University of Technology, Jamaica

SYLLABUS OUTLINE
FACULTY Health and Applied Sciences COURSE OF STUDY MODULE TITLE MODULE CODE DURATION (HOURS) CREDIT VALUE PREREQUISITES
SCHOOL/ DEPT Pharmacy and

Health Science Medical Technology IMMUNOLOGY IMM 2002 40 hrs 3 Pass at 1st Year Medical Technology Year 2

1.0

MODULE DESCRIPTION

This module is designed to familiarize students with basic principle of immunology and its applications to various disciplines in Medical Technology. It develops an appreciation of the fundamentals of immune system, components of immune system and the nature of their interactions in specific types of immune responses. It will introduce current concepts of immune responses and some basic immunological techniques commonly used through out the biomedical sciences. 1

2.0

MODULE OBJECTIVES / LEARNING OUTCOMES General Objectives: On completion of the module students will: 1. Discuss the structure and function of the cells, tissues of the immune system and the nature of immune responses. 2. Describe the origin of lymphocytes and the structure and function of lymphoid organs. 3. To summarize the differences between the effector and affector arms of the immune response. 4. Describe the structure and functions of antigens and antibodies. 5. Understand the components and role of complements in immune system. 6. Explain the immunological basis of hypersensitivity, autoimmunity and major histocompatibility reactions. 7. Appreciate the implications of immunotolerance, immunogenetics and immunopathology. 8. Discuss the role and application of immuno diagnostictechniques. 9. Appreciate the role and contribution of immunity to modern medicine.

2.0

MODULE CONTENT AND CONTEXT

UNIT 1 IMMUNITY AND MORPHOLOGICAL ASPECTS OF THE IMMUNE SYSTEM ( 5 hours) On completion of this unit students will be able to: 1. Outline cell morphology, lymphocyte subpopulations and enumeration of lymphocyte subpopulations. 2. Identify the other cells involved in the immune responses. 3. Describe the structure and function of the lymphoid organs (Lymphoid tissue, Spleen, Lymph nodes, Thymus, Bursa of fabricus) 4. Discuss lymphocyte circulation , site of maturation, site of antigen contact, site of effector function. 5. Describe innate and specific immunity. 2

CONTENT Structure and function of the lymphoid system. Cell morphology, identification and enumeration of lymphocyte Sub populations. Cells involved in immune responses. Lymphocyte circulation and site of maturation. Site of antigen contact and site of effector functions. Innate and specific immunity. UNIT 2 CELLS INVOLVED IN IMMUNE RESPONSES (5 hours) On completion of this unit students will be able to: 1. Describe Major histocompatibility antigens. 2. Explain the mechanism of T-cell regulation. 3. Outline antigen processing and presentation by antigen Presenting cells. 4. Explain the interaction of cellular and humoral immunity 5. Explain the effector mechanism of cellular and humoral Interactions. CONTENT Major histocompatibility antigens T-cell regulation Antigen presentation and processing Interaction of cell and humoral immune responses. Effector mechanism of cellular and humoral interactions. UNIT 3 ANTIGENS (5 hours)

On completion of this unit students will be able to: 1. Describe immunogens 2. List different types of antigens. 3. Define Haptens and carrier molecules. 4. State the nature of antigens and cross reactivities. 5. Discuss antigenic tolerance. 6. Describe antigenic determinant. 3

CONTENT Immunogens Types of antigens Haptens and carrier molecules Nature and cross reactivity of antigens Antigenic tolerance Antigenic determinants UNIT 4 IMMUNOGLOBULINS (5 hours)

On completion of this unit students will be able to: 1. List the types of immunoglobulins. 2. Discuss types of antibodies. 3. Describe the structure and function of immunoglobulins. 4. Discuss the synthesis , assembly and secretion of Immunoglobulins. 5. Out line genetic basis of immunoglobulin production. 6. Discuss deficiencies of immunoglobulins 7. State the clinical significance of immunoglobulin deficiencies 8. Describe immunoglobulin levels of the new borne. CONTENT Types of immunoglobulins Structure and function of immunoglobulins Synthesis , assembly and secretion of immunoglobulins Genetic basis of immunoglobulin production Immunoglobulin deficiencies Clinical significance of immunoglobulin deficiencies Immunoglobulin levels of new borne 4

UNIT 5

COMPLEMENT SYSTEM

( 5 hours)

On completion of this unit students will be able to: 1. Define complement and list the components of complement. 2. Describe classical and alternative pathways. 3. Out line the biological activity of complement. 4. State the soluble factor of complement involved in immune responses. 5. Discuss the genetic deficiencies of complement. 6. Explain the clinical significance of complement deficiencies. CONTENT Classical and alternative pathways Biological activity of complement Soluble factor involved in immune responses Genetic deficiencies of complement Clinical significance of complement deficiencies. UNIT 6 MAJOR HISTOCOMPATIBILITY COMPLEX (4 hours) On completion of this unit students will be able to: 1. Describe Major Histocompatibility Complex ( MHC) 2. Illustrate the techniques for the identification of MHC antigens 3. Explain the genetic control of immune responses. 4. Outline the relationship between HLA and diseases CONTENT Major Histocompatibility Complex Techniques for identifying HLA antigens. Genetic control of immune responses HLA and diseases 5 UNIT 7 IMMUNOPATHOLOGY (5 hours)

On completion of this unit students will be able to: 1. Discuss autoimmune diseases 2. State the hypersensitivity reactions 3. Outline the hemolytic disease of the newborn 4. Explain the role of immunology in laboratory analysis of viral, parasitic infections. 5. Explain the role of immunology in endocrinology and histopathology CONTENT Autoimmune diseases Hypersensitivity reactions Hemolytic disease of new born Role of immunology in laboratory diagnosis of viral, parasitic infections Role of immunology in endocrinological and histopathological analysis UNIT 8 IMMUNODIAGNOSTIC TECHNIQUES (6 hours)

On completion of this unit students will be able to: Discuss the principle and application of the following techniques: 1. 2. 3. 4. 5. 6. 7. 8. 9. ELISA and RIA Complement Fixation tests Neutralization tests Hemagglutination tests Mancini techniques Immunoelectrophoresis techniques Separation , detection and enumeration of lymphocytes Cytotoxicity tests preparation of monoclonal antibodies 10. Separation of immunoglobulin 6

CONTENT Principle and application of the following techniques: ELISA and RIA Complement Fixation tests Neutralization tests Hemagglutination tests Mancini techniques Immunoelectrophoresis techniques Separation , detection and enumeration of lymphocytes Cytotoxicity tests preparation of monoclonal antibodies Separation of immunoglobulins 5.0 ASSESMENT PROCEDURES

Midsession tests. 25% Assignments / group presentations25% Final exams.50% 6.0 BREAKDOWN OF HOURS Numbers of hours allocated to: Class room lectures/tutorials/seminars..40 hours 7.0 TEXT BOOKS AND REFERENCES Ivan Roitt , Essential immunology, Blackwell Science Latest or 8th Edition (Student text) 7

Board Review series: Microbiology and Immunology, Johnson A.G, Lieger R, Lukasebylz O.A, Hawley, L.B Lippincott Willia A Walters Kluwer Company. (Reference Text) Immunology: An outline for students of Medicine, Ivan Roitt Blackwell Scientific Publishers (Students Text) 8.0 NAME OF SYLLABUS WRITER / DEVELOPER Leena Dasari 9. O DATE OF PRESENTATION OR REVISION JULY 10.0 , 2008

DATE OF ACCEPTANCE ---------------------------------------------Programme Director --------------------------------------------OCDE