Entrenet Nutritionals

Aloe Oral Gel

Dental Guide

INDEX

SECTION 1

INTRODUCTION

SECTION 2

ENTRENET ALOE INFORMATION

SECTION 3

ALOE VERA DENTAL RESEARCH

SECTION 4

DENTAL APPLICATIONS

SECTION 5

COMPANY INFORMATION

Entrenet Nutritionals continues to expand its line of healthcare professional products. The most recent addition is our state of the art Aloe Oral & Topical Gels. Aloe Vera has quickly become recognized for its healing potential both internally and externally. As you will learn from recent articles such as the one found in General Dentistry/May-June 1999, Aloe Vera has now entered into the field of dentistry. The benefits of Aloe Vera have been confirmed by research in medical schools, independent laboratories, and by a large number of clinical cases. Aloe Vera gel anesthetizes tissue, is bactericidal, is virucidal, is fungicidal, is hemostatic, is an antipyretic, is an anti-inflammatory, is antipruretic, is a capillary dilator, is an enhancer of normal cell proliferation and epithelialization, and is a tissue moisturizer. Entrenet Aloe Vera products are currently recognized as the most scientifically advanced and research documented in the healthcare industry. This dental guide will provide you with Aloe Vera research, dental research, and dental applications. Entrenet is proud to serve the dental industry. You will be provided with the highest quality product and service available. I. General Description

A. Location: Dry regions of Northern Mexico B. Plant Characteristics: Tough, fleshy, spear-like or triangular leaves rising in a rosette configuration; as many as 30 leaves per plant, saw-like leaf margins; leaf is filled with gel from a central, clear mucilaginous pulp; plant grows from 1.5 to 4 feet high. Of the 200 plus species of Aloe Vera, four have nutritional value, and Aloe Barbadensis Miller is the most common. II. Entrenet Aloe XL Qualifications

Exceeds all standards set by the International Aloe & Science Council. Boasts the IASC certification label and information on products. Created using the Active Aloe process. Active Aloe guarantees that our product contains biologically active aloe. Active Aloe maintains a 50,000-100,000 polysaccharide molecular weight. This molecular weight relates to a 75% Immune Recovery. Combined with the IASC & Aloe Corp, Entrenet Aloe consistently ranks as the most scientifically advanced aloe in the market to date.

III.

Chemical Composition

A. Active Compounds (Currently 250 identifiable elements) Anthraquinones (aloin, barboloin, aloe-emodin): cathartics.

 Saccharides (acetylated mannose): antiviral and immunopotentiating action. Prostaglandins and fatty acids (gamma-linoleic acidprostaglandin 1 series): favorable effects on inflammation, allergy, platelet aggregation, wound healing. Others: enzymes, amino acids, vitamins, minerals. B. Other compounds Cholesterol, triglycerides, steroids, uric acid, lignins, beta-sitosterol, glibberellin, salicylic acid. IV. Pharmacology

Antibacterial and antifungal 69% extract: bactericidal against Pseudomonas a., Klebsiella p., Serratia m., Citrobacter, Enterobacter c., Strep. Pyogenes and Agalactiae. 77% extract: bactericidal against Staph. A. 80% for E. coli, 90% for Strep f. and Candida a. Inhibition of growth: Mycobacterium 5., Trichophyton, and Bacillus subtilis. Antiviral: acemannan Direct antiviral activity against HIV1 by inhibiting glycosylation of glycoproteins. Acts synergistically with AZT or acyclovir by inhibiting the replication of HIV and HSV1. Also effective against feline leukemia, influenza, measles. Immune enhancement: acemannan Enhancement of macrophage activity, release of immune system potentiators, T-cell function, interferon production. Possible activity in sarcomas and spontaneous tumors. Anti-allergy and anti-inflammatory: glycoproteins and anthraquinones Block generation of thromboxanes and bradykinin. Inhibit and break down bradykinin. Wound Healing Vitamin C, E and Zinc. Stimulate fibroblast and connective tissue formation, promoting wound repair. Stimulate repair process and epidermal growth. Stimulate cell division three-fold. V. Clinical Application Specific to Inflammation and Wound Healing

 Aloe Vera has anti-inflammatory components such as amino acids, vitamin C, aspirin-like compounds, and mannose which can normalize the acute vascular response. Aloe Vera can block the polymorphonuclear leucocyte response, but does not reduce connective tissue formation. Aloe Vera inhibits acute inflammation but unlike steroids it stimulates fibroblast growth to improve wound healing. Aloe Vera contains amino acids such as phenylalanine and tryptophane, which have anti-inflammatory activity. Aloe Vera can block prostaglandin synthesis. Aloe Vera contains bradykinase, which breaks down into bradykinin, a vasodilator, and at the same time stimulates the angiotensin, a potent vasoconstrictor. Aloe Vera can act as a modulator of both immune and inflammatory reactions. VI. Toxicity Allergic Reactions: generalized eczematous and popular dermatitis (from topical application). VII. Dosage

Oral Gel: apply liberally. Juice: 2-4 ounces per day for general usage. May increase up to one liter per day depending upon condition. References: Danhof, Ivan E., Ph. D., M.D. Aloe Leaf Handling and Constituent VariabilityAloe . Today. Autumn/Winter. 1991, pp. 12-15 Davis, RH, et al. Anti-inflammatory and wound healing activity of a growth substance in Aloe Vera. Journal of the American Podiatric Medical Association. 84(2): 77-81, 1994 Feb. Davis, RH, et al. Aloe Vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. Journal of the American Podiatric Medical Association. 84(12): 614-21, 1994 Dec. Karaca, K., et al. Nitric Oxide production by chicken macrophages activate by Acemannan, a complex carbohydrate extracted from Aloe Vera. International Journal of Immunopharmacology. 17 (3): 183-8, 1995 March IASC (International Aloe and Science Council) research and information. Website and information maintained by MultiMark Communication. Research dates between June 1996-August 1999. Unlimited resources.

H.R. McDaniel, R.H. Carpenter, D.V.M., and B.H. McAnalley, Ph.D. Identification of Gigantic Circulation Monocytic Cell in Warm-Blooded AnimalsAbstract of Papers and . Poster. ASCP Scientific Assembly. American Society of Clinical Pathologist. New Orleans, 1987. p. 118 H. Saito, T. Ishiguro, G. Imanishi, I. Suzuki. Pharmacological Studies on Plant Lectins. Aloctin-A. Inhibitory Effect of Aloctin-A on Experimental Models of Inflammation in RatsJournal of Pharmacology. Japan. Vol 32., pp. 139-142 .

Dental Applications 1. Apply Aloe Oral Gel directly to the sites of periodontal surgery. 2. Apply Aloe Oral Gel to the gum tissues when they have been traumatized or scratched by toothbrush-dentifrice abrasion, sharp foods, dental floss and toothpick injuries. 3. Apply Aloe Oral Gel to extraction sites. (Dry sockets do not develop when Aloe Oral Gel is applied). 4. Apply Aloe Oral Gel to herpetic viral lesions, aphthous ulcers, cankar sores and cracks occurring at the corner of lips. Gum abscesses are soothed by applications as well. 5. Apply Aloe Oral Gel to Lichen Planus and Benign Pemphigus. Aloe Oral Gel can provide relief to gum problems associated with AIDS and Leukemia. Migratory glossititis, geographic tongue and Burning Mouth Syndrome are improved. 6. Apply Aloe Oral Gel to denture patients with sore ridges and ill fitting dentures. Partials can benefit from a reduction in funguses and bacterial contamination, as well as reduced inflammation. 7. Aloe Oral Gel can be used around dental implants to control inflammation from bacteria contamination. 8. Aloe Oral Gel can also be used to help a wide variety of oral disorders which include: Candidiasis, Desquamative Gingivitis, Vesiculobullous disease, acute Monocytic Leukemia, hematological disorders and nutritional problems all respond well. **Apply Entrenet Aloe Oral Gel liberally throughout the day. You may saturate gauze with Aloe Oral Gel to keep in contact with affected area for an extended period of time. Aloe Oral Gel is completely non-toxic and will not contradict any pharmaceutical medications.**

Entrenet Nutritionals Company Bio

Entrenet was founded in May 1998 by Judy Hannan and Tracy Belcastro, both of whom reside in Pittsburgh, PA. Entrenet has quickly forged itname as one of the leading professional nutritional s suppliers in the country, with more than 20,000 business associates. Entrenet is well known for itsuperiority in the field of Aloe Vera and associated nutritional s supplements. Entrenetlarge healthcare professional clientele is based on the fact of s outstanding merit in the field of medical nutritional support data and clinical studies. Most recently, our Activin Grape Seed antioxidant was presented at the American Association of Cancer Research. Medical reports released indicate Activinability to s reduce breast, lung and stomach cancer cells by as much as 48%. EntrenetAloe s dominance is scientifically supported by itrepresentation as a member of the s International Aloe Science Council. Research has also supported the fact that Entrenet s Active Aloe process creates an aloe with a 75% immune recovery rate. This is nearly three times the strength of our closest competitor. Entrenet provides independent assays on every one of its products. Whichever products you choose from Entrenet Nutritionals for your practice, you can be assured that you are receiving the most potent nutritional supplements that our industry has to offer.