RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCE, KARNATAKA BANGALORE

ANNEXURE II SYNOPSIS FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

1. Name of the Candidate And Address (in Block Letters) Dr. RADHA KRISHNA SHETTY K POST GRADUATE STUDENT IN M.D. ANATOMY VIMS, BELLARY. Vijayanagar Institute of Medical Sciences Bellary. Medical, M.D. ANATOMY 18.06.2007

2. 3. 4. 5.

Name of the institution Course of Study and subject Date of admission to course

Title of Topic : A STUDY OF CORONARY ARTERIES AND ITS BRANCHES NORMAL ANATOMY AND VARIATIONS IN 50 CADAVERIC HUMAN HEARTS BRIEF RESUME OF THE INTENDED WORK: 6.1 Need for the study: The coronary arteries have some features which distinguish them from the medium sized arteries, both in health and diseases. The Coronary arteries may present several anomalies in terms of both number and position. An anomalous origin and proximal course of the coronary arteries may be associated with myocardial infarction and sudden death. Thus the knowledge of normal and variant anatomy of coronay circulation is an increasingly vital component in the management of congenital and acquired heart diseases. Many congenital, inflammatory, metabolic and degenerative diseases may involve the coronary circulation. Increasingly complex cardiac surgical repairs demand the understanding the basic anatomy to improve the operative outcomes. The recent introduction of selective coronary arteriography provides an accurate localization of the anatomical variations and underlying pathology. The advance made in coronary arterial bypass surgeries and modern methods of mycordial revascularisation demands thorough, sound and complex knowledge of the normal and variant anatomy of coronary artery and circulation. With this aim the coronary arteries are studied with reference to the branching patterns and variations.

6.2 Review of literature: 1. Edward Jenner (1799) established the understanding of the relationship of coronary artery obstructive disease to angina pectoris and mycordial ischaemia. 2. W. Henry Hollinshead (1956) described right coronary artery is that which arises from right anterior aortic sinus. Left coronary arises from left posterior aortic sinus. According to him right coronary artery is the dominant artery in majority of the cases. 3. According to James (1961) Right and left coronary arteries supply the sino-atrial node in 55% and 45% respectively. For atrioventicular node it is 90% and 10% respectively. 4. S.N. Sahana (1962) described coronary arteries are those which supply the musculature of the heart, the visceral pericardium and the roots of the ascending aorta and pulmonary trunk. Right coronary artery is the dominant artery. 5. Rene Favaloro and Dudley Johnson (1968) performed 1st coronary bypass surgery and created further interest in coronary anatomy. 6. From Hutchisons results (1978) it is apparent that is over 50% of the right atrium is supplied only by the right coronary, the rest receiving a dual supply. More than 62% of left atria are largely supplied by the left and about 27% by the right coronary artery. 11% being supplied by the both. 7. American Heart Journal (1989) Paolo Angelini, M.D. Houston : Teras. Normal and anomalous coronary arteries : Definition and classification. 8. Peter L Williams (1995) described right coronary artery as that which arises from anterior aortic sinus and left coronary artery as that which arises from the posterior aortic sinus. Righ coronary artery is the dominant artery in majority of the cases. 9. Inderbir Sigh (2002) stated that right coronary is the dominant artery in 85% of the cases. 10. J. Anat. Soc. Of India 52(2) 137-140 (2003) Kalpana R Department of Anatomy. A study on principal branches of coronary arteries in humans. 11. Eur. J. Anat. 8(1): 39-53: 2004. 1. J Reig Villallonga Anatomical variations in the coronary arteries. 2. Less prevalent variations: coronary anomalies. 12. Coronary artery dominance Anatomica Karnataka, by Dr. K.V. Venkateshu. 13. eMedicine Isolated coronary artery anamolies: Article by Jamshid Shirani, M.D. FAC .. Last updated June 20th 2006. 6.3 Objectives of the study To study the normal anatomy & variations of coronary arteries & their branches by Gross Anatomical Study.

7.

MATERIALS AND METHODS 7.1 Source of data For the prospective study of two years duration from Jan 2008 to Dec 2009. (40) specimens shall be brought from the unclaimed post mortem bodies in the Department of Forensic Medicine, VIMS, Bellary and (10) from the dissected cadavers in Anatomy Department , VIMS, Bellary. 7.2 Method of collection After opening the thorax in the postmortem bodies (age and sex noted) in the department of Forensic Medicine, VIMS, Bellary. the pericardial sac is opened to expose the heart. The heart with proximal part of great vessels is identified, dissected & taken out. After cleaning, the specimens are kept in 10% formalin. Later on specimens are studied by dissection method. 7.3 Does the study require any investigation and intervention to be conducted on patients or other humans or animal? If so, describe briefly. No. Utmost care will be taken to treat the cadavers with due to respect human body. The organ collected will not be used for any other purpose except for my study. 7.4 Has ethical clearance been obtained from the Institution in case of 7.3? Yes, Ethical clearance has been obtained fro I.E.C. of VIMS, Bellary. LIST OF REFERENCES: 1. Cardiovascular system in Grays Anatomy, 38th edn, (Georgio Gabella) London 1995: Churchill Livingstone p.no.1505-1510 2. Principles of Anatomy & Physiology, 11th Edn., Tortora, Derrickson. 3. Cardiac Surgery 2nd Edn., 1993, John W. Kirlin, Prian G. Barrawt Boys. 4. James T.N., Anatomy of Coronary Arteries, 1st Edn. Hoeber Med. Div. Harper & & Row Newyork (1961). 5. Sudden death due to coronary artery anomalies: A case report & clinical review: Forensic science 39(1): 246-256. 6. A study on Principle branches of coronary arteries in human J.Anat. Soc. India 52(2): 137-140: Kalpana R 2003. 7. A.K. Datta, Human Anatomy (Thorax and Abdomen): Arterial Supply of Heart: p.no.68-73.

8.

1.

Signature of Candidate

2.

Remarks of the Guide

3.

Name & Designation of (in block letters) 11.1. Guide 11.2 Signature

DR. RAMAIAH. PROFESSOR & HOD Department of Anatomy , VIMS, Bellary

11.3 Co-guide (if any)

11.4 Signature

11.5 Head of Department

DR. RAMAIAH. PROFESSOR & HOD Department of Anatomy, VIMS, Bellary.

11.6 Signature

12

12.1 Remarks of the Chairman & Principal

12.2 Signature

Place: Bellary Date: From,

Dr. RADHA KRISHNA SHETTY K POST GRADUATE STUDENT IN M.D. ANATOMY VIMS, BELLARY.

To, The Principal, Vijayanagar Institute of Medical Sciences, Bellary. THROUGH PROPER CHANNEL Respected Sir, Subject: Acceptance, Registration and forwarding of dissertation topic reg. In accordance with the above cited subject, I undersigned studying Post Graduate course in M.D. Anatomy has been allotted the dissertation topic A
STUDY OF CORONARY ARTERIES AND ITS BRANCHES NORMAL ANATOMY AND VARIATIONS IN 50 CADAVERIC HUMAN HEARTS. Under the guidance of Dr. RAMAIAH., Professor & HOD, Department of Anatomy,

VIMS, Bellary. I request you to kindly forward the synopsis in the prescribed form to the university for approval.

Thanking you, Yours faithfully,

Dr. RADHA KRISHNA SHETTY K

Signature of the Guide

DR. RAMAIAH. PROFESSOR & HOD Department of Anatomy, VIMS, Bellary.

Place: Bellary Date: From, The Professor. & Head of the Department, Department of Anatomy, VIMS, Bellary. To, The Registrar, Rajiv Gandhi University of Health Sciences, Bangalore. THROUGH PROPER CHANNEL Respected Sir, As per the regulations of the University for registration of Dissertation topic, the following Post Graduate in M.D. Anatomy has been allotted the dissertation topic as follows by the Official Registration Committee of all qualified and eligible guides of the department of Anatomy. NAME TOPIC GUIDE
Dr. RADHAKRISHNA SHETTY. K Post Graduate Student in M.D. Dept. of Anatomy, VIMS, Bellary. A STUDY OF CORONARY ARTERIES AND ITS BRANCHES NORMAL ANATOMY AND VARIATIONS IN 50 CADAVERIC HUMAN HEARTS. DR. RAMAIAH. PROFESSOR & HOD Department of Anatomy, VIMS, Bellary.

Therefore, I kindly request you to communicate the acceptance of this synopsis allotted to the PG student at an early date. Thanking you, Yours faithfully,

DR. RAMAIAH. PROFESSOR & HOD Department of Anatomy, VIMS, Bellary.