Course Outline

School: Department: Program: Course Title: Course Code: Total Course Hours: Prerequisites/Co-requisites: Eligible for Prior Learning Assessment and Recognition: Originated by: Revised by: Date: Effective Semester: Approved by:
________________________________________ Chairperson/Dean

School of Engineering Technology and Applied Science Information and Communication Engineering Technology Biomedical Engineering Technology Advanced Topics in Biomedical Engineering BTEC321 60 BTEC211, BTEC221

Yes Charanjit Bambra, PhD Charanjit Bambra, PhD August 2011 Fall 2011

Students are expected to review the course outline and to discuss with the professor any areas where clarification is required. Students should keep all course outlines for each course taken at Centennial College. These may be used to apply for transfer of credit to other educational institutions. A fee may be charged for additional or replacement copies.

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

Course Description
Biomedical engineering technology includes biomechanics, modeling of the human body, biomaterials, tissue engineering, modeling of biological systems, medical informatics, medical electronics, medical imaging systems, design of medical devices and biosensors. Modeling using the latest biomedical engineering tools impacts on medical diagnosis, design of medical equipment and therapeutic applications. This advanced course will provide an introduction to applied biomedical applications in biotechnology, bioelectric phenomena and biological effects of nonionizing electromagnetic field. It will also provide an overview of important applications of biomedical engineering that will include modeling of organs and tissues, developing diagnostic applications and designing medical equipment for novel therapeutic procedures.

Course Learning Outcomes

The student will reliably demonstrate the ability to: 1. Examine current biomedical engineering technology literature. 2. Apply theoretical and practical knowledge of approaches used in biomaterials, tissue engineering, modeling of body systems, medical electronics, imaging systems and design of medical devices and biosensors. 3. Research, analyze, prepare, document and write well reasoned research papers. 4. State the principles behind biomechanics, modeling of the human body, biomaterials, tissue engineering, modeling of biological systems, medical informatics, medical electronics, medical imaging systems, design of medical devices and biosensors. 5. Demonstrate a good working knowledge of some specialized areas within Medical Engineering such as Rehabilitation Engineering, Bioengineering, Biomaterials, Biotechnology and Medical Instrumentation. 6. Identify problem areas in the area of biomedical engineering applications. 7. Evaluate practical solutions for biomedical engineering instrumentation.

Essential Employability Skills (EES)

The student will reliably demonstrate the ability to: 1. Communicate clearly, concisely, and correctly in the written, spoken, and visual form that fulfills the purpose and meets the needs of the audience. 2. Apply a systematic approach to solve problems. 3. Research, analyze, evaluate, and apply relevant information from a variety of sources. 4. Interact with others in groups or teams in ways that contribute to effective working relationships and the achievement of goals. 5. Locate, select, organize, and document information using appropriate technology and information systems 6. Manage the use of time and other resources to complete projects.

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

Global Citizenship and Equity (GC&E) Outcomes

The student will reliably demonstrate the ability to: 1. Identify ones roles and responsibilities as a global citizen in personal and professional life. 2. Support personal and social responsibility initiatives at the local, national or global level.

Prior Learning Assessment & Recognition (PLAR) Process (es)

This course is eligible for PLAR through the Registrar and SETAS offices. Assessment of portfolio and/or testing may be discussed with faculty.

Text and Other Instructional/Learning Materials

There is no single text book for this course and weekly study material from textbooks, journal articles and other online sources, presentations and tutorials will be provided. The course outline and projects will be provided on the first day of class when the students will chose the project and form the project groups. These selected projects will then be developed through the semester with students obtaining further advice and guidance at designated weekly times. Teaching and learning is through presentations, discussions, students own reading, research and group project work.

Evaluation and Grading System

Evaluation Description
Theory Test Assignments Three, each worth 10 marks Group Project

Weight /100
30 30 40

In consultation with the Chair or Dean, a faculty member or instructor may administer additional or alternative evaluations to fully assess the capability of a student. When writing a test or examination, students must put their official College photo-ID cards in full view for review by the invigilator. Students who do not have official photo-ID will be permitted to write the examination with a substitute photo-ID, but they will be required to produce photo-ID at the program or department office within 24 hours or the next business day following the examination, or else the examination results will be void.

Student Accommodation

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

All students have the right to study in an environment that is free from discrimination and/or harassment. It is College Policy to provide accommodation based on grounds defined in the Ontario Human Rights Code. Accommodation may include changes or modifications to standard practices. This document is available in alternative formats upon request. Please contact the originating department or school of study. Students with disabilities who require academic accommodations must register with the Centre for Student with Disabilities. Please see the Centre for Students with Disabilities for details. Students requiring accommodation based on human rights grounds should talk with their professors as early as possible. Details are available on the Centennial College website (www.centennialcollege.ca ). If students are unable to write an examination due to a medical problem or unforeseen family problems, they should immediately contact their professor or program Chair for advice. In exceptional and well documented circumstances (e.g. unexpected family problems, serious illness, or death of a close family member), students should be able to write a make-up examination to replace an examination missed.

Use of Dictionaries
Any dictionary (hard copy or electronic) may be used in regular class work; Dictionary use is not permitted in test or examination settings.

Course, Program or School Policies

N/A

Student Rights and Responsibilities

Students should familiarize themselves with all College Policies that cover students rights and responsibilities. For more information on the following and other policies, please visit www.centennialcollege.ca/aboutus/respect or consult the Academic Matters Section in the fulltime and Continuing Education catalogues. Respect at Centennial At Centennial College, we are committed to providing a safe and respectful learning, teaching and working environment for all students, faculty and staff that promotes equity. Policies have been put in place to ensure that Centennial is a place that demonstrates respect and consistency with the Ontario Human Rights Code. All incidents of harassment, discrimination, bullying and violence will be addressed and responded to. As a college, we take the position that all forms of harassment, including personal harassment and bullying, must be stopped. Please refer to www.centennialcollege.ca/aboutus/respect and www.stopbullyingnow.ca. Academic Honesty Academic honesty is integral to the learning process and a necessary ingredient of academic integrity. Students have a responsibility to be aware of and comply with College standards of academic conduct. Academic dishonesty includes cheating, plagiarism, and impersonation.

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

All of these occur when the work of others is presented by a student as their own and/or without citing sources of information. Breaches of academic honesty will be investigated and if warranted, appropriate remedies and penalties will be applied, which may include a failing grade on the assignment/course, suspension or expulsion from the college. Grades Appeal Students and faculty have rights and responsibilities in the Grades Appeal process. Students who need to appeal a grade should consult the Grades Appeal policy and procedures. Progression and Academic Standing Students are expected to meet the academic standards of their School or program. The academic standing of each Centennial student is monitored during, as well as at the end of, each semester. Any student not demonstrating satisfactory progress will be informed of his/her standing in the College and will receive academic advising within their School. Unsatisfactory academic performance may result in conditional academic standing, probation or suspension.

Faculty Support
Professors are available to see students outside of class time. Students can contact professors via voice mail, email, or through their program or department office. Information regarding how to contact teachers will be provided at the beginning of the course and is also available in the program or department office.

Campus Safety
As part of our efforts to maintain a safe and secure teaching, learning and working environment, professors and instructors will review emergency procedures for fire, evacuations, emergency lock-downs and safe exit for those with disabilities at the beginning of each course. Students must produce official photo identification when requested to do so by any college staff at any time during the semester.

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

Topical Outline
WEEK
1

TOPICS
Fundamentals of Research

READINGS/ MATERIALS
Course material from textbooks, journal articles and online sources

WEEKLY LEARNING OUTCOMES

Explain the scientific method Explore research design Discuss research purpose Differentiate between pure and applied research Explore different types of research Practice writing your own research paper Correlate Strategies and approaches for protein engineering research Discuss rational research design and directed research evolution and industrial applications Explain how antisense works Depict proof of mechanism Describe molecular mechanisms of antisense drugs Describe structure and function of monoclonal antibodies Debate monoclonal antibody cloning technologies Explain what genetically engineered monoclonal antibodies are Explore applications of monoclonal antibodies Outline tools and database Examine microarray informatics Assess online tools Outline vaccine production technologies Debate current vaccine issues

INSTRUCTIONAL STRATEGIES
Instructor-led presentation and group discussions Seminar: Current Research Presentation

COURSE EVALUATIONS
Project selection and Groups

Protein engineering - Research and industrial Applications

Course material from textbooks, journal articles and online sources

Instructor-led presentation and group discussions

Discussion Topic: Antisense Technologies

Monoclonal Antibodies

Course material from textbooks, journal articles and online sources

Instructor-led presentation and group discussions

Assignment One

Discussion Topic: Gene Discovery Tools

Vaccine Production

Course material from textbooks, journal articles and online sources

Instructor-led presentation and group discussions

Rev. COLT: May 2010

CENTENNIAL COLLEGE

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

WEEK

TOPICS

READINGS/ MATERIALS

WEEKLY LEARNING OUTCOMES

and challenges Depict timing and technology choices Investigate Avian Flu Review gene therapy Explore recent developments in gene therapy Clarify the barriers preventing gene therapy from becoming the treatment of choice Review tissue engineering Illustrate advances in tissue science Specify goals of cell and tissue engineering Explore control of cellular responses Relate development of scaffolds to tissue matrix environment Investigate developing tools Explore the scope of metabolic engineering Describe recombinant DNA based metabolic engineering Describe membranes Examine bioelectric current loops Illustrate membrane polarization Construct action potentials initiation and propagation Review extracellular waveforms Relate basic relations in idealized homogenous volume conductor to function Compare monopole and dipole fields State volume conductor properties Explain electrical properties of membranes

INSTRUCTIONAL STRATEGIES

COURSE EVALUATIONS

Discussion Topic: Gene Therapy

Tissue Engineering

Course material from textbooks, journal articles and online sources

Instructor-led presentation and group discussions

Discussion Topic: Metabolic Engineering

Electro-physiology

Course material from textbooks, journal articles and online sources

Instructor-led presentation and group discussions

Assignment Two

Discussion Topic: Volume Conductor Theory

Membrane Models

Course material from textbooks, journal articles

Instructor-led presentation and group

7

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

WEEK

TOPICS

READINGS/ MATERIALS
and online sources

WEEKLY LEARNING OUTCOMES

Discuss different cell types Illustrate simplified membrane models Describe characteristics of normal ECG Justify voltage and time calibrations Assess heart rate Explore rhythms and arrhythmias Clarify extra heart beats and heart blocks Interpret hypertrophy Describe muscle activation Illustrate motor unit Review electrical responses to neural activation Explain the determinants of EMG Amplitude Diagram EMG equipment Discuss clinical uses of EEG Describe electrode placement Discuss factors affecting EEG interpretation List common EEG artifacts Relate fundamental principles of electrical stimulation to EEG Review the theory of biomagnetic fields Explain Maxwells equations Compute magnetic fields Define the electrical fields in volume conductors Explain membrane electric field Interactions Specify electrochemistry of stimulation Describe electrode and tissue damage

INSTRUCTIONAL STRATEGIES
discussions Group Project Review Instructor-led presentation and group discussions

COURSE EVALUATIONS

Electro-cardiogram

Course material from textbooks, journal articles and online sources

Discussion Topic: Electro-myography

Principles and Biological basis of Electroencephalography

Course material from textbooks, journal articles and online sources

Instructor-led presentation and group discussions

Discussion Topic: Biomagnetism

10

Electrical Stimulation of Excitable Tissue

Course material from textbooks, journal articles and online sources

Instructor-led presentation and group discussions

Assignment Three

Group Projects:

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

WEEK
11

TOPICS
Biologic Effects of Extremely Low Frequency Electric and Magnetic Fields

READINGS/ MATERIALS
Course material from textbooks, journal articles and online

WEEKLY LEARNING OUTCOMES

Sequence physical interactions dosimetry, basic principles, people and animals, cells and cell assemblies Review biological effects, human data, laboratory animals and cellular systems

INSTRUCTIONAL STRATEGIES
Instructor-led presentation and group discussions

COURSE EVALUATIONS

Group Projects:

12

Radiofrequency Exposure and Potential Health Effects

Course material from textbooks, journal articles and online sources

Radiofrequency Hyperthermia in Cancer Treatment

13

Ethical Issues in Biomedical Engineering

Course material from textbooks, journal articles and online sources

Correlate types of tissue interactions categorize thermal/non-thermal effects Review biological mechanisms Interpret in vitro and in vivo studies List safety standards Explore pain relief Discuss treatment of cancer Explain simulation of nerve block Review healing of bone fracture Discuss hyperthermia Relate hyperthermia to cancer treatment Explore side effects of hyperthermia Review breast cancer therapy Depict nature and origin of pores Illustrate prompt membrane destruction using electroporation Explore advantages and disadvantages of electroporation Describe fundamentals of bioethics Review research ethics Review professional ethics Review social ethics Demonstrate biomedical decision making models

Instructor-led presentation and group discussions

Hand in Group Projects

Discussion Topic: Therapeutic Applications of Low Frequency Pulsed Electric and Magnetic Fields

Electroporation

Instructor-led presentation and group discussions

Discussion Topic: Bioethical Decision

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

Advanced Topics in Biomedical Engineering

CENTENNIAL COLLEGE

BTEC321

WEEK
14 15

TOPICS
Group Project Presentations Revision

READINGS/ MATERIALS

WEEKLY LEARNING OUTCOMES

INSTRUCTIONAL STRATEGIES
Making

COURSE EVALUATIONS

Final Exam

Rev. COLT: May 2010 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar)

10