moshage, H. Simple and reliable measurement of nitric oxide metabolites in plasma. Clinical Chemistry 55(10): 1881-1882, 2009. Mulder, J., Karpen, S. J., Tietge, U. J. F., Kuipers, F. Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis. Frontiers in Bioscience 14: 2599-2630, 2009. Nijstad, N., Wiersma, H., Gautier, T., van der Giet, M., Maugeais, C., Tietge, U. J. F. Scavenger Receptor BI-mediated Selective Uptake Is Required for the Remodeling of High Density Lipoprotein by

Endothelial Lipase. Journal of Biological Chemistry 284(10): 6093-6100, 2009. Oosterveer, M. H., Grefhorst, A., van Dijk, T. H., Havinga, R., Staels, B., Kuipers, F., Groen, A. K., Reijngoud, D. J. Fenofibrate Simultaneously Induces Hepatic Fatty Acid Oxidation, Synthesis, and Elongation in Mice. Journal of Biological Chemistry 284(49): 34036-34044, 2009. Oosterveer, M. H., van Dijk, T. H., Tietge, U. J. F., Boer, T., Havinga, R., Stellaard, F., Groen, A. K., Kuipers, F., Reijngoud, D. J. High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice. PLoS ONE 4(6 AR e6066 DI 10.1371/journal.pone.0006066) 2009. Plomgaard, P., Dullaart, R. P. F., de Vries, R., Groen, A. K., Dahlback, B., Nielsen, L. B. Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects. Journal of Internal Medicine 266(3): 258-267, 2009. Reiling, E., van Vliet-Ostaptchouk, J. V., van't Riet, E., van Haeften, T. W., Arp, P. A., Hansen, T., Kremer, D., Groenewoud, M. J., van Hove, E. C., Romijn, J. A., Smit, J. W. A., Nijpels, G., Heine, R. J., Uitterlinden, A. G., Pedersen, O., Slagboom, P. E., Maassen, J. A., Hofker, M. H., 't Hart, L. M., Dekker, J. M. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. European Journal of Human Genetics 17(8): 1056-1062, 2009. Sauer, P. J. J., Verhagen, A. A. E. The Groningen Protocol, Unfortunately Misunderstood. Neonatology 96(1): 11-12, 2009. Scheenstra, R., Peeters, P. M. G. J., Verkade, H. J., Gouw, A. S. H. Graft Fibrosis After Pediatric Liver Transplantation: Ten Years of Follow-up. Hepatology 49(3): 880-886, 2009. Schreurs, M., van Dijk, T. H., Gerding, A., Havinga, R., Reijngoud, D. J., Kuipers, F. Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet. Diabetes Obesity & Metabolism 11(10): 987-991, 2009. Serre-Beinier, V., Bosco, D., Zulianello, L., Charollais, A., Caille, D., Charpantier, E., Gauthier, B. R., Diaferia, G. R., Giepmans, B. N., Lupi, R., Marchetti, P., Deng, S. P., Buhler, L., Berney, T., Cirulli, V., Meda, P. Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Human Molecular Genetics 18(3): 428-439, 2009. Siskova, Z., Yong, V. W., Nomden, A., van Strien, M., Hoekstra, D., Baron, W. Fibronectin attenuates process outgrowth in oligodendrocytes by mislocalizing MMP-9 activity. Molecular and Cellular Neuroscience 42(3): 234-242, 2009. Stellaard, F., Brufau, G., Boverhof, R., Jonkers, E. Z., Boer, T., Kuipers, F. Developments in bile acid kinetic measurements using C-13 and H-2: 10(5) times improved sensitivity during the last 40 years. Isotopes in Environmental and Health Studies 45(4): 275-288, 2009. GUIDE Annual Publication Report 2009 26

Stellaard, F., Brufau, G., Boverhof, R., Jonkers, E. Z., Boer, T., Kuipers, F. Developments in bile acid kinetic measurements using C-13 and H-2: 10(5) times improved sensitivity during the last 40 years. Isotopes in Environmental and Health Studies 45(4): 275288, 2009. Stolk, R. P., Hutter, I., Wittek, R. P. M. Population ageing research: a family of disciplines. European Journal of Epidemiology 24(11): 715-718, 2009. Tancevski, I., Wehinger, A., Demetz, E., Hoefer, J., Eller, P., Huber, E., Stanzl, U., Duwensee, K., Auer, K., Schgoer, W., Kuhn, V., Fievet, C., Stellaard, F., Rudling, M., Foeger, B., Patsch, J. R., Ritsch, A. The thyromimetic T-0681 protects from atherosclerosis. Journal of Lipid Research 50(5): 938-944, 2009. van Bruggen, R., Gorter, K., Stolk, R., Klungel, O., Rutten, G. Clinical inertia in general practice: widespread and related to the outcome of diabetes care. Family Practice 26(6): 428-436, 2009. van Bruggen, R., Gorter, K., Stolk, R. P., Zuithoff, P., Klungel, O. H., Rutten, G. E. H. M. Refill adherence and polypharmacy among patients with type 2 diabetes in general practice. Pharmacoepidemiology and Drug Safety 18(11): 983-991, 2009. van den Berg, S. W., Dolle, M. E. T., Imholz, S., van, der A., van 't Slot, R., Wijmenga, C., Verschuren, W. M. M., Strien, C., Siezen, C. L. E., Hoebee, B., Feskens, E. J. M., Boer, J. M. A. Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study. International Journal of Obesity 33(10): 1143-1152, 2009. van der Heijden, G. J., Toffolo, G., Manesso, E., Sauer, P. J. J., Sunehag, A. L. Aerobic Exercise Increases Peripheral and Hepatic Insulin Sensitivity in Sedentary Adolescents. Journal of Clinical Endocrinology & Metabolism 94(11): 4292-4299, 2009. van der Veen, J. N., van Dijk, T. H., Vrins, C. L. J., van Meer, H., Havinga, R., Bijsterveld, K., Tietge, U. J. F., Groen, A. K., Kuipers, F. Activation of the Liver X Receptor Stimulates Trans-intestinal Excretion of Plasma Cholesterol. Journal of Biological Chemistry 284(29): 19211-19219, 2009. van Dijk, T. H., Grefhorst, A., Oosterveer, M. H., Bloks, V. W., Staels, B., Reijngoud, D. J., Kuipers, F. An Increased Flux through the Glucose 6-Phosphate Pool in Enterocytes Delays Glucose Absorption in Fxr(-/-) Mice. Journal of Biological Chemistry 284(16): 10315-10323, 2009. van Straten, E. M. E., van Meer, H., Huijkman, N. C. A., van Dijk, T. H., Baller, J. F. W., Verkade, H. J., Kuipers, F., Plosch, T. Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice. American Journal of Physiology-Endocrinology and Metabolism 297(5): E1171-E1178, 2009.

van Vliet-Ostaptchouk, J. V., Hofker, M. H., van der Schouw, Y. T., Wijmenga, C., Onland-Moret, N. C. Genetic variation in the hypothalamic pathways and its role on obesity. Obesity Reviews 10(6): 593-609, 2009. Vrins, C. L. J., van der Velde, A. E., van den Oever, K., Levels, J. H. M., Huet, S., Elferink, R. P. J. O., Kuipers, F., Groen, A. K. Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. Journal of Lipid Research 50(10): 2046-2054, 2009. Wiersma, H., Gatti, A., Nijstad, N., Kuipers, F., Tietge, U. J. F. Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice. Journal of Lipid Research 50(8): 1571-1580, 2009. Wiersma, H., Nijstad, N., de Boer, J. F., Out, R., Hogewerf, W., van Berkel, T. J., Kuipers, F., Tietge, U. J. F. Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet. Atherosclerosis 206(1): 141-147, 2009. Wiersma, H., Gatti, A., Nijstad, N., Elferink, R. P. J. O., Kuipers, F., Tietge, U. J. F. Scavenger Receptor Class B Type I Mediates Biliary Cholesterol Secretion Independent of ATP-Binding Cassette Transporter g5/g8 in Mice. Hepatology 50(4): 12631272, 2009. Wijmenga, C., van Haeften, T. W., Hofker, M. H. Genetic background of type 2 diabetes mellitus. Nederlands Tijdschrift voor Geneeskunde 153(46): 2252-2256, 2009. Wijmenga, C., van Haeften, T. W., Hofker, M. H. Genetic background of diabetes mellitus type 2. Nederlands Tijdschrift voor Geneeskunde 153: A959, 2009.

Windler, E., Zyriax, B. C., Kuipers, F., Linseisen, J., Boeing, H. Association of plasma phytosterol concentrations with incident coronary heart disease Data from the CORA study, a case-control study of coronary artery disease in women. Atherosclerosis 203(1): 284-290, 2009. Wojtal, K. A., Diskar, M., Herberg, F. W., Hoekstra, D., van IJzendoorn, S. C. D. Regulatory Subunit I-controlled Protein Kinase A Activity Is Required for Apical Bile Canalicular Lumen Development in Hepatocytes. Journal of Biological Chemistry 284(31): 20773-20780, 2009. Wolfs, M. G. M., Hofker, M. H., Wijmenga, C., van Haeften, T. W. Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics. Current Genomics 10(2): 110-118, 2009. Yang, H. Q., Plosch, T., Lisman, T., Gouw, A. S. H., Porte, R. J., Verkade, H. J., Hulscher, J. B. F. Inflammation Mediated DownRegulation of Hepatobiliary Transporters Contributes to Intrahepatic Cholestasis and Liver Damage in Murine Biliary Atresia. Pediatric Research 66(4): 380-385, 2009. Yang, H. Q., Porte, R. J., Verkade, H. J., de Langen, Z. J., Hulscher, J. B. F. Partial External Biliary Diversion in Children With Progressive Familial Intrahepatic Cholestasis and Alagille Disease. Journal of Pediatric Gastroenterology and Nutrition 49(2): 216-221, 2009. Zijtregtop, E. A. M., Wilschut, J., Koelma, N., van Delden, J. J. M., Stolk, R. P., van Steenbergen, J., Broer, J., Wolters, B., Postma, M. J., Hak, E. Which factors are important in adults' uptake of a (pre)pandemic influenza vaccine? Vaccine 28(1): 207-227, 2009.

Research line Intestinal function, mucosal immunity and inflammation

Dissertations
Priebe-Geyersberger, G. M. Whole grain foods and the prevention of type 2 diabetes mellitus. (2009) Vonk, R. J. van Straten, E. M. E. Programming of lipid metabolism. (2009) Kuipers, F., Verkade, H. J., and Plsch, T. Yang, H. Aspects of biliary atresia and other pediatric cholestatic diseases. (2009) Porte, R. J., Verkade, H. J., and Hulscher, J. B. F.

Journal articles
Bauer, F., Elbers, C. C., Adan, R. A. H., Loos, R. J. F., Onland-Moret, N. C., Grobbee, D. E., van Vliet-Ostaptchouk, J. V., Wijmenga, C., van der Schouw, Y. T. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. American Journal of Clinical Nutrition 90(4): 951-959, 2009. GUIDE Annual Publication Report 2009 27 Claessen, M. M. H., Lutgens, M. W. M. D., van Buuren, H. R., Oldenburg, B., Stokkers, P. C. F., van der Woude, C. J., Hommes, D. W., de Jong, D. J., Dijkstra, G., van Bodegraven, A. A., Siersema, P. D., Vleggaar, F. P. More Right-sided IBD-associated Colorectal Cancer in Patients with Primary Sclerosing Cholangitis. Inflammatory Bowel Diseases 15(9): 1331-1336, 2009.

Coenen, M. J. H., Trynka, G., Heskamp, S., Franke, B., van Diemen, C. C., Smolonska, J., van Leeuwen, M., Brouwer, E., Boezen, M. H., Postma, D. S., Platteel, M., Zanen, P., Lammers, J. W. W. J., Groen, H. J. M., Mali, W. P. T. M., Mulder, C. J., Tack, G. J., Verbeek, W. H. M., Wolters, V. M., Houwen, R. H. J., Mearin, M. L., van Heel, D. A., Radstake, T. R. D. J., van Riel, P. L. C. M., Wijmenga, C., Barrera, P., Zhernakova, A. Common and different genetic background for rheumatoid arthritis and coeliac disease. Human Molecular Genetics 18(21): 4195-4203, 2009. Corporaal, S., Karrenbeld, A., van der Linde, K., Voskuil, J. H., Kleibeuker, J. H., Dijkstra, G. Diffuse enteritis after colectomy for ulcerative colitis: two case reports and review of the literature. European Journal of Gastroenterology & Hepatology 21(6): 710-715, 2009. de Vries, J. J. C., Bredius, R. G. M., van Rheenen, P. F., Smiers, F. J. W., Scholvinck, E. H., Vossen, A. C. T. M., Claas, E. C. J., Niesters, H. G. M. Human Bocavirus in an Immunocompromised Child Presenting with Severe Diarrhea. Journal of Clinical Microbiology 47(4): 1241-1243, 2009. Elbers, C. C., van der Schouw, Y. T., Wijmenga, C., Onland-Moret, N. C. Comment on: Perry et al. (2009) Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes;58:1463- 1467. Diabetes 58(9): e9, 2009. Elbers, C. C., van Eijk, K. R., Franke, L., Mulder, F., van der Schouw, Y. T., Wijmenga, C., Onland-Moret, N. C. Using Genome-Wide Pathway Analysis to Unravel the Etiology of Complex Diseases. Genetic Epidemiology 33(5): 419-431, 2009. Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C., Johnson, M. D., Cambi, A., Huysamen, C., Jacobs, L., Jansen, T., Verheijen, K., Masthoff, L., Morre, S. A., Vriend, G., Williams, D. L., Perfect, J. R., Joosten, L. A. B., Wijmenga, C., van der Meer, J. W. M., Adema, G. J., Kullberg, B. J., Brown, G. D., Netea, M. G. Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections. New England Journal of Medicine 361(18): 1760-1767, 2009. Festen, E. A., Szperl, A. M., Weersma, R. K., Wijmenga, C., Wapenaar, M. C. Inflammatory bowel disease and celiac disease: overlaps in the pathology and genetics, and their potential drug targets. Endocrine, metabolic & immune disorders drug targets 9(2): 199-218, 2009. Festen, E. A. M., Goyette, P., Scott, R., Annese, V., Zhernakova, A., Lian, J., Lefebvre, C., Brant, S. R., Cho, J. H., Silverberg, M. S., Taylor, K. D., de Jong, D. J., Stokkers, P. C., Mcgovern, D., Palmieri, O., Achkar, J. P., Xavier, R. J., Daly, M. J., Duerr, R. H., Wijmenga, C., Weersma, R. K., Rioux, J. D. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut 58(6): 799-804, 2009.

Flierman, A., Koornstra, J. J., Weersma, R. K. Unexpected cause of iron deficiency detected by capsule endoscopy RESPONSE. Netherlands Journal of Medicine 67(9): 317, 2009. Forabosco, P., Neuhausen, S. L., Greco, L., Naluai, A. T., Wijmenga, C., Saavalainen, P., Houlston, R. S., Ciclitira, P. J., Babron, M. C., Lewis, C. M. Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. Human Heredity 68(4): 223-230, 2009. Franke, L., Jansen, R. C. eQTL analysis in humans. Methods in molecular biology (Clifton, N. J. ) 573: 311-328, 2009. Giepmans, B. N. G., van IJzendoorn, S. C. D. Epithelial cell-cell junctions and plasma membrane domains. Biochimica et Biophysica Acta-Biomembranes 1788(4): 820-831, 2009. Hafkamp, A. M., Verkade, H. J. Untitled Response. Pediatric Research 65(1): 126, 2009. Heinz-Erian, P., Muller, T., Krabichler, B., Schranz, M., Becker, C., Ruschendorf, F., Nurnberg, P., Rossier, B., Vujic, M., Booth, I. W., Holmberg, C., Wijmenga, C., Grigelioniene, G., Kneepkens, C. M. F., Rosipal, S., Mistrik, M., Kappler, M., Michaud, L., Doczy, L. C., Siu, V. M., Krantz, M., Zoller, H., Utermann, G., Janecke, A. R. Mutations in SPINT2 Cause a Syndromic Form of Congenital Sodium Diarrhea. American Journal of Human Genetics 84(2): 188-196, 2009. Hofker, M., Wijmenga, C. A supersized list of obesity genes. Nature Genetics 41(2): 139-140, 2009. Koornstra, J. J., Weersma, R. K. Agile patency system. Gastrointestinal Endoscopy 69(3): 602-603, 2009. Koornstra, J. J., Corporaal, S., Giezen-Beintema, W. M., De Vries, S. E., van Dullemen, H. M. Colonoscopy training for nurse endoscopists: a feasibility study. Gastrointestinal Endoscopy 69(3): 688-695, 2009. Koskinen, L., Romanos, J., Kaukinen, K., Mustalahti, K., KorponaySzabo, I., Barisani, D., Bardella, M. T., Ziberna, F., Vatta, S., Szeles, G., Pocsai, Z., Karell, K., Haimila, K., Adany, R., Not, T., Ventura, A., Maki, M., Partanen, J., Wijmenga, C., Saavalainen, P. Costeffective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations. Immunogenetics 61(4): 247-256, 2009. Koskinen, L. L. E., Einarsdottir, E., Dukes, E., Heap, G. A. R., Dubois, P., Korponay-Szabo, I. R., Kaukinen, K., Kurppa, K., Ziberna, F., Vatta, S., Not, T., Ventura, A., Sistonen, P., Adany, R., Pocsai, Z., Szeles, G., Maki, M., Kere, J., Wijmenga, C., van Heel, D. A., Saavalainen, P. Association study of the IL18RAP locus in three European populations with coeliac disease. Human Molecular Genetics 18(6): 1148-1155, 2009. Lukovac, S., Los, E. L., Stellaard, F., Rings, E. H. H. M., Verkade, H. J. Effects of essential fatty acid deficiency on enterohepatic

GUIDE Annual Publication Report 2009 28

circulation of bile salts in mice. American Journal of PhysiologyGastrointestinal and Liver Physiology 297(3): G520-G531, 2009. Lutgens, M. W. M. D., Oldenburg, B., Siersema, P. D., van Bodegraven, A. A., Dijkstra, G., Hommes, D. W., de Jong, D. J., Stokkers, P. C. F., van der Woude, C. J., Vleggaar, F. P. Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease. British Journal of Cancer 101(10): 1671-1675, 2009. Mesker, T., van Rheenen, P. F., Norbruis, O. F., Uitentuis, J., Waalkens, H. J., Gonera, G., van Overbeek, L. A. T., Butler, J., Rings, E. H. H. M. Pediatric Crohn's Disease Activity at Diagnosis, Its Influence on Pediatrician's Prescribing Behavior, and Clinical Outcome 5 Years Later. Inflammatory Bowel Diseases 15(11): 1670-1677, 2009. Muller P.A.J., De Sluis B.V., Groot A.J., Verbeek D., Vonk W.I.M., Maine G.N., Burstein E., Wijmenga C., Vooijs M., Reits E., Klomp L.W.J. Nuclear-cytosolic transport of COMMD1 regulates NFkB and HIF-1 activity. Traffic 10(5): 514-527, 2009. Padmos, R. C., Van Baal, G. C. M., Vonk, R., Wijkhuijs, A. J. M., Kahn, R. S., Nolen, W. A., Drexhage, H. A. Genetic and Environmental Influences on Pro-Inflammatory Monocytes in Bipolar Disorder A Twin Study. Archives of General Psychiatry 66(9): 957-+, 2009. Roelofsen, H., Dijkstra, M., Weening, D., de Vries, M. P., Hoek, A., Vonk, R. J. Comparison of Isotope-labeled Amino Acid Incorporation Rates (CILAIR) Provides a Quantitative Method to Study Tissue Secretomes. Molecular and Cellular Proteomics 8(2): 316-324, 2009. Romanos, J., van Diemen, C. C., Nolte, I. M., Trynka, G., Zhernakova, A., Fu, J. Y., Bardella, M. T., Barisani, D., McManus, R., van Heel, D. A., Wijmenga, C. Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac Disease. Gastroenterology 137(3): 834-840, 2009. Romanos, J., Wijmenga, C. Comment on: Barker et al. (2008) Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: Diabetes 57:3152-3155, 2008. Diabetes 58(1): e1, 2009. Romanos, J., Barisani, D., Trynka, G., Zhernakova, A., Bardella, M. T., Wijmenga, C. Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease. Journal of Medical Genetics 46(1): 60-63, 2009. Schellekens, R. C. A., Olsder, G. G., Langenberg, S. M. C. H., Boer, T., Woerdenbag, H. J., Frijlink, H. W., Kosterink, J. G. W., Stellaard, F. Proof-of-concept study on the suitability of C-13urea as a marker substance for assessment of in vivo behaviour of oral colon-targeted dosage forms. British Journal of Pharmacology 158(2): 532-540, 2009.

Szalowska, E., Elferink, M. G. L., Hoek, A., Groothuis, G. M. M., Vonk, R. J. Resistin Is More Abundant in Liver Than Adipose Tissue and Is Not Up-Regulated by Lipopolysaccharide. Journal of Clinical Endocrinology & Metabolism 94(8): 3051-3057, 2009. Trynka, G., Zhernakova, A., Romanos, J., Franke, L., Hunt, K. A., Turner, G., Bruinenberg, M., Heap, G. A., Platteel, M., Ryan, A. W., de Kovel, C., Holmes, G. K. T., Howdle, P. D., Walters, J. R. F., Sanders, D. S., Mulder, C. J. J., Mearin, M. L., Verbeek, W. H. M., Trimble, V., Stevens, F. M., Kelleher, D., Barisani, D., Bardella, M. T., McManus, R., van Heel, D. A., Wijmenga, C. Coeliac diseaseassociated risk variants in TNFAIP3 and REL implicate altered NFkappa B signalling. Gut 58(8): 1078-1083, 2009. Tuin, A., Poelstra, K., de Jager-Krikken, A., Bok, L., Raaben, W., Velders, M. P., Dijkstra, G. Role of alkaline phosphatase in colitis in man and rats. Gut 58(3): 379-387, 2009. van de Sluis, B., Groot, A. J., Vermeulen, J., van der Wall, E., van Diest, P. J., Wijmenga, C., Klomp, L. W., Vooijs, M. COMMD1 Promotes pVHL and O-2-Independent Proteolysis of HIF-1 alpha via HSP90/70. PLoS ONE 4(10 AR e7332 DI 10.1371/journal.pone.0007332) 2009. van de Sluis, B., Groot, A. J., Vermeulen, J., van der Wall, E., van Diest, P. J., Wijmenga, C., Klomp, L. W., Vooijs, M. COMMD1 Promotes pVHL and O-2-Independent Proteolysis of HIF-1 alpha via HSP90/70. PLoS ONE 4(10 AR e7332 DI 10.1371/journal.pone.0007332) 2009. van der Heide, F., Dijkstra, A., Weersma, R. K., Albersnagel, F. A., van der Loyt, E. M. J., Faber, K. N., Sluiter, W. J., Kleibeuker, J. H., Dijkstra, G. Effects of Active and Passive Smoking on Disease Course of Crohn's Disease and Ulcerative Colitis. Inflammatory Bowel Diseases 15(8): 1199-1207, 2009. van der Heide, F., Dijkstra, G., Porte, R. J., Kleibeuker, J. H., Haagsma, E. B. Smoking Behavior in Liver Transplant Recipients. Liver Transplantation 15(6): 648-655, 2009. van der Wouden, E. J., Karrenbeld, A., Kleibeuker, J. H., Dijkstra, G. Microscopic colitis: an unfamiliar but treatable disease. Netherlands Journal of Medicine 67(2): 41-45, 2009. van Straten, E. M. E., van Meer, H., Huijkman, N. C. A., van Dijk, T. H., Baller, J. F. W., Verkade, H. J., Kuipers, F., Plosch, T. Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice. American Journal of Physiology-Endocrinology and Metabolism 297(5): E1171-E1178, 2009. van Vilet, M. J., Tissing, W. J. E., Rings, E. H. H. M., Koetse, H. A., Stellaard, F., Kamps, W. A., de Bont, E. S. J. M. Citrulline as a Marker for Chemotherapy Induced Mucosal Barrier Injury in Pediatric Patients. Pediatric Blood & Cancer 53(7): 1188-1194, 2009.

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van Vliet-Ostaptchouk, J. V., Hofker, M. H., van der Schouw, Y. T., Wijmenga, C., Onland-Moret, N. C. Genetic variation in the hypothalamic pathways and its role on obesity. Obesity Reviews 10(6): 593-609, 2009. Visschedijk, M. C., Festen, E. A. M., Wijmenga, C., Weersma, R. K. Genetic background of inflammatory bowel diseases unraveled by genome-wide association studies. Nederlands Tijdschrift voor Geneeskunde 153(40): 1963-1968, 2009. Vrins, C. L. J., van der Velde, A. E., van den Oever, K., Levels, J. H. M., Huet, S., Elferink, R. P. J. O., Kuipers, F., Groen, A. K. Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. Journal of Lipid Research 50(10): 2046-2054, 2009. Weersma, R. K., Stokkers, P. C. F., Cleynen, I., Wolfkamp, S. C. S., Henckaerts, L., Schreiber, S., Dijkstra, G., Franke, A., Nolte, I. M., Rutgeerts, P., Wijmenga, C., Vermeire, S. Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large DutchBelgian Cohort. American Journal of Gastroenterology 104(3): 630-638, 2009. Weersma, R. K., Stokkers, P. C. F., van Bodegraven, A. A., van Hogezand, R. A., Verspaget, H. W., de Jong, D. J., van der Woude, C. J., Oldenburg, B., Linskens, R. K., Festen, E. A. M., van der Steege, G., Hommes, D. W., Crusius, J. B. A., Wijmenga, C., Nolte, I. M., Dijkstra, G. Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut 58(3): 388395, 2009. Westerhof, J., Koornstra, J. J., Weersma, R. K. Can we reduce capsule endoscopy reading times? Gastrointestinal Endoscopy 69(3): 497-502, 2009. Westerhof, J., Weersma, R. K., Koornstra, J. J. Diabetes mellitus is a risk factor for incomplete small-bowel capsule endoscopy Response. Gastrointestinal Endoscopy 69(7): 1409, 2009.

Westerhof, J., Weersma, R. K., Koornstra, J. J. Investigating obscure gastrointestinal bleeding: capsule endoscopy or double balloon enteroscopy? Netherlands Journal of Medicine 67(7): 260-265, 2009. Westerhof, J., Weersma, R. K., Koornstra, J. J. Risk factors for incomplete small-bowel capsule endoscopy: should capsule retention be considered independently? Response. Gastrointestinal Endoscopy 70(4): 820, 2009. Westerhof, J., Weersma, R. K., Koornstra, J. J. Risk factors for incomplete small-bowel capsule endoscopy. Gastrointestinal Endoscopy 69(1): 74-80, 2009. Wijmenga, C., van Haeften, T. W., Hofker, M. H. Genetic background of type 2 diabetes mellitus. Nederlands Tijdschrift voor Geneeskunde 153(46): 2252-2256, 2009. Wijmenga, C., van Haeften, T. W., Hofker, M. H. Genetic background of diabetes mellitus type 2. Nederlands Tijdschrift voor Geneeskunde 153: A959, 2009. Wolfs, M. G. M., Hofker, M. H., Wijmenga, C., van Haeften, T. W. Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics. Current Genomics 10(2): 110-118, 2009. Yuvaraj, S., Dijkstra, G., Burgerhof, J. G. M., Dammers, P. M., Stoel, M., Visser, A., Kroese, F. G. M., Bos, N. A. Evidence for Local Expansion of IgA Plasma Cell Precursors in Human Ileum. Journal of Immunology 183(8): 4871-4878, 2009. Zhernakova, A., van Diemen, C. C., Wijmenga, C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nature Reviews Genetics 10(1): 43-55, 2009. Zhou, L., Braat, H., Faber, K. N., Dijkstra, G., Peppelenbosch, M. P. Monocytes and their pathophysiological role in Crohn's disease. Cellular and Molecular Life Sciences 66(2): 192-202, 2009.

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INSTITUTE FOR TRANSPLANTATION, IMMUNITY AND INFLAMMATION - TRIO

Research line Transplantation
Dissertations
Drent, G. Life after liver transplantation : studies on medication nonadherence, symptom experience and long-term healthrelated quality of life. (2009) Kleibeuker, J. H., de Geest, S., and Haagsma, E. B. Engelsman, A. F. Bacterial contamination of surgical meshes. (2009) van der Mei, H. C., Ploeg, R. J., Busscher, H. J., and van Dam, G. M. Hger, S. The alloantigen-independent factors brain death and cold ischemia: prospects for a better graft survival through different donor management concepts. (2009) Ploeg, R. J., Yard, B., Seelen, M., and Leuvenink, H. Knibbe, M. E. 'Not a matter of choice' : ethical perspectives on decision making about living parental liver donation. (2009) Verkerk, M. A., Slooff, M. J. H., and Maeckelberghe, E. L. M. Koudstaal, L. G. The impact of cerebral injury in donation and transplantation : a central role of the intestine. (2009) Ploeg, R. J., van Goor, H., and Leuvenink, H. G. D. Krenning, G. Endothelial progenitor cells in vascular regenerative medicine : towards 'designer blood vessels' and 'therapeutic neovascularization'. (2009) van Luyn, M. J. A. and Harmsen, M. C. Rook, M. Living kidney donor safety : insights & outcome. (2009) Navis, G. J., Ploeg, R. J., van Goor, H., van Son, W. J., and Homan van der Heide, J. J. Smelt, M. J. The role of CMV in the pathology and etiology of islet graft failure. (2009) de Leij, L. F. M. H., de Vos, P., Faas, M. M., and de Haan, A. van Ree, R. M. Chronic low-grade inflammation in renal transplantation. (2009) Gans, R. O. B., Bakker, S. J. L., van Son, W. J., and Homan van der Heide, J. J. Warnaar, N. Thrombotic complications in liver transplantation. (2009) Porte, R. J., Lisman, J., and Molenaar, I. Q. Yang, H. Aspects of biliary atresia and other pediatric cholestatic diseases. (2009) Porte, R. J., Verkade, H. J., and Hulscher, J. B. F.

Journal articles
Adler, F. R., Aurora, P., Barker, D. H., Barr, M. L., Blackwell, L. S., Bosma, O. H., Brown, S., Cox, D. R., Jensen, J. L., Kurland, G., Nossent, G. D., Quittner, A. L., Robinson, W. M., Romero, S. L., Spencer, H., Sweet, S. C., van der Bij, W., Vermeulen, J., Verschuuren, E. A. M., Vrijlandt, E. J. L. E., Walsh, W., Woo, M. S., Liou, T. G. Lung transplantation for cystic fibrosis. Proceedings of the American Thoracic Society 6(8): 619, 2009. Alkozai, E. M., Lisman, T., Porte, R. J. Bleeding in Liver Surgery: Prevention and Treatment. Clinics in Liver Disease 13(1): 1451DI, 2009. Bekker, J., Ploem, S., de Jong, K. P. Early Hepatic Artery Thrombosis after Liver Transplantation: A Systematic Review of the Incidence, Outcome and Risk Factors. American Journal of Transplantation 9(4): 746-757, 2009. Boersema, M., Rienstra, H., van den Heuvel, M., van Goor, H., van Luyn, M. J. A., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Contribution to Transplant Vasculopathy in Chronic Renal Transplant Dysfunction. Transplantation 88(12): 13861392, 2009. Boersema, M., Rienstra, H., van den Heuvel, M., van Goor, H., van Luyn, M. J. A., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Contribution to Transplant Vasculopathy in Chronic Renal Transplant Dysfunction. Transplantation 88(12): 13861392, 2009. Boonstra, E. A., Molenaar, I. Q., Porte, R. J., de Boer, M. T. Topical haemostatic agents in liver surgery: Do we need them? HPB 11(4): 306-310, 2009. Bos, E. M., Leuvenink, H. G. D., Snijder, P. M., Kloosterhuis, N. J., Hillebrands, J. L., Leemans, J. C., Florquin, S., van Goor, H. Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury. Journal of the American Society of Nephrology 20(9): 1901-1905, 2009. Bossenbrock, L., ten Thicken, N. H. T., van der Bij, W., Verschuuren, E. A. M., Koeter, G. H., de Greef, M. H. G. Cross-sectional Assessment of Daily Physical Activity in Chronic Obstructive Pulmonary Disease Lung Transplant Patients. Journal of Heart and Lung Transplantation 28(2): 149-155, 2009.

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Bouma, H. R., Ploeg, R. J., Schuurs, T. A. Signal Transduction Pathways Involved in Brain Death-Induced Renal Injury. American Journal of Transplantation 9(5): 989-997, 2009. Broekema, M., Harmsen, M. C., Koerts, J. A., van Kooten, T. G., Uges, D. R. A., Petersen, A. H., van Luyn, M. J. A., Navis, G., Popa, E. R. Ciclosporin Does Not Influence Bone Marrow-Derived Cell Differentiation to Myofibroblasts Early after Renal Ischemia/Reperfusion. American Journal of Nephrology 30(1): 73-83, 2009. Brugemann, J., van der Bij, W., Verschuuren, E. A. M., Klungel, A. A., van der Horst, I. C. C., Erasmus, M. E., Kerstjens, H. A. M., van Veldhuisen, D. J., Zijlstra, F. Experience with combined heartlung transplant at the University Medical Center Groningen. Nederlands Tijdschrift voor Geneeskunde 153(27): 1314-1319, 2009. Buis, C. L., Geuken, E., Visser, D. S., Kuipers, F., Haagsma, E. B., Verkade, H. J., Porte, R. J. Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures. Journal of Hepatology 50(1): 69-79, 2009. Busscher, H. J., Ploeg, R. J., van der Mei, H. C. SnapShot: Biofilms and biomaterials; mechanisms of medical device related infections. Biomaterials 30(25): 4247-4248, 2009. de Boer, M. T., Porte, R. J. Platelets and Survival After Liver Transplantation Response. Anesthesia and Analgesia 108(4): 1355, 2009. de Haas, C. J. C., Weeterings, C., Vughs, M. M., de Groot, P. G., Strijp, J. A., Lisman, T. Staphylococcal superantigen-like 5 activates platelets and supports platelet adhesion under flow conditions, which involves glycoprotein Ib alpha and alpha(IIb)beta(3). Journal of Thrombosis and Haemostasis 7(11): 1867-1874, 2009. de Vos, P., Bucko, M., Gemeiner, P., Navratil, M., Svitel, J., Faas, M., Strand, B. L., Skjak-Braek, G., Morch, Y. A., Vikartovska, A., Lacik, I., Kollarikova, G., Orive, G., Poncelet, D., Pedraz, J. L., nsorgeSchumacher, M. B. Multiscale requirements for bioencapsulation in medicine and biotechnology. Biomaterials 30(13): 2559-2570, 2009. de Vries, B. M. W., Hillebrands, J. L., van Dam, G. M., Tio, R. A., de Jong, J. S., Slart, R. H. J. A., Zeebregts, C. J. Multispectral NearInfrared Fluorescence Molecular Imaging of Matrix Metalloproteinases in a Human Carotid Plaque Using a MatrixDegrading Metalloproteinase-Sensitive Activatable Fluorescent Probe. Circulation 119(20): E534-E536, 2009. Drent, G., Graveland, C. W., Hazenberg, B. P. C., Haagsma, E. B. Quality of life in patients with familial amyloidotic polyneuropathy long-term after liver transplantation. AmyloidJournal of Protein Folding Disorders 16(3): 133-141, 2009.

Drent, G., de Geest, S., Dobbels, F., Kleibeuker, J. H., Haagsma, E. B. Symptom experience, nonadherence and quality of life in adult liver transplant recipients. Netherlands Journal of Medicine 67(5): 161-168, 2009. Engelsman, A. F., Krom, B. P., Busscher, H. J., van Dam, G. M., Ploeg, R. J., van der Mei, H. C. Antimicrobial effects of an NO-releasing poly(ethylene vinylacetate) coating on soft-tissue implants in vitro and in a murine model. Acta Biomaterialia 5(6): 1905-1910, 2009. Engelsman, A. F., van der Mei, H. C., Francis, K. P., Busscher, H. J., Ploeg, R. J., van Dam, G. M. Real Time Noninvasive Monitoring of Contaminating Bacteria in a Soft Tissue Implant Infection Model. Journal of Biomedical Materials Research Part B-Applied Biomaterials 88B(1): 123-129, 2009. Feng, Y. X., Wang, Y. M., Pfister, F., Hillebrands, J. L., Deutsch, U., Hammes, H. P. Decreased Hypoxia-Induced Neovascularization in Angiopoietin-2 Heterozygous Knockout Mouse through Reduced MMP Activity. Cellular Physiology and Biochemistry 23(4-6): 277-284, 2009. Fidler, V., van Roest, M. H. G., de Jong, K. P. On Hazard Ratios and Magnitude of Impact on Prognosis Reply. Annals of Surgery 249(3): 545-546, 2009. Freeman, R. B., Jamieson, N., Schaubel, D. E., Porte, R. J., Villamil, F. G. Who should get a liver graft? Journal of Hepatology 50(4): 664-673, 2009. Guimaraes, A. H. C., de Bruijne, E. L. E., Lisman, T., Dippel, D. W. J., Deckers, J. W., Poldermans, D., Rijken, D. C., Leebeek, F. W. G. Hypofibrinolysis is a risk factor for arterial thrombosis at young age. British Journal of Haematology 145(1): 115-120, 2009. Haagsma, E. B., Niesters, H. G. M., van den Berg, A. P., RiezebosBrilman, A., Porte, R. J., Vennema, H., Reimerink, J. H. J., Koopmans, M. P. G. Prevalence of Hepatitis E Virus Infection in Liver Transplant Recipients. Liver Transplantation 15(10): 12251228, 2009. Hartog, J. W. L., Gross, S., Oterdoom, L. H., van Ree, R. M., de Vries, A. P. J., Smit, A. J., Schouten, J. P., Nawroth, P. P., Gans, R. O. B., van Son, W. J., Bierhaus, A., Bakker, S. J. L. Skin-Autofluorescence Is an Independent Predictor of Graft Loss in Renal Transplant Recipients. Transplantation 87(7): 1069-1077, 2009. Hoeger, S., Petrov, K., Reisenbuechler, A., Fontana, J., Selhorst, J., Hanusch, C., Beck, G., Seelen, M. A., van Son, W. J., Waldherr, R., Schnuelle, P., Yard, B. A. The Additional Detrimental Effects of Cold Preservation on Transplantation-Associated Injury in Kidneys from Living and Brain-Dead Donor Rats. Transplantation 87(1): 52-58, 2009. Hoekstra, H., Buis, C. I., Verdonk, R. C., van der Hilst, C. S., van der Jagt, E. J., Haagsma, E. B., Porte, R. J. Is Roux-en-Y Choledochojejunostomy an Independent Risk Factor for

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Nonanastomotic Biliary Strictures After Liver Transplantation? Liver Transplantation 15(8): 924-930, 2009. Holm, P. W., Slart, R. H. J. A., Zeebregts, C. J., Hillebrands, J. L., Tio, R. A. Atherosclerotic plaque development and instability: A dual role for VEGF. Annals of Medicine 41(4): 257-264, 2009. Hugenholtz, G. G. C., Porte, R. J., Lisman, T. The Platelet and Platelet Function Testing in Liver Disease. Clinics in Liver Disease 13(1): 11, 2009. IJtsma, A. J. C., van der Hilst, C. S., de Boer, M. T., de Jong, K. P., Peeters, P. M. J. G., Porte, R. J., Slooff, M. J. H. The Clinical Relevance of the Anhepatic Phase During Liver Transplantation. Liver Transplantation 15(9): 1050-1055, 2009. Khan, A. A., Chow, E. C. Y., van Loenen-Weemaes, A. M. M. A., Porte, R. J., Pang, K. S., Groothuis, G. M. M. Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. European Journal of Pharmaceutical Sciences 37(2): 115125, 2009. Khan, A. A., Chow, E. C. Y., Porte, R. J., Pang, K. S., Groothuis, G. M. M. Expression and Regulation of the Bile Acid Transporter, OST alpha-OST beta in Rat and Human Intestine and Liver. Biopharmaceutics & Drug Disposition 30(5): 241-258, 2009. Koning, M., Harmsen, M. C., van Luyn, M. J. A., Werker, P. M. N. Current opportunities and challenges in skeletal muscle tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 3(6): 407-415, 2009. Koornstra, J. J., de Vries, E. G. E., Porte, R. J. Improvements in small bowel carcinoid diagnosis and staging: 18F-DOPA PET, capsule endoscopy and double balloon enteroscopy. Digestive and Liver Disease 41(7): e35-e38, 2009. Koudstaal, L. G., Ottens, P. J., Uges, D. R. A., Ploeg, R. J., van Goor, H., Leuvenink, H. G. D. Increased Intestinal Permeability in Deceased Brain Dead Rats. Transplantation 88(3): 444-446, 2009. Krenning, G., van der Strate, B. W. A., Schipper, M., van Seijen, X. J. G. Y., Fernandes, B. C. A., van Luyn, M. J. A., Harmsen, M. C. CD34+cells augment endothelial cell differentiation of CD14+endothelial progenitor cells in vitro. Journal of Cellular and Molecular Medicine 13(8B): 2521-2533, 2009. Krenning, G., Dankers, P. Y. W., Drouven, J. W., Waanders, F., Franssen, C. F. M., van Luyn, M. J. A., Harmsen, M. C., Popa, E. R. Endothelial progenitor cell dysfunction in patients with progressive chronic kidney disease. American Journal of Physiology-Renal Physiology 296(6): F1314-F1322, 2009. Krenning, G., van Luyn, M. J. A., Harmsen, M. C. Endothelial progenitor cell-based neovascularization: implications for therapy. Trends in Molecular Medicine 15(4): 180-189, 2009. GUIDE Annual Publication Report 2009 33

Kuiper, E. M. M., Hansen, B. E., de Vries, R. A., den Ouden-Muller, J. W., van Ditzhuijsen, T. J. M., Haagsma, E. B., Houben, M. H. M. G., Witteman, B. J. M., van Erpecum, K. J., van Buuren, H. R. Improved Prognosis of Patients With Primary Biliary Cirrhosis That Have a Biochemical Response to Ursodeoxycholic Acid. Gastroenterology 136(4): 1281-1287, 2009. Lisman, T., Porte, R. J. Hepatic artery thrombosis after liver transplantation: more than just a surgical complication? Transplant International 22(2): 162-164, 2009. Maathuis, M. H. J., de Groot, M., Ploeg, R. J., Leuvenink, H. G. D. Deterioration of Endothelial and Smooth Muscle Cell Function in DCD Kidneys After Static Cold Storage in IGL-1 or UW. Journal of Surgical Research 152(2): 231-237, 2009. Martens, H. A., Stoof, S. P., Kobold, A. M., Haagsma, E. B., Stegeman, C. A., Brouwer, E. Serious effects of cooling in cryoglobulinemia. Nederlands Tijdschrift voor Geneeskunde 153(39): 1908-1912, 2009. Martens, H. A., Stoof, S. P., Kobold, A. M., Haagsma, E. B., Stegeman, C. A., Brouwer, E. Serious sequelae of hypothermia in cryoglobulinaemia. Nederlands Tijdschrift voor Geneeskunde 153: B432, 2009. Meerwaldt, R., Zeebregts, C. J., Navis, G., Hillebrands, J. L., Lefrandt, J. D., Smit, A. J. Accumulation of Advanced Glycation End Products and Chronic Complications in ESRD Treated by Dialysis. American Journal of Kidney Diseases 53(1): 138-150, 2009. Meijer, E., Bakker, S. J. L., de Jong, P. E., van der Heide, J. J. H., van Son, W. J., Struck, J., Lems, S. P. M., Gansevoort, R. T. Copeptin, a Surrogate Marker of Vasopressin, Is Associated With Accelerated Renal Function Decline in Renal Transplant Recipients. Transplantation 88(4): 561-567, 2009. Meltzer, M. E., Doggen, C. J. M., de Groot, P. G., Meijers, J. C. M., Rosendaal, F. R., Lisman, T. Low thrombin activatable fibrinolysis inhibitor activity levels are associated with an increased risk of a first myocardial infarction in men. Haematologica-the Hematology Journal 94(6): 811-818, 2009. Meltzer, M. E., Doggen, C. J. M., de Groot, P. G., Rosendaal, F. R., Lisman, T. Reduced plasma fibrinolytic capacity as a potential risk factor for a first myocardial infarction in young men. British Journal of Haematology 145(1): 121-127, 2009. Meltzer, M. E., Doggen, C. J. M., de Groot, P. G., Rosendaal, F. R., Lisman, T. The Impact of the Fibrinolytic System on the Risk of Venous and Arterial Thrombosis. Seminars in Thrombosis and Hemostasis 35(5): 468-477, 2009. Moers, C., Maathuis, M. H. J., Ploeg, R. J. Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation THE AUTHORS REPLY. New England Journal of Medicine 360(14): 1461, 2009.

Moers, C., Smits, J. M., Maathuis, M. H. J., Treckmann, J., van Gelder, F., Napieralski, B. P., van Kasterop-Kutz, M., van der Heide, J. J. H., Squifflet, J. P., van Heurn, E., Kirste, G. R., Rahmel, A., Leuvenink, H. G. D., Paul, A., Pirenne, J., Ploeg, R. J. Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation. New England Journal of Medicine 360(1): 7-19, 2009. Moers, C., Maathuis, M. H. J., Ploeg, R. J. The authors reply. New England Journal of Medicine 360(14): 1461, 2009. Moers, C., Kornmann, N. S. S., Leuvenink, H. G. D., Ploeg, R. J. The Influence of Deceased Donor Age and Old-for-Old Allocation on Kidney Transplant Outcome. Transplantation 88(4): 542552, 2009. Monbaliu, D., Vekemans, K., Hoekstra, H., Vaahtera, L., Libbrecht, L., Derveaux, K., Parkkinen, J., Liu, Q., Heedfeld, V., Wylin, T., Deckx, H., Zeegers, M., Balligand, E., Buurman, W., van Pelt, J., Porte, R. J., Pirenne, J. Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity. Annals of Surgery 250(5): 808-815, 2009. Nellensteijn, D., Porte, R. J., van Zuuren, W., ten Duis, H. J., Hulscher, J. B. F. Paediatric Blunt Liver Trauma in a Dutch Level 1 Trauma Center. European Journal of Pediatric Surgery 19(6): 358-361, 2009. Nellensteijn, D., Porte, R. J., van Zuuren, W., ten Duis, H. J., Hulscher, J. B. F. Paediatric Blunt Liver Trauma in a Dutch Level 1 Trauma Center. European Journal of Pediatric Surgery 19(6): 358-361, 2009. Nijboer, W. N., Schuurs, T. A., Damman, J., van Goor, H., Vaidya, V. S., van der Heide, J. J. H., Leuvenink, H. G. D., Bonventre, J. V., Ploeg, R. J. Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation. American Journal of Transplantation 9(8): 1752-1759, 2009. Oterdoom, L. H., de Vries, A. P. J., van Ree, R. M., Gansevoort, R. T., van Son, W. J., van der Heide, J. J. H., Navis, G., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. N-Terminal Pro-B-Type Natriuretic Peptide and Mortality in Renal Transplant Recipients Versus the General Population. Transplantation 87(10): 1562-1570, 2009. Pereboom, I. T. A., Adelmeijer, J., van Leeuwen, Y., Hendriks, H. G. D., Porte, R. J., Lisman, T. Development of a Severe von Willebrand Factor/ADAMTS13 Dysbalance During Orthotopic Liver Transplantation. American Journal of Transplantation 9(5): 1189-1196, 2009. Pereboom, I. T. A., Adelmeiijer, J., van Leeuwen, Y., Hendriks, H. G. D., Porte, R. J., Lisman, T. No Evidence for Systemic Platelet Activation During or After Orthotopic Liver Transplantation. Liver Transplantation 15(8): 956-962, 2009.

Pereboom, I. T. A., de Boer, M. T., Haagsma, E. B., Hendriks, H. G. D., Lisman, T., Porte, R. J. Platelet Transfusion During Liver Transplantation Is Associated with Increased Postoperative Mortality Due to Acute Lung Injury. Anesthesia and Analgesia 108(4): 1083-1091, 2009. Peters, J., Nieuwenhuijs, V. B., Morphett, A., Porte, R. J., Padbury, R. T. A., Barritt, G. J. Increasing Cycles of Intermittent Ischemia Can Effectively Maintain Liver Function during the Acute Phase of Ischemia Reperfusion Injury by Promotion of Bile Flow and Reduction in Bile Salt Toxicity. Digestive Surgery 26(6): 455-464, 2009. Polak, W. G., Peeters, P. M. J. G., Slooff, M. J. H. The evolution of surgical techniques in clinical liver transplantation. A review. Clinical Transplantation 23(4): 546-564, 2009. Ramaker, A. J. D. W., Meyer, P., van der Meer, J., Struys, M. M. R. F., Lisman, T., van Oeveren, W., Hendriks, H. G. D. Effects of acidosis, alkalosis, hyperthermia and hypothermia on haemostasis: results of point of care testing with the thromboelastography analyser. Blood Coagulation & Fibrinolysis 20(6): 436-439, 2009. Rienstra, H., Boersema, M., Onuta, G., Boer, M. W., Zandvoort, A., van Riezen, M., Rozing, J., van Goor, H., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Origin of Mesenchymal and Endothelial Cells in Chronic Renal Allograft Remodeling. American Journal of Transplantation 9(3): 463-472, 2009. Ruers, T. J. M., Wiering, B., van der Sijp, J. R. M., Roumen, R. M., de Jong, K. P., Comans, E. F. I., Pruim, J., Dekker, H. M., Krabbe, P. F. M., Oyen, W. J. G. Improved Selection of Patients for Hepatic Surgery of Colorectal Liver Metastases with F-18-FDG PET: A Randomized Study. Journal of Nuclear Medicine 50(7): 10361041, 2009. Scheenstra, R., Peeters, P. M. G. J., Verkade, H. J., Gouw, A. S. H. Graft Fibrosis After Pediatric Liver Transplantation: Ten Years of Follow-up. Hepatology 49(3): 880-886, 2009. Song, H., Bergstrasser, C., Rafat, N., Hoger, S., Schmidt, M., Endres, N., Goebeler, M., Hillebrands, J. L., Brigelius-Flohe, R., Banning, A., Beck, G., Loesel, R., Yard, B. A. The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression. British Journal of Pharmacology 157(5): 769-780, 2009. Tam, S. K., de Haan, B. J., Faas, M. M., Halle, J. P., Yahia, L., de Vos, P. Adsorption of human immunoglobulin to implantable alginatepoly-L-lysine microcapsules: Effect of microcapsule composition. Journal of Biomedical Materials Research Part A 89A(3): 609-615, 2009. van der Heide, F., Dijkstra, G., Porte, R. J., Kleibeuker, J. H., Haagsma, E. B. Smoking Behavior in Liver Transplant Recipients. Liver Transplantation 15(6): 648-655, 2009.

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van der Hilst, C. S., IJtsma, A. J. C., Slooff, M. J. H., TenVergert, E. M. Cost of Liver Transplantation A Systematic Review and Meta-Analysis Comparing the United States With Other OECD Countries. Medical Care Research and Review 66(1): 3-22, 2009. van der Werf, J., Porte, R. J., Lisman, T. Hemostasis in patients with liver disease. Acta Gastro-Enterologica Belgica 72(4): 433-440, 2009. van der Werf, J., Porte, R. J., Lisman, T. Hemostasis in patients with liver disease. Acta Gastro-Enterologica Belgica 72(4): 433-440, 2009. van Goor, H., Leuvenink, H. G. D. The goddess of the waters. Kidney International 75(8): 767-769, 2009. van Putten, S. M., Wubben, M., Hennink, W. E., van Luyna, M. J. A., Harmsen, M. C. The downmodulation of the foreign body reaction by cytomegalovirus encoded interleukin-10. Biomaterials 30(5): 730-735, 2009. van Ree, R. M., de Vries, A. P. J., Oterdoom, L. H., Seelen, M. A., Gansevoort, R. T., Schouten, J. P., Struck, J., Navis, G., Gans, R. O. B., van der Heide, J. J. H., van Son, W. J., Bakker, S. J. L. Plasma Procalcitonin Is an Independent Predictor of Graft Failure Late After Renal Transplantation. Transplantation 88(2): 279-287, 2009. Vermeijden, J. W., Zijlstra, J. G., Erasmus, M. E., Bij, W. D., Verschuuren, E. A. Lung Transplantation for VentilatorDependent Respiratory Failure. Journal of Heart and Lung Transplantation 28(4): 347-351, 2009. Visser, A., Hoeksema, A. R., de Baat, C., Vissink, A. Treatment and subsequent care of oral implants for care-dependent patients. Nederlands Tijdschrift voor Tandheelkunde 116(10): 559-563, 2009. Vlaar, A. P. J., van Son, W. J., Bakker, W. W. Histochemical Detection of Ischemia-Like Alterations Induced in Kidney Tissue in vitro - Different Sensitivity to Oxidant Stress of Glomerular ENTPD1 versus E5NT. Nephron Physiology 111(1): 1-8, 2009.

Waanders, F., Vaidya, V. S., van Goor, H., Leuvenink, H., Damman, K., Hamming, I., Bonventre, J. V., Vogt, L., Navis, G. Effect of Renin-Angiotensin-Aidosterone System Inhibition, Dietary Sodium Restriction, and/or Diuretics on Urinary Kidney Injury Molecule 1 Excretion in Nondiabetic Proteinuric Kidney Disease: A Post Hoc Analysis of a Randomized Controlled Trial. American Journal of Kidney Diseases 53(1): 16-25, 2009. Waanders, F., Rienstra, H., Boer, M. W., Zandvoort, A., Rozing, J., Navis, G., van Goor, H., Hillebrands, J. L. Spironolactone ameliorates transplant vasculopathy in renal chronic transplant dysfunction in rats. American Journal of Physiology-Renal Physiology 296(5): F1072-F1079, 2009. Warnaar, N., Mallett, S. V., Klinck, J. R., de Boer, M. T., Rolando, N., Burroughs, A. K., Jamieson, N. V., Rolles, K., Porte, R. J. Aprotinin and the Risk of Thrombotic Complications After Liver Transplantation: A Retrospective Analysis of 1492 Patients. Liver Transplantation 15(7): 747-753, 2009. Westerkamp, A. C., Lisman, T., Porte, R. J. How to minimize blood loss during liver surgery in patient with cirrhosis. HPB 11(6): 453458, 2009. Yang, H. Q., Plosch, T., Lisman, T., Gouw, A. S. H., Porte, R. J., Verkade, H. J., Hulscher, J. B. F. Inflammation Mediated DownRegulation of Hepatobiliary Transporters Contributes to Intrahepatic Cholestasis and Liver Damage in Murine Biliary Atresia. Pediatric Research 66(4): 380-385, 2009. Yang, H. Q., Porte, R. J., Verkade, H. J., de Langen, Z. J., Hulscher, J. B. F. Partial External Biliary Diversion in Children With Progressive Familial Intrahepatic Cholestasis and Alagille Disease. Journal of Pediatric Gastroenterology and Nutrition 49(2): 216-221, 2009. Zijlstra, G. S., Wolting, J., Prop, J., Petersen, A. H., Hinrichs, W. L. J., Uges, D. R. A., Kerstjens, H. A. M., van der Bij, W., Frijlink, H. W. Efficacy of a New Pulmonary Cyclosporine A Powder Formulation for Prevention of Transplant Rejection in Rats. Journal of Heart and Lung Transplantation 28(5): 486-492, 2009.

Research line Clinical and Applied Immunology

Dissertations
Alffenaar, J. W. C. Pharmacokinetics of antimicrobial agents : optimization and treatment individualization. (2009) Uges, D. R. A., van der Werf, T. S., and Kosterink, J. G. W. Borensztajn, K. S. Action and Function of coagulation FXa on cellular signaling. (2009) Peppelenbosch, M. P., Amselem, S., and Spek, C. A.

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Brouwer, J. L. P. Clinical implications of deficiencies of protein S, protein C or antithrombin. (2009) Kluin-Nelemans, J. C. and van der Meer, J. Chen, Min. Pathogenetic and clinical aspects of ANCA-associated vasculitis. (2009) Kallenberg, C. G. M., Zhao, M., and Heeringa, P. Folkeringa, N. Pregnancy-related thrombosis and fetal loss in women with thrombophilia. (2009) van der Meer, J. and Erwich, J. J. H. M. Holvast, A. Influenza vaccination in systemic autoimmune diseases. (2009) Kallenberg, C. G. M., Wilschut, J. C., and Bijl, M. Kok, K. Expression, action and function of phosphoinositide 3kinase p110delta. (2009) Peppelenbosch, M. P., Vanhaesebroeck.B., and Hommes, D. W. Kouwen, R. H. M. Protein secretion and disulfide bond handling in Bacillus subtilis. (2009) van Dijl, J. M. and Dubois, J.-Y. Leffers, N. Targeted immunotherapy for ovarian cancer. (2009) Nijman, H. W., Daemen, C. A. H. H., and van der Zee, A. G. J. Loef, B. G. Acute kidney injury after cardiac surgery : impact on long-term outcome and target for intervention. (2009) Ebels, T., Navis, G. J., Epema, A. H., and Stegeman, C. A. Martens, H. A. Genetic and prognostic factors in lupus. (2009) Kallenberg, C. G. M. and Bijl, M. Nap, R. E. Preparedness for pandemic influenza : hospital and intensive care resources. (2009) Werf, T. S. and Meessen, N. E. L.

Rafat, N. The endothelium in sepsis: inflammatory response and progenitor cell involvement. (2009) Molema, G., Beck, G., and Yard, B. Sanders, J. S. F. Disease-activity in ANCA-associated vasculitis. (2009) Kallenberg, C. G. M. and Stegeman, C. A. Smelt, M. J. The role of CMV in the pathology and etiology of islet graft failure. (2009) de Leij, L. F. M. H., de Vos, P., Faas, M. M., and de Haan, A. Tan, Lu Ping. MiRNAs and their target genes in B cell lymphomas. (2009) van den Berg, J. H. M., Poppema, S., and Kroesen, B.-J. van der Ploeg, R. The minimal Tat translocase. (2009) van Dijl, J. M. and Dubois, J.-Y. van der Schaar, H. M. Cell entry mechanisms of dengue virus. (2009) Wilschut, J. C. and Smit, J. M. van Gameren, I. I. Diagnostic and therapeutic modalitis in systemic amyloidosis. (2009) van Rijswijk, M. H., Vellenga, E., and Hazenberg, B. P. C. Veenstra van Nieuwenhoven, A. L. Immunology of pregnancy. (2009) Heineman, M. J., Leij, L. F. M. H., and Faas, M. M. Visser, A. Care and aftercare related to implant-retained prostheses. (2009) Vissink, A., Meijer, H. J. A., and Raghoebar, G. M. vom Hagen, F. M. Experimental models of retinal angiogenesis : the effect of angiopoietin-2 and TNFa modulation. (2009) Molema, G., Hammes, H.-P., and Gans, R. O. B. Zeng, W. Angiogenesis in human liver tumors. (2009) Poppema, S., Molema, G., Zhang, N., Gouw, A. S. H., and de Jong, K. P.

Journal articles
Abdulahad, W. H., Stegeman, C. A., Kallenberg, C. G. M. Review article: The role of CD4(+) T cells in ANCA-associated systemic vasculitis. Nephrology 14(1): 26-32, 2009. Abdulahad, W. H., Kallenberg, C. G. M., Limburg, P. C., Stegeman, C. A. Urinary CD4+ Effector Memory T Cells Reflect Renal Disease Activity in Antineutrophil Cytoplasmic AntibodyAssociated Vasculitis. Arthritis and Rheumatism 60(9): 28302838, 2009. Al-Ansari, S., Zeebregts, C. J., Slart, R. H. J. A., Peppelenbosch, M., Tio, R. A. Galectins in Atherosclerotic Disease. Trends in Cardiovascular Medicine 19(5): 164-169, 2009. Alffenaar, J. W. C., van Assen, S., van der Werf, T. S., Kosterink, J. G. W., Uges, D. R. A. Omeprazole Significantly Reduces Posaconazole Serum Trough Level. Clinical Infectious Diseases 48(6): 839, 2009. Alffenaar, J. W. C., van Altena, R., Bokkerink, H. J., Luijckx, G. J., van Soolingen, D., Aarnoutse, R. E., van der Werf, T. S. Pharmacokinetics of Moxifloxacin in Cerebrospinal Fluid and Plasma in Patients with Tuberculous Meningitis. Clinical Infectious Diseases 49(7): 1080-1082, 2009. Ananias, H. J. K., van den Heuvel, M. C., Helfrich, W., de Jong, I. J. Expression of the Gastrin-Releasing Peptide Receptor, the Prostate Stem Cell Antigen and the Prostate-Specific Membrane Antigen in Lymph Node and Bone Metastases of Prostate Cancer. Prostate 69(10): 1101-1108, 2009.

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Assink, M. D. M., Kiewiet, J. P., Rozenbaum, M. H., van den Berg, P. B., Hak, E., Buskens, E. J., Wilschut, J. C., Kroes, A. C. M., Postma, M. J. Excess drug prescriptions during influenza and RSV seasons in the Netherlands: Potential implications for extended influenza vaccination. Vaccine 27(7): 1119-1126, 2009. Badeloe, S., van, Spaendonck, van Steensel, M. A. M., van Marion, A. M. W., van Essen, A. J., Jonkman, M. F., Steijlen, P. M., Gutierrez, P., van Geel, M., Frank, J. Wilms tumour as a possible early manifestation of hereditary leiomyomatosis and renal cell cancer? British Journal of Dermatology 160(3): 707-709, 2009. Bakker, W. W., Henning, R. H., van Son, W. J., van Pampus, M. G., Aarnoudse, J. G., Niezen-Koning, K. E., Borghuis, T., Jongman, R. M., van Goor, H., Poelstra, K., Navis, G., Faas, M. M. Vascular Contraction and Preeclampsia Downregulation of the Angiotensin Receptor 1 by Hemopexin In Vitro. Hypertension 53(6): 959-U127, 2009. Barnett, J. P., van der Ploeg, R., Eijlander, R. T., Nenninger, A., Mendel, S., Rozeboom, R., Kuipers, O. P., van Dijl, J. M., Robinson, C. The twin-arginine translocation (Tat) systems from Bacillus subtilis display a conserved mode of complex organization and similar substrate recognition requirements. Febs Journal 276(1): 232-243, 2009. Barogui, Y., Johnson, R. C., van der Werf, T. S., Sopoh, G., Dossou, A., Dijkstra, P. U., Stienstra, Y. Functional Limitations after Surgical or Antibiotic Treatment for Buruli Ulcer in Benin. American Journal of Tropical Medicine and Hygiene 81(1): 8287, 2009. Bartels, A. L., Zeebregts, C. J., Bijl, M., Tio, R. A., Slart, R. H. J. A. Fused FDG-PET and MRI imaging of Takayasu arteritis in vertebral arteries. Annals of Nuclear Medicine 23(8): 753-756, 2009. Becher, D., Hempel, K., Sievers, S., Zuhlke, D., Pane-Farre, J., Otto, A., Fuchs, S., Albrecht, D., Bernhardt, J., Engelmann, S., Volker, U., van Dijl, J. M., Hecker, M. A Proteomic View of an Important Human Pathogen - Towards the Quantification of the Entire Staphylococcus aureus Proteome. PLoS ONE 4(12 AR e8176 DI 10.1371/journal.pone.0008176) 2009. Berden, A. E., Kallenberg, C. G. M., Savage, C. O. S., Yard, B. A., Abdulahad, W. H., de Heer, E., Bruijn, J. A., Bajema, I. M. Cellular Immunity in Wegener's Granulomatosis. Arthritis and Rheumatism 60(6): 1578-1587, 2009. Bertsias, G. K., Ioannidis, J. P. A., Boletis, J., Bombardieri, S., Cervera, R., Dostal, C., Font, J., Gilboe, I. M., Houssiau, F., Huizinga, T., Isenberg, D., Kallenberg, C. G. M., Khamashta, M., Piette, J. C., Schneider, M., Smolen, J., Sturfelt, G., Tincani, A., van Vollenhoven, R., Boumpas, D. T., Gordon, C. EULAR points to consider for conducting clinical trials in systemic lupus erythematosus: literature based evidence for the selection of endpoints. Annals of the Rheumatic Diseases 68(4): 477-483, 2009.

Bijlsma, M. F., Groot, A. P., Oduro, J. P., Franken, R. J., Schoenmakers, S. H. H. F., Peppelenbosch, M. P., Spek, C. A. Hypoxia induces a hedgehog response mediated by HIF-1 alpha. Journal of Cellular and Molecular Medicine 13(8B): 2053-2060, 2009. Bolling, M. C., Jonkman, M. F. Skin and heart: une liaison dangereuse. Experimental Dermatology 18(8): 658-668, 2009. Boot, H. J., van der Waaij, L. A., Schirm, J., Kallenberg, C. G. M., van Steenbergen, J., Wolters, B. Acute hepatitis B in a healthcare worker: A lesson in awareness of failure of hepatitis B vaccination. Journal of Hepatology 51(4): 826-827, 2009. Boot, H. J., van der Waaij, L. A., Schirm, J., Kallenberg, C. G. M., van Steenbergen, J., Wolters, B. Acute hepatitis B in a healthcare worker: A case report of genuine vaccination failure. Journal of Hepatology 50(2): 426-431, 2009. Borensztajn, K., Bijlsma, M. F., Reitsma, P. H., Peppelenbosch, M. R., Spek, C. A. Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation. Thrombosis Research 124(2): 219-225, 2009. Borensztajn, K., Peppelenbosch, M. P., Spek, C. A. Coagulation factor Xa signaling: the link between coagulation and inflammatory bowel disease? Trends in Pharmacological Sciences 30(1): 8-16, 2009. Borensztajn, K., Aberson, H., Peppelenbosch, M. P., Spek, C. A. FXainduced intracellular signaling links coagulation to neoangiogenesis: Potential implications for fibrosis. Biochimica et Biophysica Acta-Molecular Cell Research 1793(5): 798-805, 2009. Borensztajn, K., Peppelenbosch, M. P., Spek, C. A. Letter in response to 'Coagulation and fibrosis in chronic liver disease'. Gut 58(11): 1565-1566, 2009. Bremer, E., de Bruyn, M., Wajant, H., Helfrich, W. Targeted Cancer Immunotherapy Using Ligands of the Tumor Necrosis Factor Super-Family. Current Drug Targets 10(2): 94-103, 2009. Brouwer, E., Gouw, A. S. H., Posthumus, M. D., van Leeuwen, M. A., Boerboom, A. L., Bijzet, J., Bos, R., Limburg, P. C., Kallenberg, C. G. M., Westra, J. Hypoxia inducible factor-1-alpha (HIF-1(alpha)) is related to both angiogenesis and inflammation in rheumatoid arthritis. Clinical and Experimental Rheumatology 27(6): 945951, 2009. Brouwer, E., Gouw, A. S. H., Posthumus, M. D., van Leeuwen, M. A., Boerboom, A. L., Bijzet, J., Bos, R., Limburg, P. C., Kallenberg, C. G. M., Westra, J. Hypoxia inducible factor-1-alpha (HIF-1 alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis. Clinical and Experimental Rheumatology 27(6): 945951, 2009.

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Brouwer, J. L. P., Lijfering, W. M., Ten Kate, M. K., Kluin-Nelemans, H. C., Veeger, N. J. G. M., van der Meer, J. High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin. Thrombosis and Haemostasis 101(1): 93-99, 2009. Brugman, S., Visser, J. T. J., Hillebrands, J. L., Bos, N. A., Rozing, J. Prolonged exclusive breastfeeding reduces autoimmune diabetes incidence and increases regulatory T-cell frequency in bio-breeding diabetes-prone rats. Diabetes-Metabolism Research and Reviews 25(4): 380-387, 2009. Buijsrogge, J. J. A., de Jong, M. C. J. M., Kloosterhuis, G. J., Vermeer, M. H., Koster, J., Sonnenberg, A., Jonkman, M. F., Pas, H. H. Antiplectin autoantibodies in subepidermal blistering diseases. British Journal of Dermatology 161(4): 762-771, 2009. Burlage, F. R., Faber, H., Kampinga, H. H., Langendijk, J. A., Vissink, A., Coppes, R. P. Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands. Radiotherapy and Oncology 90(2): 253-256, 2009. Chen, M., Kallenberg, C. G. M., Zhao, M. H. ANCA-negative pauciimmune crescentic glomerulonephritis. Nature Reviews Nephrology 5(6): 313-318, 2009. Chen, M., Kallenberg, C. G. M. New advances in the pathogenesis of ANCA-associated vasculitides. Clinical and Experimental Rheumatology 27(1): S108-S114, 2009. Chen, M., Kallenberg, C. G. M. Novel territory for neutrophils in the pathogenesis of ANCA-associated vasculitides. Nephrology Dialysis Transplantation 24(12): 3618-3620, 2009. Damoiseaux, J., Dahnrich, C., Rosemann, A., Probst, C., Komorowski, L., Stegeman, C. A., Egerer, K., Hiepe, F., van Paassen, P., Stocker, W., Schlumberger, W., Tervaert, J. W. C. A novel enzyme-linked immunosorbent assay using a mixture of human native and recombinant proteinase-3 significantly improves the diagnostic potential for antineutrophil cytoplasmic antibody-associated vasculitis. Annals of the Rheumatic Diseases 68(2): 228-233, 2009. de Goffau, M. C., Yang, X. M., van Dijl, J. M., Harmsen, H. J. M. Bacterial pleomorphism and competition in a relative humidity gradient. Environmental Microbiology 11(4): 809-822, 2009. de Leeuw, K., Smit, A. J., de Groot, E., van Roon, A. M., Kallenberg, C. G., Bijl, M. Longitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus. Atherosclerosis 206(2): 546-550, 2009. de Smet, A. M. G. A., Kluytmans, J. A. J. W., Cooper, B. S., Mascini, E. M., Benus, R. F. J., van der Werf, T. S., van der Hoeven, J. G., Pickkers, P., Bogaers-Hofman, D., van der Meer, N. J. M., Bernards, A. T., Kuijper, E. J., Joore, J. C. A., Hall, M. A. L. V., GUIDE Annual Publication Report 2009 38

Bindels, A. J. G. H., Jansz, A. R., Wesselink, R. M. J., de Jongh, B. M., Dennesen, P. J. W., van Asselt, G. J., Velde, L. F. T., Frenay, I. H. M. E., Kaasjager, K., Bosch, F. H., van Iterson, M., Thijsen, S. F. T., Kluge, G. H., Pauw, W., de Vries, J. W., Kaan, J. A., Arends, J. P., Aarts, L. P. H. J., Sturm, P. D. J., Harinck, H. I. J., Voss, A., Uijtendaal, E. V., Blok, H. E. M., Groen, E. S. T., Pouw, M. E., Kalkman, C. J., Bonten, M. J. M. Decontamination of the Digestive Tract and Oropharynx in ICU Patients. New England Journal of Medicine 360(1): 20-31, 2009. de Vries, J. J. C., Bredius, R. G. M., van Rheenen, P. F., Smiers, F. J. W., Scholvinck, E. H., Vossen, A. C. T. M., Claas, E. C. J., Niesters, H. G. M. Human Bocavirus in an Immunocompromised Child Presenting with Severe Diarrhea. Journal of Clinical Microbiology 47(4): 1241-1243, 2009. de Vries, J. J. C., Bungener, L., ter Veer, W., van Alphen, L., van der Ley, R., Wilschut, J., Huckriede, A. Incorporation of LpxL1, a detoxified lipopolysaccharide adjuvant, in influenza H5N1 virosomes increases vaccine immunogenicity. Vaccine 27(6): 947-955, 2009. de Vries, M. K., van Eijk, I. C., van der Horst-Bruinsma, I. E., Peters, M. J. L., Nurmohamed, M. T., Dijkmans, B. A. C., Hazenberg, B. P. C., Wolbink, G. J. Erythrocyte Sedimentation Rate, C-Reactive Protein Level, and Serum Amyloid A Protein for Patient Selection and Monitoring of Anti-Tumor Necrosis Factor Treatment in Ankylosing Spondylitis. Arthritis & Rheumatism-Arthritis Care & Research 61(11): 1484-1490, 2009. Diercks, G. F. H., Pas, H. H., Jonkman, M. F. The ultrastructure of acantholysis in pemphigus vulgaris. British Journal of Dermatology 160(2): 460-461, 2009. Ding, Z., Verbaan, F. J., Bivas-Benita, M., Bungener, L., Huckriede, A., van den Berg, D. J., Kersten, G., Bouwstra, J. A. Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice. Journal of Controlled Release 136(1): 71-78, 2009. Dolff, S., Abdulahad, W. H., Bijl, M., Kallenberg, C. G. M. Regulators of B-cell activity in SLE: a better target for treatment than B-cell depletion? Lupus 18(7): 575-580, 2009. Drent, G., Graveland, C. W., Hazenberg, B. P. C., Haagsma, E. B. Quality of life in patients with familial amyloidotic polyneuropathy long-term after liver transplantation. AmyloidJournal of Protein Folding Disorders 16(3): 133-141, 2009. Dubois, J. Y. F., Kouwen, T. R. H. M., Schurich, A. K. C., Reis, C. R., Ensing, H. T., Trip, E. N., Zweers, J. C., van Dijl, J. M. Immunity to the Bacteriocin Sublancin 168 Is Determined by the SunI (YolF) Protein of Bacillus subtilis. Antimicrobial Agents and Chemotherapy 53(2): 651-661, 2009. Feng, Y. X., vom Hagen, F., Wang, Y. M., Beck, S., Schreiter, K., Pfister, F., Hoffmann, S., Wagner, P., Seeliger, M., Molema, G., Deutsch, U., Hammes, H. P. The absence of angiopoietin-2 leads

to abnormal vascular maturation and persistent proliferative retinopathy. Thrombosis and Haemostasis 102(1): 120-130, 2009. Folkeringa, N., Korteweg, F. J., Veeger, N. J., Middeldorp, S., Hamulyak, K., Prins, M. H., Erwich, J. J. H. M., Buller, H. R., van der Meer, J. Thrombin activatable fibrinolysis inhibitor (TAFI) is not associated with fetal loss, a retrospective study. Thrombosis Research 123(3): 511-514, 2009. Geel, T. M., Meiss, G., van der Gun, B. T., Kroesen, B. J., de Leij, L. F., Zaremba, M., Silanskas, A., Kokkinidis, M., Pingoud, A., Ruiters, M. H., McLaughlin, P. M., Rots, M. G. Endonucleases induced TRAIL-insensitive apoptosis in ovarian carcinoma cells. Experimental Cell Research 315(15): 2487-2495, 2009. Geel, T. M., Meiss, G., van der Gun, B. T., Kroesen, B. J., de Leij, L. F., Zaremba, M., Silanskas, A., Kokkinidis, M., Pingoud, A., Ruiters, M. H., McLaughlin, P. M., Rots, M. G. Endonucleases induced TRAIL-insensitive apoptosis in ovarian carcinoma cells. Experimental Cell Research 315(15): 2487-2495, 2009. Gibcus, J. H., Tan, L. P., Harms, G., Schakel, R. N., de Jong, D., Blokzijl, T., Moller, P., Poppema, S., Kroesen, B. J., van den Berg, A. Hodgkin Lymphoma Cell Lines Are Characterized by a Specific miRNA Expression Profile. Neoplasia 11(2): 167-U86, 2009. Glaudemans, A. W. J. M., Slart, R. H. J. A., Zeebregts, C. J., Veltman, N. C., Tio, R. A., Hazenberg, B. P. C., Dierckx, R. A. J. O. Nuclear imaging in cardiac amyloidosis. European Journal of Nuclear Medicine and Molecular Imaging 36(4): 702-714, 2009. Gordon, C., Bertsias, G., Ioannidis, J. P. A., Boletis, J., Bombardieri, S., Cervera, R., Dostal, C., Font, J., Gilboe, I. M., Houssiau, F., Huizinga, T. W. J., Isenberg, D., Kallenberg, C. G. M., Khamashta, M. A., Piette, J. C., Schneider, M., Smolen, J. S., Sturfelt, G., Tincani, A., van Vollenhoven, R., Boumpas, D. T. EULAR points to consider for conducting clinical trials in systemic lupus erythematosus. Annals of the Rheumatic Diseases 68(4): 470476, 2009. Gostynski, A., Deviaene, F. C. L., Pasmooij, A. M. G., Pas, H. H., Jonkman, M. F. Adhesive stripping to remove epidermis in junctional epidermolysis bullosa for revertant cell therapy. British Journal of Dermatology 161(2): 444-447, 2009. Haegens, A., Heeringa, P., van Suylen, R. J., Steele, C., Aratani, Y., O'Donoghue, R. J. J., Mutsaers, S. E., Mossman, B. T., Wouters, E. F. M., Vernooy, J. H. J. Myeloperoxidase Deficiency Attenuates Lipopolysaccharide-Induced Acute Lung Inflammation and Subsequent Cytokine and Chemokine Production. Journal of Immunology 182(12): 7990-7996, 2009. Hazenberg, A. J. C., Dikkers, F. G., Hawkins, P. N., Bijzet, J., Rowczenio, D., Gilbertson, J., Posthumus, M. D., Leijsma, M. K., Hazenberg, B. P. C. Laryngeal Presentation of Systemic

Apolipoprotein A-I-Derived Amyloidosis. Laryngoscope 119(3): 608-615, 2009. Herbinger, K. H., Adjei, O., wua-Boateng, N. Y., Nienhuis, W. A., Kunaa, L., Siegmund, V., Nitschke, J., Thompson, W., Klutse, E., Agbenorku, P., Schipf, A., Reu, S., Racz, P., Fleischer, B., Beissner, M., Fleischmann, E., Helfrich, K., van der Werf, T. S., Loscher, T., Bretzel, G. Comparative Study of the Sensitivity of Different Diagnostic Methods for the Laboratory Diagnosis of Buruli Ulcer Disease. Clinical Infectious Diseases 48(8): 1055-1064, 2009. Hettema, M. E., Zhang, D., Stienstra, Y., Smit, A. J., Bootsma, H., Kallenberg, C. G. M. No effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis. Clinical Rheumatology 28(7): 825-833, 2009. Holvast, A., van Assen, S., de Haan, A., Huckriede, A., Benne, C. A., Westra, J., Palache, A., Wilschut, J., Kallenberg, C. G. M., Bijl, M. Effect of a second, booster, influenza vaccination on antibody responses in quiescent systemic lupus erythematosus: an open, prospective, controlled study. Rheumatology 48(10): 1294-1299, 2009. Holvast, A., van Assen, S., de Haan, A., Huckriede, A., Benne, C. A., Westra, J., Palache, A., Wilschut, J., Kallenberg, C. G. M., Bijl, M. Studies of Cell-Mediated Immune Responses to Influenza Vaccination in Systemic Lupus Erythematosus. Arthritis and Rheumatism 60(8): 2438-2447, 2009. Holvast, A., Stegeman, C. A., Benne, C. A., Huckriede, A., Wilschut, J. C., Palache, A. M., Kallenberg, C. G. M., Bij, M. Wegener's granulomatosis patients show an adequate antibody response to influenza vaccination. Annals of the Rheumatic Diseases 68(6): 873-878, 2009. Hu, N., Westra, J., Huitema, M. G., Stegeman, C. A., Limburg, P. C., Kallenberg, C. G. M. Autoantibodies against glomerular endothelial cells in anti-neutrophil cytoplasmic autoantibodyassociated systemic vasculitis. Nephrology 14(1): 11-15, 2009. Hu, N., Westra, J., Huitema, M. G., Bijl, M., Brouwer, E., Stegeman, C. A., Heeringa, P., Limburg, P. C., Kallenberg, C. G. M. Coexpression of CD177 and Membrane Proteinase 3 on Neutrophils in Antineutrophil Cytoplasmic AutoantibodyAssociated Systemic Vasculitis. Arthritis and Rheumatism 60(5): 1548-1557, 2009. Hu, N., Westra, J., Kallenberg, C. G. M. Membrane-bound proteinase 3 and its receptors: Relevance for the pathogenesis of Wegener's Granulomatosis. Autoimmunity reviews 8(6): 510514, 2009. Hu, S., Zhou, M., Jiang, J., Wang, J. H., Elashoff, D., Gorr, S., Michie, S. A., Spijkervet, F. K. L., Bootsma, H., Kallenberg, C. G. M., Vissink, A., Horvath, S., Wong, D. T. Systems Biology Analysis of Sjogren's Syndrome and Mucosa-Associated Lymphoid Tissue Lymphoma in Parotid Glands. Arthritis and Rheumatism 60(1): 81-92, 2009.

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Huygen, K., Adjei, O., Affolabi, D., Bretzel, G., Demangel, C., Fleischer, B., Johnson, R. C., Pedrosa, J., Phanzu, D. M., Phillips, R. O., Pluschke, G., Siegmund, V., Singh, M., van der Werf, T. S., Wansbrough-Jones, M., Portaels, F. Buruli ulcer disease: prospects for a vaccine. Medical Microbiology and Immunology 198(2): 69-77, 2009. Jakab, A., Schlosser, G., Feijlbrief, M., Welling-Wester, S., Manea, M., Vila-Perello, M., Andreu, D., Ferenc, H., Mezo, G. Synthesis and Antibody Recognition of Cyclic Epitope Peptides, Together with Their Dimer and Conjugated Derivatives Based on Residues 9-22 of Herpes Simplex Virus Type 1 Glycoprotein D. Bioconjugate Chemistry 20(4): 683-692, 2009. Jonkman, M. F., De Groot, A. C., Slegers, T. P. A. M., de Jong, M. C. J. M., Pas, H. H. Immune diagnosis of pure ocular mucous membrane pemphigoid: indirect immunofluorescence versus immunoblot. European Journal of Dermatology 19(5): 456-460, 2009. Jonkman, M. F., Pasmooij, A. M. G. Revertant Mosaicism Patchwork in the Skin. New England Journal of Medicine 360(16): 1680-1682, 2009. Kalsch, A. I., Peters, A., Buhl, B., Breedijk, A., Prem, K., Schmitt, W. H., Weiss, C., Heeringa, P., Kallenberg, C., Birck, R., Yard, B. A. Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplasmic antibody associated vasculitis patients. Autoimmunity 42(5): 467-474, 2009. Knol, H. M., Veeger, N. J. G. M., Middeldorp, S., Hamulyak, K., van der Meer, J. High thrombin-activatable fibrinolysis inhibitor levels may protect against recurrent fetal loss. Journal of Thrombosis and Haemostasis 7(5): 903-906, 2009. Kok, K., Nock, G. E., Verrall, E. A. G., Mitchell, M. P., Hommes, D. W., Peppelenbosch, M. P., Vanhaesebroeck, B. Regulation of p110 delta PI 3-Kinase Gene Expression. PLoS ONE 4(4) 9-42009. Koopman, K., Uyttenboogaart, M., Vroomen, P. C., van der Meer, J., de Keyser, J., Luijckx, G. J. Development and validation of a predictive outcome score of cerebral venous thrombosis. Journal of the Neurological Sciences 276(1-2): 66-68, 2009. Koopman, K., Mulder, A. B., de Keyser, J., Luijckx, G. J., van der Meer, J. JAK2-V617F mutation in cerebral venous thrombosis. Journal of Thrombosis and Haemostasis 7(6): 1039-1040, 2009. Koopman, K., Uyttenboogaart, M., Vroomen, P. C., van der Meer, J., de Keyser, J., Luijckx, G. J. Long-Term Sequelae after Cerebral Venous Thrombosis in Functionally Independent Patients. Journal of Stroke & Cerebrovascular Diseases 18(3): 198-202, 2009. Koopman, K., Uyttenboogaart, M., Vroomen, P. C. A. J., van der Meer, J., de Keyser, J., Luijckx, G. J. Risk factors for cerebral GUIDE Annual Publication Report 2009 40

venous thrombosis and deep venous thrombosis in patients aged between 15 and 50 years. Thrombosis and Haemostasis 102(4): 620-622, 2009. Koopman, K., Uyttenboogaart, M., Hendriks, H. G. D., Luijckx, G. J., Cramwinckel, I. R., Vroomen, P. C., de Keyser, J., van der Meer, J. Thromboelastography in patients with cerebral venous thrombosis. Thrombosis Research 124(2): 185-188, 2009. Korteweg, F. J., Erwich, J. J. H. M., Holm, J. P., Ravise, J. M., van der Meer, J., Veeger, N. J. G. M., Timmer, A. Diverse Placental Pathologies as the Main Causes of Fetal Death. Obstetrics and Gynecology 114(4): 809-817, 2009. Kouwen, T. R. H. M., van Dijl, J. M. Applications of thiol-disulfide oxidoreductases for optimized in vivo production of functionally active proteins in Bacillus. Applied Microbiology and Biotechnology 85(1): 45-52, 2009. Kouwen, T. R. H. M., van Dijl, J. M. Interchangeable modules in bacterial thiol-disulfide exchange pathways. Trends in Microbiology 17(1): 6-12, 2009. Kouwen, T. R. H. M., Antelmann, H., van der Ploeg, R., Denham, E. L., Hecker, M., van Dijl, J. M. MscL of Bacillus subtilis prevents selective release of cytoplasmic proteins in a hypotonic environment. Proteomics 9(4): 1033-1043, 2009. Kouwen, T. R. H. M., van der Ploeg, R., Antelmann, H., Hecker, M., Homuth, G., Mader, U., van Dijl, J. M. Overflow of a hyperproduced secretory protein from the Bacillus Sec pathway into the Tat pathway for protein secretion as revealed by proteogenomics. Proteomics 9(4): 1018-1032, 2009. Kouwen, T. R. H. M., Trip, E. N., Denham, E. L., Sibbald, M. J. J. B., Dubois, J. Y. F., van Dijl, J. M. The Large Mechanosensitive Channel MscL Determines Bacterial Susceptibility to the Bacteriocin Sublancin 168. Antimicrobial Agents and Chemotherapy 53(11): 4702-4711, 2009. Kumpers, P., van Meurs, M., David, S., Molema, G., Bijzet, J., Lukasz, A., Biertz, F., Haller, H., Zijlstra, J. G. Time course of angiopoietin2 release during experimental human endotoxemia and sepsis. Critical Care 13(3 AR R64 DI 10.1186/cc7866) 2009. Lamprecht, P., Wieczorek, S., Epplen, J. T., Ambrosch, P., Kallenberg, C. G. M. Granuloma formation in ANCA-associated vasculitides. Apmis 117(Suppl. 127): 32-36, 2009. Langenkamp, E., Molema, G. Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer. Cell and Tissue Research 335(1): 205-222, 2009. Leffers, N., Gooden, M. J. M., Mokhova, A. A., Kast, W. M., Boezen, H. M., ten Hoor, K. A., Hollema, H., Daemen, T., van der Zee, A. G. J., Nijman, H. W. Down-regulation of proteasomal subunit MB1 is

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ten Cate, B., Bremer, E., de Bruyn, M., Bijma, T., Samplonius, D., Schwemmlein, M., Huls, G., Fey, G., Helfrich, W. A novel AMLselective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability. Leukemia 23(8): 1389-1397, 2009. Thompson, B. S., Moesker, B., Smit, J. M., Wilschut, J., Diamond, M. S., Fremont, D. H. A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within Endosomes. PLoS Pathogens 5(5 AR e1000453 DI 10.1371/journal.ppat.1000453) 2009. van Deemter, M., Pas, H. H., Kuijer, R., van der Worp, R. J., Hooymans, J. M. M., Los, L. I. Enzymatic Breakdown of Type II Collagen in the Human Vitreous. Investigative Ophthalmology & Visual Science 50(10): 4552-4560, 2009. Van Den Akker, P. C., Hettema, W., Meijer, R., Jonkman, M. F., Hofstra, R. M. W., Scheffer, H. Design and Validation of a Conformation-Sensitive Capillary Electrophoresis System for Mutation Identification of the COL7A1 Gene with Automated Peak Comparison. Genetic Testing and Molecular Biomarkers 13(5): 589-597, 2009. Van Den Akker, P. C., van Essen, A. J., Kraak, M. M. J., Meijer, R., Nijenhuis, M., Meijer, G., Hofstra, R. M. W., Pas, H. H., Scheffer, H., Jonkman, M. F. Long-term follow-up of patients with recessive dystrophic epidermolysis bullosa in the Netherlands: Expansion of the mutation database and unusual phenotype-genotype correlations. Journal of Dermatological Science 56(1): 9-18, 2009. van den Brande, J. M. H., Hommes, D. W., Peppelenbosch, M. P. A possible link between TIMP-1 induction and response to infliximab Response. Gut 58(6): 888-889, 2009. van der Schaar, H. M., Wilschut, J. C., Smit, J. M. Role of antibodies in controlling dengue virus infection. Immunobiology 214(7): 613-629, 2009. Van der Veen, B. S., Heeringa, P. ANCA-small vessel vasculitides: what have we (not yet) learned from animal models? Apmis 117(Suppl. 127): 21-26, 2009. Van der Veen, B. S., de Winther, M. P. J., Heeringa, P. Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease. Antioxidants & Redox Signaling 11(11): 2899-2937, 2009. Van der Veen, B. S., Petersen, A. H., Belperio, J. A., Satchell, S. C., Mathieson, P. W., Molema, G., Heeringa, P. Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clinical and Experimental Immunology 158(1): 143-153, 2009. van der Veer, W. M., Bloemen, M. C. T., Ulrich, M. M. W., Molema, G., van Zuijlen, P. P., Middelkoop, E., Niessen, F. B. Potential

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cellular and molecular causes of hypertrophic scar formation. Burns 35(1): 15-29, 2009. van der Zanden, E. P., Snoek, S. A., Heinsbroek, S. E., Stanisor, O. I., Verseijden, C., Boeckxstaens, G. E., Peppelenbosch, M. P., Greaves, D. R., Gordon, S., de Jonge, W. J. Vagus Nerve Activity Augments Intestinal Macrophage Phagocytosis via Nicotinic Acetylcholine Receptor alpha 4 beta 2. Gastroenterology 137(3): 1029-1039, 2009. van der Zwaag, P. A., Jongbloed, J. D. H., van den Berg, M. P., Jonkman, M. F., van Tintelen, J. P. Letter regarding the article: "R298Q mutation of p63 gene in autosomal dominant ectodermal dysplasia associated with arrhythmogenic right ventricular cardiomyopathy" by Valenzise et al. European Journal of Medical Genetics 52(4): 277, 2009. van Eijk, I. C., de Vries, M. K., Levels, J. H. M., Peters, M. J. L., Huizer, E. E., Dijkmans, B. A. C., van der Horst-Bruinsma, I. E., Hazenberg, B. P. C., van de Stadt, R. J., Wolbink, G. J., Nurmohamed, M. T. Improvement of Lipid Profile Is Accompanied by Atheroprotective Alterations in High-Density Lipoprotein Composition Upon Tumor Necrosis Factor Blockade A Prospective Cohort Study in Ankylosing Spondylitis. Arthritis and Rheumatism 60(5): 1324-1330, 2009. van Gameren, I. I., van Rijswijk, M. H., Bijzet, J., Vellenga, E., Hazenberg, B. P. Histological regression of amyloid in AL amyloidosis is exclusively seen after normalization of serum free light chain. Haematologica-the Hematology Journal 94(8): 1094-1100, 2009. van Leeuwen, M., Damoiseaux, J., Duijvestijn, A., Heeringa, P., Gijbels, M., de Winther, M., Tervaert, J. W. C. The IgM Response to Modified LDL in Experimental Atherosclerosis Hypochlorite-modified LDL IgM Antibodies versus Classical Natural T15 IgM Antibodies. Contemporary Challenges in Autoimmunity 1173: 274-279, 2009. van Meurs, M., Kumpers, P., Ligtenberg, J. J. M., Meertens, J. H. J. M., Molema, G., Zijlstra, J. G. Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target? Critical Care 13(2 AR 207 DI 10.1186/cc7153): 207, 2009. van Meurs, M., Kurniati, N. F., Wulfert, F. M., Asgeirsdottir, S. A., de Graaf, I. A., Satchell, S. C., Mathieson, P. W., Jongman, R. M., Kumpers, P., Zijlstra, J. G., Heeringa, P., Molema, G. Shockinduced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function. American Journal of Physiology-Renal Physiology 297(2): F272-F281, 2009. van Timmeren, M. M., Chen, M., Heeringa, P. Review article: Pathogenic role of complement activation in anti-neutrophil cytoplasmic auto-antibody-associated vasculitis. Nephrology 14(1): 16-25, 2009.

van Vliet, M. J., Tissing, W. J. E., Dun, C. A. J., Meessen, N. E. L., Kamps, W. A., de Bont, E. S. J. M., Harmsen, H. J. M. Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut. Clinical Infectious Diseases 49(2): 262-270, 2009. van Vliet, M. J., Tissing, W. J. E., de Bont, E. S. J. M., Meessen, N. E. L., Kamps, W. A., Harmsen, H. J. M. Denaturing Gradient Gel Electrophoresis of PCR-Amplified gki Genes: a New Technique for Tracking Streptococci. Journal of Clinical Microbiology 47(7): 2181-2186, 2009. Visser, J., Hillebrands, J. L., Boer, M. W., Bos, N. A., Rozing, J. Prevention of diabetes by a hydrolysed casein-based diet in diabetes-prone BioBreeding rats does not involve restoration of the defective natural regulatory T cell function. Diabetologia 52(7): 1445-1447, 2009. Visser, J., Rozing, J., Sapone, A., Lammers, K., Fasano, A. Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Diabetes Paradigms. Annals of the New York Academy of Sciences (1165): 195-205, 2009. MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. Vogt, M. R., Moesker, B., Goudsmit, J., Jongeneelen, M., Austin, S. K., Oliphant, T., Nelson, S., Pierson, T. C., Wilschut, J., Throsby, M., Diamond, M. S. Human Monoclonal Antibodies against West Nile Virus Induced by Natural Infection Neutralize at a Postattachment Step. Journal of Virology 83(13): 6494-6507, 2009. Voigt, B., Antelmann, H., Albrecht, D., Ehrenreich, A., Maurer, K. H., Evers, S., Gottschalk, G., van Dijl, J. M., Schweder, T., Hecker, M. Cell Physiology and Protein Secretion of Bacillus licheniformis Compared to Bacillus subtilis. Journal of Molecular Microbiology and Biotechnology 16(1-2): 53-68, 2009. Vonk, M. C., Broers, B., Heijdra, Y. F., Ton, E., Snijder, R., van Dijk, A. P. J., van Laar, J. M., Bootsma, H., van Hal, P. T. W., van den Hoogen, F. H. J., van Daele, P. L. A. Systemic sclerosis and its pulmonary complications in The Netherlands: an epidemiological study. Annals of the Rheumatic Diseases 68(6): 961-965, 2009. Vos, M. D., Raghoebar, G. M., van der Wal, J. E., Kalk, W. W. I., Vissink, A. Autogenous femoral head as grafting material for mandibular augmentation. International Journal of Oral and Maxillofacial Surgery 38(12): 1320-1323, 2009. Wagemakers, M., Van Der Wal, G. E., Cuberes, R., Alvarez, I., Andres, E. Ma., Buxens, J., Vela, J. M., Moorlag, H., Mooij, J. J. A., Molema, G. COX-2 inhibition combined with radiation reduces orthotopic glioma outgrowth by targeting the tumor vasculature. Translational Oncology 2(1): 1-7, 2009.

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Wagemakers, M., Van Der Wal, G. E., Cuberes, R., Alvarez, I., Andres, E. M., Buxens, J., Vela, J. M., Moorlag, H., Mooij, J. J. A., Molema, G. COX-2 inhibition combined with radiation reduces orthotopic glioma outgrowth by targeting the tumor vasculature. Translational Oncology 2(1): 1-7, 2009. Westra, J., Brouwer, E., Bouwman, E., Doornbos-van der Meer, B., Posthumus, M. D., van Leeuwen, M. A., Limburg, P. C., Ueda, Y., Kallenberg, C. G. M. Role for CaMKII Inhibition in Rheumatoid Arthritis Effects on HIF-1-Induced VEGF Production by Rheumatoid Synovial Fibroblasts. Contemporary Challenges in Autoimmunity 1173: 706-711, 2009. Westra, T. A., Daemen, T., Postma, M. J., Wilschut, J. C. Efficiency of human papillomavirus vaccination: Estimates based on Dutch cost-effectiveness analysis. Nederlands Tijdschrift voor Geneeskunde 153(45): 2206-2211, 2009. Westra, T. A., Daemen, T., Postma, M. J., Wilschut, J. C. Efficiency of human papillomavirus vaccination--estimates based on Dutch cost effectiveness analyses. Nederlands Tijdschrift voor Geneeskunde 153: A356, 2009. Wildenberg, M. E., Welzen-Coppens, J. M. C., van HeldenMeeuwsen, C. G., Bootsma, H., Vissink, A., van Rooijen, N., de Merwe, J. P. V., Drexhage, H. A., Versnel, M. A. Increased frequency of CD16+monocytes and the presence of activated dendritic cells in salivary glands in primary Sjogren syndrome. Annals of the Rheumatic Diseases 68(3): 420-426, 2009. Wilschut, J. Influenza vaccines: The virosome concept. Immunology Letters 122(2): 118-121, 2009. Xing, G. Q., Chen, M., Liu, G., Heeringa, P., Zhang, J. J., Zheng, X., Jie, E., Kallenberg, C. G. M., Zhao, M. H. Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis. Journal of Clinical Immunology 29(3): 282-291, 2009.

Yuvaraj, S., Dijkstra, G., Burgerhof, J. G. M., Dammers, P. M., Stoel, M., Visser, A., Kroese, F. G. M., Bos, N. A. Evidence for Local Expansion of IgA Plasma Cell Precursors in Human Ileum. Journal of Immunology 183(8): 4871-4878, 2009. Zambuzzi, W. F., Yano, C. L., Cavagis, A. D. M., Peppelenbosch, M. P., Granjeiro, J. M., Ferreira, C. V. Ascorbate-induced osteoblast differentiation recruits distinct MMP-inhibitors: RECK and TIMP2. Molecular and Cellular Biochemistry 322(1-2): 143-150, 2009. Zambuzzi, W. F., Bruni-Cardoso, A., Granjeiro, J. M., Peppelenbosch, M. P., de Carvalho, H. F., Aoyama, H., Ferreira, C. V. On the Road to Understanding of the Osteoblast Adhesion: Cytoskeleton Organization Is Rearranged by Distinct Signaling Pathways. Journal of Cellular Biochemistry 108(1): 134-144, 2009. Zhou, L., Braat, H., Faber, K. N., Dijkstra, G., Peppelenbosch, M. P. Monocytes and their pathophysiological role in Crohn's disease. Cellular and Molecular Life Sciences 66(2): 192-202, 2009. Zijtregtop, E. A. M., Wilschut, J., Koelma, N., van Delden, J. J. M., Stolk, R. P., van Steenbergen, J., Broer, J., Wolters, B., Postma, M. J., Hak, E. Which factors are important in adults' uptake of a (pre)pandemic influenza vaccine? Vaccine 28(1): 207-227, 2009. Zijtregtop, E. A. M., Wilschut, J., Koelma, N., van Delden, J. J. M., Stolk, R. P., van Steenbergen, J., Broer, J., Wolters, B., Postma, M. J., Hak, E. Which factors are important in adults' uptake of a (pre)pandemic influenza vaccine? Vaccine 28(1): 207-227, 2009. Zweers, J. C., Wiegert, T., van Dijl, J. M. Stress-Responsive Systems Set Specific Limits to the Overproduction of Membrane Proteins in Bacillus subtilis. Applied and Environmental Microbiology 75(23): 7356-7364, 2009.

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NORTHERN NETHERLANDS ONCOLOGY CENTER- NNOC

Research line Cancer: genes, mutations and their consequences
Dissertations
de Graeff, P. Molecular markers in epithelial ovarian cancer : paving the way to innovative therapies. (2009) van der Zee, A. G. J., de Vries, E. G. E., Hollema, H., de Jong, S., and Wisman, G. B. A. de Vries, A. R. The value of haplotypes. (2009) Hofstra, R. M. W. and te Meerman, G. J. Ferreira, A. M. Monteiro. Microsatellite instability profiling of Lynch syndrome-associated cancers. (2009) Hofstra, R. M. W., Seruca, R., Westers, H., and Sijmons, R. H. Qi, L. MicroRNA expression patterns in precursor lesions and (hereditary) breast cancer. (2009) Hollema, H., van den Berg, J. H. M., Bart, J., and Oosterwijk, J. C. van Ham, T. J. Caenorhabditis elegans models for protein misfolding diseases. (2009) Hofstra, R. M. W. and Nollen, E. A. A.

Journal articles
Arnold, S., Pelet, A., Amiel, J., Borrego, S., Hofstra, R., Tam, P., Ceccherini, I., Lyonnet, S., Sherman, S., Chakravarti, A. Interaction Between a Chromosome 10 RET Enhancer and Chromosome 21 in the Down Syndrome-Hirschsprung Disease Association. Human Mutation 30(5): 771-775, 2009. Boelens, M. C., van den Berg, A., Fehrmann, R. S. N., Geerlings, M., de Jong, W. K., Meerman, G. J. T., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M. Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. Journal of Pathology 218(2): 182-191, 2009. Boelens, M. C., Kok, K., van der Vlies, P., van der Vries, G., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M., van den Berg, A. Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. Lung Cancer 66(3): 372378, 2009. Boelens, M. C., Kok, K., van der Vlies, P., van der Vries, G., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M., van den Berg, A. Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. Lung Cancer 66(3): 372378, 2009. Carra, S., Brunsting, J. F., Lambert, H., Landry, J., Kampinga, H. H. HspB8 Participates in Protein Quality Control by a Nonchaperone-like Mechanism That Requires eIF2 alpha Phosphorylation. Journal of Biological Chemistry 284(9): 55235532, 2009. Checinska, A., Giaccone, G., Rodriguez, J. A., Kruyt, F. A. E., Jimenez, C. R. Comparative proteomics analysis of caspase-9protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells. Journal of Proteomics 72(4): 575-585, 2009. Crijns, A. P. G., Fehrmann, R. S. N., de Jong, S., Gerbens, F., Meersma, G. J., Klip, H. G., Hollema, H., Hofstra, R. M. W., Meerman, G. J. T., de Vries, E. G. E., Zee, A. G. J. D. SurvivalRelated Profile, Pathways, and Transcription Factors in Ovarian Cancer. PLoS Medicine 6(2): 181-193, 2009. den Dunnen, J. T., Sijmons, R. H., Andersen, P. S., Vihinen, M., Beckmann, J. S., Rossetti, S., Talbot, C. C., Hardison, R. C., Povey, S., Cotton, R. G. H. Sharing Data between LSDBs and Central Repositories. Human Mutation 30(4): 493-495, 2009. Ferreira, A. M., Westers, H., Wu, Y., Niessen, R. C., OlderodeBerends, M., van der Sluis, T., van der Zee, A. G., Hollema, H., Kleibeuker, J. H., Sijmons, R. H., Hofstra, R. M. W. Do Microsatellite Instability Profiles Really Differ Between Colorectal and Endometrial Tumors? Genes Chromosomes & Cancer 48(7): 552-557, 2009. Ferreira, A. M., Westers, H., Albergaria, A., Seruca, R., Hofstra, R. M. W. Estrogens, MSI and Lynch syndrome-associated tumors. Biochimica et Biophysica Acta - Reviews on Cancer 1796(2): 194200, 2009. Ferreira, A. M., Westers, H., Sousa, S., Wu, Y., Niessen, R. C., Olderode-Berends, M., van der Sluis, T., Reuvekamp, P. T. W., Seruca, R., Kleibeuker, J. H., Hollema, H., Sijmons, R. H., Hofstra, R. M. W. Mononucleotide precedes dinucleotide repeat instability during colorectal tumour development in Lynch syndrome patients. Journal of Pathology 219(1): 96-102, 2009. Geel, T. M., Meiss, G., van der Gun, B. T., Kroesen, B. J., de Leij, L. F., Zaremba, M., Silanskas, A., Kokkinidis, M., Pingoud, A., Ruiters,

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M. H., McLaughlin, P. M., Rots, M. G. Endonucleases induced TRAIL-insensitive apoptosis in ovarian carcinoma cells. Experimental Cell Research 315(15): 2487-2495, 2009. Gerrits, A., Li, Y., Tesson, B. M., Bystrykh, L. V., Weersing, E., Ausema, A., Dontje, B., Wang, X. S., Breitling, R., Jansen, R. C., de Haan, G. Expression Quantitative Trait Loci Are Highly Sensitive to Cellular Differentiation State. PLoS Genetics 5(10 AR e1000692 DI 10.1371/journal.pgen.1000692) 2009. Griseri, P., Vos, Y., Giorda, R., Gimelli, S., Beri, S., Santamaria, G., Mognato, G., Hofstra, R. M., Gimelli, G., Ceccherini, I. Complex pathogenesis of Hirschsprung's disease in a patient with hydrocephalus, vesico-ureteral reflux and a balanced translocation t(3;17)(p12;q11). European Journal of Human Genetics 17(4): 483-490, 2009. Hageman, J., Kampinga, H. H. Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library. Cell Stress & Chaperones 14(1): 1-21, 2009. Kampinga, H. H., Hageman, J., Vos, M. J., Kubota, H., Tanguay, R. M., Bruford, E. A., Cheetham, M. E., Chen, B., Hightower, L. E. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress & Chaperones 14(1): 105-111, 2009. Kaput, J., Cotton, R. G. H., Hardman, L., Watson, M., Al Aqeel, A. I., Al-Aama, J. Y., Al-Mulla, F., Alonso, S., Aretz, S., Auerbach, A. D., Bapat, B., Bernstein, I. T., Bhak, J., Bleoo, S. L., Blocker, H., Brenner, S. E., Burn, J., Bustamante, M., Calone, R., CambonThomsen, A., Cargill, M., Carrera, P., Cavedon, L., Cho, Y. S., Chung, Y. J., Claustres, M., Cutting, G., Dalgleish, R., den Dunnen, J. T., Diaz, C., Dobrowolski, S., dos Santos, M. R. N., Ekong, R., Flanagan, S. B., Flicek, P., Furukawa, Y., Genuardi, M., Ghang, H., Golubenko, M. V., Greenblatt, M. S., Hamosh, A., Hancock, J. M., Hardison, R., Harrison, T. M., Hoffmann, R., Horaitis, R., Howard, H. J., Barash, C. I., Izagirre, N., Jung, J., Kojima, T., Laradi, S., Lee, Y. S., Lee, J. Y., Gil-da-Silva-Lopes, V. L., Macrae, F. A., Maglott, D., Marafie, M. J., Marsh, S. G. E., Matsubara, Y., Messiaen, L. M., Moslein, G., Netea, M. G., Norton, M. L., Oefner, P. J., Oetting, W. S., O'Leary, J. C., de Ramirez, A. M. O., Paalman, M. H., Parboosingh, J., Patrinos, G. P., Perozzi, G., Phillips, I. R., Povey, S., Prasad, S., Qi, M., Quin, D. J., Ramesar, R. S., Richards, C. S., Savige, J., Scheible, D. G., Scott, R. J., Seminara, D., Shephard, E. A., Sijmons, R. H., Smith, T. D., Sobrido, M. J., Tanaka, T., Tavtigian, S. V., Taylor, G. R., Teague, J., Topel, T., Ullman-Cullere, M., Utsunomiya, J., van Kranen, H. J., Vihinen, M., Webb, E., Weber, T. K., Yeager, M., Yeom, Y. I., Yim, S. H., Yoo, H. S. Planning the Human Variome Project: The Spain Report. Human Mutation 30(4): 496-510, 2009. Klug, S. J., Ressing, M., Koenig, J., Abba, M. C., Agorastos, T., Brenna, S. M. F., Ciotti, M., Das, B. R., Del Mistro, A., Dybikowska, A., Giuliano, A. R., Gudleviciene, Z., Gyllensten, U., Haws, A. L. F., Helland, A., Herrington, C. S., Hildesheim, A., Humbey, O., Jee, S. H., Kim, J. W., Madeleine, M. M., Menczer, J., Ngan, H. Y. S., Nishikawa, A., Niwa, Y., Pegoraro, R., Pillai, M.

R., Ranzani, G., Rezza, G., Rosenthal, A. N., Roychoudhury, S., Saranath, D., Schmitt, V. M., Sengupta, S., Settheetham-Ishida, W., Shirasawa, H., Snijders, P. J. F., Stoler, M. H., Suarez-Rincon, A. E., Szarka, K., Tachezy, R., Ueda, M., van der Zee, A. G. J., Doeberitz, M. V., Wu, M. T., Yamashita, T., Zehbe, I., Blettner, M. TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncology 10(8): 772-784, 2009. Koornstra, J. J., de Jong, S., Boersma-van Eck, W., Zwart, N., Hollema, H., de Vries, E. G. E., Kleibeuker, J. H. Fas Ligand Expression in Lynch Syndrome-Associated Colorectal Tumours. Pathology & Oncology Research 15(3): 399-406, 2009. Lammens, C., Bleiker, E., Aaronson, N., Vriends, A., Ausems, M., Jansweijer, M., Wagner, A., Sijmons, R., van den Ouweland, A., van der Luijt, R., Spruijt, L., Garcia, E. G., Ruijs, M., Verhoef, S. Attitude towards pre-implantation genetic diagnosis for hereditary cancer. Familial Cancer 8(4): 457-464, 2009. Leffers, N., Gooden, M. J. M., Mokhova, A. A., Kast, W. M., Boezen, H. M., ten Hoor, K. A., Hollema, H., Daemen, T., van der Zee, A. G. J., Nijman, H. W. Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer. Gynecologic Oncology 113(2): 256-263, 2009. Mohammadi, L., Vreeswijk, M. P., Oldenburg, R., van den Ouweland, A., Oosterwijk, J. C., van der Hout, A. H., Hoogerbrugge, N., Ligtenberg, M., Ausems, M. G., van der Luijt, R. B., Dommering, C. J., Gille, J. J., Verhoef, S., Hogervorst, F. B., van Os, T. A., Garcia, E. G., Blok, M. J., Wijnen, J. T., Helmer, Q., Devilee, P., van Asperen, C. J., van Houwelingen, H. C. A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example. BMC Cancer 9 AR 211 DI 10.1186/1471-2407-9-211 2009. Niessen, R. C., Hofstra, R. M. W., Westers, H., Ligtenberg, M. J. L., Kooi, K., Jager, P. O. J., de Groote, M. L., Dijkhuizen, T., OlderodeBerends, M. J. W., Hollema, H., Kleibeuker, J. H., Sijmons, R. H. Germline Hypermethylation of MLH1 and EPCAM Deletions Are a Frequent Cause of Lynch Syndrome. Genes Chromosomes & Cancer 48(8): 737-744, 2009. Niessen, R. C., Kleibeuker, J. H., Westers, H., Jager, P. O. J., Rozeveld, D., Bos, K. K., Boersma-van Ek, W., Hollema, H., Sijmons, R. H., Hofstra, R. M. W. PMS2 Involvement in Patients Suspected of Lynch Syndrome. Genes Chromosomes & Cancer 48(4): 322329, 2009. Ou, J. H., Rasmussen, M., Westers, H., Andersen, S. D., Jager, P. O., Kooi, K. A., Niessen, R. C., Eggen, B. J. L., Nielsen, F. C., Kleibeuker, J. H., Sijmons, R. H., Rasmussen, L. J., Hofstra, R. M. W. Biochemical Characterization of MLH3 Missense Mutations Does Not Reveal an Apparent Role of MLH3 in Lynch Syndrome. Genes Chromosomes & Cancer 48(4): 340-350, 2009. Pinto, C., Veiga, I., Pinheiro, M., Peixoto, A., Pinto, A., Lopes, J. M., Reis, R. M., Oliveira, C., Baptista, M., Roque, L., Regateiro, F.,

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Cirnes, L., Hofstra, R. M. W., Seruca, R., Castedo, S., Teixeira, M. R. TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset. Familial Cancer 8(4): 383-390, 2009. Qi, L. Q., Bart, J., Tan, L. P., Platteel, I., van der Sluis, T., Huitema, S., Harms, G., Fu, L., Hollema, H., van den Berg, A. Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma. BMC Cancer 9 AR 163 DI 10.1186/14712407-9-163 2009. Robertus, J. L., Harms, G., Blokzijl, T., Booman, M., de Jong, D., van Imhoff, G., Rosati, S., Schuuring, E., Kluin, P., van den Berg, A. Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. Modern Pathology 22(4): 547-555, 2009. Van Den Akker, P. C., Hettema, W., Meijer, R., Jonkman, M. F., Hofstra, R. M. W., Scheffer, H. Design and Validation of a Conformation-Sensitive Capillary Electrophoresis System for Mutation Identification of the COL7A1 Gene with Automated Peak Comparison. Genetic Testing and Molecular Biomarkers 13(5): 589-597, 2009. van der Vegt, B., de Bock, G. H., Hollema, H., Wesseling, J. Microarray methods to identify factors determining breast cancer progression: Potentials, limitations, and challenges. Critical Reviews in Oncology Hematology 70(1): 1-11, 2009. Vekony, H., Roser, K., Loning, T., Ylstra, B., Meijer, G. A., van Wieringen, W. N., van de Wiel, M. A., Carvalho, B., Kok, K., Leemans, C. R., van der Waal, I., Bloemena, E. Copy Number

Gain at 8q12.1-q22.1 is Associated with a Malignant Tumor Phenotype in Salivary Gland Myoepitheliomas. Genes Chromosomes & Cancer 48(2): 202-212, 2009. Vos, M. J., Kanon, B., Kampinga, H. H. HSPB7 is a SC35 speckle resident small heat shock protein. Biochimica et Biophysica ActaMolecular Cell Research 1793(8): 1343-1353, 2009. Wijnen, J. T., Brohet, R. M., van Eijk, R., Jagmohan-Changur, S., Middeldorp, A., Tops, C. M., van Puijenbroek, M., Ausems, M. G. E. M., Garcia, E. G., Hes, F. J., Hoogerbrugge, N., Menko, F. H., Van Os, T. A. M., Sijmons, R. H., Verhoef, S., Wagner, A., Nagengast, F. M., Kleibeuker, J. H., Devilee, P., Morreau, H., Goldgar, D., Tomlinson, I. P., Houlston, R. S., van Wezel, T., Vasen, H. F. A. Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome. Gastroenterology 136(1): 131137, 2009. Yang, N., Eijsink, J. J. H., Lendvai, A., Volders, H. H., Klip, H., Buikema, H. J., van Hemel, B. M., Schuuring, E., van der Zee, A. G. J., Wisman, G. B. A. Methylation Markers for CCNA1 and C13ORF18 Are Strongly Associated with High-Grade Cervical Intraepithelial Neoplasia and Cervical Cancer in Cervical Scrapings. Cancer Epidemiology Biomarkers & Prevention 18(11): 3000-3007, 2009. Yi, X., de Vries, H. I., Siudeja, K., Rana, A., Lemstra, W., Brunsting, J. F., Kok, R. M., Smulders, Y. M., Schaefer, M., Dijk, F., Shang, Y. F., Eggen, B. J. L., Kampinga, H. H., Sibon, O. C. M. Stwl Modifies Chromatin Compaction and Is Required to Maintain DNA Integrity in the Presence of Perturbed DNA Replication. Molecular Biology of the Cell 20(3): 983-994, 2009.

Research line Hematopoetic development and hemato-oncology

Dissertations
Boerma, E.-J. G. Molecular definition of Burkitt Lymphoma. (2009) Kluin, P. M., Kluin-Nelemans, J. C., van Imhoff, G. W., and Schuuring, E. Brouwer, J. L. P. Clinical implications of deficiencies of protein S, protein C or antithrombin. (2009) Kluin-Nelemans, J. C. and van der Meer, J. Jansen, N. C. A. J. Cognitive functioning of children treated for acute lymphoblastic leukaemia with chemotherapy-only. (2009) Kamps, W. A., Bouma, J. M., and Kingma, A. Koopman, K. Clinical and haematological aspects of cerebral venous thrombosis. (2009) de Keyser, J. H. A., Kluin-Nelemans, J. C., Luyckx, G. J., and Vroomen, C. A. J. Tan, L. P., Wang, M., Robertus, J. L., Schakel, R. N., Gibcus, J. H., Diepstra, A., Harms, G., Peh, S. C., Reijmers, R. M., Pals, S. T., Kroesen, B. J., Kluin, P. M., Poppema, S., van den Berg, A. miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes. Laboratory Investigation 89(6): 708-716, 2009.

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Journal articles
Alffenaar, J. W. C., de Vos, T., Uges, D. R. A., Daenen, S. M. G. J. High voriconazole trough levels in relation to hepatic function: how to adjust the dosage? British Journal of Clinical Pharmacology 67(2): 262-263, 2009. Alffenaar, J. W. C., van der Elst, K. C. M., Uges, D. R. A., Kosterink, J. G. W., Daenen, S. M. G. J. Phenytoin-induced reduction of voriconazole serum concentration is not compensated by doubling the dosage. British Journal of Clinical Pharmacology 68(3): 462-463, 2009. Boerma, E. G., Siebert, R., Kluin, P. M., Baudis, M. Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge. Leukemia 23(2): 225-234, 2009. Brouwer, J. L. P., Lijfering, W. M., Ten Kate, M. K., Kluin-Nelemans, H. C., Veeger, N. J. G. M., van der Meer, J. High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin. Thrombosis and Haemostasis 101(1): 93-99, 2009. de Jonge-Peeters, S. D. P. W., van der Weide, K., Kuipers, F., Sluiter, W. J., de Vries, E. G. E., Vellenga, E. Variability in responsiveness to lovastatin of the primitive CD34(+) AML subfraction compared to normal CD34(+) cells. Annals of Hematology 88(6): 573-580, 2009. de Jonge, H. J. M., de Bont, E. S. J. M., Valk, P. J. M., Schuringa, J. J., Kies, M., Woolthuis, C. M., Delwel, R., Veeger, N. J. G. M., Vellenga, E., Lowenberg, B., Huls, G. AML at older age: agerelated gene expression profiles reveal a paradoxical downregulation of p16(INK4A) mRNA with prognostic significance. Blood 114(14): 2869-2877, 2009. de Jonge, H. J. M., Woolthuis, C. M., de Bont, E. S. J. M., Huls, G. Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia. Aging-Us 1(11): 949-953, 2009. den Boer, M. L., van Slegtenhorst, M., De Menezes, R. X., Cheok, M. H., Buijs-Gladdines, J. G. C. A., Peters, S. T. C. J., Van Zutven, L. C. M., Beverloo, H. B., Van der Spek, P. J., Escherich, G., Horstmann, M. A., Janka-Schoub, G. E., Kamps, W. A., Evans, W. E., Pieters, R. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncology 10(2): 125-134, 2009. Diepstra, A., van Imhoff, G. W., Schaapveld, M., Karim-Kos, H., van den Berg, A., Vellenga, E., Poppema, S. Latent Epstein-Barr Virus Infection of Tumor Cells in Classical Hodgkin's Lymphoma Predicts Adverse Outcome in Older Adult Patients. Journal of Clinical Oncology 27(23): 3815-3821, 2009. Erjavec, Z., Kluin-Nelemans, H., Verweij, P. E. Trends in invasive fungal infections, with emphasis on invasive aspergillosis. Clinical Microbiology and Infection 15(7): 625-633, 2009. Fickweiler, W., Aries, M. J. H., Enting, R. H., Vellenga, E., de Keyser, J. Cryptococcal cerebellitis after chemotherapy and autologous stem cell re-infusion in a patient with multiple myeloma. Journal of Neurology 256(1): 145-146, 2009. Fuhler, G. M., Tyl, M. R., Olthof, S. G., Drayer, A. L., Blom, N., Vellenga, E. Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells. European Journal of Haematology 83(3): 235-245, 2009. Geest, C. R., Buitenhuis, M., Vellenga, E., Coffer, P. J. Ectopic expression of C/EBP alpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia. Haematologica-the Hematology Journal 94(8): 1075-1084, 2009. Geest, C. R., Zwartkruis, F. J., Vellenga, E., Coffer, P. J., Buitenhuis, M. Mammalian target of rapamycin activity is required for expansion of CD34(+) hematopoietic progenitor cells. Haematologica-the Hematology Journal 94(7): 901-910, 2009. Geest, C. R., Buitenhuis, M., Laarhoven, A. G., Bierings, M. B., Bruin, M. C. A., Vellenga, E., Coffer, P. J. p38 MAP Kinase Inhibits Neutrophil Development Through Phosphorylation of C/EBP alpha on Serine 21. Stem Cells 27(9): 2271-2282, 2009. Geest, C. R., Buitenhuis, M., Koerkamp, M. J. A. G., Holstege, F. C. P., Vellenga, E., Coffer, P. J. Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34(+)-derived neutrophil progenitors. Blood 114(16): 3402-3412, 2009. Gerrits, A., Li, Y., Tesson, B. M., Bystrykh, L. V., Weersing, E., Ausema, A., Dontje, B., Wang, X. S., Breitling, R., Jansen, R. C., de Haan, G. Expression Quantitative Trait Loci Are Highly Sensitive to Cellular Differentiation State. PLoS Genetics 5(10 AR e1000692 DI 10.1371/journal.pgen.1000692) 2009. Gibcus, J. H., Tan, L. P., Harms, G., Schakel, R. N., de Jong, D., Blokzijl, T., Moller, P., Poppema, S., Kroesen, B. J., van den Berg, A. Hodgkin Lymphoma Cell Lines Are Characterized by a Specific miRNA Expression Profile. Neoplasia 11(2): 167-U86, 2009. Gualco, G., Chioato, L., van den Berg, A., Weiss, L. M., Bacchi, C. E. Composite Lymphoma: EBV-positive Classic Hodgkin Lymphoma and Peripheral T-cell Lymphoma A Case Report. Applied Immunohistochemistry & Molecular Morphology 17(1): 72-76, 2009. Hagenbeek, A., Gascoyne, R. D., Dreyling, M., Kluin, P., Engert, A., Salles, G. Biomarkers and Prognosis in Malignant Lymphomas. Clinical Lymphoma and Myeloma 9(2): 160-166, 2009.

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Han, L., Wierenga, A. T. J., Rozenveld-Geugien, M., van de Lande, K., Vellenga, E., Schuringa, J. J. Single-Cell STAT5 Signal Transduction Profiling in Normal and Leukemic Stem and Progenitor Cell Populations Reveals Highly Distinct Cytokine Responses. PLoS ONE 4(11 AR e7989 DI 10.1371/journal.pone.0007989) 2009. Houwerzijl, E. J., Pol, H. W. D., Blom, N. R., van der Want, J. J. L., de Wolf, J. T., Vellenga, E. Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced autophagy of mitochondria. Leukemia 23(5): 886891, 2009. Jansen, H., Postma, A., Stolk, R., Kamps, W. Acute lymphoblastic leukemia and obesity: increased energy intake or decreased physical activity? Supportive Care in Cancer 17(1): 103-106, 2009. Kelly, J. L., Toothaker, S. R., Ciminello, L., Hoelzer, D., Holte, H., LaCasce, A. S., Mead, G., Thomas, D., van Imhoff, G. W., Kahl, B. S., Cheson, B. D., Magrath, I. T., Fisher, R. I., Friedberg, J. W. Outcomes of Patients With Burkitt Lymphoma Older Than Age 40 Treated With Intensive Chemotherapeutic Regimens. Clinical Lymphoma and Myeloma 9(4): 307-310, 2009. Kluin-Nelemans, H. C., Ferenc, V., van Doormaal, J. J., van Iperen, C., Peters, W. G., Akin, C., Valent, P. Lenalidomide therapy in systemic mastocytosis. Leukemia Research 33(3): e19-e22, 2009. Lowenberg, B., Ossenkoppele, G. J., van Putten, W., Schouten, H. C., Graux, C., Ferrant, A., Sonneveld, P., Maertens, J., JongenLavrencic, M., von Lilienfeld-Toal, M., Biemond, B. J., Vellenga, E., Kooy, M. V., Verdonck, L. F., Beck, J., Dohner, H., Gratwohl, A., Pabst, T., Verhoef, G. High-Dose Daunorubicin in Older Patients with Acute Myeloid Leukemia. New England Journal of Medicine 361(13): 1235-1248, 2009. Mahmoodi, B. K., Gansevoort, R. T., Kluin-Nelemans, H. C. Antiphospholipid Syndrome, Microalbuminuria, and Risk of Venous Thromboembolism Reply. JAMA - Journal of the American Medical Association 302(9): 945-946, 2009. Montesinos, P., Bergua, J. M., Vellenga, E., Rayon, C., Parody, R., de la Serna, J., Leon, A., Esteve, J., Milone, G., Deben, G., Rivas, C., Gonzalez, M., Tormo, M., az-Mediavilla, J., Gonzalez, J. D., Negri, S., Amutio, E., Brunet, S., Lowenberg, B., Sanz, M. A. Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors. Blood 113(4): 775-783, 2009. Otte, A., van de Wiele, C., Dierckx, R. A. Radiolabeled immunotherapy in non-Hodgkin's lymphoma treatment: the next step. Nuclear Medicine Communications 30(1): 5-15, 2009.

Poele, E. M. T., Tissing, W. J. E., Kamps, W. A., de Bont, E. S. J. M. Risk assessment in fever and neutropenia in children with cancer: What did we learn? Critical Reviews in Oncology Hematology 72(1): 45-55, 2009. Pullarkat, V. A., Gernsheirner, T. B., Wasser, J. S., Newland, A., Guthrie, T. H., de Wolf, J. T. M., Stewart, R., Berger, D. Quantifying the reduction in immunoglobulin use over time in patients with chronic immune thrombocytopenic purpura receiving romiplostim (AMG 531). American Journal of Hematology 84(8): 538-540, 2009. Rizo, A., Olthof, S., Han, L., Vellenga, E., de Haan, G., Schuringa, J. J. Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis. Blood 114(8): 1498-1505, 2009. Robertus, J. L., Harms, G., Blokzijl, T., Booman, M., de Jong, D., van Imhoff, G., Rosati, S., Schuuring, E., Kluin, P., van den Berg, A. Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. Modern Pathology 22(4): 547-555, 2009. Roorda, B. D., ter Elst, A., Kamps, W. A., de Bont, E. S. J. M. Bone marrow-derived cells and tumor growth: Contribution of bone marrow-derived cells to tumor micro-environments with special focus on mesenchymal stem cells. Critical Reviews in Oncology Hematology 69(3): 187-198, 2009. Schaar, C. G., Le Cessie, S., Snijder, S., Franck, P. F. H., Wijermans, P. W., Ong, C., Kluin-Nelemans, H. Long-term follow-up of a population based cohort with monoclonal proteinaemia. British Journal of Haematology 144(2): 176-184, 2009. Schraders, M., Oeschger, S., Kluin, P. M., Hebeda, K., Schuuring, E., Groenen, P. J. T. A., Hansmann, M. L., van Krieken, J. H. J. M. Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentity. Modern Pathology 22(3): 416425, 2009. Schuringa, J. J., Schepers, H. Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells. Methods in molecular biology (Clifton, N. J. ) 538: 287-300, 2009. Silva, F. P. G., Almeida, I., Morolli, B., Brouwer-Mandema, G., Wessels, H., Vossen, R., Vrieling, H., Marijt, E. W. A., Valk, P. J. M., Kluin-Nelemans, H. C., Sperr, W. R., Ludwig, W. D., GiphartGassler, M. Genome wide molecular analysis of minimally differentiated acute myeloid leukemia. Haematologica-the Hematology Journal 94(11): 1546-1554, 2009. Tan, L. P., Seinen, E., Duns, G., de Jong, D., Sibon, O. C. M., Poppema, S., Kroesen, B. J., Kok, K., van den Berg, A. A high throughput experimental approach to identify miRNA targets in human cells. Nucleic Acids Research 37(20 AR e137 DI 10.1093/nar/gkp715) 2009.

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Tromp, Y. H., Daenen, S. M. G. J., Sluiter, W. J., Vellenga, E. The predictive value of interleukin-8 (IL-8) in hospitalised patients with fever and chemotherapy-induced neutropenia. European Journal of Cancer 45(4): 596-600, 2009. van 't Veer, M. B., de Jong, D., MacKenzie, M., Kluin-Nelemans, H. C., van Oers, M. H. J., Zijlstra, J., Hagenbeek, A., van Putten, W. L. J. High-dose Ara-C and beam with autograft rescue in RCHOP responsive mantle cell lymphoma patients. British Journal of Haematology 144(4): 524-530, 2009. van der Kaaij, M. A. E., Heutte, N., van Echten-Arends, J., Raemaekers, J. M. M., Carde, P., Noordijk, E. M., Ferme, C., Thomas, J., Eghbali, H., Brice, P., Bonmati, C., Henry-Amar, M., Kluin-Nelemans, H. C. Sperm quality before treatment in patients with early stage Hodgkin's lymphoma enrolled in EORTC-GELA Lymphoma Group trials. Haematologica 94(12): 1691-1697, 2009. van der Kaalj, M. A. E., Heutte, N., Echten-Arends, J., Raemaekers, J. M. M., Carde, P., Noordijk, E. M., Ferme, C., Thomas, J., Eghbali, H., Brice, P., Bonmati, C., Henry-Amar, M., KluinNelemans, H. C. Sperm quality before treatment in patients with early stage Hodgkin's lymphoma enrolled in EORTC-GELA Lymphoma Group trials. Haematologica-the Hematology Journal 94(12): 1691-1697, 2009. van der Weide, K., de Jonge-Peeters, S. D. P. W., Kuipers, F., Devries, E. G. E., Vellenga, E. Combining Simvastatin with the Farnesyltransferase Inhibitor Tipifarnib Results in an Enhanced Cytotoxic Effect in a Subset of Primary CD34(+) Acute Myeloid Leukemia Samples. Clinical Cancer Research 15(9): 3076-3083, 2009. van Dijk, N., Haijema, R., van der Wal, J., Sibinga, C. S. Blood platelet production: a novel approach for practical optimization. Transfusion 49(3): 411-420, 2009. van Gameren, I. I., van Rijswijk, M. H., Bijzet, J., Vellenga, E., Hazenberg, B. P. Histological regression of amyloid in AL amyloidosis is exclusively seen after normalization of serum

free light chain. Haematologica-the Hematology Journal 94(8): 1094-1100, 2009. van Vilet, M. J., Tissing, W. J. E., Rings, E. H. H. M., Koetse, H. A., Stellaard, F., Kamps, W. A., de Bont, E. S. J. M. Citrulline as a Marker for Chemotherapy Induced Mucosal Barrier Injury in Pediatric Patients. Pediatric Blood & Cancer 53(7): 1188-1194, 2009. van Vliet, M. J., Tissing, W. J. E., Dun, C. A. J., Meessen, N. E. L., Kamps, W. A., de Bont, E. S. J. M., Harmsen, H. J. M. Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut. Clinical Infectious Diseases 49(2): 262-270, 2009. van Vliet, M. J., Tissing, W. J. E., de Bont, E. S. J. M., Meessen, N. E. L., Kamps, W. A., Harmsen, H. J. M. Denaturing Gradient Gel Electrophoresis of PCR-Amplified gki Genes: a New Technique for Tracking Streptococci. Journal of Clinical Microbiology 47(7): 2181-2186, 2009. Veerman, A. J., Kamps, W. A., van den Berg, H., van den Berg, E., Bokkerink, J. P. M., Bruin, M. C. A., van den Heuvel-Eibrink, M. M., Korbijn, C. M., Korthof, E. T., van der Pal, K., Stijnen, T., Sipman, M. H. V. W., van Weerden, F., van Wering, E. R., van der Does-van den Berg. Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (19972004). Lancet Oncology 10(10): 957-966, 2009. Wang, M., Atayar, C., Rosati, S., Bosga-Bouwer, A., Kluin, P., Visser, L. JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125. Journal of Pathology 218(1): 95-103, 2009.

Research line Translational Oncology

Dissertations
Bodei, L. Peptide receptor radionuclide therapy with radiolabelled somatostatin analogues. (2009) Dierckx, R. A. J. O., Signore, A., and Paganelli, G. Breeuwsma, A. J. Molecular medicine in staging and restaging of prostate cancer. (2009) Nijman, J. M., Dierckx, R. A. J. O., de Jong, I. J., and Pruim, J. de Graeff, P. Molecular markers in epithelial ovarian cancer : paving the way to innovative therapies. (2009) van der Zee, A. G. J., de Vries, E. G. E., Hollema, H., de Jong, S., and Wisman, G. B. A. Di Pietro, A. Role of apoptotic pathways in chemosensitivity of testicular germ cell tumour. (2009) de Vries, E. G. E. and Gietema, J. A.

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Eshuis, S. A. Radiotracer imaging in PD : value of in vivo presynaptic dopaminergic measures in animal models and human disease. (2009) Leenders, K. L., Dierckx, R. A. J. O., and Jager, P. L. Lazzeri, E. Nuclear Medicine imaging of vertebral infections: role of radiolabelled biotin. (2009) Dierckx, R. A. J. O., Signore, A., and Paganelli, G. Leffers, N. Targeted immunotherapy for ovarian cancer. (2009) Nijman, H. W., Daemen, C. A. H. H., and van der Zee, A. G. J.

Maduro, J. H. TRAILs towards improved cervical cancer treatment. (2009) de Vries, E. G. E., van der Zee, A. G. J., and de Jong, S. Nagengast, W. B. New molecular imaging in oncology : a focus on angiogenesis. (2009) de Vries, E. G. E., de Hooge, M. N., Hospers, G. A. P., and Brouwers, A. H. Novkov, A. New considerations in predicting toxicity from partial irradiation of the lung. (2009) Kampinga, H. H. and Coppes, R. P.

Journal articles
Altena, R., Perik, P. J., van Veldhuisen, D. J., de Vries, E. G. E., Gietema, J. A. Cardiovascular toxicity caused by cancer treatment: strategies for early detection. Lancet Oncology 10(4): 391-399, 2009. Been, L. B., Hoekstra, H. J., Suurmeijer, A. J. H., Jager, P. L., van der Laan, B. F. A. M., Elsinga, P. H. [F-18]FLT-PET and [F-18]FDG-PET in the evaluation of radiotherapy for laryngeal cancer. Oral Oncology 45(12): E211-E215, 2009. Bodei, L., Ferone, D., Grana, C. M., Cremonesi, M., Signore, A., Dierckx, R. A., Paganelli, G. Peptide receptor therapies in neuroendocrine tumors. Journal of Endocrinological Investigation 32(4): 360-369, 2009. Boelens, M. C., Kok, K., van der Vlies, P., van der Vries, G., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M., van den Berg, A. Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. Lung Cancer 66(3): 372378, 2009. Burlage, F. R., Faber, H., Kampinga, H. H., Langendijk, J. A., Vissink, A., Coppes, R. P. Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands. Radiotherapy and Oncology 90(2): 253-256, 2009. Campbell-Verduyn, L. S., Mirfeizi, L., Dierckx, R. A., Elsinga, P. H., Feringa, B. L. Phosphoramidite accelerated copper(I)-catalyzed [3+2] cycloadditions of azides and alkynes. Chemical Communications (16): 2139-2141, 2009. Coppes, R. P., van der Goot, A., Lombaert, I. M. A. Stem Cell Therapy to Reduce Radiation-Induced Normal Tissue Damage. Seminars in Radiation Oncology 19(2): 112-121, 2009. Crijns, A. P. G., Fehrmann, R. S. N., de Jong, S., Gerbens, F., Meersma, G. J., Klip, H. G., Hollema, H., Hofstra, R. M. W., Meerman, G. J. T., de Vries, E. G. E., Zee, A. G. J. D. SurvivalRelated Profile, Pathways, and Transcription Factors in Ovarian Cancer. PLoS Medicine 6(2): 181-193, 2009. de Bruijn, M. J., ten Bosch, L., Kuik, D. J., Quene, H., Langendijk, J. A., Leemans, C. R., Verdonck-de Leeuw, I. M. Objective AcousticPhonetic Speech Analysis in Patients Treated for Oral or Oropharyngeal Cancer. Folia Phoniatrica et Logopaedica 61(3): 180-187, 2009. de Graeff, P., Crijns, A. P. G., de Jong, S., Boezen, M., Post, W. J., de Vries, E. G. E., van der Zee, A. G. J., de Bock, G. H. Modest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian cancer: a meta-analysis. British Journal of Cancer 101(1): 149-159, 2009. de Haas, E. C., Zwart, N., Meijer, C., Nuver, J., Boezen, H. M., Suurmeijer, A. J., Hoekstra, H. J., van der Steege, G., Sleijfer, D. T., Gieterna, J. A. Variation in Bleomycin Hydrolase Gene is Associated With Reduced Survival After Chemotherapy for Testicular Germ Cell Cancer. Journal of Urology 181(2): 639, 2009. de Jong, R. A., Leffers, N., Boezen, H. M., ten Hoor, K. A., van der Zee, A. G. J., Hollema, H., Nijman, H. W. Presence of tumorinfiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer. Gynecologic Oncology 114(1): 105-110, 2009. de Jong, W. H. A., Eisenhofer, G., Post, W. J., Muskiet, F. A. J., de Vries, E. G. E., Kema, I. P. Dietary Influences on Plasma and Urinary Metanephrines: Implications for Diagnosis of Catecholamine-Producing Tumors. Journal of Clinical Endocrinology & Metabolism 94(8): 2841-2849, 2009. de Jong, W. H. A., Smit, R., Bakker, S. J. L., de Vries, E. G. E., Kema, I. P. Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry. Journal of Chromatography BAnalytical Technologies in the Biomedical and Life Sciences 877(7): 603-609, 2009.

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de Jong, W. H. A., de Vries, E. G. E., Kema, I. P. Serotonin Rising. New England Journal of Medicine 360(24): 2580-2581, 2009. de Jong, W. K., Verpooten, G. F., Kramer, H., Louwagie, J., Groen, H. J. M. Promoter Methylation Primarily Occurs in Tumor Cells of Patients with Non-small Cell Lung Cancer. Anticancer Research 29(1): 363-369, 2009. Dierckx, R., Maes, A., Peeters, M., van de Wiele, C. FDG PET for monitoring response to local and locoregional therapy in HCC and liver metastases. Quarterly Journal of Nuclear Medicine and Molecular Imaging 53(3): 336-342, 2009. Dijkers, E. C. F., Kosterink, J. G. W., Rademaker, A. P., Perk, L. R., van Dongen, G. A. M. S., Bart, J., de Jong, J. R., de Vries, E. G. E., Lub-de Hooge, M. N. Development and Characterization of Clinical-Grade Zr-89-Trastuzumab for HER2/neu ImmunoPET Imaging. Journal of Nuclear Medicine 50(6): 974-981, 2009. Duiker, E. W., de Vries, E. G. E., Mahalingam, D., Meersma, G. J., Ek, W. B. V., Hollema, H., Hooge, M. N. L. D., van Dam, G. M., Cool, R. H., Quax, W. J., Samali, A., van der Zee, A. G. J., de Jong, S. Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model. Clinical Cancer Research 15(6): 20482057, 2009. Eijsink, J. J. H., de Bock, G. H., Kuiper, J. L., Reesink-Peters, N., van Hemel, B. M., Hollema, H., Nijman, H. W., Mourits, M. J. E., van der Zee, A. G. J. Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after Large Loop Excision of the Transformation Zone (LLETZ). Gynecologic Oncology 113(3): 348-351, 2009. Feng, J. L., van der Zwaag, M., Stokman, M. A., van Os, R., Coppes, R. P. Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiotherapy and Oncology 92(3): 466-471, 2009. Fiebrich, H. B., Brouwers, A. H., Kerstens, M. N., Pijl, M. E. J., Kema, I. P., de Jong, J. R., Jager, P. L., Elsinga, P. H., Dierckx, R. A. J. O., van der Wal, J. E., Sluiter, W. J., de Vries, E. G. E., Links, T. P. 6-[F18]Fluoro-L-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to Conventional Imaging with I-123Metaiodobenzylguanidine Scintigraphy, Computer Tomography, and Magnetic Resonance Imaging in Localizing Tumors Causing Catecholamine Excess. Journal of Clinical Endocrinology & Metabolism 94(10): 3922-3930, 2009. Fiebrich, H. B., Brouwers, A. H., Koopmans, K. P., de Vries, E. G. E. Combining 6-fluoro-[F-18]L-dihydroxyphenylalanine and [F18]fluoro-2-deoxy-D-glucose positron emission tomography for distinction of non-carcinoid malignancies in carcinoid patients. European Journal of Cancer 45(13): 2312-2315, 2009.

Flierman, A., Koornstra, J. J., Weersma, R. K. Unexpected cause of iron deficiency detected by capsule endoscopy RESPONSE. Netherlands Journal of Medicine 67(9): 317, 2009. Fonteyne, P., Casneuf, V., Pauwels, P., Van Damme, N., Peeters, M., Dierckx, R., van de Wiele, C. Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. Histology and Histopathology 24(8): 971-977, 2009. Geel, T. M., Meiss, G., van der Gun, B. T., Kroesen, B. J., de Leij, L. F., Zaremba, M., Silanskas, A., Kokkinidis, M., Pingoud, A., Ruiters, M. H., McLaughlin, P. M., Rots, M. G. Endonucleases induced TRAIL-insensitive apoptosis in ovarian carcinoma cells. Experimental Cell Research 315(15): 2487-2495, 2009. Govorukhina, N. I., de Vries, M., Reijmers, T. H., Horvatovich, P., van der Zee, A. G. J., Bischoff, R. Influence of clotting time on the protein composition of serum samples based on LC-MS data. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877(13): 1281-1291, 2009. Honing, J., Pultrum, B. B., van der Jagt, E. J., Groen, H., Plukker, J. T. M. Routine or on Demand Radiological Contrast Examination in the Diagnosis of Anastomotic Leakage After Esophagectomy. Journal of Surgical Oncology 100(8): 699-702, 2009. Hospers, G. A. P., Meijer, C., Dam, W. A., Roossink, F., Mulder, N. H. Construction of a triple modified p53 containing DNA vaccine to enhance processing and presentation of the p53 antigen. Vaccine 28(2): 386-391, 2009. Hospers, G. A. P., Meijer, C., Dam, W. A., Roossink, F., Mulder, N. H. Construction of a triple modified p53 containing DNA vaccine to enhance processing and presentation of the p53 antigen. Vaccine 28(2): 386-391, 2009. Huang, Y. W., Jansen, R. A., Fabbri, E., Potter, D., Liyanarachchi, S., Chan, M. W. Y., Liu, J. C., Crijns, A. P. G., Brown, R., Nephew, K. P., van der Zee, A. G. J., Cohn, D. E., Yan, P. S., Huang, T. H. M., Lin, H. J. L. Identification of candidate epigenetic biomarkers for ovarian cancer detection. Oncology Reports 22(4): 853-861, 2009. Jongen, V., Briet, J., de Jong, R., ten Hoor, K., Boezen, M., van der Zee, A., Nijman, H., Hollema, H. Expression of estrogen receptoralpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer. Gynecologic Oncology 112(3): 537-542, 2009. Jongen, V. H. W. M., Briet, J. M., de Jong, R. A., Joppe, E., ten Hoor, K. A., Boezen, H. M., Evans, D. B., Hollema, H., van der Zee, A. G. J., Nijman, H. W. Aromatase, Cyclooxygenase 2, HER-2/neu, and P53 as Prognostic Factors in Endometrioid Endometrial Cancer. International Journal of Gynecological Cancer 19(4): 670-676, 2009. Jorna, F. H., Hollema, H., Hendrikse, H. N., Bart, J., Brouwers, A. H., Plukker, J. T. M. P-gp and MRP1 Expression in Parathyroid

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Tumors Related to Histology, Weight and Tc-99m-Sestamibi Imaging Results. Experimental and Clinical Endocrinology & Diabetes 117(8): 406-412, 2009. Klug, S. J., Ressing, M., Koenig, J., Abba, M. C., Agorastos, T., Brenna, S. M. F., Ciotti, M., Das, B. R., Del Mistro, A., Dybikowska, A., Giuliano, A. R., Gudleviciene, Z., Gyllensten, U., Haws, A. L. F., Helland, A., Herrington, C. S., Hildesheim, A., Humbey, O., Jee, S. H., Kim, J. W., Madeleine, M. M., Menczer, J., Ngan, H. Y. S., Nishikawa, A., Niwa, Y., Pegoraro, R., Pillai, M. R., Ranzani, G., Rezza, G., Rosenthal, A. N., Roychoudhury, S., Saranath, D., Schmitt, V. M., Sengupta, S., Settheetham-Ishida, W., Shirasawa, H., Snijders, P. J. F., Stoler, M. H., Suarez-Rincon, A. E., Szarka, K., Tachezy, R., Ueda, M., van der Zee, A. G. J., Doeberitz, M. V., Wu, M. T., Yamashita, T., Zehbe, I., Blettner, M. TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncology 10(8): 772-784, 2009. Koopmans, K. P., Neels, O. N., Kema, I. P., Elsinga, P. H., Links, T. P., de Vries, E. G. E., Jager, P. L. Molecular imaging in neuroendocrine tumors: Molecular uptake mechanisms and clinical results. Critical Reviews in Oncology Hematology 71(3): 199-213, 2009. Koornstra, J. J., de Jong, S., Boersma-van Eck, W., Zwart, N., Hollema, H., de Vries, E. G. E., Kleibeuker, J. H. Fas Ligand Expression in Lynch Syndrome-Associated Colorectal Tumours. Pathology & Oncology Research 15(3): 399-406, 2009. Koornstra, J. J., de Jong, S., Boersma-van Eck, W., Zwart, N., Hollema, H., de Vries, E. G. E., Kleibeuker, J. H. Fas Ligand Expression in Lynch Syndrome-Associated Colorectal Tumours. Pathology & Oncology Research 15(3): 399-406, 2009. Kruijff, S., Bastiaannet, E., Kobold, A. C. M., van Ginkel, R. J., Suurmeijer, A. J. H., Hoekstra, H. J. S-100B Concentrations Predict Disease-Free Survival in Stage III Melanoma Patients. Annals of Surgical Oncology 16(12): 3455-3462, 2009. Kruizinga, R. C., Bestebroer, J., Berghuis, P., de Haas, C. J. C., Links, T. P., de Vries, E. G. E., Walenkamp, A. M. E. Role of Chemokines and Their Receptors in Cancer. Current Pharmaceutical Design 15(29): 3396-3416, 2009. Langendijk, J. A., Doornaert, P., Rietveld, D. H. F., Verdonck-de Leeuw, I. M., Leemans, C. R., Slotman, B. J. A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiotherapy and Oncology 90(2): 189-195, 2009. Le Cessie, S., de Vries, E. G. E., Buijs, C., Post, W. J. Analyzing longitudinal data with patients in different disease states during follow-up and death as final state. Statistics in Medicine 28(30): 3829-3843, 2009. Leffers, N., Gooden, M. J. M., Mokhova, A. A., Kast, W. M., Boezen, H. M., ten Hoor, K. A., Hollema, H., Daemen, T., van der

Zee, A. G. J., Nijman, H. W. Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer. Gynecologic Oncology 113(2): 256-263, 2009. Leffers, N., Lambeck, A. J. A., Gooden, M. J. M., Hoogeboom, B. N., Wolf, R., Hamming, I. E., Hepkema, B. G., Willemse, P. H. B., Molmans, B. H. W., Hollema, H., Drijfhout, J. W., Sluiter, W. J., Valentijn, A. R. P. M., Fathers, L. M., Oostendorp, J., van der Zee, A. G. J., Melief, C. J., van der Burg, S. H., Daemen, T., Nijman, H. W. Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial. International Journal of Cancer 125(9): 2104-2113, 2009. Leffers, N., Gooden, M. J. M., de Jong, R. A., Hoogeboom, B. N., ten Hoor, K. A., Hollema, H., Boezen, H. M., van der Zee, A. G. J., Daemen, T., Nijman, H. W. Prognostic significance of tumorinfiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer. Cancer Immunology Immunotherapy 58(3): 449-459, 2009. Leffers, N., Daemen, T., van der Zee, A. G. J., Nyman, H. W. Multimodality treatment warranted for ovarian cancer: immunotherapy, a prerequisite to improve prognosis for this vicious disease. Immunotherapy 1(2): 163-165, 2009. Maduro, J. H., Noordhuis, M. G., ten Hoor, K. A., Pras, E., Arts, H. J. G., Eijsink, J. J. H., Hollema, H., Mom, C. H., de Jong, S., de Vries, E. G. E., de Bock, G. H., van der Zee, A. G. J. THE PROGNOSTIC VALUE OF TRAIL AND ITS DEATH RECEPTORS IN CERVICAL CANCER. International Journal of Radiation Oncology Biology Physics 75(1): 203-211, 2009. Mahalingam, D., Szegezdi, E., Keane, M., de Jong, S., Samali, A. TRAIL receptor signalling and modulation: Are we on the right TRAIL? Cancer Treatment Reviews 35(3): 280-288, 2009. Malviya, G., D'Alessandria, C., Bonanno, E., Vexler, V., Massari, R., Trotta, C., Scopinaro, F., Dierckx, R., Signore, A. Radiolabeled Humanized Anti-CD3 Monoclonal Antibody Visilizumab for Imaging Human T-Lymphocytes. Journal of Nuclear Medicine 50(10): 1683-1691, 2009. Mees, G., Fonteyne, P., Ceelen, W., Boterberg, T., Pauwels, P., Vangestel, C., Van Damme, N., Peeters, M., Dierckx, R., van de Wiele, C. Combined Effect of EPO and Radiotherapy on the Expression of Endogenous Molecular Markers of Tumor Metabolism and Metastasis. Cancer Biotherapy and Radiopharmaceuticals 24(5): 565-572, 2009. Mees, G., Dierckx, R., Vangestel, C., van de Wiele, C. Molecular imaging of hypoxia with radiolabelled agents. European Journal of Nuclear Medicine and Molecular Imaging 36(10): 1674-1686, 2009. Mom, C. H., Verweij, J., Oldenhuis, C. N. A. M., Gietema, J. A., Fox, N. L., Miceli, R., Eskens, F. A. L. M., Loos, W. J., de Vries, E. G. E., Sleijfer, S. Mapatumumab, a Fully Human Agonistic Monoclonal

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Antibody That Targets TRAIL-R1, in Combination with Gemcitabine and Cisplatin: a Phase I Study. Clinical Cancer Research 15(17): 5584-5590, 2009. Noordhuis, M. G., Eijsink, J. J. H., ten Hoor, K. A., Roossink, F., Hollema, H., Arts, H. J. G., Pras, E., Maduro, J. H., Reyners, A. K. L., de Bock, G. H., Wisman, G. B. A., Schuuring, E., van der Zee, A. G. J. Expression of Epidermal Growth Factor Receptor (EGFR) and Activated EGFR Predict Poor Response to (Chemo)radiation and Survival in Cervical Cancer. Clinical Cancer Research 15(23): 7389-7397, 2009. Otte, A., van de Wiele, C., Dierckx, R. A. Radiolabeled immunotherapy in non-Hodgkin's lymphoma treatment: the next step. Nuclear Medicine Communications 30(1): 5-15, 2009. Pultrum, B. B., van der Jagt, E. J., van Westreenen, H. L., van Dullemen, H. M., Kappert, P., Groen, H., Sietsma, J., Oudkerk, M., Plukker, J. Th, van Dam, G. M. Detection of lymph node metastases with ultrasmall super paramagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging in oesophageal cancer: A feasibility study. Cancer Imaging 9(1): 19-28, 2009. Qi, L. Q., Bart, J., Tan, L. P., Platteel, I., van der Sluis, T., Huitema, S., Harms, G., Fu, L., Hollema, H., van den Berg, A. Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma. BMC Cancer 9 AR 163 DI 10.1186/14712407-9-163 2009. Rikhof, B., van Doorn, J., Suurmeijer, A. J. H., Rautenberg, M. W., Groenen, P. J. T. A., Verdijk, M. A. J., Jager, P. L., de Jong, S., Gietema, J. A., van der Graaf, W. T. A. Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour. Annals of Oncology 20(9): 1582-1588, 2009. Rikhof, B., de Jong, S., Suurmeijer, A. J. H., Meijer, C., van der Graaf, W. T. A. The insulin-like growth factor system and sarcomas. Journal of Pathology 217(4): 469-482, 2009. Robertus, J. L., Harms, G., Blokzijl, T., Booman, M., de Jong, D., van Imhoff, G., Rosati, S., Schuuring, E., Kluin, P., van den Berg, A. Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. Modern Pathology 22(4): 547-555, 2009. Roorda, B. D., ter Elst, A., Diks, S. H., Meeuwsen-de Boer, T. G. J., Kamps, W. A., de Bont, E. S. J. M. PTK787/ZK 222584 inhibits tumor growth promoting mesenchymal stem cells Kinase activity profiling as powerful tool in functional studies. Cancer Biology & Therapy 8(13): 1239-1248, 2009. Russo, S., Kema, I. P., Bosker, F., Haavik, J., Korf, J. Tryptophan as an evolutionarily conserved signal to brain serotonin: Molecular

evidence and psychiatric implications. World Journal of Biological Psychiatry 10(4): 258-268, 2009. Rybczynska, A. A., Elsinga, P. H., Sijbesma, J. W., Ishiwata, K., de Jong, J. R., de Vries, E. F., Dierckx, R. A., van Waarde, A. Steroid hormones affect binding of the sigma ligand C-11-SA4503 in tumour cells and tumour-bearing rats. European Journal of Nuclear Medicine and Molecular Imaging 36(7): 1167-1175, 2009. Sikkema, A. H., Diks, S. H., den Dunnen, W. F. A., ter Elst, A., Scherpen, F. J. G., Hoving, E. W., Ruijtenbeek, R., Boender, P. J., de Wijn, R., Kamps, W. A., Peppelenbosch, M. P., de Bont, E. S. J. M. Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery. Cancer Research 69(14): 5987-5995, 2009. Speetjens, F. M., Kuppen, P. K., Welters, M. J. P., Essahsah, F., van den Brink, A. M. E. G., Lantrua, M. G. K., Valentijn, A. R. P. M., Oostendorp, J., Fathers, L. M., Nijman, H. W., Drijfhout, J. W., van de Velde, C. J. H., Melief, C. J. M., van der Burg, S. H. Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer. Clinical Cancer Research 15(3): 1086-1095, 2009. ten Heuvel, S. E., Hoekstra, H. J., Bastiaannet, E., Suurmeijer, A. J. H. The Classic Prognostic Factors Tumor Stage, Tumor Size, and Tumor Grade are the Strongest Predictors of Outcome in Synovial Sarcoma No Role for SSX Fusion Type or Ezrin Expression. Applied Immunohistochemistry & Molecular Morphology 17(3): 189-195, 2009. van den Broek, G. B., Wildeman, M., Rasch, C. R. N., Armstrong, N., Schuuring, E., Begg, A. C., Looijenga, L. H. J., Scheper, R., van der Wal, J. E., Menkema, L., van Diest, P. J., Balm, A. J. M., van Velthuysen, M. L. F., van den Brekel, M. W. M. Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation. International Journal of Cancer 124(11): 2643-2650, 2009. van der Groep, P., van Diest, P. J., Menko, F. H., Bart, J., de Vries, E. G. E., van der Wall, E. Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers. Journal of Clinical Pathology 62(10): 926-930, 2009. van der Vegt, B., de Bock, G. H., Hollema, H., Wesseling, J. Microarray methods to identify factors determining breast cancer progression: Potentials, limitations, and challenges. Critical Reviews in Oncology Hematology 70(1): 1-11, 2009. van der Vegt, B., de Bock, G. H., Bart, J., Zwartjes, N. G., Wesseling, J. Validation of the 4B5 rabbit monoclonal antibody in determining Her2/neu status in breast cancer. Modern Pathology 22(7): 879-886, 2009. van Hemel, B. M., Buikema, H. J., Groen, H., Suurmeijer, A. J. H. Accuracy of a Low Priced Liquid-Based Method for Cervical Cytology in 632 Women Referred for Colposcopy After a

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Positive Pap Smear. Diagnostic Cytopathology 37(8): 579-583, 2009. van Veelen, W., de Groot, J. W. B., Acton, D. S., Hofstra, R. M. W., Hoppener, J. W. M., Links, T. P., Lips, C. J. M. Medullary thyroid carcinoma and biomarkers: past, present and future. Journal of Internal Medicine 266(1): 126-140, 2009. van Waarde, A., Ramakrishnan, N. K., Rybczynska, A. A., Elsinga, P. H., Berardi, F., de Jong, J. R., Kwizera, C., Perrone, R., Cantore, M., Sijbesma, J. W. A., Dierckx, R. A., Colabufo, N. A. Synthesis and Preclinical Evaluation of Novel PET Probes for P-Glycoprotein Function and Expression. Journal of Medicinal Chemistry 52(14): 4524-4532, 2009. Vangestel, C., van de Wiele, C., Mees, G., Peeters, M. Forcing Cancer Cells to Commit Suicide. Cancer Biotherapy and Radiopharmaceuticals 24(4): 395-407, 2009. Wildeman, M. A. M., Gibcus, J. H., Hauptmann, M., Begg, A. C., van Velthuysen, M. L. F., Hoebers, F. J., Mastik, M. F., Schuuring, E., van der Wal, J. E., van den Brekel, M. W. M. Radiotherapy in Laryngeal Carcinoma: Can a Panel of 13 Markers Predict Response? Laryngoscope 119(2): 316-322, 2009. Woodward, W. A., Bristow, R. G., Clarke, M. F., Coppes, R. P., Cristofanilli, M., Duda, D. G., Fike, J. R., Hambardzumyan, D., Hill, R. P., Jordan, C. T., Milas, L., Pajonk, F., Curran, W. J., Dicker, A. P., Chen, Y. RADIATION THERAPY ONCOLOGY GROUP TRANSLATIONAL RESEARCH PROGRAM STEM CELL SYMPOSIUM: INCORPORATING STEM CELL HYPOTHESES

INTO CLINICAL TRIALS. International Journal of Radiation Oncology Biology Physics 74(5): 1580-1591, 2009. Xu, D. M., van Klaveren, R. J., de Bock, G. H., Leusveld, A. L. M., Dorrius, M. D., Zhao, Y., Wang, Y., de Koning, H. J., Scholten, E. T., Verschakelen, J., Prokop, M., Oudkerk, M. Role of baseline nodule density and changes in density and nodule features in the discrimination between benign and malignant solid indeterminate pulmonary nodules. European Journal of Radiology 70(3): 492-498, 2009. Xu, D. M., van der Zaag-Loonen, H. J., Oudkerk, M., Wang, Y., Vliegenthart, R., Scholten, E. T., Verschakelen, J., Prokop, M., de Koning, H. J., van Klaveren, R. J. Smooth or Attached Solid Indeterminate Nodules Detected at Baseline CT Screening in the NELSON Study: Cancer Risk during 1 Year Follow-up. Radiology 250(1): 264-272, 2009. Yang, N., Eijsink, J. J. H., Lendvai, A., Volders, H. H., Klip, H., Buikema, H. J., van Hemel, B. M., Schuuring, E., van der Zee, A. G. J., Wisman, G. B. A. Methylation Markers for CCNA1 and C13ORF18 Are Strongly Associated with High-Grade Cervical Intraepithelial Neoplasia and Cervical Cancer in Cervical Scrapings. Cancer Epidemiology Biomarkers & Prevention 18(11): 3000-3007, 2009. Zimmermann, M., Armeanu, S., Smirnow, I., Kupka, S., Wagner, S., Wehrmann, M., Rots, M. G., Groothuis, G. M. M., Weiss, T. S., Konigsrainer, A., Gregor, M., Bitzer, M., Lauer, U. M. Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses. International Journal of Oncology 34(5): 1247-1256, 2009.

Research line Clinical Studies

Dissertations
Breeuwsma, A. J. Molecular medicine in staging and restaging of prostate cancer. (2009) Nijman, J. M., Dierckx, R. A. J. O., de Jong, I. J., and Pruim, J. Di Pietro, A. Role of apoptotic pathways in chemosensitivity of testicular germ cell tumour. (2009) de Vries, E. G. E. and Gietema, J. A. Jansen, N. C. A. J. Cognitive functioning of children treated for acute lymphoblastic leukaemia with chemotherapy-only. (2009) Kamps, W. A., Bouma, J. M., and Kingma, A. Karliczek, A. Anastomotic leakage: risk assessment in gastrointestinal surgery. (2009) Wiggers, T. and van Dam, G. Kroon, H. M. Isolated limb infusion. (2009) Hoekstra, H. J., Thomson, J. F., and Chang, A. E. Persoon, A. C. M. New insights in the follow-up of differentiated thyroid carcinoma. (2009) Wolfenbuttel, B. H. R., Jager, P. L., and Links, T. P. Pultrum, B. B. Staging and treatment related problems of locoregional disease in patients with esophageal cancer. (2009) Plukker, J. T. M., Hollema, H., van Dullemen, H. M., and van Dam, G. M.

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Journal articles
Altena, R., Perik, P. J., van Veldhuisen, D. J., de Vries, E. G. E., Gietema, J. A. Cardiovascular toxicity caused by cancer treatment: strategies for early detection. Lancet Oncology 10(4): 391-399, 2009. Altena, R., de Haas, E. C., Nuver, J., Brouwer, C. A. J., van den Berg, M. P., Smit, A. J., Postma, A., Sleijfer, D. T., Gietema, J. A. Evaluation of sub-acute changes in cardiac function after cisplatin-based combination chemotherapy for testicular cancer. British Journal of Cancer 100(12): 1861-1866, 2009. Bastiaannet, E., Hoekstra-Weebers, J. E., Francken, A. B., Jager, P. L., van der Jagt, E. J., Hoekstra, H. J. Perception of burden experienced during diagnostic tests by melanoma patients with lymph node metastases. Melanoma Research 19(1): 36-41, 2009. Bastiaannet, E., Wobbes, T., Hoekstra, O. S., van der Jagt, E. J., Brouwers, A. H., Koelemij, R., de Klerk, J. M. H., Oyen, W. J. G., Meijer, S., Hoekstra, H. J. Prospective Comparison of [F-18] Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography in Patients With Melanoma With Palpable Lymph Node Metastases: Diagnostic Accuracy and Impact on Treatment. Journal of Clinical Oncology 27(28): 4774-4780, 2009. Been, L. B., Hoekstra, H. J., Suurmeijer, A. J. H., Jager, P. L., van der Laan, B. F. A. M., Elsinga, P. H. [F-18]FLT-PET and [F-18]FDG-PET in the evaluation of radiotherapy for laryngeal cancer. Oral Oncology 45(12): E211-E215, 2009. Bijen, C. B. M., de Bock, G. H., ten Hoor, K. A., Nijman, H. W., Hollema, H., Mourits, M. J. E. Role of endocervical curettage in the preoperative staging of endometrial carcinoma. Gynecologic Oncology 112(3): 521-525, 2009. Bijen, C. B. M., Vermeulen, K. M., Mourits, M. J. E., de Bock, G. H. Costs and Effects of Abdominal versus Laparoscopic Hysterectomy: Systematic Review of Controlled Trials. PLoS ONE 4(10 AR e7340 DI 10.1371/journal.pone.0007340) 2009. Bijen, C. B. M., Briet, J. M., de Bock, G. H., Arts, H. J. G., BergsmaKadijk, J. A., Mourits, M. J. E. Total laparoscopic hysterectomy versus abdominal hysterectomy in the treatment of patients with early stage endometrial cancer: A randomized multi center study. BMC Cancer 9 AR 23 DI 10.1186/1471-2407-9-23 2009. Bijen, C. B. M., de Bock, G. H., Mourits, M. J. E. Total laparoscopic hysterectomy versus abdominal hysterectomy with lymphadenectomy for early-stage endometrial cancer: A prospective randomized study. Gynecologic Oncology 113(2): 295, 2009. Bijen, C. B. M., Vermeulen, K. M., Mourits, M. J. E., de Bock, G. H. Costs and Effects of Abdominal versus Laparoscopic Hysterectomy: Systematic Review of Controlled Trials. PLoS ONE 4(10 AR e7340 DI 10.1371/journal.pone.0007340) 2009. Blaauwbroek, R., Bouma, M. J., Tuinier, W., Groenier, K. H., de Greef, M. H. G., de Jong, B., Kamps, W. A., Postma, A. The effect of exercise counselling with feedback from a pedometer on fatigue in adult survivors of childhood cancer: a pilot study. Supportive Care in Cancer 17(8): 1041-1048, 2009. Bocca, G., van Beek, A. P., de Bont, E. S. Grow hormone deficiency in children after radiation for a brain tumor. Quickly start with substitution. Nederlands Tijdschrift voor Geneeskunde 153(17): 792-793, 2009. Breukink, S. O., Wouda, J. C., van der Werf-Eldering, M. J., van de Wiel, H. B. M., Bouma, E. M. C., Pierie, J. P. E. N., Wiggers, T., Meijerink, J. W. J. H., Schultz, W. C. M. W. Psychophysiological Assessment of Sexual Function in Women After Radiotherapy and Total Mesorectal Excision for Rectal Cancer: A Pilot Study on Four Patients. Journal of Sexual Medicine 6(4): 1045-1053, 2009. Buijs, C., Willemse, P. H. B., de Vries, E. G. E., ten Hoor, K. A., Boezen, H. M., Hollema, H., Mourits, M. J. E. Effect of Tamoxifen on the Endometrium and the Menstrual Cycle of Premenopausal Breast Cancer Patients. International Journal of Gynecological Cancer 19(4): 677-681, 2009. Buijs, C., Mom, C. H., Willemse, P. H. B., Boezen, H. M., Maurer, J. M., Wymenga, A. N. M., de Jong, R. S., Nieboer, P., de Vries, E. G. E., Mourits, M. J. E. Venlafaxine versus clonidine for the treatment of hot flashes in breast cancer patients: a double-blind, randomized cross-over study. Breast Cancer Research and Treatment 115(3): 573-580, 2009. Chianelli, M., Todino, V., Graziano, F. M., Panunzi, C., Pace, D., Guglielmi, R., Signore, A., Papini, E. Low-activity (2.0 GBq; 54 mCi) radioiodine post-surgical remnant ablation in thyroid cancer: comparison between hormone withdrawal and use of rhTSH in low-risk patients. European Journal of Endocrinology 160(3): 431-436, 2009. de Bock, G. H., Putter, H., Bonnema, J., van der Hage, J. A., Bartelink, H., van de Velde, C. J. The impact of loco-regional recurrences on metastatic progression in early-stage breast cancer: a multistate model. Breast Cancer Research and Treatment 117(2): 401-408, 2009. de Bruin, D., de Jong, I. J., Arts, E. G. J. M., Nuver, J., Dullaart, R. P. F., Sluiter, W. J., Hoekstra, H. J., Sleijfer, D. T., Gietema, J. A. Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones. Fertility and Sterility 91(6): 2481-2486, 2009. de Graeff, P., Crijns, A. P. G., de Jong, S., Boezen, M., Post, W. J., de Vries, E. G. E., van der Zee, A. G. J., de Bock, G. H. Modest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian

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cancer: a meta-analysis. British Journal of Cancer 101(1): 149159, 2009. de Haas, E. C., Zwart, N., Meijer, C., Nuver, J., Boezen, H. M., Suurmeijer, A. J., Hoekstra, H. J., van der Steege, G., Sleijfer, D. T., Gieterna, J. A. Variation in Bleomycin Hydrolase Gene is Associated With Reduced Survival After Chemotherapy for Testicular Germ Cell Cancer. Journal of Urology 181(2): 639, 2009. de Vries, M., Hoekstra, H. J., Hoekstra-Weebers, J. E. H. M. Quality of Life After Axillary or Groin Sentinel Lymph Node Biopsy, With or Without Completion Lymph Node Dissection, in Patients With Cutaneous Melanoma. Annals of Surgical Oncology 16(10): 2840-2847, 2009. Dreijerink, K. M. A., Varier, R. A., van Nuland, R., Broekhuizen, R., Valk, G. D., van der Wal, J. E., Lips, C. J. M., Kummer, J. A., Timmers, H. T. M. Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas. Molecular and Cellular Endocrinology 313(1-2): 1-8, 2009. Eijsink, J. J. H., de Bock, G. H., Kuiper, J. L., Reesink-Peters, N., van Hemel, B. M., Hollema, H., Nijman, H. W., Mourits, M. J. E., van der Zee, A. G. J. Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after Large Loop Excision of the Transformation Zone (LLETZ). Gynecologic Oncology 113(3): 348-351, 2009. Engelen, M. J. A., Snel, B. J., Schaapueld, M., Pras, E., de Vries, E. G. E., Gietema, J. A., van der Zee, A. G. J., Willemse, P. H. B. Longterm morbidity of adjuvant whole abdominal radiotherapy (WART) or chemotherapy for early stage ovarian cancer. European Journal of Cancer 45(7): 1193-1200, 2009. Fiebrich, H. B., Brouwers, A. H., Kerstens, M. N., Pijl, M. E. J., Kema, I. P., de Jong, J. R., Jager, P. L., Elsinga, P. H., Dierckx, R. A. J. O., van der Wal, J. E., Sluiter, W. J., de Vries, E. G. E., Links, T. P. 6-[F18]Fluoro-L-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to Conventional Imaging with I-123Metaiodobenzylguanidine Scintigraphy, Computer Tomography, and Magnetic Resonance Imaging in Localizing Tumors Causing Catecholamine Excess. Journal of Clinical Endocrinology & Metabolism 94(10): 3922-3930, 2009. Fons, G., Groenen, S. M. A., Oonk, M. H. M., Ansink, A. C., van der Zee, A. G. J., Burger, M. P. M., Stalpers, L. J. A., van der Velden, J. Adjuvant radiotherapy in patients with vulvar cancer and one intra capsular lymph node metastasis is not beneficial. Gynecologic Oncology 114(2): 343-345, 2009. Franssen, S. J., Lagarde, S. M., van Werven, J. R., Smets, E. M. A., Tran, K. T. C., Plukker, J. T. M., van Lanschot, J. J. B., de Haes, H. C. J. M. Psychological factors and preferences for communicating prognosis in esophageal cancer patients. Psycho-Oncology 18(11): 1199-1207, 2009.

Garcia, E. B. G., Oosterwijk, J. C., Timmermans, M., van Asperen, C. J., Hogervorst, F. B. L., Hoogerbrugge, N., Oldenburg, R., Verhoef, S., Dommering, C. J., Ausems, M. G. E. M., Van Os, T. A. M., van der Hout, A. H., Ligtenberg, M., van den Ouweland, A., van der Luijt, R. B., Wijnen, J. T., Gille, J. J. P., Lindsey, P. J., Devilee, P., Blok, M. J., Vreeswijk, M. P. G. A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history. Breast Cancer Research 11(1 AR R8 DI 10.1186/bcr2223) 2009. Gazendam-Donofrio, S., Hoekstra, H., van der Graaf, W., van de Wiel, H., Visser, A., Huizinga, G., Hoekstra-Weebers, J. ParentChild Communication Patterns During the First Year After a Parent's Cancer Diagnosis The Effect on Parents' Functioning. Cancer 115(18): 4227-4237, 2009. Giro, C., Berger, B., Bolke, E., Ciernik, I. F., Duprez, F., Locati, L., Maillard, S., Ozsahin, M., Pfeffer, R., Robertson, A. G., Langendijk, J. A., Budach, W. High rate of severe radiation dermatitis during radiation therapy with concurrent cetuximab in head and neck cancer: Results of a survey in EORTC institutes. Radiotherapy and Oncology 90(2): 166-171, 2009. Groen, E. J., Roos, A., Muntinghe, F. L., Enting, R. H., de Vries, J., Kleibeuker, J. H., Witjes, M. J. H., Links, T. P., van Beek, A. P. Patients with Familial Adenomatous Polyposis Reply. Annals of Surgical Oncology 16(5): 1449-1450, 2009. Halmos, G. B., van der Laan, B. F. A. M., Dikkers, F. G. Groningen Dilatation Tracheoscope in Treatment of Moderate Subglottic and Tracheal Stenosis. Annals of Otology Rhinology and Laryngology 118(5): 329-335, 2009. Honing, J., Pultrum, B. B., van der Jagt, E. J., Groen, H., Plukker, J. T. M. Routine or on Demand Radiological Contrast Examination in the Diagnosis of Anastomotic Leakage After Esophagectomy. Journal of Surgical Oncology 100(8): 699-702, 2009. Honing, J., Pultrum, B. B., van der Jagt, E. J., Groen, H., Plukker, J. T. M. Routine or on Demand Radiological Contrast Examination in the Diagnosis of Anastomotic Leakage After Esophagectomy. Journal of Surgical Oncology 100(8): 699-702, 2009. Hospers, G. A. P., Meijer, C., Dam, W. A., Roossink, F., Mulder, N. H. Construction of a triple modified p53 containing DNA vaccine to enhance processing and presentation of the p53 antigen. Vaccine 28(2): 386-391, 2009. Jacobi, C. E., de Bock, G. H., Siegerink, B., van Asperen, C. J. Differences and similarities in breast cancer risk assessment models in clinical practice: which model to choose? Breast Cancer Research and Treatment 115(2): 381-390, 2009. Jager-Wittenaar, H., Dijkstra, P. U., Vissink, A., van Oort, R. P., Roodenburg, J. L. N. Variation in repeated mouth-opening measurements in head and neck cancer patients with and without trismus. International Journal of Oral and Maxillofacial Surgery 38(1): 26-30, 2009.

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Karliczek, A., Benaron, D. A., Zeebregts, C. J., Wiggers, T., van Dam, G. M. Intraoperative Ischemia of the Distal End of Colon Anastomoses as Detected With Visible Light Spectroscopy Causes Reduction of Anastomotic Strength. Journal of Surgical Research 152(2): 288-295, 2009. Karliczek, A., Harlaar, N. J., Zeebregts, C. J., Wiggers, T., Baas, P. C., van Dam, G. M. Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery. International Journal of Colorectal Disease 24(5): 569-576, 2009. Kelder, W., Inberg, B., Schaapveld, M., Karrenbeld, A., Grond, J., Wiggers, T., Plukker, J. T. Impact of the Number of Histologically Examined Lymph Nodes on Prognosis in Colon Cancer: A Population-Based Study in The Netherlands. Diseases of the Colon & Rectum 52(2): 260-267, 2009. Kelder, W., Inberg, B., Schaapveld, M., Karrenbeld, A., Grond, J., Wiggers, T., Plukker, J. T. Impact of the Number of Histologically Examined Lymph Nodes on Prognosis in Colon Cancer: A Population-Based Study in The Netherlands. Diseases of the Colon & Rectum 52(2): 260-267, 2009. Koopmans, K. P., Neels, O. N., Kema, I. P., Elsinga, P. H., Links, T. P., de Vries, E. G. E., Jager, P. L. Molecular imaging in neuroendocrine tumors: Molecular uptake mechanisms and clinical results. Critical Reviews in Oncology Hematology 71(3): 199-213, 2009. Koornstra, J. J., de Vries, E. G. E., Porte, R. J. Improvements in small bowel carcinoid diagnosis and staging: 18F-DOPA PET, capsule endoscopy and double balloon enteroscopy. Digestive and Liver Disease 41(7): e35-e38, 2009. Koornstra, J. J., Mourits, M. J. E., Sijmons, R. H., Leliveld, A. M., Hollema, H., Kleibeuker, J. H. Management of extracolonic tumours in patients with Lynch syndrome. Lancet Oncology 10(4): 400-408, 2009. Krabbe, C. A., Pruim, J., Dijkstra, P. U., Balink, H., van der Laan, B. F., de Visscher, J. G., Roodenburg, J. L. F-18-FDG PET as a Routine Posttreatment Surveillance Tool in Oral and Oropharyngeal Squamous Cell Carcinoma: A Prospective Study. Journal of Nuclear Medicine 50(12): 1940-1947, 2009. Krabbe, C. A., Pruim, J., van der Laan, B. F. A. M., Rodiger, L. A., Roodenburg, J. L. N. FDG-PET and detection of distant metastases and simultaneous tumors in head and neck squamous cell carcinoma: A comparison with chest radiography and chest CT. Oral Oncology 45(3): 234-240, 2009. Kruijff, S., Bastiaannet, E., Kobold, A. C. M., van Ginkel, R. J., Suurmeijer, A. J. H., Hoekstra, H. J. S-100B Concentrations Predict Disease-Free Survival in Stage III Melanoma Patients. Annals of Surgical Oncology 16(12): 3455-3462, 2009. Kruizinga, R. C., Bestebroer, J., Berghuis, P., de Haas, C. J. C., Links, T. P., de Vries, E. G. E., Walenkamp, A. M. E. Role of Chemokines GUIDE Annual Publication Report 2009 59

and Their Receptors in Cancer. Current Pharmaceutical Design 15(29): 3396-3416, 2009. Leffers, N., Lambeck, A. J. A., Gooden, M. J. M., Hoogeboom, B. N., Wolf, R., Hamming, I. E., Hepkema, B. G., Willemse, P. H. B., Molmans, B. H. W., Hollema, H., Drijfhout, J. W., Sluiter, W. J., Valentijn, A. R. P. M., Fathers, L. M., Oostendorp, J., van der Zee, A. G. J., Melief, C. J., van der Burg, S. H., Daemen, T., Nijman, H. W. Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial. International Journal of Cancer 125(9): 2104-2113, 2009. Lu, W. L., Jansen, L., Post, W. J., Bonnema, J., Van de Velde, J. C., de Bock, G. H. Impact on survival of early detection of isolated breast recurrences after the primary treatment for breast cancer: a meta-analysis. Breast Cancer Research and Treatment 114(3): 403-412, 2009. Lu, W. L., Schaapveld, M., Jansen, L., Bagherzadegan, E., Sahinovic, M. M., Baas, P. C., Hanssen, L. M. H. C., van der Mijle, H. C. J., Brandenburg, J. D., Wiggers, T., de Bock, G. H. The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer. European Journal of Cancer 45(17): 3000-3007, 2009. Lubinski, J., Sijmons, R. H., Scott, R. J. Hereditary Cancer in Clinical Practice transfers to BioMed Central. Hereditary Cancer in Clinical Practice 7 AR 1 DI 10.1186/1897-4287-7-1 2009. Meek, M. F., Wolf, R., Coert, J. H., Hoekstra, H. J., Nicolai, J. P. A. Plexiform malignant peripheral nerve sheath tumour of infancy and childhood of the index finger: Surgical treatment. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 43(4): 230-235, 2009. Melchers, L. J., van Weert, E., Beurskens, C. H. G., Reintsema, H., Slagter, A. P., Roodenburg, J. L. N., Dijkstra, P. U. Exercise adherence in patients with trismus due to head and neck oncology: a qualitative study into the use of the Therabite (R). International Journal of Oral and Maxillofacial Surgery 38(9): 947-954, 2009. Mom, C. H., Verweij, J., Oldenhuis, C. N. A. M., Gietema, J. A., Fox, N. L., Miceli, R., Eskens, F. A. L. M., Loos, W. J., de Vries, E. G. E., Sleijfer, S. Mapatumumab, a Fully Human Agonistic Monoclonal Antibody That Targets TRAIL-R1, in Combination with Gemcitabine and Cisplatin: a Phase I Study. Clinical Cancer Research 15(17): 5584-5590, 2009. Mourits, M. J., de Bock, G. H. Managing hereditary ovarian cancer. Maturitas 64(3): 172-176, 2009. Mourits, M. J., de Bock, G. H. Ovarian cancer Symptoms are not early signs of ovarian cancer. British Medical Journal 339 AR b3955 DI 10.1136/bmj.b3955 2009.

Mourits, M. J. E., Bijen, C. B. M., de Bock, G. H. Lymphadenectomy in endometrial cancer. Lancet 373(9670): 1169, 2009. Muijs, C. T., Schreurs, L. M., Busz, D. M., Beukema, J. C., van der Borden, A. J., Pruim, J., van der Jagt, E. J., Plukker, J. T., Langendijk, J. A. Consequences of additional use of PET information for target volume delineation and radiotherapy dose distribution for esophageal cancer. Radiotherapy and Oncology 93(3): 447453, 2009. Muijs, C. T., Beukema, J. C., Mul, V. E., Langendijk, J. A. IN RESPONSE TO: STUDY TO DETERMINE ADEQUATE MARGINS IN RADIOTHERAPY PLANNING FOR ESOPHAGEAL CARCINOMA BY DETAILING PATTERNS OF RECURRENCE AFTER DEFINITIVE CHEMORADIOTHERAPY. International Journal of Radiation Oncology Biology Physics 75(5): 1623, 2009. Nout, R. A., Putter, H., Jurgenliemk-Schulz, I. M., Jobsen, J. J., Lutgens, L. C. H. W., Van der Steen-Banasik, E. M., Mens, J. W. M., Slot, A., Kroese, M. C. S., van Bunningen, B. N. F. M., Smit, V. T. H. B., Nijman, H. W., van den Tol, P. P., Creutzberg, C. L. Quality of Life After Pelvic Radiotherapy or Vaginal Brachytherapy for Endometrial Cancer: First Results of the Randomized PORTEC-2 Trial. Journal of Clinical Oncology 27(21): 3547-3556, 2009. Oonk, M. H. M., van Os, M. A., de Bock, G. H., De Hullu, J. A., Ansink, A. C., van der Zee, A. G. J. A comparison of quality of life between vulvar cancer patients after sentinel lymph node procedure only and inguinofemoral lymphadenectomy. Gynecologic Oncology 113(3): 301-305, 2009. Oonk, M. H. M., van de Nieuwenhof, H. P., De Hullu, J. A., van der Zee, A. G. J. The role of sentinel node biopsy in gynecological cancer: a review. Current Opinion in Oncology 21(5): 425-432, 2009. Oosting, S., Nagengast, W., de Vries, E. More on Bevacizumab in Hereditary Hemorrhagic Telangiectasia. New England Journal of Medicine 361(9): 931, 2009. Poos, H. P. A. M., Kruijff, S., Bastiaannet, E., van Ginkel, R. J., Hoekstra, H. J. Therapeutic groin dissection for melanoma: Risk factors for short term morbidity. EJSO 35(8): 877-883, 2009. Pultrum, B. B., Honing, J., Smit, J. K., van Dullemen, H. M., van Dam, G. M., Groen, H., Hollema, H., Plukker, J. Th. A Critical Appraisal of Circumferential Resection Margins in Esophageal Carcinoma. Annals of Surgical Oncology : 1-9, 2009. Pultrum, B. B., van der Jagt, E. J., van Westreenen, H. L., van Dullemen, H. M., Kappert, P., Groen, H., Sietsma, J., Oudkerk, M., Plukker, J. Th, van Dam, G. M. Detection of lymph node metastases with ultrasmall super paramagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging in oesophageal cancer: A feasibility study. Cancer Imaging 9(1): 19-28, 2009.

Rickelt, J., Hoekstra, H., van Coevorden, F., de Vreeze, R., Verhoef, C., van Geel, A. N. Forequarter amputation for malignancy. British Journal of Surgery 96(7): 792-798, 2009. Rikhof, B., van Doorn, J., Suurmeijer, A. J. H., Rautenberg, M. W., Groenen, P. J. T. A., Verdijk, M. A. J., Jager, P. L., de Jong, S., Gietema, J. A., van der Graaf, W. T. A. Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour. Annals of Oncology 20(9): 1582-1588, 2009. Rinkel, R. N., Verdonck-de Leeuw, I. M., Langendijk, J. A., van Reij, E. J., Aaronson, N. K., Leemans, C. R. The psychometric and clinical validity of the SWAL-QOL questionnaire in evaluating swallowing problems experienced by patients with oral and oropharyngeal cancer. Oral Oncology 45(8): E67-E71, 2009. Ruers, T. J. M., Wiering, B., van der Sijp, J. R. M., Roumen, R. M., de Jong, K. P., Comans, E. F. I., Pruim, J., Dekker, H. M., Krabbe, P. F. M., Oyen, W. J. G. Improved Selection of Patients for Hepatic Surgery of Colorectal Liver Metastases with F-18-FDG PET: A Randomized Study. Journal of Nuclear Medicine 50(7): 10361041, 2009. Ruers, T. J. M., Wiering, B., van der Sijp, J. R. M., Roumen, R. M., de Jong, K. P., Comans, E. F. I., Pruim, J., Dekker, H. M., Krabbe, P. F. M., Oyen, W. J. G. Improved Selection of Patients for Hepatic Surgery of Colorectal Liver Metastases with F-18-FDG PET: A Randomized Study. Journal of Nuclear Medicine 50(7): 10361041, 2009. Schrijvers, M. L., van Riel, E. L., Langendijk, J. A., Dikkers, F. G., Schuuring, E., van der Wal, J. E., van der Laan, B. F. A. M. HIGHER LARYNGEAL PRESERVATION RATE AFTER CO2 LASER SURGERY COMPARED WITH RADIOTHERAPY IN T1A GLOTTIC LARYNGEAL CARCINOMA. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 31(6): 759764, 2009. Smit, E. F., Burgers, S. A., Biesma, B., Smit, H. J. M., Eppinga, P., Dingemans, A. M. C., Joerger, M., Schellens, J. H., Vincent, A., van Zandwijk, N., Groen, H. J. M. Randomized Phase II and Pharmacogenetic Study of Pemetrexed Compared With Pemetrexed Plus Carboplatin in Pretreated Patients With Advanced Non-Small-Cell Lung Cancer. Journal of Clinical Oncology 27(12): 2038-2045, 2009. Stigt, J. A., Oostdijk, A. H., Timmer, P. R., Shahin, G. M., Boers, J. E., Groen, H. M. Comparison of EUS-guided fine needle aspiration and integrated PET-CT in restaging after treatment for locally advanced non-small cell lung cancer. Lung Cancer 66(2): 198204, 2009. Tates, K., Zwaanswijk, M., Otten, R., van Dulmen, S., Hoogerbrugge, P. M., Kamps, W. A., Bensing, J. M. Online focus groups as a tool to collect data in hard-to-include populations: examples from

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paediatric oncology. BMC Medical Research Methodology 9 AR 15 DI 10.1186/1471-2288-9-15 2009. ten Heuvel, S. E., Hoekstra, H. J., Bastiaannet, E., Suurmeijer, A. J. H. The Classic Prognostic Factors Tumor Stage, Tumor Size, and Tumor Grade are the Strongest Predictors of Outcome in Synovial Sarcoma No Role for SSX Fusion Type or Ezrin Expression. Applied Immunohistochemistry & Molecular Morphology 17(3): 189-195, 2009. Tromp, Y. H., Daenen, S. M. G. J., Sluiter, W. J., Vellenga, E. The predictive value of interleukin-8 (IL-8) in hospitalised patients with fever and chemotherapy-induced neutropenia. European Journal of Cancer 45(4): 596-600, 2009. van de Water, T. A., Bijl, H. P., Westerlaan, H. E., Langendijk, J. A. Delineation guidelines for organs at risk involved in radiationinduced salivary dysfunction and xerostomia. Radiotherapy and Oncology 93(3): 545-552, 2009. van den Belt-Dusebout, A. W., Aleman, B. M. P., Besseling, G., de Bruin, M. L., Hauptmann, M., van 't Veer, M. B., de Wit, R., Ribot, J. G., Noordijk, E. M., Kerst, J. M., Gietema, J. A., van Leeuwen, F. E. ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY. International Journal of Radiation Oncology Biology Physics 75(5): 1420-1429, 2009. van der Haring, I. S., Schaapveld, M. S., Roodenburg, J. L. N., de Bock, G. H. Second primary tumours after a squamous cell carcinoma of the oral cavity or oropharynx using the cumulative incidence method. International Journal of Oral and Maxillofacial Surgery 38(4): 332-338, 2009. van der Horst-Schrivers, A. N. A., van Ieperen, E., Wymenga, A. N. M., Boezen, H. M., Weijmar-Schultz, W. C. M., Kema, I. P., Meijer, W. G., de Herder, W. W., Willemse, P. H. B., Links, T. P., de Vries, E. G. E. Sexual Function in Patients with Metastatic Midgut Carcinoid Tumours. Neuroendocrinology 89(2): 231236, 2009. van der Velde, N. M., Mourits, M. J. E., Arts, H. J. G., de Vries, J., Leegte, B. K., Dijkhuis, G., Osterwijk, J. C., de Bock, G. H. Time to stop ovarian cancer screening in BRCA1/2 mutation carriers? International Journal of Cancer 124(4): 919-923, 2009. van der Zee, A. G. J., de Vries, E. G. E., Schaapveld, M., Willemse, P. H. B. Limitations of observational research [1]. Nederlands Tijdschrift voor Geneeskunde 153(3): 102, 2009. van der Zee, A. G. J., Engelen, M. J. A., Schaapveld, M., Karim-Kos, H. E., de Vries, E. G. E., Willemse, P. H. B., Otter, R. Primary surgery by gynecological oncologist improves the prognosis of patients with ovarian carcinoma. Nederlands Tijdschrift voor Geneeskunde 153(1-2): 15-19, 2009. van Gaal, J. C., Bastiaannet, E., Schaapveld, M., Otter, R., KluinNelemans, J. C., de Bont, E. S. J. M., van der Graaf, W. T. A. GUIDE Annual Publication Report 2009 61

Cancer in adolescents and young adults in north Netherlands (1989-2003): increased incidence, stable survival and high incidence of second primary tumours. Annals of Oncology 20(2): 365-373, 2009. van Klaveren, R. J., Oudkerk, M., Prokop, M., Scholten, E. T., Nackaerts, K., Vernhout, R., van Iersel, C. A., van den Bergh, K. A. M., van't Westeinde, S., van der Aalst, C., Thunnissen, E., Xu, D. M., Wang, Y., Zhao, Y. R., Gietema, H. A., de Hoop, B. J., Groen, H. J. M., de Bock, G. H., van Ooijen, P., Weenink, C., Verschakelen, J., Lammers, J. W. J., Timens, W., Willebrand, D., Vink, A., Mali, W., de Koning, H. J. Management of Lung Nodules Detected by Volume CT Scanning. New England Journal of Medicine 361(23): 2221-2229, 2009. van Luijk, P., Faber, H., Schippers, J. M., Brandenburg, S., Langendijk, J. A., Meertens, H., Coppes, R. P. BATH AND SHOWER EFFECTS IN THE RAT PAROTID GLAND EXPLAIN INCREASED RELATIVE RISK OF PAROTID GLAND DYSFUNCTION AFTER INTENSITYMODULATED RADIOTHERAPY. International Journal of Radiation Oncology Biology Physics 74(4): 1002-1005, 2009. van Veelen, W., de Groot, J. W. B., Acton, D. S., Hofstra, R. M. W., Hoppener, J. W. M., Links, T. P., Lips, C. J. M. Medullary thyroid carcinoma and biomarkers: past, present and future. Journal of Internal Medicine 266(1): 126-140, 2009. Vergeer, M. R., Doornaert, P. A. H., Rietveld, D. H. F., Leemans, C. R., Slotman, B. J., Langendijk, J. A. INTENSITY-MODULATED RADIOTHERAPY REDUCES RADIATION-INDUCED MORBIDITY AND IMPROVES HEALTH-RELATED QUALITY OF LIFE: RESULTS OF A NONRANDOMIZED PROSPECTIVE STUDY USING A STANDARDIZED FOLLOW-UP PROGRAM. International Journal of Radiation Oncology Biology Physics 74(1): 1-8, 2009. Vissink, A., Raghoebar, G. M., Roodenburg, J. L. N., Reintsema, H., Spijkervet, F. K. L., Witjes, M. J. H., Schoen, P. J., Bouma, J., Burlage, F. R., Langendijk, J. A. Does hyperbaric oxygen therapy improve quality of life? International Journal of Oral and Maxillofacial Surgery 38(1): 99-100, 2009. Vos, M. D., Raghoebar, G. M., van der Wal, J. E., Kalk, W. W. I., Vissink, A. Autogenous femoral head as grafting material for mandibular augmentation. International Journal of Oral and Maxillofacial Surgery 38(12): 1320-1323, 2009. Vos, M. D., Raghoebar, G. M., van der Wal, J. E., Kalk, W. W. I., Vissink, A. Autogenous femoral head as grafting material for mandibular augmentation. International Journal of Oral and Maxillofacial Surgery 38(12): 1320-1323, 2009. Walenkamp, A. M. E., Sonke, G. S., Sleijfer, D. T. Clinical and therapeutic aspects of extrapulmonary small cell carcinoma. Cancer Treatment Reviews 35(3): 228-236, 2009. Wedman, J., Pruim, J., Langendijk, J. A., van der Laan, B. F. A. M. Visualization of small glottic laryngeal cancer using methyl-

labeled C-11-methionine positron emission tomography. Oral Oncology 45(8): 703-705, 2009. Wolberink, S. V. R. C., Beets-Tan, R. G. H., de Haas-Kock, D. F. M., van de Jagt, E. J., Span, M. M., Wiggers, T. Multislice CT as a Primary Screening Tool for the Prediction of an Involved Mesorectal Fascia and Distant Metastases in Primary Rectal Cancer: A Multicenter Study. Diseases of the Colon & Rectum 52(5): 928-934, 2009. Wolberink, S. V. R. C., Beets-Tan, R. G. H., Haas-Kock, D. F. M., van de Jagt, E. J., Span, M. M., Wiggers, T. Multislice CT as a Primary

Screening Tool for the Prediction of an Involved Mesorectal Fascia and Distant Metastases in Primary Rectal Cancer: A Multicenter Study. Diseases of the Colon & Rectum 52(5): 928934, 2009. Xu, D. M., van Klaveren, R. J., de Bock, G. H., Leusveld, A. L. M., Dorrius, M. D., Zhao, Y., Wang, Y., de Koning, H. J., Scholten, E. T., Verschakelen, J., Prokop, M., Oudkerk, M. Role of baseline nodule density and changes in density and nodule features in the discrimination between benign and malignant solid indeterminate pulmonary nodules. European Journal of Radiology 70(3): 492-498, 2009.

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INSTITUTE FOR BIOPHARMACEUTICALS: DISCOVERY, DESIGN AND DELIVERY - BDDD

Research line Pharmaceutical Biology
Dissertations
Krzeslak, J. K. Pseudomonas as a microbial enzyme factory. The source of industrially potent enzymes and the hist for heterologous enzyme production. (2009) Quax, W. J.

Journal articles
Aslan, S., Kartal, M., Kurucu, S., Kuiper, J. M., Kruizinga, W. H., Bos, R., Woerdenbag, H. J., Kayser, O. Composition of the Essential Oil From Roots and Rhizomes of Valeriana phu L. Growing Wild in Turkey. Journal of Essential Oil Research 21(5): 437-440, 2009. Azizi, M., Davareenejad, G., Bos, R., Woerdenbag, H. J., Kayser, O. Essential Oil Content and Constituents of Black Zira (Bunium persicum [Boiss.] B. Fedtsch.) From Iran During Field Cultivation (Domestication) (vol 21, pg 78, 2009). Journal of Essential Oil Research 21(3): 193-194, 2009. Dubois, J. Y. F., Kouwen, T. R. H. M., Schurich, A. K. C., Reis, C. R., Ensing, H. T., Trip, E. N., Zweers, J. C., van Dijl, J. M. Immunity to the Bacteriocin Sublancin 168 Is Determined by the SunI (YolF) Protein of Bacillus subtilis. Antimicrobial Agents and Chemotherapy 53(2): 651-661, 2009. Duiker, E. W., de Vries, E. G. E., Mahalingam, D., Meersma, G. J., Ek, W. B. V., Hollema, H., Hooge, M. N. L. D., van Dam, G. M., Cool, R. H., Quax, W. J., Samali, A., van der Zee, A. G. J., de Jong, S. Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model. Clinical Cancer Research 15(6): 20482057, 2009. Griewel, A., Kayser, O., Schlosser, J., Rarey, M. Conformational Sampling for Large-Scale Virtual Screening: Accuracy versus Ensemble Size. Journal of Chemical Information and Modeling 49(10): 2303-2311, 2009. Krzeslak, J., Braun, P., Voulhoux, R., Cool, R. H., Quax, W. J. Heterologous production of Escherichia coli penicillin G acylase in Pseudomonas aeruginosa. Journal of Biotechnology 142(3-4): 250-258, 2009. Limsuwan, S., Trip, E. N., Kouwen, T. R. H. M., Piersma, S., Hiranrat, A., Mahabusarakam, W., Voravuthikunchai, S. P., van Dijl, J. M., Kayser, O. Rhodomyrtone: A new candidate as natural antibacterial drug from Rhodomyrtus tomentosa. Phytomedicine 16(6-7): 645-651, 2009. Muntendam, R., Melillo, E., Ryden, A., Kayser, O. Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts. Applied Microbiology and Biotechnology 84(6): 10031019, 2009. Ozbay, O., Aslan, S., Kartal, M., Kurucu, S., Bos, R., Woerdenbag, H. J., Kayser, O. Preliminary Examination of the Composition of the Essential Oil From the Roots and Rhizomes of Valeriana alpestris Stev. Growing in Turkey. Journal of Essential Oil Research 21(6): 555-557, 2009. Papaioannou, E., Wahjudi, M., Nadal-Jimenez, P., Koch, G., Setroikromo, R., Quax, W. J. Quorum-Quenching Acylase Reduces the Virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans Infection Model. Antimicrobial Agents and Chemotherapy 53(11): 4891-4897, 2009. Raj, H., Weiner, B., Veetil, V. P., Reis, C. R., Quax, W. J., Janssen, D. B., Feringa, B. L., Poelarends, G. J. Alteration of the Diastereoselectivity of 3-Methylaspartate Ammonia Lyase by Using Structure-Based Mutagenesis. ChemBioChem 10(13): 2236-2245, 2009. Reis, C. R., van der Sloot, A. M., Szegezdi, E., Natoni, A., Tur, V., Cool, R. H., Samali, A., Serrano, L., Quax, W. J. Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase toward Its Death Receptors. Biochemistry 48(10): 2180-2191, 2009. Staniek, A., Woerdenbag, H. J., Kayser, O. Taxomyces andreanae: A Presumed Paclitaxel Producer Demystified? Planta Medica 75(15): 1561-1566, 2009. Veetil, V. P., Raj, H., Quax, W. J., Janssen, D. B., Poelarends, G. J. Sitedirected mutagenesis, kinetic and inhibition studies of aspartate ammonia lyase from Bacillus sp YM55-1. Febs Journal 276(11): 2994-3007, 2009. Wu, B., Szymanski, W., Wietzes, P., de Wildeman, S., Poelarends, G. J., Feringa, B. L., Janssen, D. B. Enzymatic Synthesis of Enantiopure alpha- and beta-Amino Acids by Phenylalanine Aminomutase-Catalysed Amination of Cinnamic Acid Derivatives. ChemBioChem 10(2): 338-344, 2009.

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Research line Pharmacokinetics and Drug Delivery

Dissertations
Khan, A. A. Regulation of metabolizing enzymes and transporters for drugd and bile salts in human and rat intestine and liver. A study with precision-cut slices. (2009) Groothuis, G. M. M.

Journal articles
Bakker, W. W., Henning, R. H., van Son, W. J., van Pampus, M. G., Aarnoudse, J. G., Niezen-Koning, K. E., Borghuis, T., Jongman, R. M., van Goor, H., Poelstra, K., Navis, G., Faas, M. M. Vascular Contraction and Preeclampsia Downregulation of the Angiotensin Receptor 1 by Hemopexin In Vitro. Hypertension 53(6): 959-U127, 2009. Chow, E. C. Y., Maeng, H. J., Liu, S. J., Khan, A. A., Groothuis, G. M. M., Pang, K. S. 1 alpha,25-Dihydroxyvitamin D-3 Triggered Vitamin D Receptor and Farnesoid X Receptor-like Effects in Rat Intestine and Liver In Vivo. Biopharmaceutics & Drug Disposition 30(8): 457-475, 2009. Khan, A. A., Chow, E. C. Y., van Loenen-Weemaes, A. M. M. A., Porte, R. J., Pang, K. S., Groothuis, G. M. M. Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. European Journal of Pharmaceutical Sciences 37(2): 115125, 2009. Khan, A. A., Chow, E. C. Y., Porte, R. J., Pang, K. S., Groothuis, G. M. M. Expression and Regulation of the Bile Acid Transporter, OST alpha-OST beta in Rat and Human Intestine and Liver. Biopharmaceutics & Drug Disposition 30(5): 241-258, 2009. Prakash, J., Bansal, R., Post, E., de Jager-Krikken, A., Lub-de Hooge, M. N., Poelstra, K. Albumin-Binding and Tumor Vasculature Determine the Antitumor Effect of 15-Deoxy-Delta(12,14)Prostaglandin-J(2) In Vivo. Neoplasia 11(12): 1348-1358, 2009. Rachmawati, H., Beljaars, L., Reker-Smit, C., Bakker, H. I., van Loenen-Weemaes, A. M., Poelstra, K. A Study on the Effects of IL-10 in Anti-Thy 1-Induced Glomerulonephritis in Rats. International Journal of Pharmacology 5(6): 346-353, 2009. Szalowska, E., Elferink, M. G. L., Hoek, A., Groothuis, G. M. M., Vonk, R. J. Resistin Is More Abundant in Liver Than Adipose Tissue and Is Not Up-Regulated by Lipopolysaccharide. Journal of Clinical Endocrinology & Metabolism 94(8): 3051-3057, 2009. Tuin, A., Poelstra, K., de Jager-Krikken, A., Bok, L., Raaben, W., Velders, M. P., Dijkstra, G. Role of alkaline phosphatase in colitis in man and rats. Gut 58(3): 379-387, 2009. Zimmermann, M., Armeanu, S., Smirnow, I., Kupka, S., Wagner, S., Wehrmann, M., Rots, M. G., Groothuis, G. M. M., Weiss, T. S., Konigsrainer, A., Gregor, M., Bitzer, M., Lauer, U. M. Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses. International Journal of Oncology 34(5): 1247-1256, 2009.

Research line Pharmaceutical Technology and BioPharmacy

Dissertations
Westerman, E. M. Studies on antibiotic aerosols for inhalation in cystic fibrosis. (2009) Frijlink, H. W. Zijlstra, G. S. Dry powder inhalation of biopharmaceuticals from formulation to proof-of-concept. (2009) Frijlink, H. W.

Journal articles
Bolhuis, G. K., Engelhart, J. J. P., Eissens, A. C. Compaction properties of isomalt. European Journal of Pharmaceutics and Biopharmaceutics 72(3): 621-625, 2009. Bolhuis, G. K., Rexwinkel, E. G., Zuurman, K. Polyols as filler-binders for disintegrating tablets prepared by direct compaction. Drug Development and Industrial Pharmacy 35(6): 671-677, 2009.

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de Vegt, O., Vromans, H., den Toonder, J., Maarschalk, K. V. Influence of flaws and crystal properties on particle fracture in a jet mill. Powder Technology 191(1-2): 72-77, 2009. de Vries, T. W., Rottier, B. L., Gjaltema, D., Hagedoorn, P., Frijlink, H. W., de Boer, A. H. Comparative in vitro evaluation of four corticosteroid metered dose inhalers: Consistency of delivered dose and particle size distribution. Respiratory Medicine 103(8): 1167-1173, 2009. de Waard, H., Grasmeijer, N., Hinrichs, W. L. J., Eissens, A. C., Pfaffenbach, P. P. F., Frijlink, H. W. Preparation of drug nanocrystals by controlled crystallization: Application of a 3-way nozzle to prevent premature crystallization for large scale production. European Journal of Pharmaceutical Sciences 38(3): 224-229, 2009. Laksmana, F. L., Kok, P. J. A. H., Vromans, H., Frijlink, H. W., Maarschalk, K. V. D. V. Development and Application of a Process Window for Achieving High-Quality Coating in a Fluidized Bed Coating Process. AAPS PharmSciTech 10(3): 732742, 2009. Laksmana, F. L., Kok, P. J. A. H., Vromans, H., Maarschalk, K. V. Predicting the diffusion coefficient of water vapor through glassy HPMC films at different environmental conditions using the free volume additivity approach. European Journal of Pharmaceutical Sciences 37(5): 545-554, 2009. Laksmana, F. L., van Vliet, L. J., Kok, P. J. A. H., Vromans, H., Frijlink, H. W., Maarschalk, K. V. Quantitative Image Analysis for Evaluating the Coating Thickness and Pore Distribution in Coated Small Particles. Pharmaceutical Research 26(4): 965976, 2009. Munnik, P., de Boer, A. H., Wissink, J., Hagedoorn, P., Heskamp, I., de Kruijf, W., van Rijn, C. J. M., Frijlink, H. W., Zanen, P. In Vivo Performance Testing of the Novel Medspray (R) Wet Aerosol

Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery 22(4): 317-321, 2009. Rasyid, H. N., van der Mei, H. C., Frijlink, H. W., Soegijoko, S., van Horn, J. R., Busscher, H. J., Neut, D. Concepts for increasing gentamicin release from handmade bone cement beads. Acta Orthopaedica 80(5): 508-513, 2009. Rottier, B. L., van Erp, C. J. P., Sluyter, T. S., Heijerman, H. G. M., Frijlink, H. W., de Boer, A. H. Changes in Performance of the Pari eFlow (R) Rapid and Pari LC Plus (TM) during 6 Months Use by CF Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery 22(3): 263-269, 2009. Schellekens, R. C. A., Olsder, G. G., Langenberg, S. M. C. H., Boer, T., Woerdenbag, H. J., Frijlink, H. W., Kosterink, J. G. W., Stellaard, F. Proof-of-concept study on the suitability of C-13-urea as a marker substance for assessment of in vivo behaviour of oral colon-targeted dosage forms. British Journal of Pharmacology 158(2): 532-540, 2009. Srinarong, P., Faber, J. H., Visser, M. R., Hinrichs, W. L. J., Frijlink, H. W. Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants. European Journal of Pharmaceutics and Biopharmaceutics 73(1): 154-161, 2009. Zijlstra, G. S., Wolting, J., Prop, J., Petersen, A. H., Hinrichs, W. L. J., Uges, D. R. A., Kerstjens, H. A. M., van der Bij, W., Frijlink, H. W. Efficacy of a New Pulmonary Cyclosporine A Powder Formulation for Prevention of Transplant Rejection in Rats. Journal of Heart and Lung Transplantation 28(5): 486-492, 2009. Zijlstra, G. S., Ponsioen, B. J., Hummel, S. A., Sanders, N., Hinrichs, W. L. J., de Boer, A. H., Frijlink, H. W. Formulation and process development of (recombinant human) deoxyribonuclease I as a powder for inhalation. Pharmaceutical Development and Technology 14(4): 358-368, 2009.

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Research line Therapeutic Gene Modulation

Journal articles
Dekker, F. J., Haisma, H. J. Histone acetyl transferases as emerging drug targets. Drug Discovery Today 14(19-20): 942-948, 2009. Dekker, F. J., Ghizzoni, M., van der Meer, N., Wisastra, R., Haisma, H. J. Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones. Bioorganic & Medicinal Chemistry 17(2): 460-466, 2009. Ghizzoni, M., Haisma, H. J., Dekker, F. J. Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase. European Journal of Medicinal Chemistry 44(12): 4855-4861, 2009. Haisma, H. J., Boesjes, M., Beerens, A. M., van der Strate, B. W. A., Curiel, D. T., Pluddemann, A., Gordon, S., Bellu, A. R. Scavenger Receptor A: A New Route for Adenovirus 5. Molecular Pharmaceutics 6(2): 366-374, 2009. Siegel, G., Obernosterer, G., Fiore, R., Oehmen, M., Bicker, S., Christensen, M., Khudayberdiev, S., Leuschner, P. F., Busch, C. J. L., Kane, C., Hubel, K., Dekker, F., Hedberg, C., Rengarajan, B., Drepper, C., Waldmann, H., Kauppinen, S., Greenberg, M. E., Draguhn, A., Rehmsmeier, M., Martinez, J., Schratt, G. M. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nature Cell Biology 11(6): 705-U36, 2009.

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CENTER FOR SYNTHESIS AND ANALYSIS S&A

Research Line Analytical Biochemistry and Pharmaceutical Analysis

Dissertations
Abello, N. J-R. Chemical labeling for the analysis of proteins, peptides and metabolites by mass spectroscopy. (2009) Bischoff, R. P. H. and Postma, D. S.

Journal articles
Abello, N., Kerstjens, H. A. M., Postma, D. S., Bischoff, R. Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins. Journal of Proteome Research 8(7): 3222-3238, 2009. Govorukhina, N. I., de Vries, M., Reijmers, T. H., Horvatovich, P., van der Zee, A. G. J., Bischoff, R. Influence of clotting time on the protein composition of serum samples based on LC-MS data. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877(13): 1281-1291, 2009. Izquierdo, E., Horvatovich, P., Marchioni, E., oude-Werner, D., Sanz, Y., Ennahar, S. 2-DE and MS analysis of key proteins in the adhesion of Lactobacillus plantarum, a first step toward early selection of probiotics based on bacterial biomarkers. Electrophoresis 30(6): 949-956, 2009. Jellema, L. C., Mey, T., Koster, S., Verpoorte, E. Charge-based particle separation in microfluidic devices using combined hydrodynamic and electrokinetic effects. Lab on a Chip 9(13): 1914-1925, 2009. Klein, T., Geurink, P. P., Overkleeft, H. S., Kauffman, H. K., Bischoff, R. Functional Proteomics on Zinc-Dependent Metalloproteinases using Inhibitor Probes. ChemMedChem 4(2): 164-170, 2009. Rosenling, T., Slim, C. L., Christin, C., Coulier, L., Shi, S., Stoop, M. P., Bosman, J., Suits, F., Horvatovich, P. L., Stockhofe-Zurwieden, N., Vreeken, R., Hankemeier, T., Gool, A. J., Luider, T. M., Bischoff, R. The Effect of Preanalytical Factors on Stability of the Proteome and Selected Metabolites in Cerebrospinal Fluid (CSF). Journal of Proteome Research 8(12): 5511-5522, 2009. van Heyningen, A. M., Levenston, M. J., Tamminga, N., ScoopMartijn, E. G., Wever, R. M. F., Verhagen, A. A. E., van der Dijs, F. P. L., Dijck-Brouwer, D. A. J., Offringa, P. J., Muskiet, F. A. J. Estimated Incidence of Sickle-Cell Disease in Aruba and St Maarten suggests Cost-effectiveness of a Universal Screening Programme for St Maarten. West Indian Medical Journal 58(4): 301-304, 2009.

Research Line Analytical Biomonitoring and Sensoring

Dissertations
Huinink, K. D. Slow microfiltration or slow microdialysis to versatile biomonitoring. (2009) Korf, J., Lambooij, B., and Cremers, T. I. F. H. van der Hart, M. G. C. Substance P and the neurokinin 1 receptor: from behavior to bioanalysis. (2009) den Boer, J. A., Fuchs, E., Westerink, B. H. C., Cremers, T. I. F. H., and Bosker, F. J.

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Journal articles
Bosker, F. J., Folgering, J. H. A., Gladkevich, A. V., Schmidt, A., van der Hart, M. C. G., Sprouse, J., den Boer, J. A., Westerink, B. H. C., Cremers, T. I. F. H. Antagonism of 5-HT1A receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT7 receptors. Journal of Neurochemistry 108(5): 1126-1135, 2009. Cremers, T. I. F. H., de Vries, M. G., Huinink, K. D., van Loon, J. P., Van der Hart, M., Ebert, B., Westerink, B. H. C., De Lange, E. C. M. Quantitative microdialysis using modified ultraslow microdialysis: Direct rapid and reliable determination of free brain concentrations with the MetaQuant technique. Journal of Neuroscience Methods 178(2): 249-254, 2009. Sotty, F., Folgering, J. H. A., Brennum, L. T., Hogg, S., Mork, A., Hertel, P., Cremers, T. I. F. H. Relevance of dorsal raphe nucleus firing in serotonin 5-HT2C receptor blockade-induced augmentation of SSRIs effects. Neuropharmacology 57(1): 18-24, 2009.

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