LEARNING OBJECTIVE PATHOLOGIC OF THE HEART FOR BLOCK 10TH

dr Henny Sulastri, spPA(K) Departement of Pathology Anatomic dr. M Hoesin Central General Hospital/ University of Sriwijaya

I. ISCHAEMIC HEART DESEASE Stable angina Unstable angina Variant (Prinz metal ) angina Syndrome associated with acute myocardial necrosis or myocard infarction Chronic pump failure

RISK FACTOR GENERAL PATHOLOGY OF ISCHAEMIC MYOCARDIAL INJURY BIOCHEMICAL CHANGES STRUCTURAL CHANGES OCCURING IN ISCHAEMIC MYOCARDIUM Ultrastructural changes Light microscope changes

MYOCARDIAL HIPERTHROPY & HEART FAILURE HYPERTENSIVE HEART DISEASE ACUTE MYOCARDIAL NECROSIS (MYOCARDIAL INFARCTION) 1. Transmural infarcts 2. Subendocardial infarcts Pathogenesis Morphology Complications

Myocardial Ruptur Intraventricular Thrombosis Extention and expansion in myocardial infark

Ventricular aneurysm formation Sudden death

II. ACUTE RHEMATIC FEVER

PATHOGENESIS PATHOLOGICAL FEATURES Disease is characterized by pancarditis Pericardial changes Myocardial changes Endocardial changes

III.

CHRONIC RHEUMATIC VALVE DISEASE

Mitral stenosis

Morphologycal changes - Commissural fusion - Cusp scarring - Dystrophic calcification Effects on the left atrium Mitral incompetence Aortic valve changes in chronic rheumatic heart disease

IV.

INFECTIVE ENDOCARDITIS
Acute endocarditis Subacute endocarditis Pathogenesis Cardiac Lessions in Infective Endocarditis -Vegetations COMPLICATIONS - Emboli - Cardiac Failure

- Immune complex -mediated complications

V. MYOCARDITIS
Viral Myocarditis Other Forms of Infectious Myocarditis Hypersensitivity Myocarditis Giant Cell Myocarditis

VI. METABOLIC DISEASES OF THE HEART

Hyperthyroid Heart Disease Hypothyroid Heart Disease Thiamine Deficiency (Beri-beri) Heart Disease

VII. CARDIOMYOPATHY
Idiopathic Dilated Cardiomyopathy Secondary Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Restrictive Cardiomyopathy

VIII. DISEASE OF THE PERICARDIUM

Pericardial Effusion Acute Pericarditis Constrictive Pericarditis

LEARNING OBJECTIVE PATHOLOGIC OF BLOOD VESSELS FOR BLOCK 10TH

dr Henny Sulastri, SpPA(K) Departement of Pathology Anatomic dr. M Hoesin Central General Hospital/ University of Sriwijaya

ARTERIOSCLEROSIS
General term Arteriolosclerosis Monckeberg medial calcific sclerosis Atherosclerosis

ATHEROSCLEROSIS Pathogenesis Chronic endothelial injury Accumulation of lipoprotein Monocyte adhesion Platelet adhesion Factor release SMCs proliferation and ECMs production Lipid accumulation

Morphology Fatty streak Atherosclerosis plaque/ Fatty plaque Advanced vulnerable plaque Ruptur, ulceration, or erosion of the luminal surface of atheromatous plaque. Atheroembolism Aneurysm formation Critical stenosis

MEDIOSCLEROSIS HYPERTENSIVE VASCULAR DISEASE

Vascular pathology in Hypertension Hyalin arteriolosclerosis Hyperplastic arteriolosclerosis

ANEURYSM VASCULITIS
Polyarteritis nodosa Wagener granulomatosis Thromboangiitis Obliterans (Buerger Disease)

RAYNOUD PHENOMENON VEINS AND LYMPHATIC

Varicose Veins Thrombophlebitis and Phlebothrombosis Superior and Inferior Vena Caval Syndromes Lympangitis and Lymphedema

TUMORS
Benign - Hemangioma Intermediate grade - Hemangioendothelioma Kaposi sarcoma Malignant Neoplasms - Angiosarcoma

Hemangiopericytoma