Professional Documents
Culture Documents
TRANSFUSION
By: John Arbie T. Tattao, RN
• Blood Groups
A. Erythrocytes carry antigens, which determine the different blood groups.
B. Blood-typing systems are based on the many possible antigens, but the most
important are antigens of the ABO and Rh blood groups because they are most
likely to be involved I transfusion reactions.
1. ABO typing
• Antigens of system are labelled A and
• Absence of both antigens results in type O blood
• Presence of both antigens is type AB
• Presence of either A or B results in type A and type B respectively
• Nearly half the population is type O, the universal donor
2. Rh typing
• Identifies presence or absence of Rh antigen (Rh positive or Rh negative).
• Anti-Rh antibodies not automatically formed in Rh-negative person, but if Rh-
positive blood is given, antibody formation starts and a second exposure to
Rh antigen will trigger a transfusion reaction.
Important for Rh-negative woman carrying Rh-positive baby; first
pregnancy not affected, but in a subsequent pregnancy with an Rh-
positive positive baby, mother’s antibodies attack baby’s RBCs.
Purposes:
a. To increase the circulating blood volume as in shock due to haemorrhage
b. To increase red cell volume of hemoglobin content of the blood as in anemia
c. To increase WBC content of the blood as in agranulocytosis and leucopenia
d. To increase the quantity of protein malnutrition, excessive loss of protein from
burns or vesicular skin diseases
4. Platelets
> 30 – 60 ml: half of the number of platelets originally found in 1 unit
whole blood
a. Will raise recipient’s platelet count by 10,000/mm3
b. For thrombocytopenia, acute leukemia, to restore platelet count
preoperatively.
b. Pooled from 4-8 units of whole blood
c. Single-donor platelet transfusions may be necessary for clients who have
developed antibodies; compatibility testing may be necessary
7. Granulocytes
> Contains mostly granulocytes and RBC’s, plasma, and platelets
a. For severe gram negative infection or severe neutropenia, unresponsive
to routine forms of therapy in immunosuppressed patients
B. Allergic Reaction
1. Causes
a. Transfer of an antigen or antibody from donor to recipient
b. Allergic donors
2. Mechanism
a. Immune sensitivity to foreign serum protein
3. Occurrence
a. Within 30 min of start of transfusion
4. Signs and symptoms
a. Urticaria
b. Laryngeal edema
c. Wheezing
d. Dyspnea
e. Brochospasm
f. Headache
g. Anaphylaxis
5. Nursing Intervention
a. Stop transfusion
b. Flush with PNSS
c. Notify Physician
d. Administer antihistamine as ordered
If (+) hypotension – signals anaphylactic shock – administer
epinephrine
e. Send blood unit to blood bank
f. Obtain urine and blood samples – send to lab
g. Treat life-threatening reactions
h. Monitor VS and I and O
C. Pyrogenic Reaction
1. Causes
a. Recipient possesses antibodies directed against WBCs
b. Bacterial contamination
c. Multitransfused clients
2. Mechanism
a. Leukocyte agglutination
b. Bacterial organisms
3. Occurrence
a. Within 15-90 min after initiation of transfusion
4. Signs and symptoms
a. Fever and chills
b. Flushing
c. Palpitations
d. Tachycardia
e. Occasional lumbar pain
5. Nursing Intervention
a. Stop transfusion
b. Flush with PNSS
c. Notify Physician
d. Administer antipyretics, antibiotics as ordered
e. Treat temperature – Tepid sponge bath
f. Transfuse with leukocyte-poor blood or washed RBC
D. Circulatory overload
1. Cause
a. Too rapid infusion in susceptible clients
2. Mechanism: Fluid volume overload
3. Occurrence: During and after transfusion
4. Signs and symptoms
a. Dyspnea
b. Tachycardia
c. Orthopnea
d. Increased blood pressure
e. Cyanosis
f. Anxiety
5. Nursing Intervention
a. Slow infusion rate
b. Use packed cells instead of whole blood
c. Monitor CVP through a separate line
E. Air embolism
1. Cause: blood given under air pressure following severe blood loss
2. Mechanism: bolus of air blocks pulmonary artery outflow
3. Occurrence: anytime
4. Signs and symptoms
a. Dyspnea
b. Increased pulse
c. Wheezing
d. Chest pain
e. Decreased blood pressure
f. Apprehension
5. Nursing Intervention
a. Clamp tubing
b. Turn client on left side
F. Thrombocytopenia
1. Cause: Use of large amounts of banked blood
2. Mechanism: Platelets deteriorate rapidly in stored blood
3. Occurrence: When large amounts of blood given over 24 hr
4. Signs and symptoms
a. Abdominal bleeding
5. Nursing Interventions
a. Assess for signs of bleeding
b. Initiate bleeding precautions
c. Use fresh blood