Uka Tarsadia University

M.Sc. PHARMACEUTICAL CHEMISTRY

PC 101 BASIC PHYSIOLOGY - PHARMACOLOGY AND PHARMACOGNOSY

Semester - I
EFFECTIVE FROM JUNE-2011

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UKA TARSADIA UNIVERSITY M.Sc. PHARMACEUTICAL CHEMISTRY EFFECTIVE from JUNE-2011 PAPER - PC-101 BASIC PHYSIOLOGY - PHARMACOLOGY AND PHARMACOGNOSY Total Periods: 48 SECTION -1 UNIT -1: (12 Periods) (A) Physiology Scope of Physiology Human Cell and Tissues With function Blood Cardiovascular system: Heart, Cardiac output, Blood Pressure and Cardiac cycle Nervous system: Eye, Ear and Skin Endocrine glands and Hormones: Pituitary, Thyroid, Adrenal and Pancreas Urinary system Digestive system. (B) Pharmacology Scope of Pharmacology and important definitions Routes of Drug administration Pharmacokinetics: Absorption, Distribution, Metabolism and excretion of Drugs UNIT -2: Pharmacognosy (12 Periods) (A) Definition and scope of Pharmacognosy Various system of classification of drugs of natural origin Occurrence, Distribution, organoleptic evaluation, Chemical constitutions including tests wherever applicable and therapeutic efficiency of following category of drugs: o Laxatives: Aloes, Rhubard, Caster oil, Isapaghula, Senna o Cardiotonics: Digitalis, Arjuna

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o Carminatives and G.I regulators: Umbelliferous fruits, Coriander, Fennel. Ajowan, Cardamom, Ginger, Black pepper, Asafoetida, Nutmeg, Cinnamon, Clove o Astringent: Catechu o Drug active on nervous system: Hyocymus, Nuxvomica o Anti hypertensive: Rauwolfia o Anti tussives: Vasaka, Tolu balasam, Tulsi. (B) Occurrence, Distribution, organoleptic evaluation, Chemical constitutions including tests wherever applicable and therapeutic efficiency of following category of drugs: o Anti rheumatics: Guggul, Colchicum o Anti tumor: Vinca o Anti leprotic: Chaulmoogra oil o Anti diabetics: Pterocarpus, Gymnema sylvestris o Diuretics: Gokhru, Punarnava o Anti dysenteric: Ipecacuanha. UNIT -3: Pharmacodynamics (12 Periods) Introduction Elementary treatment of enzyme stimulation Enzymes inhibition Sulphonamides Member active drugs Drug metabolism Xenobiotics Biotransformation Significance of drugs metabolism in medicinal chemistry. Mechanism of drugs action, structure activity relationship, Factors assisting drug action and dosage, Biopharmaceuticals Concept of Receptors and Theory. Unit 4: Chemical Toxicology: (12 Periods) Toxic element in Water pesticides in water impact of toxic chemical on enzymes Remedial measure biochemical effects on pesticides.

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REFERENCE BOOKS: 1. Principle of Anatomy and Physiology by Tortora. 2. Pharmacology and Pharmacotherapeutics by R.S.Satosker 3. Essentials of Pharmacotherapeutics by F.S.K. Barar. 4. Elements of Pharmacology by Derasavi and Goyal. 5. Essentials of mediacal Pharmacology by K.D.Tripathi. 6. Text book of Pharmacognosy by Trease and Evans. 7. Text book of Pharmacognosy by T.E. Wallis. 8. Elements of Human Anatomy, (PHYSIOLOGY AND HEALTH EDUCATION BY DERASAVI AND GOYAL). 9. Human Physiology by C.C.Chatterjee. 10. Introduction to Medical Chemistry, A Gringuage, Wiley VCH. 11. Wilson and Gisvolds Text book of medicinal and pharmaceutical chemistry, Ed Robert F. Dorge. 12. Elements of Human Anatomy by Derasari and Gandhi.