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A. ALBENDAZOLE
Roundworms MECH OF ACTION – blocks glucose uptake in
both larval and adult parasite , which
leads to decrease formation of atp
- inhibition of microtubule assembly
CLINICAL USE : broad anthelintic spectrum
first drug of choice for larve migrans(
ancylostoma spc)
alternative drug for roundworms , whipworm,
A. LUMBRICOIDES E. hookworms,pinworms and threadworm
VERMICULARIS TOXICITY : reversible leukopenia ,
ROUNDWORM PINWORM alopecia and changes in the liver
anzymes
LONG TERM USE : bone marrow suppresion
and fetal toxicity
B. DITHYLCARBAMAZINE
MECHANISM OF ACTION : immobilizes
N. AMERICANUS T. TRICHURA
HOOKWORM WHIPWORM microfilariae
CLINICAL USE: drug of choice for filariasis
alternative for onchocerciasis ( in
combination with suramin)
TOXICITY : headache, malaise, weakness,
anorexia
can cause the mazzotti reaction in
S. STERCORALIS onchocerciasis – hypotension, pyrexia
THREADWORM respiratory distress and prostration
fever, rashes and ocular damage
Tissue Nematodes
C. IVERMECTIN
MECHANISM OF ACTION : intesifies gaba
mediated neurotransmission in
nematodes resulting to paralysis
CLINICAL USE : drug of choice for
ONCHOCERCA Wuchereria onchocerciasis : drug of first choice for
bancrofti strongloidiasis and alternative drug for
filariasis
TOXICITY : fever, headache ,dizziness
,rashes, pruritus, tachycardia
,hypotension , joint pains , muscle [ain
and pain ion lymph nodes
ANCYCLOSTOMA D. MEBENDAZOLE
MECHANISM OF ACTION – selctively inhibit
microtubule syntheisi and glucose uptake in
nematodes
CLINICAL USE :
drug of first choice for pinworms ,
whipworms and round worms
second drug of choice for cestodes
nad trematode infection
TOXICITY : only limited to gastrointestinal CLINICAL USE : drug of choice for
irritation . embyrotoxic schistosomiasis, clornorchiasis and
paragonimiasis
it is also one of the drug of choice for
E. PIPERAZINE cestodes
MECH. OF ACTION – acting as agonist at gaba TOXICITY – headache , dizziness, malaise and
recptors git irritation , skin rashes and fever
CLINICAL USE ; drug of choice for ascariasis CONTRAINDICATION : ocular cysticercosis
TOXICITY : git irritation
TREMATODES
D. OXAMNIQUINE – effective solely in
schistosoma mansoni infections
TOXICITY : dizziness ,git irritation , pruritus
REACTION TO DYING PARASITES –
eosinophilia ,urticaria and pulmonary
infiltrates
CLONORCHIS SINENSIS(LIVER
FLUKE)