THE

AMERICAN

JOURNAL

OF June,

(LINICAL

NUTRITION

Vol.

22,

No.

6,

1969, zn

PP.

686695

Prz,hd

Special

Article

Chorionic
Further

Gonadotropin
Clinical
A.

in Obesity

Observations
GUSMAN,

HARRY

M.D.1

Sciences arc judged by their fruits and in medical practice the outcome of a treatment is no less a test of the doctors use of his conceptual scheme than is the outcome of a laboratory experiment a test of the theory of the experiment.
Lord Bacon (1)

remember proaches search ment not past

some

I have for a of obesity

of been

the far-fetched willing to try in I know that any the that until matter

in

apthe

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breakthrough (2), and

treatI am the how

alone. decade,

Suffice it to say no technique-no brought research much in the evidence

It is universally overweight erature

acknowledged handicap. insurance

that

to be

imaginative-has success. Although has developed

significant

is a serious abounds with

The litstatistics

which show that the death rate is higher among the obese of every age group. No informed person would deny that obesity is a cause for concern or that it is a legitimate-even essential-subject for much further scientific and clinical investigation. The truth is that science has not yet produced an explanation for the disease, and obesity remains puzzling subjects in cine. At a time of successfully heart, it pricked seemingly is only when simple one of the practice the of most medi-

past 20 years to refute the

traditional concepts of the cause of obesity, most physicians have clung to the view that obesity is caused by overeating, pure and simple, i.e., greater than energy. Naturally, the intake of calories as food the expenditure of calories the treatment offered by these is as

when medicine transplanting

can boast a human ego is the some

physicians consists of a reduced diet, a lecture on self-discipline, haps some medication. Otherwise, control has been relegated to

calorie and perweight a do-it-

natural that our we cannot answer question of why

people get fat. The result is that a subject that is, in fact, still enshrouded in mystery calls forth many dogmatic and doctrinaire pronouncements from people otherwise famous for professional caution. It over is a little embarrassing my 40 years of medical
address: Ohio 16611 44120. 686 Chagrin

yourself project. Some have treated it as a moral problem rather than a medical problem, verbally punishing the patient for alleged deviation from the diet and thus adding more guilt guilt-laden obese patient. This treatment most cases, and it produces has give sionally up treating there The is is doomed the inevitable caused many obesity a tendency been subtly-other result has to the to already in to dis-

to look practice

back and

failure frustration physicians even to

altogether.

Occaphysicians a flourish-

1Present
Shaker Heights,

Boulevard,

parage-albeit who persist.

Chorionic ing of fad diets and parascientific of metabolism. I am one of the diehards who to treat the condition seriously. that obesity is more than a simple ance of the caloric balance sheet there During ing Dr. is a more the obesity A. T. past intricate 10 years process
I have

Gonadotropin theories continue I believe disturband that at

been

in facts, cable easily

Obesity

687 afford a precise, replithe results of which are In my judgment, Dr. satisfies Dr. the he which all Simeons theoretical developed of these method framethe re-

and should technique, assessed. method understand must out appreciate of

Simeons quirements. To one work technique.

work.
treat-

with a method developed by W. Simeons (3) that uses human (HCG). patients I of have both

chorionic treated

gonadotropin well over 2,500

Basic theoretical 1) Definition 2) Fat-regulating 3) Existence 4) Obesity 5) Nature

6) Safety

considerations: center cells

sexes, aged 15 to 75.2 Since all were private patients no double-blind tests or other experimental studies were undertaken. It is with consternation that I must admit I cannot yet fully explain why Dr.

of different types of fat during pregnancy of HCG of HCG in the treatment new definite concept of metabolic

of

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obesity Dr. Simeons that it is a obesity disorder, is

Simeons method works. noted that not everyone that it does work My quickly nit) clinic has
most but also

And, shares

it should be my finding

own early dissipated to observe in Rome.

skepticism of the method after I had an opportuDr. Since

method approach and

much as is diabetes, down of a regulating the diencephalon,

caused by a breakmechanism located in or hypothalamus. He center (3). among the hypothalamus first in eviin intake

Simeons work at his that time, experience

to most be not only the

shown scientific the

his safest

calls this the fat-regulating Although Simeons was to suggest the role of the obesity, dence the of

to

the

problem scientific cannot

productive.

the literature abounds with some regulating mechanism that governs the

According to the dictates method, a new theoretical be incorporated knowledge except research. replication here
is

of the concept body basis

hypothalamus

into on to to
the

the the

of accepted of empirical idea, adtheory techthe

con-

of food and its the field have presence of a nism. noted insects Sir Vincent

utilization (4-8). Others in expressed belief in the similar regulating mechaB. Wigglesworth in his importance work (9), the with of the

In

order research However,

test must, the while

practicing

the new of course, authors a new the

it is clinician

meticulously
being tested,

original
clinicians

British biologist, emphasizes the

techniques. main nique

meantime,

nervous system as a source of secretions that regulate metabolism and insists that evidence points to similar action in mammals. The genetic this concept, various from that (10, types their they 11).

concern works-as
as

is
far

whether long as
as the

new
safe. In is

cerned, the new theory should tellectually satisfying interpretation processes underlying observable ena,
2

give

an inof the phenomclinical

order
Auxiliary

factor in obesity fits into since offspring can inherit of regulating antecedents in various the other mechanisms same way attributes

should
For

not
original
00337
from

violate
data of
ASIS

known
these
National

inherit

the

patients,

Document
Publications

Service, c/o CCM Information Sciences, Inc., 22 West 34th Street, New York, N. Y. 10001, remitting $1.00 for microfiche or $3.00 for photocopies.

Different

Types

of Fat

Tissue his co-workers found that

Dr. Lester B. (12) at Rockefeller

Salans and University

688
adipose cells in the obese mal fat cells. These obese more numerous, but the larger these less cells. dicate the and seems overstuffed efficiently This that abnormal

Gusman differ from norcells are not only individual cell is point, the patient often and frustrated, and the The increased food intake replenishes the normal tient feels much better, is perpetuated the best to reduce and does are or even explanation weight. probably failures Pregnancy There
nutritional

overstuffed. Furthermore, cells metabolize glucose than the normal adipose infrom evidence fat tissue of the would differs obese. to good as strucstorage serves to and a pad which for prothe in we

becomes depressed diet is abandoned. that follows soon fat stores, the paand the overweight increased. for This the many is

cytological normal fat

deposits

Normal health and tural fuel. As tect material structural such

fat tissue is essential serves two functions, and as reserve it the

Obesity exist one

when

emergency

special all the

kind
types

of
of

fat material, as and foot, organs arteries of the kidneys

cells

immediately every ounce

utilizable. of

During normal refixed of the that of about two

pregnancy

coronary the sole

it provides without

serve fat as well as the abnormal deposits are placed at the disposal growing fetus. Simeons has suggested it is HCG this center. the presence of during pregnancy change If true, large that quantities brings

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could not walk. ding underneath firm and smooth.

Since fat is

It also provides the skin which the for all highest energy, over the possible a certain body

the padkeeps it concenamount and serves conis

through the hypothalamic this would account for of pregnancy:

tration

of fuel

interesting a) A pregnancy the true is more body. b) come easiest, harm

phenomena

is distributed as a reserve verted into

storage energy

of fuel. when

This is starvation

forced on the individual protracted illness. Even if this normal fat to capacity sidered to be obesity. A bnormal fat tissue tion, in certain parts which the obese patient of fat is also a potential
but tional is not immediately Only emergencies.

or during a the body stocks this is not con-

woman may gain weight during but she never becomes obese in sense of the word. The excess fat evenly distributed all over the if an obese woman best time, does and without bethe

Secondly, pregnant, to to reduce herself

it is the

is that accumulaof the body, from suffers. This type reserve for fuel,
available after in nutri-

her excess weight or the fetus.

the will

fat

reserves

are

exhausted

normal the body

The presence of HCG in the body as such has no reducing action. A loss of weight can only be brought about by a concomitant nutritional deficit. During pregnancy the needs of the embryo act in this direction with HCG this a very low (500 The Nature but in treating deficit must be kcal) diet. the obese obtained by

yield its abnormal fat to be utilized for the emergency. When an obese patient severely reduces his diet he first utilizes his normal fat reserves By the hausted to make time and the the up the normal abnormal nutritional deficit. exbereserves are fat tissues

of HCG pregnancy, on the HCG health has and

Found only during a protective influence nutrition of mother has long been called mone of pregnancy. of the most important nancy and, therefore,

gin to make up the nutritional deficit, the patient is already complaining of weakness and hunger while the ugly fat deposits-of which he originally wished to rid himself-have hardly been reduced. At this

and baby. In fact, it the protective horIt could well be one hormones in pregin the propagation

Chorionic of our attention Human first utilized Aschheim the urine eral
rhagic

Gonadotrcipin much was scientists, it in sevsubhemor-

in pregnancy, units daily, only 125

Obesity reaching as much as compared with units daily for

689 as a million a dosage of of treatto time, of insuothers. where single has HCG clini-

race. Yet, it has in research. chorionic by the two and Zondek, of pregnant centimeters
into immature

not

received

gonadotropin German who discovered women. When were produced the basis pregnancy,
test

a course

ment lasting 40 days. Many physicians needlessly hesitate use small doses of HCG for a limited although such lin, powerful cortisone, they prescribe hormones estrogen, daily as and thyroid, many doses

cubic

injected
mice,

cutaneously

follicles this

were became test for

in

their for the known

ovaries and first biological

as the

Aschheim-Zondek

Because
stimulated,

thought

the the to be

immature material in gonadotropic,

(13). ovaries were the urine was and it was

In the many thousands of cases HCG has been employed, not a substantiated case of adverse reaction been reported. Clearly, Dr. treatment can be acceptable cian as a safe procedure. What Much method, Reports most of from men the basic I have criticism my own I have or in the Let A bout has both have Its Effectiveness? been in written this been about Simeons to the

misnamed human chorionic gonadotropin (HCG). It has since been established that the observed changes can be brought about
only anterior in immature pituitary animals glands with intact

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Simeons abroad. but

(14).

The

conclu-

country and controversial,

sion, tropic

therefore, and not

is that a sex

HCG is not gonadohormone at all. Its

action is probably produced by stimulation of the hypothalamus, which in turn influences the anterior pituitary gland. It should not be confused with gonadotropic hormones of the pituitary, namely, follicle-stimulating mone Only properties searched. nal of a metabolic Is HGG (FSH) quite of and luteinizing recently HCG an have been article referred with (15). hormone the true anterior hor(LH). the re-

the adverse criticism has come who have disregarded some of rules of the procedure. carefully examined all the adverse in an attempt to reconcile it with clinical found observations. In basic methodological errors, and my remains unshaken. the opposition. six negative articles criticism has been 33 patients with a diet saline. of
I

each

case flaws

interpretive procedure us examine have been all adverse

I).

confidence In all,

some of actively in to

In 1967, Endocrinology capabilities Safe?

the JourHCG as probable

there which

from quoted HCG groups 500-600

hormone

complex

(Table Sohar. and were 11

He patients

treated

with Both

prescribed

about

Consider the following facts a) Its universal existence and in large amounts, during

about

HCG: exclusively, a most imin the

TABLE

Author

Year

Number of

portant stage of human development. b) Its presence in large quantities

Doubleblind tests

Sohar Came Kalina Craig Frank

McGanity

(16) (17) (18)

Ct

1959 1961 1961 1963 1964 (21)

in parentheses

33 196 42 20 48 none
reference

11 12 none 11 24 none
numbers.

blood stream of both mother and fetus during the entire pregnancy, without any untoward effect on any organ system of
either the mother or a fetus of either sex.

al. (19)

(20)

1962
are

c) The through

excretion the kidneys

of for

surplus 9 months

HCG during

Numbers

690
kcal (in food amounts instead of calories),

Gusman One significant bears emphasis. laboratory tests tients treated, feature of this report A considerable number of was performed on all paincluding BMR, fasting

and a nurse visited their homes daily to administer the HCG. Patients were not observed by a physician except at the beginning and end of the experiment. Average loss of weight in all 44 patients was 20 lb. in 40 days. His series proved that patients can lead a normal life and perform their usual daily tasks on the prescribed diet. Conclusion: Simeons method is effective, but HCG is only a placebo. Came. He used Simeons method in about tests) over proved 200 and 20 of lb. the patients (only 12 were placebo his patients lost an average of in a 500 6-week kcal admitted but saline and period. the time the found injections He aplimit

blood sugars, PBI, serum cholesterol, and serum lipid concentrations. All of these were done at the beginning and end of treatments with no appreciable change in values. produce organ
Frank.

This any systems. This with

indicates untoward author HCG,

that HCG does not effect on any of the treated but because 24 it obese was

subjects

thought to be impractical standpoint of office traffic of the patient he altered technique recognizable to such from

from both the and convenience the diet and the

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of 6 weeks. He has some value, patients receiving

treatment that those in place

a degree that the original.

it was unTo list a

of HCG lost in weight almost as much as those that received HCG. In other words, he approved of the method, but questioned the effectiveness Kalina. He of HCG. used Simeons method in 42

few of the authors important discrepancies: a) He prescribed a daily diet of 1,030 kcal (instead of 500); b) Each patient received three weekly injections of 200 units of HCG (instead of daily injections of 125 units); c) Each injection was given by an Army deep that corpsman subcutaneously (instead of intramuscularly). The author states he examined and interviewed each at tloes not the beginning mention of whether the he study, ever

patients over a period of 2 years. His report was in the form of a letter to the editor of The Lancet, in which he claimed that he did not get the good results reported by the others, but concluded, In spite of the shortcomings mechanisms involved, this procedure a useful pdtients.
about

participant but he

and the unknown continue to find tool in some obese

saw them again after that. Naturally, this study failed to prove or disprove anything. McGanity. His criticisms were published in the Journal of the American Medical Association in answer to a query on HCG. Since lie does not claim to have tried HCG in to assume treating that he obesity, it is reasonable was asked by the editors

raig

He further agrees with Sohar the doubtful value of HCG. et al. This report covers 20 women 11 of whom
technique.

patients,
double-blind

received The

HCG diet many 500 all treated

by confoods kcal by

sisted of not found of Simeons

550 kcal, in the diet.

including recommended They were

of the journal he is a member ogy Department Medical Branch

to answer the query because of the Obstetrics-Gynecolof the University of Texas and is undoubtedly famil-

a clinic nurse and The average weight

weighed once loss in a 6-week

weekly. period

was about 6.5 lb., considerably expected 20 lb. or more Sohar and Came. Thus,

less than the as reported by the technique

received another negative vote, despite the small number of cases in the study and the admittedly poor cooperation of the subje(ts in the matter of proper diet.

iar with the physiology of the human hormone of pregnancy known as HCG. He takes Dr. Simeons to task for choosing a commercial lay magazine to disseminate his information instead of a medical journal. This publications Tue Journal is entirely appeared of the untrue in The American as the first Lancet and Geriatric

Chorionic Society in the caustic years lay and before press. His decidedly not claim anything remarks unjust, to have

Gonadotropin appeared are rather considering tried the tried tients-yet adherence is the some In

in the

Obesity method only to the clinically McGanity daily 500 more than found no continued untoward the these in obese

691 pa-

contends that kcal for 40 days to obesity. effects diet of critical the paAll and

that he does method. Furthermore, the background was attacking.3 with book the author which

potentially health others

hazardous

tients he neglected to investigate of the individual whom he He carelessly links him of Calories the Pure Food made Fiction Dont and possible List Count-a Drug of Deto be best-

actually praised an overview of

500 kcal. articles,

partment transferred sellers. linking with Dr.

finally to the This link the author McGanity and

several points emerge: a) The number of cases author is too small to draw I well in about skeptical claimed. recall the about Only that after using

studied by each any conclusions. the technique

is about as pertinent as of Calories Dont Count because method both of are ob-

first 200 patients, I too was the results that Dr. Simeons after my visit to his clinic in exactly improve. only the to his

stetricians McGanity

gynecologists. prefers his of usual

choice

Rome and technique4

after adjusting did my results

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for weight reduction, reliable reduction maintaining the ing level tion ing sole must treatment, exercise longer disturbance it were, long It above
Long

namely, calorie level demands

the old unintake while of activity by the recommendaas recommendfor regimens during that we can sheet. have of all has
in this

b) Although admit that he the

that

Sohar was the assumed from would

also

author to start that it appears

at the

the while as of all

or same

procedure
the others

not
had

work,
misgivings

increase activity of is the calorie about

of energy intake.

increas-

maintaining This sugar realistic of diabetes weight-reducing deficit true programs, balance would to only note that

outset

of their

studies.

This

is unfortunate,

reduction that and will claim of the ago. help that the

intake mellitus.

the

treatment include

While the normal no a If been the not

field,

for it is hardly conducive to unbiased research. c) Where individual adherence to a strict diet is the key factor of a clinical experiment, little the ber the value same of double-blind unless
prepared

it is true

method the daily

for all

is of of

very food
in

a calorie it is also all

intake
participants

is carefully

diet calories

kitchen for each this of the This is the to a rigid

diet of 300

and of

the them by

exact

numthe particiinof since his inof his

overweight caloric

is simply

carefully

calculated. dividual pant the the ability food

Unless variance

is observed, diet is each

problem

solved

invalidates experiment. obese patient to evaluate or to keep

1) The exact

double-blind important for values notorious caloric diet.

kcal (of the

aspect

is interesting authors,
before he

McGanity
interested

became

Dr.
search
With ment

Simeons scientist
his of malaria,

had in
contributions

distinguished the
bubonic

himself of
the plague

as
and leprosy,

represcribed

field
to

tropical
diagnosis and

medicine.
treatcan

foods) daily

in the exact minimum intake

division of
of

of two
units of

meals, of liquids.
HCG

including
given deep

2 quarts for 40

be included the discovery of the use of injectable atebrin for malaria (for which he was awarded Red Cross Order of Merit) and a new method
staining malaria parasites now known as Simeons

2) The

daily

dose
6 days

125 weekly

a of

intragluteally, 3) Daily

discuss
to approximate

daily

interviews progress.
normal

with
to stay

patient
with is

treatments. to scrutinize
program and

and
until attempt

stain.

He

also

built

the

first

model

leper

colony

1) Encouragement to and direct normal reeducation amount

the reached

in India

and

has

a long

list of scientific papers

weight

his credit.

Under

the British

he

was

Director
Who

of

Medical

Government and Health

of India Services

toward of exercise

good

eating

habits

at the

conclusion

(Whos

in Europe).

of the program.

692 d) tially Of the above the six original studies, cannot authors five

Gusman
substanof Dr. claim stressed they the eral hundred clinicians all over the world

altered

technique

Simeons, tested his e) Most

so that they method. of the above

treating many thousands of cases successfully is completely discounted. These include published papers by Simeons (2224); Lebon (25-27); Harris and (28); Hutton (29-31); Politzer, and Flaks (32); and others. Neither alleged technique Dr. several have Simeons nor any hundred adherents ever claimed that Warsaw Bersohn of the to his this is

same criticism no significant difference in weight loss between patients given HCG or a placebo. It is my impression that Dr. Simeons concurs with this conclusion. Neither Simeons nor anyone else ever claimed that the injection of HCG alone could accomplish Even without there has always overweight duced his patient weight the loss of weight. any medication at existed the strong-willed in who spite successfully of all the all, rediffi-

the last word on the subject. those of us older physicians who

However, have been who other each than

treating obesity for a long time and have had an opportunity to employ methods and compare them with fruitful other find this method more any other so far recommended. Clinical I have Findings chosen to study the records

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culties. Unfortunately, the vast majority of obese patients do not fall into this category. To most of them, dieting is a most unhappy time of their lives. They are constantly hungry, weak, complaining, and generally patients out of sorts. This under the HCG is not so with and 500 kcal profestheir they feel hungry of on enis are con-

of my

last 500 patients current picture The patients

groups,

only in order of about the were divided

to present a last 3 years. into two

technique. The most hardened sional dieters will often volunteer reactions different. nor tired, well-being, previous The that Most somehow of them this time are neither

and they something six

experience a sense they never had constitute the

those of 3 weeks treatment and those of 6 weeks. If they did not conclude at least 20 days they were not included. For those patients who did not conclude 6 weeks, the weight recorded at the end of 3 weeks changed was used to 3 weeks. and their category

diets. above

reports

tire literature quoted against put trolled is not not feel forth as

from Simeons scientific

which criticism method. They evidence from that the use of careful scrutiny, holds up.

Of the last 500 patients who consulted me, 450 completed 3- or 6-week courses. This in itself indicates an advantage over previous methods in that 90% of those attempting treatment for their obesity were enough who able to stay with the to receive some benefit Table
ii
II

experiments effective. After the criticism

HCG
I do

program long of treatment. of 450 patients

On the other

hand,

the evidence

of sevTArni

is a record

Patients
Number

receiving
Age, years

treatment
Average age Number at 3 weeks Average loss, lb., at 3 weeks Number at 6 weeks Average loss lb., at 6 weeks

Males Females

81

18
82 100

15-75
15-72

41
39 40

67
327 394

15
12 13.5

90
320 410

28
23 25.5

369 450

Total

Chorionic received
of either

Gonadotropin of treatment (Some pa6)

in

Obesity the the other methods of markedly obese

693 treatshow

a total of 804 3 or 6 weeks received the

separately.)5

courses duration. than of one

ment

As in all of obesity

tients treatment;
charted

more outcome all

course course patients status

can

of is in of
how-

each

the most striking and the most satisfying results. With regulated rest periods between 6-week courses of treatment, many of these more. sults who obese Of successfully special reduced those markedly diabetes 100 are lb. the or regratification

A follow-up of order to establish

their ever, drawn overweight several from the pertinent

these 450 the present

impossible; conclusions

proved study

be atable

we obtain with have accompanying onset show diabetic

obese mellitus

1) tempting
to ment. 2)

Ninety
some

percent to reduce
degree

as a whole: of the patients their

of

obesity
benefit

were
of

of the maturity of these patients ment in their

or stable type. Most a marked improvestate as well as in

receive

treat-

About

60-70% weight of

were

able

to reach

its so. when

their obesity. While this is true with all forms of successful weight reduction, the improvement is more marked with HCG.

desired
3)

normal A majority

or approximately the patients, regimen with proclaimed

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SUMMARY

asked to compare this ous forms of treatment,

the easiest 4) Many gained some be

previthis to had reclaimed

After proach

40 years of trying to the treatment

of

every new apobesity with

and most successful. of the patients who or all of their weight

little or no success, I believe a new method that works has been made available to us. It works with about 60-70% of obese patients vided as the of both sexes aged 15 and up, prothe method is followed meticulously author has developed it. say for a great that certain how or deal of research this report of with will

that down and

fessing

they were able to keep their weight for longer periods than previously did not mind returning for further
Some that they even went as far as con-

treatment.

keep that

their they

weight could almost

did not try very hard to down because they knew return universal and repeat finding their in loss nearly

No one can yet why it works, and will be needed.

I hope

of weight. 5) An

my own clinical findings together some possible tentative explanations act as a stimulus for this research. While excessive nothing further mechanisms and output failure of it

all of the patients is the euphoria that patients experience. This occurs in spite of the marked low intake of food. I have worked with many obese patients on diets twice the 500 kcal used were We here happy do not and do not recall many who situation of dieting. about their yet have an

is true that obesity is due to calorie intake, this tells us of the basic causes. What needs explanation that as these and regulate well as the regulating discovery calorie are the the in intake

reason for mechanisms

exact explanation for the euphoria and the high rate of patient acceptance so often encountered with our method, but I cannot believe that it is due to a placebo effect or a psychological reaction between patient and physician. It is far too regular.
In

some individuals that results in obesity. Recently, Dr. Margaret Aibrink (34) has made a very interesting observation that while man has elaborate and efficient mechanisms for surviving starvation, his techniques for handling a surplus of food-a societies
easily

1964

Simeons

published
closely match

a series
my
in

of 500 cases
own (33). His age of 41

with 122
lost

results which males

an

and

378
of

females
nearly 17

with
lb.

average 20 days.

average

the

frequent necessity of abundance-are saturated. As a result, metabolic abnormalities

in modern limited and she suggests, leading to

694 atherosclerosis burdening fuel, i.e., is intriguing planation that leads Further tion may be a result of

Gusman overdiet the delays the onset of development in rodents of all (and

the mechanisms for storage of overstuffing the adipose cell. It to speculate on a parallel exfor the metabolic abnormality to obesity. weight to this possible explanato bear by the fact that the to It been found fat cell. least cell

degenerative

diseases

presumably in man) and obesity speeds their development. Medicine must neither accept nor abandon Dr. Simeons method until it has been properly tested through research or until a completely discovered. different and Dr. Simeons a better himself method is has begun

is brought

adipose cell in the obese has be larger than the normal follows, therefore, of fat cells exist, reserve health becomes fat tissue This that at the normal

two types storing the for good cell that the also excess lends

such testing and research in his clinic. He has often told me in person and has more than once said publicly that critics and researchers in this field are welcome at Clinic to study his results and observations. Let us hope some of them will accept offer soon. his his

fuel that is necessary and the abnormally large overstuffed of the approach obese. to obesity and forms

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further credence to the belief that the manner in which food is utilized and stored in the body is a more complicated mechanism than previously believed and that there is a controlling center in the brain. Medicine must not neglect nor abandon the problem of obesity for many reasons, not the least of which is its relationship to cancer and the process of aging. A. Tanenbaum and H. Silverstone (35) suggest that nutrition plays a role in the formation of cancer in man. When living cells are subjected to carcinogenic influences finally energy of the cipally increases trients they result and may undergo in growing substance for changes neoplasm. the development
4. 5.

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