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Neurohistology
II. Neurons
-constitute the genetic, anatomic, trophic, and functional units of the nervous
system (known as the neuron doctrine).
-have lost the capacity to undergo cell division.
-have the capacity to receive impulses from receptor organs or other
neurons.
-have the capacity to transmit impulses to other neurons or effector organs.
-consist of the cell body and its processes, dendrites, and a single axon.
A. Classification of neurons (Figure)
1. Processes-
a. Unipolar or pseudounipolar neurons
-are sensory neurons located in the dorsal root and cranial nerve ganglia and
in the mesencephalic nucleus of the trigeminal nerve (CN V) of the
brainstem.
b. Bipolar neurons -are located in the vestibular and cochlear ganglia of the
vestibulocochlear nerve (CN VIII), the retina, and the olfactory epithelium
(CN I).
c. Multipolar neurons
-possess one axon and more than one dendrite.
-are the largest population of nerve cells in the nervous system.
-include motor neurons, interneurons, pyramidal cells of the cerebral cortex,
and Purkinje' cells of the cerebellar cortex.
2. Axonal length
a. Goigi type I neurons
-have long axons (e.g., giant pyramidal cells of Betz of the motor cortex).
b. Goigi type II neurons
-have short axons (e.g., interneurons).
3. Function
a. Motor neurons
-conduct impulses to muscles, glands, and blood vessels (e.g., ventral horn
cells).
b. Sensory neurons
-receive stimuli from the external and internal environment (e.g., dorsal root
ganglion cells).
c. Interneurons
-are intercalated or internuncial neurons that interconnect motor or sensory
neurons.
4. Neurotransmitter (cholinergic neurons)
-elaborates acetylcholine as a neurotransmitter (e.g., ventral horn motor
neurons).
B. Nerve cell body
-is also called the soma or perikaryon.
-contains the organelles found in other cells, including a large nucleus and a
prominent nucleolus.
-has receptor molecules on its pbsmalemmal surface that confer sensitivity
to various neurotransmitters.
-incorporates or gives rise to the following structures:
1. Nissl substance
-is characteristic of nerve cells and consists of rosettes of polysomes and
rough endoplasmic reticulum.
-plays a role in protein synthesis.
-is abundant throughout cytoplasm and dendrites but is not found in the axon
hillock or in the axon.
2. Lysosomes
-are membrane-bound dense bodies that contain hydrolytic enzymes and are
involved in the process of intracellular digestion.
-A genetic defect in the synthesis oflysosomal enzymes results in a storage
disease [e.g., Tay-Sachs disease (GM2 gangliosidosis)].
3. Filamentous protein structures
-form an internal supportive network, the cytoskeleton, consisting of:
a. Microtubules (25 nm in diameter)
-are found in the cell body, dendrites, and axons.
-playa role in the development and maintenance of cell shape.
-playa role in the intracellular transport of peptide vesicles and
organelles.
b. Neurofilaments (10 nm in diameter)
-consist of spiral protein threads that playa role in developing and
regenerating nerve fibers.
-degenerate in Alzheimer·disease to form neurofibrillary tangles.
-contain neurofilament protein, which is exclusive to neurons and
their precursors.
c. Microfilaments (5 nm in diameter)
-are composed of actin.
-are found in the tips of growing axons.
-facilitate movement of plasma membrane and growth of nerve cell
processes.
4. Inclusion bodies
-include pigment granules:
a. Lipofuscin (lipochrome) granules
-are common pigmented inclusions of cytoplasm that accumulate' with
aging.
-are considered to be residual bodies derived from lysosomes.
b. Neuromelanin (melanin)
-is a blackish pigment in the neurons of the substantia nigra and
locus ceruleus.
-disappears from the substantia nigra and the locus ceruleus
inParkinson disease
c. Lewy bodies
-are eosinophilic intracytoplasmic inclusion bodies found in the sub. I stantia
nigra in patients with Parkinson disease.
d. Hirano bodies
-are intracytoplasmic inclusion bodies found in the hippocampus in patients
with Alzheimer disease.
e. Negri and lyssa bodies
-are intracytoplasmic inclusion bodies found in people with rabies.
5. Dendrites
-are processes that extend from the cell body.
-contain cytoplasm similar in composition to that of the cell body; however,
no Golgi apparatus is present.
-conduct in a decremental fashion but may be capable of generating action
potentials.
-receive synaptic input and transmit it toward the cell body.
6. Axons
-arise from either the cell body or a dendrite.
-originate from the axon hillock, which lacks Nissl substance.
-give rise to collateral branches.
-may be myelinated or unmyelinated.
-generate, propagate, and transmit action potentials.
-end distally in terminal boutons in synapses with neurons, muscle cells, and
glands.
7. Nerve fibers
The nerve fibers are classified by different methods. The basis of
classification differs in each method. Following are the various methods of
classification of the nerve fibers.
1. DEPENDING UPON THE STRUCTURE
Depending upon the structure, the nerve fibers are classified into two types
namely:
1. The myelinated nerve fibers- nerve fibers are covered by myelin sheath.
2. The nonmyelinated nerve fibers-The nerve fibers of this type do not have
myelin sheath.
• The sensory nerve fibers carry sensory impulses form different parts
of the body to the central nervous system.
These nerve fibers are also known as afferent nerve fibers.
5.DEPENDING UPON THE CHEMICAL NEUROTRANSMITTER
1. Adrenergic Nerve Fibers Adrenergic nerve fibers secrete noradrenaline.
2. Cholinergic Nerve Fibers- secrete acetylcholine
6.DEPENDING UPON THE DIAMETER AND CONDUCTION
9. Synapses
-are the sites of functional contact of a nerve cell with another nerve cell, an
effector cell, or a sensory receptor cell.