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Defective placental implantation Release of placental factor Factor X Endovascular trophoblastic cells invade the maternal spiral arteries Replacement of endothelium, destruction of medial musculoelastic tissue, and fibrinoid change in the vessel wall Fibrin, platelets, lipophages aggregates Acute atherosis partially or completely blocking the arterioles Placental infarction
Placental ischemia
Increased thromboxane A2
Vasospasm Vasoconstriction
Kidney Decreases glumerular filtration rate Increased creatinine, increased uric acid, decreased urine output
Pancreas
Epigastric pain
Stillbirth
PATHOPHYSIOLOGY (Patient Based) Non Modifiable Factors: Age ( 21 y/o) Family history of Eclampsia Gender (Female) Primiparity
Defective placental implantation Release of placental factor Factor X Endovascular trophoblastic cells invade the maternal spiral arteries Replacement of endothelium, destruction of medial musculoelastic tissue, and fibrinoid change in the vessel wall Fibrin, platelets, lipophages aggregates Acute atherosis partially or completely blocking the arterioles Placental infarction
Placental ischemia
Increased thromboxane A2
Vasospasm Vasoconstriction
Kidney Decreases glumerular filtration rate Increased creatinine, decreased urine output
Pancreas
Brain
Placenta