Professional Documents
Culture Documents
members, certain foodsnotably barley and black beanscan
lower blood glucose levels. Incorporating these foods into your diet
can help prevent glycemic-related disorders such as diabetes, heart
disease, cancer, and obesity.
54 SHIELD YOURSELF FROM ENVIRONMENTAL CANCER RISKS
On a daily basis we are surrounded by environmental toxins found
in drinking water, pesticides, and plastics that can trigger the onset
of cancer. Decades of research have shown that cruciferous
vegetables help your body neutralize these toxins and slash your
risk of cancer by up to 54%.
68 MISCONCEPTIONS ABOUT ATHEROSCLEROSIS
Cardiovascular disease causes one of every three deaths in the
United States. Most heart attacks and strokes are caused by athero-
sclerosis. Because mainstream doctors only treat one or two of the
multifactorial causes of this disease, heart attacks remain the leading
cause of death. Reduce your risk by taking steps to manage and
eliminate all 17 proven causes of arterial disease.
78 HOW ATHEROSCLEROSIS DEVELOPS IN AGING HUMANS
At least one of every two Americans over the age of 65 has athero-
sclerosis. By understanding the development of this disease and
controlling the risk factors, you can potentially reverse dangerous
occlusions of vital arteries.
86 REJUVENATE YOUR AGING NECK
Most skin care regimens target the face in order to reduce the signs
of aging. However, the thin skin on your neck quickly reveals the pas-
sage of time through accelerated sagging and wrinkles. Formulators
have combined specic cell-communicating compounds that reacti-
vate aging skin cells to repair and tighten the necks delicate skin.
TABLE OF CONTENTS
17 IN THE NEWS
Grape seed extract protects against
colorectal cancer; magnesium intake low-
ers fasting glucose and insulin; anthocya-
nins reduce heart attack risk up to 32%;
curcumin lowers rheumatoid arthritis pain
better than common medication; partici-
pants sought for study examining calorie
restrictions effect on telomere length;
and more.
95 AUTHOR INTERVIEW
In his new book, Dr. Neal Barnard reveals
how new imag ing techniques allow
scientists to better understand the aging
brain. Here, he reveals his groundbreak-
ing 3-step plan that incorporates spe-
cic foods, nutrients, and environmental
factors to help you prevent Alzheimers
disease and dementia.
ON THE COVER
7 REBUTTAL TO ATTACK
AGAINST FISH OIL
Despite improvements in
prevention and treatment,
heart disease kills 600,000
Americans each year, and
stroke nearly 130,000. In the
face of this epidemic carnage,
the American Medical
Association published a report
questioning the value of sh
oil in cardiovascular disease
patients. This rebuttal
exposes the many aws in the
American Medical Association
report, the inaccurate portrayal
of it by the media, and the
inability of most doctors to
understand that successful
treatment of atherosclerotic
disease requires more
than one intervention.
46 FRAN DRESCHERS
CRUSADE TO END CANCER
After eight doctors and as
many misdiagnosis, TV
star Fran Drescher nally
discovered that she had
gynecological cancer. Based
on this medical ordeal,
Drescher founded the Cancer
Schmancer movement, which
focuses on early diagnosis,
prevention through healthy
choices, and avoiding
cancer-causing environmental
toxins. Her mission is to have all
Americans either prevent cancer
or be diagnosed no later
than stage one.
LifeExtension
does not
endorse any of the businesses or the products and/or services that may appear in advertisements for non-Life Extension branded products or services contained in Life Extension magazine
except to state that they are advertisers who may have paid Life Extension for placement of an advertisement in this publication. Life Extension disclaims any and all responsibilities or
warranties as to the accuracy of information contained in advertisements for non-Life Extension branded products or services. For Canadian customers send change of address informa-
tion and blocks of undeliverable copies to P.O. Box 1051, Fort Erie, ON L2A 6C7.
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EDITORIAL
Editor-in-Chief Philip Smith
Executive Managing Editor Penee Price
Senior Copy Editor Laurie Mathena
Medical Editor Andrea Pryce, ND
Senior Staff Writer Michael Downey
Department Editor 1on Finkel
Creative Director Pobert vergara
Art Director Alexandra Maldonado
CHIEF MEDICAL OFFICER
Steven Joyal, MD
SCIENTIFIC ADVISORY BOARD
rn Adalsteinsson, PhD Pussell L. Blaylock, MD 1ohn Boik, PhD
Eric P. Braverman, MD Aubrey de Grey, PhD Frank Eichorn, MD
Deborah F. Harding, MD Steven B. Harris, MD Stanley W. 1acob, MD
Pichard Kratz, MD, DSci Peter H. Langsjoen, MD, FACC Palph W. Moss, PhD
Michael D. Ozner, MD, FACC Pobert Pastore, PhD, CNS
1onathan Treasure, AHG, MNlMH 1onathan v. Wright, MD
CONTRIBUTORS
Neal D. Barnard, MD Michael Downey D. Dye William Faloon
Steve Frankel Gary Goldladen, MD Pobert Goldladen Liam Hawkins
ADVERTISING
Vice President of Marketing Pey Searles rsearleslileextension.com
National Advertising Manager Eric Brown 40434?8992
VICE PRESIDENT OF SALES AND BUSINESS DEVELOPMENT
Pon Antriasian rantriasianlileextension.com ?812?10089
CIRCULATION & DISTRIBUTION
Lile Extension 3600 West Commercial Blvd., Fort Lauderdale, FL 33309
Editorial olhces: 954?668433 lax: 9544915306
Customer Service: 800-678-8989 emaiI: customerservice@Ief.org
Advisors: 80022623?0 Advisory email: advisorylel.org
At Life Extension Magazine
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Attn: Letters to the Editor, PO Box 407198, Fort Lauderdale, FL 33340
or email us: LEmagazinelel.org
To order Optimized Cran-Max
with UTIRose,
call 1-800-544-4440 or visit www.LifeExtension.com
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The anatomy of the female
urinary tract diers greatly from
men, resulting in the need for
additional nutritional support
for women.
A wealth of published studies indicates that
cranberry polyphenols may help to support a
healthy urinary tract.
1-5
Of particular importance is the avonoid content
of the cranberry, including anthocyanins and proantho-
cyanidins. These natural compounds exert powerful
antioxidant eects that can reduce oxidative stress.
Recent clinical data suggest that the proantho-
cyanidins found only in cranberries also possess unique
molecular features that specically promote urinary
system health.
6-8
A Synergistic Compound Available
Only in EuropeUntil Now
In a signicant advance, Life Extension
has
identied a unique compound available overseas
but little-known in the United States that provides a
synergistic complement to the whole cranberrys
phytonutrient prole.
UTIRose
is derived from Hibiscus sabdaria, a
species native to Europe, Asia, and Africa. Scientic
analysis has shown that this species ower and calyx
(the green oral envelope surrounding the blossom)
are rich in active polyphenols, including avonoids,
sambubiosides, and anthocyanins.
Optimized Cran-Max
with UTIRose
Featuring a Novel High-Concentration
Hibiscus Polyphenol Blend
NEXT-GENERATION FORMULA
Life Extension
with UTIRose. Each daily serving supplies the
complete phenolic prole of the whole cranberry plus
hibiscus polyphenols in a standardized, highly absorb-
able, concentrated form. Two capsules of Optimized
Cran-Max
Cranberry
Juice Cocktail.
9
The price for one bottle of Optimized
Cran-Max
registered trademark of BDM Technologies, LLC. UTIrose is a trademark of Burgundy Botanical Extract. Bio-Shield
long ago recommended that mem-
bers should supplement with
2,400 mg of EPA/DHA each day.
This recommendation was based
on the three assumptions listed on
the next page.
AS WE SEE IT
average daily intake of only 1,370
mg of EPA/DHA in individuals
who mostly suffered signicant
pre-existing arterial disease, i.e.,
atherosclerosis. In fact, half of
the studies included in the meta-
analysis used an omega-3 dose of
less than 1,000 mg daily. This
amount of EPA/DHA is too low to
reverse the underlying progression
of atherosclerosis that most of the
study group suffered.
The unhealthy study subjects
used in the JAMA study consisted
of population groups in countries
throughout the world. Based on
what the JAMA authors wrote,
these study subjects presumably
consumed less than 58% of the
minimum amount of EPA/DHA
that Life Extension members take.
Some of these population groups
took no other supplement to pro-
tect against heart attack since
these nutrients are not openly sold
in those countries.
I use the term presumably
consumed in the previous para-
graph because it is not clear that
study subjects even got 58% of the
EPA/DHA they needed. The JAMA
study results were based either on
patients instructed to take sh oil
capsules or patients provided with
dietary guidance counseling.
This kind of diet counseling is
10 | LIFE EXTENSION | APRIL 2013
notoriously unreliable, especially
over the longer term when people
tend to gravitate back to unhealthy
dietary habits. The same is often
true of people who are told to swal-
low large sh oil capsules by their
doctors but fail to comply for all
kinds of reasons including the fact
that they dont like swallowing
large capsules!
As you will read in the sidebar
on page 13, the ndings from the
JAMA study (where lower-dose
EPA/DHA was inconsistently used
on unhealthy patient groups for
a relative short term) have noth-
ing to do with what health-con-
scious people are doing today to
guard against heart attack, which
includes taking the proper dose of
EPA/DHA each day.
Why Most Consumers
Dont Benet From Fish Oil
The environment that we at Life
Extension exist in is far removed
from the mainstream. We are
privileged to interact with excep-
tional physician/scientists and the
worlds most knowledgeable health
consumers (i.e., our members).
Recently, we found ourselves so
out of touch with the mainstream
that we went to considerable
expense to empanel outside focus
groups to educate us on how the
lay public thinks about nutrition
and their health. To participate in
these focus groups, people had to
be health-conscious consumers
who used dietary supplements.
The level of ignorance uncovered
by these focus group sessions
was appalling.
Virtually all the focus group par-
ticipants had heard good things
about omega-3s, but they had no
idea how much they were taking or
how much EPA/DHA they should
use. Most of them claimed to
1. Foundation members are
health-conscious individuals
who consume food sources
of omega-3s like cold-water
sh, thus providing greater
average intake of omega-3
than 2,400 mg daily.
2. Foundation members take
annual blood tests that
measure triglyceride levels.
If triglycerides are over 100
mg/dL of blood, there would
be a greater consumption of
omega-3s, along with life-
style, drug, and other supple-
ment alterations. (Some
people, for instance, require
daily doses of 4,800 mg of
EPA/DHA to suppress artery-
clogging triglycerides.)
3. Findings from Omega Score
blood test results show that
at least 2,400 mg a day
of EPA/DHA is needed to
achieve optimal omega-3
blood levels. (Some people
require more than 2,400 mg
of omega-3s to boost blood
levels.)
The media used the JAMA study
to create headlines like Fish oil
supplements dont prevent heart
attacks, study says.
4
The JAMA
report, however, was based on an
AS WE SEE IT
APRIL 2013 | LIFE EXTENSION | 11
purchase omega-3 supplements on
a somewhat irregular basis, usu-
ally when they saw them displayed
on a pharmacy or supermarket
shelf. Some claimed to take one
sh oil capsule daily while others
claimed to take them when they
would remember.
If a survey were conducted to
identify people who took omega-3
supplements, virtually every par-
ticipant in these focus groups
would have been categorized as
an omega-3 supplement user. Yet
virtually none of them were tak-
ing the potency needed to stave off
heart disease.
When conventional doctors and
the media claim that people dont
benet from supplements, they are
often correct in that most consum-
ers have no idea how much of what
supplement they should take to
stave off disease. This should not
dissuade knowledgeable individu-
als, who know what to take and
have the discipline to do so on a
consistent basis, from following
an evidence-based program that
includes at least 2,400 mg of sup-
plemental EPA/DHA daily along
with healthy dietary patterns.
Good Ratings for the Media
Just imagine being in the
news business where every day
you have to generate attention-
grabbing headlines to sell newspa-
pers or attract viewers.
You see a study published in the
Journal of the American Medical
Association meant for doctors,
but since it relates to a popular
dietary supplement, you have a
sound-bite headline for the day. No
need to look at details such as
the JAMA study stating that even
subjects who consumed inad-
equate doses of sh oil appeared
to derive some reductions in heart
attack risk.
Just hype up the JAMA studys
conclusion and you have your-
self a startling headline that most
of your audience will want to
know more about, i.e. ambush
journalism.
This is how the general public
makes their life-and-death deci-
sions, which is rather pathetic con-
sidering we live in a world where
most everyone has Internet access
to assess the facts for themselves.
AS WE SEE IT
Methodology Problems
with the JAMA Meta-Analysis
Flaws in the design of the JAMA meta-analysis of 20 self-selected
studies call its findings into question for the following reasons:
Inclusion of trials of poor methodological quality. Nearly half
of the sample size of the meta-analysis came from two open-label trials.
Open-label trials allow both the subjects and researchers to know what
treatment is being provided in the study. This type of study is considered
to be of inferior quality compared to double-blind, placebo-controlled tri-
als, where researchers and subjects do not know which intervention the
subjects are receiving.
High level of variability in the trials cardiovascular event
rates & baseline risk. There was a high degree of variability in the
baseline cardiovascular risk and cardiovascular event rates in the tri-
als included in this meta-analysis. This means it was difficult to assess
which subjects were at greater risk of heart attack at baseline. If those
given fish oil, for instance, also had higher vascular risk at the beginning
of the study, then the validity of the data is severely compromised.
Limited number of studies included. Only 20 of 3,635 studies
the authors examined were used in this meta-analysis. This provides a
very limited view of the research that has been conducted on fish oil for
cardiovascular disease.
There has been a significant amount of research conducted on the
cardiovascular benefits of fish oil beyond what was selected for the
JAMA analysis. For example, in a PubMed.gov (U.S. National Library of
Medicine) search for clinical trials of fish oil and triglycerides, there
were over 500 results.
take months, and some patients
are aficted with lifetime impair-
ments such as memory loss,
chronic inammation, and depres-
sion. Coronary artery stenting has
become more common in recent
years, but this is not a cure for sys-
temic atherosclerosis.
The scientic literature reveals
that atherosclerosis is associated
with high blood levels of C-reactive
protein,
18-26
insulin,
27-32
iron,
33-36
LDL,
37-42
homocysteine,
25,26,43-46
fibrinogen,
25,47-50
and triglycer-
ides,
51-53
along with low levels of
HDL
54-56
and testosterone
57-62
(in
men). Optimizing blood levels of
these substances can dramatically
reduce heart attack and stroke risk.
Cardiologists Only
Partially Correct
Atherogenic Risk Factors
Prescribing a statin drug is what
doctors typically do to prevent and
treat coronary atherosclerosis.
Cholesterol and LDL, however, are
only two players in the atheroscle-
rosis process.
There are now two fish oil
drugs approved by the FDA to
lower triglycerides. Fish oil also
protects against atherosclero-
sis by reducing inammation
63-71
and inhibiting abnormal platelet
aggregation.
72-76
But even sh oil
and statin drugs are not going
to adequately counteract all fac-
tors involved in coronary artery
disease.
Mainstream cardiologists fail
to appreciate that coronary ath-
erosclerosis is a sign of systemic
arterial dysfunction requiring
aggressive therapy to correct.
To read more about the steps
you need to take to reduce your
odds of being stricken with a vas-
cular disorder, refer to the articles
on pages 68 and 78 of this months
issue.
12 | LIFE EXTENSION | APRIL 2013
How We Protect You
Life Extensions annual Blood
Test Super Sale commences April
1, 2013. The reason I am alerting
you early is to enable you to start
preparing for your annual compre-
hensive blood tests.
Make sure, for example, that
you take your omega-3 and vita-
min D supplements with the
heaviest meal of the day. These
fat-soluble nutrients absorb far
better when consumed with the
meal of the day that contains the
most fat. A problem we fear occurs
in clinical studies is that partici-
pants take fat-soluble nutrients on
relatively empty stomachs, which
leads to poor absorption and sub-
sequent failure to derive benets.
The extensive focus group
sessions we conducted reveal the
typical consumer has no idea what
they need to do to protect against
the degenerative diseases of aging.
We provide our members with
every means of support possible,
from access to knowledgeable
health advisors and low-cost com-
prehensive blood testing, to accu-
rately reported scientic data and
ongoing clinical research.
The public, on the other hand,
is left to rely on a sound-bite fren-
zied news media for health data,
which often involves outing a
scary medical headline without
assessing a storys veracity. I call
this science by ambush because
it blind sides an established prin-
ciple, and denies an opportunity
for meaningful rebuttal!
For longer life,
William Faloon
Bottom Line: The subjects in
the JAMA report were people with
existing heart problems, the dos-
ages they were taking were too
small, and they probably were not
taking the additional supplements
that have long been recommended
to generate a multi-pronged attack
against heart disease.
What Do Humans
Need To Do To
Prevent Atherosclerosis?
The aging process damages
blood vessels even when conven-
tional risk factors such as cho-
lesterol and blood pressure are
within normal ranges.
Despite aggressive intervention
with diet, exercise, supplements,
and drugs, pathological changes
still occur in the arterial wall that
predispose aging adults to vascular
diseases. The encouraging news is
that validated methods have been
developed to address the underly-
ing reason why arteries become
occluded as people reach the later
stages of their lives.
For the past 40 years, the stan-
dard way to treat coronary ath-
erosclerosis has been to bypass
the blocked arteries. Recuperation
from coronary bypass surgery can
AS WE SEE IT
A coronary artery
with atherosclerosis
Atherosclerotic
plaque
Endothelium
APRIL 2013 | LIFE EXTENSION | 13
A number of studies have indicated that higher
doses of fish oil leads to beneficial effects in prevent-
ing cardiovascular disease events or reducing risk fac-
tors. For example:
A randomized, placebo-controlled trial found 1,800
mg of combined EPA plus DHA was associated with
a 10% lower rate of cardiac events, 12% lower rate of
non-fatal infarctions, and an almost 11% lower rate of
cardiac deaths.
5
In a large intervention study, 18,000 patients were
randomized to receive either a statin medication alone
or a statin plus 1,800 mg of EPA-fish oil daily. After 5
years, those with a history of coronary artery disease
had a 19% lower rate of major coronary events in the
statin-plus EPA-fish oil group compared to the statin-
only group.
6
A randomized, double-blind, placebo-controlled
trial with chronic hemodialysis patients found that
1,700 mg of omega-3 fatty acids daily was associated
with a 70% reduction in the relative risk of myocardial
infarction.
7
A randomized, controlled trial using 3,300 mg of
EPA and DHA (and then a decreased dosage) found
a trend toward lower cardiovascular event occurrence
with fish oil supplementation. Seven cardiovascular
events occurred in the placebo group (not given fish
oil) while only two cardiovascular events occurred in
the fish oil-supplemented group during the study.
8
A meta-analysis with an average fish oil dose of
3,700 mg found lowered systolic blood pressure by
an average 2.1 mmHg and diastolic by 1.6 mmHg.
9
In a randomized trial with peripheral arterial dis-
ease patients, 2,000 mg of omega-3 fatty acids daily
resulted in a 49% improvement in flow-mediated dila-
tion, a marker of endothelial cell health.
10
In contrast to the findings of the JAMA meta-anal-
ysis, two important studies demonstrated significant
benefits with even moderate fish oil doses:
The GISSI-Prevenzione study (a large, randomized,
controlled trial) found that 1,000 mg/day of EPA and
DHA in 11,323 patients with a history of recent myo-
cardial infarction reduced the risk of total mortality
by 20% and sudden death by 45%.
11,12
The DART study a randomized, controlled trial
that examined the effects of advising 2,033 subjects
to increase dietary fatty fish revealed a 29% reduc-
tion in all-cause mortality compared with those not
advised.
13
The Journal of the American Medical Associ-
ation (JAMA) meta-analysis also conflicts with other
reviews of fish-oil research. Other meta-analyses have
demonstrated a reduced risk of cardiovascular disease
outcomes in those supplemented with omega-3 fatty
acids from fish oil. For example:
A 2009 meta-analysis of randomized, controlled tri-
als found that dietary supplementation with omega-3
fatty acids reduced the incidence of sudden cardiac
death in subjects with prior myocardial infarction.
14
Another 2009 meta-analysis of randomized, con-
trolled trials found that dietary supplementation with
omega-3 fatty acids reduced the risk of cardiovascular
death, sudden cardiac death, all-cause mortality, and
non-fatal cardiovascular events in patients with a his-
tory of certain cardiovascular events or risk factors.
15
A 2008 meta-analysis found a significant reduction
in death from cardiac causes with fish oil supplemen-
tation.
16
A 2002 meta-analysis of randomized, controlled tri-
als concluded that omega-3 fatty acids reduced over-
all mortality, mortality due to myocardial infarction, and
sudden death in patients with coronary heart disease.
17
Higher-Dose Fish Oil Provides Heart Benefits
AS WE SEE IT
13. Burr ML, Fehily AM, Gilbert JF, et al. Ef-
fects of changes in fat, sh, and bre in-
takes on death and myocardial reinfarc-
tion: diet and reinfarction trial (DART).
Lancet. 1989 Sep 30;2(8666):757-61.
14. Zhao YT, Chen Q, Sun YX, et al. Pre-
vention of sudden cardiac death with
omega-3 fatty acids in patients with
coronary artery disease: a meta-analysis
of randomized controlled trials. Ann
Med. 2009;41(4):301-10.
15. Marik PE and Varon J. Omega-3 dietary
supplements and the risk of cardiovas-
cular events: a systematic review. Clin
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16. Len H, Shibata MC, Sivakumaran S,
et al. Effect of sh oil on arrhythmias
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17. Bucher HC, Hengstler P, Schindler C,
et al. N-3 polyunsaturated fatty acids in
coronary heart disease: a meta-analysis
of randomized controlled trials. Am J
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18. Piechota W, Piechota W. Correlation of
high-sensitivity CRP concentration with
the extent of coronary atherosclerosis
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May;18(107):511-5.
19. Choi EY, Yan RT, Fernandes VR, et al.
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an independent predictor of progressive
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20. Van Der Meer IM, De Maat MP, Hak
AE, et al. C-reactive protein predicts
progression of atherosclerosis mea-
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tree: the Rotterdam Study. Stroke. 2002
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21. Masood A, Jafar SS, Akram Z. Serum
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22. Ridker PM, Buring JE, Shih J, Matias
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23. Auer J, Berent R, Lassnig E, Eber B.
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24. Agmon Y, Khandheria BK, Meissner I, et
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graphic study. Arch Intern Med. 2004 Sep
13;164(16):1781-7.
25. Ridker PM, Stampfer MJ, Rifai N. Novel
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a comparison of C-reactive protein, -
brinogen, homocysteine, lipoprotein(a),
and standard cholesterol screening as
predictors of peripheral arterial disease.
JAMA. 2001 May 16;285(19):2481-5.
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26. Jarosz A, Nowicka G. C-reactive protein
and homocysteine as risk factors of
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268-72.
27. Bonora E, Kiechl S, Willeit J, et al. Insu-
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29. Stochmal E, Szurkowska M, Czarnecka
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tients with impaired glucose tolerance.
Acta Cardiol. 2005 Jun;60(3):325-31.
30. Takahashi F, Hasebe N, Kawashima E,
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dent predictor for complex atheroscle-
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Natl Sci Counc Repub China B. 2000
Oct;24(4):151-5.
35. Kraml P, Potockova J, Koprivova H,
et al. Ferritin, oxidative stress and
coronary atherosclerosis. Vnitr Lek. 2004
Mar;50(3):197-202.
36. Minqin R, Watt F, Huat BT, Halliwell B.
Correlation of iron and zinc levels with
lesion depth in newly formed atheroscle-
rotic lesions. Free Radic Biol Med. 2003
Mar 15;34(6):746-52.
37. Montalcini T, Gorgone G, Federico D, et
al. Association of LDL cholesterol with
carotid atherosclerosis in menopausal
women affected by the metabolic syn-
drome. Nutr Metab Cardiovasc Dis. 2005
Oct;15(5):368-72.
38. Nissen SE, Tuzcu EM, Schoenhagen P,
et al. Effect of intensive compared with
moderate lipid-lowering therapy on pro-
gression of coronary atherosclerosis: a
randomized controlled trial. JAMA. 2004
Mar 3;291(9):1071-80.
39. Reed DM, Strong JP, Resch J, Hayashi T.
Serum lipids and lipoproteins as predic-
tors of atherosclerosis. An autopsy study.
Arteriosclerosis. 1989 Jul-Aug;9(4):560-4.
References
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between omega-3 fatty acid supplemen-
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disease events: a systematic review
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agement/cardiology/heart-disease-risk-
reduction/. Accessed January 15, 2013.
3. Chang CY, Ke DS, Chen JY. Essential
fatty acids and human brain. Acta Neu-
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4. Available at: http://www.usatoday.com/
news/health/story/2012-09-11/heart-ome-
ga-3/57750182/1. Accessed December 3,
2012.
5. Singh RB, Niaz MA, Sharma JP, et al.
Randomized, double-blind, placebo-con-
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patients with suspected acute myocar-
dial infarction: the Indian experiment of
infarct survival. Cardiovasc Drugs Ther.
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6. Yokoyama M, Origasa H, Matsuzawa M,
et al. Effects of eicosapentaenoic acid on
major coronary events in hypercholes-
terolaemic patients (JELIS): a ran-
domised open-label, blinded endpoint
analysis. Lancet. 2007;369(9567):1090-8.
7. Svensson M, Schmidt EB, Jrgensen
KA, et al. N-3 fatty acids as second-
ary prevention against cardiovascular
events in patients who undergo chronic
hemodialysis: a randomized, placebo-
controlled intervention trial. Clin J Am
Soc Nephrol. 2006 Jul;1(4):780-6.
8. von Schacky C, Angerer P, Kothny W,
et al. The effect of dietary omega-3
fatty acids on coronary atheroscle-
rosis. A randomized, double-blind,
placebo-controlled trial. Ann Intern Med.
1999;130(7):554-62.
9. Geleijnse JM, Giltay EJ, Grobbee DE, et
al. Blood pressure response to sh oil
supplementation: metaregression analy-
sis of randomized trials. J Hypertens.
2002;20(8):1493-9.
10. Schiano V, Laurenzano E, Brevetti G, et
al. Omega-3 polyunsaturated fatty acid
in peripheral arterial disease: effect on
lipid pattern, disease severity, inamma-
tion prole, and endothelial function.
Clin Nutr. 2008 Apr;27(2):241-7.
11. Marchioli R, Barzi F, Bomba E, et al.
Early protection against sudden death
by n-3 polyunsaturated fatty acids after
myocardial infarction: time-course
analysis of the results of the Gruppo
Italiano per lo Studio della Soprav-
vivenza nellInfarto Miocardico (GISSI)-
Prevenzione. Circulation. 2002 Apr
23;105(16):1897-903.
12. Available at: http://www.ncbi.nlm.nih.
gov/pmc/articles/PMC2909229/. Ac-
cessed January 15, 2013.
APRIL 2013 | LIFE EXTENSION | 15
AS WE SEE IT
40. Cromwell WC, Otvos JD. Low-density
lipoprotein particle number and risk for
cardiovascular disease. Curr Atheroscler
Rep. 2004 Sep;6(5):381-7.
41. Teo KK, Burton JR, Buller C, Plante S,
Yokoyama S, Montague TJ. Rationale
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inhibition on coronary atherosclerosis:
Simvastatin/Enalapril Coronary Ath-
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1997 Jun;13(6):591.
42. Ridker PM, Rifai N, Rose L, Buring JE,
Cook NR. Comparison of C-reactive
protein and low-density lipoprotein cho-
lesterol levels in the prediction of rst
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2002 Nov 14;347(20):1557-65.
43. Rasouli ML, Nasir K, Blumenthal RS,
Park R, Aziz DC, Budoff MJ. Plasma
homocysteine predicts progression of
atherosclerosis. Atherosclerosis. 2005
Jul;181(1):159-65.
44. Montalescot G, Ankri A, Chadefaux-
Vekemans B, et al. Plasma homocysteine
and the extent of atherosclerosis in
patients with coronary artery disease.
Int J Cardiol. 1997 Aug 8;60(3):295-300.
45. Fernndez-Miranda C, Paz M, Aranda
JL, et al. Homocysteine and progression
of carotid atherosclerosis in patients
with coronary disease. Med Clin (Barc).
2003 Nov 1;121(15):561-4.
46. Cacciapuoti F. Lowering homocyste-
ine levels may prevent cardiovascular
impairments? Possible therapeutic be-
haviors. Blood Coagul Fibrinolysis. 2012
Dec;23(8):677-9
47. Liu MY, Hu DY. The predictive value of
serum advanced brinogen and uric acid
for acute coronary event risk. Zhonghua
Yi Xue Za Zhi. 2006 Mar 14;86(10):
678-80.
48. Wattanakit K, Folsom AR, Chambless
LE, Nieto FJ. Risk factors for cardiovas-
cular event recurrence in the Atheroscle-
rosis Risk in Communities (ARIC)study.
Am Heart J. 2005 Apr;149(4):606-12.
49. Maresca G, Di Blasio A, Marchioli R, Di
Minno G. Measuring plasma brinogen
to predict stroke and myocardial infarc-
tion: an update. Arterioscler Thromb Vasc
Biol. 1999 Jun;19(6):1368-77.
50. Acevedo M, Foody JM, Pearce GL, Spre-
cher DL. Fibrinogen: associations with
cardiovascular events in an outpatient
clinic. Am Heart J. 2002 Feb;143(2):
277-82.
51. Drexel H, Amann FW, Beran J, et al.
Plasma triglycerides and three lipopro-
tein cholesterol fractions are indepen-
dent predictors of the extent of coronary
atherosclerosis. Circulation. 1994
Nov;90(5):2230-5.
52. Bansal S, Buring JE, Rifai N, Mora S,
Sacks FM, Ridker PM. Fasting com-
pared with nonfasting triglycerides and
risk of cardiovascular events in women.
JAMA. 2007 Jul 18;298(3):309-16.
53. Nordestgaard BG, Benn M, Schnohr P,
Tybjaerg-Hansen A. Nonfasting triglyc-
erides and risk of myocardial infarc-
tion, ischemic heart disease, and death
in men and women. JAMA. 2007 Jul
18;298(3):299-308.
54. Toikka JO, Ahotupa M, Viikari JS, et al.
Constantly low HDL-cholesterol concen-
tration relates to endothelial dysfunction
and increased in vivo LDL-oxidation
in healthy young men. Atherosclerosis.
1999 Nov 1;147(1):133-8.
55. Viles-Gonzalez JF, Fuster V, Corti R,
Badimon JJ. Emerging importance of
HDL cholesterol in developing high-risk
coronary plaques in acute coronary
syndromes. Curr Opin Cardiol. 2003
Jul;18(4):286-94.
56. Spieker LE, Sudano I, Hurlimann D,
et al. High-density lipoprotein restores
endothelial function in hypercholes-
terolemic men. Circulation. 2002 Mar
26;105(12):1399-402.
57. Hak AE, Witteman JC, de Jong FH,
Geerlings MI, Hofman A, Pols HA. Low
levels of endogenous androgens increase
the risk of atherosclerosis in elderly
men: the Rotterdam study. J Clin Endo-
crinol Metab. 2002 Aug;87(8):3632-9.
58. English KM, Mandour O, Steeds RP, et
al. Men with coronary artery disease
have lower levels of androgens than men
with normal coronary angiograms. Eur
Heart J. 2000 Jun;21(11):890-4.
59. Tivesten A, Mellstrm D, Jutberger H,
et al. Low serum testosterone and high
serum estradiol associate with lower
extremity peripheral arterial disease
in elderly men. The MrOS Study in
Sweden. J Am Coll Cardiol. 2007 Sep
11;50(11):1070-6.
60. Dunajska K, Milewicz A, Szymczak J,
et al. Evaluation of sex hormone levels
and some metabolic factors in men with
coronary atherosclerosis. Aging Male.
2004 Sep;7(3):197-204.
61. Phillips GB, Pinkernell BH, Jing TY. The
association of hypotestosteronemia with
coronary artery disease in men. Arterio-
scler Thromb. 1994 May;14(5):701-6.
62. Jones RD, Nettleship JE, Kapoor D,
Jones HT, Channer KS. Testosterone and
atherosclerosis in aging men: purported
association and clinical implications.
Am J Cardiovasc Drugs. 2005;5(3):
141-54.
63. Kiecolt-Glaser JK, Belury MA, Andridge
R, Malarkey WB, Hwang BS, Glaser
R. Omega-3 supplementation lowers
inammation in healthy middle-aged
and older adults: a randomized con-
trolled trial. Brain Behav Immun. 2012
Aug;26(6):988-95.
64. Wu D, Han SN, Meydani M, Meydani
SN. Effect of concomitant consumption
of sh oil and vitamin E on production
of inammatory cytokines in healthy
elderly humans. Ann NY Acad Sci. 2004
Dec;1031:422-4.
65. Pischon T, Hankinson SE, Hotamis-
ligil GS, et al. Habitual dietary intake
of n-3 and n-6 fatty acids in relation
to inammatory markers among US
men and women. Circulation. 2003 Jul
15;108(2):155-60.
66. Mori TA, Beilin LJ. Omega-3 fatty acids
and inammation. Curr Atheroscler Rep.
2004 Nov;6(6):461-7.
67. James MJ, Gibson RA, Cleland LG.
Dietary polyunsaturated fatty acids and
inammatory mediator production. Am
J Clin Nutr. 2000 Jan;71(1 Suppl):
343S-8S.
68. Adam O, Beringer C, Kless T, et al. Anti-
inammatory effects of a low arachi-
donic acid diet and sh oil in patients
with rheumatoid arthritis. Rheumatol
Int. 2003 Jan;23(1):27-36.
69. Lopez-Garcia E, Schulze MB, Manson
JE, et al. Consumption of (n-3) fatty
acids is related to plasma biomarkers of
inammation and endothelial activation
in women. J Nutr. 2004 Jul;134(7):
1806-11.
70. Lorenz R, Weber PC, Szimnau P,
Heldwein W, Strasser T, Loeschke K.
Supplementation with n-3 fatty acids
from sh oil in chronic inammatory
bowel disease: A randomized, placebo-
controlled, double-blind cross-over trial.
J Intern Med Suppl. 1989;225(731):
225-32.
71. Foitzik T, Eibl G, Schneider P, Wenger
FA, Jacobi CA, Buhr HJ. Omega-3 fatty
acid supplementation increases anti-
inammato ry cytokines and attenuates
systemic disease sequelae in experimen-
tal pancreatitis. J Parenter Enteral Nutr.
2002 Nov-Dec;26(6):351-6.
72. Nomura S, Kanazawa S, Fukuhara S.
Effects of eicosapentaenoic acid on
platelet activation markers and cell
adhesion molecules in hyperlipidemic
patients with Type 2 diabetes mellitus.
J Diabetes Complications. 2003 May-
Jun;17(3):153-9.
73. Mori TA, Beilin LJ, Burke V, Morris J,
Ritchie J. Interactions between dietary
fat, sh, and sh oils and their effects on
platelet function in men at risk of car-
diovascular disease. Arterioscler Thromb
Vasc Biol. 1997 Feb;17(2):279-86.
74. Abeywardena MY, Head RJ. Longchain
n-3 polyunsaturated fatty acids and
blood vessel function. Cardiovasc Res.
2001 Dec;52(3):361-71.
75. Thorngren M, Gustafson A. Effects of
11-week increases in dietary eicosapen-
taenoic acid on bleeding time, lipids,
and platelet aggregation. Lancet. 1981
Nov 28;2(8257):1190-3.
76. Vanschoonbeek K, Feijge MAH, Paquay
M, et al. Variable hypocoagulant effect
of sh oil intake in humans: modulation
of brinogen level and thrombin genera-
tion. Arterioscler Thromb Vasc Biol. 2004
Sept;24(9):173440.
Tender, sensltlve [olnts can llmlt everyday actlvltles. As you age
and contlnue to put stress on your [olnts, you can compromlse
[olnt cartllagewhlch exposes small collagen bers.
our bodys lmmune system mlstakenly ldentles these
collagen bers as foreign cells. Thls trlggers an lnammatory
response agalnst the collagen-containing cartllage ln your own
[olnts. |nammatlon and [olnt dlscomfort can soon follow.
Data shows that a patented collagen provldes targeted
support for the lmmune lssues related to [olnt dlscomfort.
!
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molecules found ln joint cartilage.
ADVANCED MOLECULAR STRUCTURE
Not [ust any form of collagen wlll do. Normally, when chlcken
collagen ls processed, lts molecular shape ls changed. |t loses
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Portunately, a unique processing technique preserves the
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produclng a form known as undenatured collagen.
The result of thls lnnovatlve process ls an undenatured chicken
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CONVENIENT ONEPERDAY DOSE
The suggested dally servlng of one capsule of Bio-Collagen
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REFERENCES
!. Int J Med Sci. 2009,6(6):3!2-2!.
2. Proc Natl Acad Sci U S A. !986 Oct,83(!9):/443-6.
3. Int Immunopharmacol. 20!! 1an,!!(!):!2-8.
4. Int J Clin Pharmacol Res. 2002,22(3-4):!0!-!0.
5. Immunol Rev. 2005,206:232-59.
6. J Vet Pharmacol Ther. 2005 Aug,28(4):385-90.
/. J Vet Pharmacol Ther. 200/ 1un,30(3):2/5-8.
8. Toxicol Mech Methods. 200/,!/(4):!89-96.
9. J Anim Physiol Anim Nutr (Berl). Lpub 20!! May 30.
!0. J Vet Pharmacol Ther. 2009 Dec,32(6):5//-84.
t-|| |: + re|:terea tr+aem+r| el |ater|e+|t| Natr+ceat|c+|:, |ac.
: |+teat Ne:. !,1!,!l, !,Jl,Jl, !,!,l, !,l!,l11, l,J,,
l,1,1l, ||l1J! l +aa wer|aw|ae j+teat: jeaa|a.
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I N THE NEWS I N THE NEWS
APRIL 2013 | LIFE EXTENSION | 17
I N THE NEWS
Meta-analysis Links
Increased Magnesium Intake
with Fasting Glucose and
Insulin Reductions
The results of a meta-analysis
published in the Journal of
Nutrition reveal an asso-
ciation between diets that
include higher amounts
of magnesium with lower
blood levels of fasting
glucose and insulin.*
Researchers sought to
determine the inuence
of genetic variations asso-
ciated with glycemic traits
or magnesium metabolism on
fasting glucose and insulin levels,
which are elevated in metabolic syndrome
and type II diabetes. They analyzed data from up
to 52,684 nondiabetic men and women who partic-
ipated in 15 studies. Participants were genotyped
for up to 25 single nucleotide polymorphisms
related to fasting glucose, insulin, or magnesium.
Reductions in both fasting glucose and fast-
ing insulin were observed in association with
increased magnesium.
Editors Note: The authors concluded that, Their results indi-
cate that higher dietary magnesium intake is inversely associated
with fasting glucose and fasting insulin in individuals free of
diabetes.
D. Dye
* J Nutr. 2013 Jan 23.
Review Explores Effects of
Curcumin on Life Span
A review published online recently in the jour-
nal BioFactors documents a benet for curcumin,
a compound that occurs in the spice turmeric, in
extending the life of several species.*
In a study involving the roundworm C. elegans,
growth media containing a low concentration of
curcumin increased mean (average) life span by
39% and maximum life span by 21.4%.
In a study with fruit ies, which generally sur-
vive an average of 64 days, an increase of mean
life span to 80 days occurred in curcumin-fed
ies. Another study involving two strains of ies
found varying effects of curcumin in male and
female ies, with females of one strain and males
of another strain experiencing an extension in life
span. A third y study also revealed a variation
in male and female response to
curcumin, although the com-
pound was shown to extend
life in both genders.
Editors Note: The curcumin
metabolite tetrahydrocurcumin
has also been associated with
life span extension. In male
mice supplemented with the
curcumin metabolite beginning
at the age of 13 months, mean
life span was increased by an
average of 84 days in comparison
with unsupplemented mice.
D. Dye
* Biofactors. 2013 Jan 17.
I N THE NEWS
18 | LIFE EXTENSION | APRIL 2013
Heart Attack Risk Lower Among
Women with High Anthocyanin Intake
An article in a recent issue of Circulation reported the nding
of a decrease in the risk of myocardial infarction in women with a
high intake of anthocyaninsavonoids that occur in signicant
amounts in such foods as blueberries and strawberries.*
The study included 93,600 women between the ages of 25
and 42 upon enrollment in the Nurses Health Study II in 1989.
Dietary questionnaires completed every four years beginning in
1991 provided information on the intake of anthocyanins. The
participants were followed for 18 years, during which 405 heart
attacks occurred.
Among women whose intake of anthocya-
nins was among the top one-fth of subjects,
there was a 32% lower risk of heart attack
in comparison with those whose intake
was among the lowest fth.
Editors Note: The authors concluded that, Bioac-
tive compounds present in red and blue fruits and
vegetables commonly consumed in the habitual diet
may be associated with a reduced risk of myocardial
infarction in young and middle-aged women.
D. Dye
* Circulation. 2013 Jan 15;127(2):188-96.
Study Conrms CoQ10
Decline in Statin-Treated Patients
The Journal of the American College of Cardiology published the
nding of Danish researchers of reductions in glucose tolerance
and coenzyme Q10 levels in men treated with simvastatin, one of
several statin drugs commonly prescribed to lower cholesterol.*
The current study included ten individuals treated for high cho-
lesterol with simvastatin for at least one year and ten healthy con-
trol subjects. Participants underwent oral glucose tolerance tests,
muscle biopsies, and blood testing for numerous factors. Four of
those in the simvastatin group reported muscle pain, compared
to none of the controls. Among simvastatin-treated subjects, glu-
cose levels were signicantly higher during two-hour oral glucose
tolerance testing in comparison with untreated controls. When
tissue biopsy results were compared, CoQ10 and the antioxidant
enzymes catalase, manganese superox-
ide dismutase, and glutathione peroxi-
dase were lower in those treated with
simvastatin (Zocor
).
Editors Note: While statin drugs are of benet to
millions of people at risk for cardiovascular events,
their effect on coenzyme Q10, an important mito-
chondrial cofactor, has not been well publicized in
mainstream medical media. (Mitochondria are the
cells energy-producing organelles.)
D. Dye
* J Am Coll Cardiol. 2013 Jan 8;61(1):44-53.
Grape Seed Extract
Goes After Aggressive
Cancer Cells
An article published in the
journal Cancer Letters reveals
a potent effect for grape seed
extract against colorectal can-
cer in experiments involving
cultured cancer cells. The nd-
ings indicate a benecial effect
for grape seed extract that
increases with higher stage
cancer.*
Molly Derry of the
University of Colorado and
her associates tested the
effect of grape seed extract in
colorectal cancer cell lines in
various stages of disease. They
observed an increase in several
of grape seed extracts antican-
cer mechanisms in association
with increasing cancer stage.
The effect is in sharp contrast
with that of chemotherapy,
which becomes less potent
in association with increased
metastatic potential.
The discovery is of signi-
cance in view of the increased
prevalence of colorectal can-
cer in Western societies, cou-
pled with the fact that many
of those diagnosed are at an
advanced stage of cancer.
Editors Note: No harmful effects
from the compound occurred in
healthy cells.
D. Dye
* Cancer Lett. 2012 Dec 22.
I N THE NEWS
APRIL 2013 | LIFE EXTENSION | 19
Calcium Supplementation Increases Fat Loss in
Obese and Overweight Young Adults
In an article published in Nutrition Journal, researchers in
China report a benecial effect for supplementation with calcium
and vitamin D in reducing the body fat of overweight and obese
college students.*
The trial included 43 men and women with a body mass index
(BMI) of 24 or higher. Participants were randomized to receive
an energy restricted diet supplemented with 600 mg of elemental
calcium and 125 IU vitamin D3, or an unsupplemented diet for
12 weeks.
While the amount of weight lost by both groups was similar, a
signicantly greater reduction in fat mass loss and fat percentage
occurred in the participants that received calcium in comparison
with unsupplemented subjects. Men and women who received
calcium and vitamin D experienced a 53.6%
greater decrease in fat mass loss than the con-
trol subjects, and had a greater reduction in
visceral fat mass and fat area.
Editors Note: Among other mechanisms of
body fat reduction, a calcium rich diet has been
demonstrated to increase fat oxidation and fat cell
apoptosis while reducing lipid absorption. Future
research in this area should be oriented toward a
better understanding of the doseresponse effect of
calcium supplementation (with or without vitamin
D) on weight management by administering differ-
ent dosages of this mineral, the authors conclude.
D. Dye
* Nutr J. 2013 Jan 8;12(1):8.
Life Extension
Products
Receive Top Awards!
Once again, Life Extension has received top ratings in
ConsumerLab.coms annual survey! Below are the areas in which
Life Extension took home the number one ranking:
I N THE NEWS
Curcumin Shows
Promise Easing
Arthritis Pain
In the medical journal
Phytotherapy Research, two
researchers, one from the
Nirmala Medical Centre in
India and the other from
Baylor Research Institute and
the Sammons Cancer Center
in Texas, published their work
on curcumin.* They showed
that curcumin is more effec-
tive than the common anti-
inflammatory medication
diclofenac for the pain associ-
ated with mild, active rheuma-
toid arthritis.
In the study, rheumatoid
arthritis patients taking cur-
cumin for eight weeks had a
44% reduction in pain symp-
toms, while those taking diclof-
enac had a 42% reduction. It
may not seem like there is a
big difference between cur-
cumin and diclofenac, but the
difference was signicant.
Interestingly, the curcumin
group also had a greater
reduction in overall inamma-
tion (rheumatoid arthritis may
have slightly improved) com-
pared to the diclofenac group.
Most importantly, there were
no adverse events with cur-
cumin.
This was an initial study,
but was well controlled and
randomized. Larger clinical
trials, however, are needed to
conrm these results.
D. Dye
* Available at: http://www.daily-
herald.com/article/20120416/
entlife/704169972/. Accesssed January.
28, 2013.
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Curcumin is the health-promoting
trace compound derived from the
Indian spice turmeric. But not all
turmeric is alike.
The curcumin found in the vast
majority of dietary supplements is
derived from turmeric that is nutri-
tionally inferior.
Why? Almost all growers harvest
turmeric at the point when the tur-
meric root turns its signature yellow
color, but before it has fully matured.
The turmeric root requires more
time in the ground for highly bene-
cial phytonutrients called curcumi-
noids and sesquiterpenoids to attain
peak concentrations.
Life Extension
s Super Bio-
Curcumin
, researchers
observed:
1,2
Nearly twice the support for
immune health.
Approximately twice the support
for inammatory issues.
Almost double the antioxidant
support.
A separate study indicated that an
antioxidant-rich curcumin extract
3
provided powerful support for heart
health.
Unrivaled Potency and
Absorbability with BCM-95
uses BCM-95
, a pat-
ented, bioenhanced preparation of
curcumin. It has been shown to
reach up to 7 times higher concen-
tration in the blood than standard
curcumin.
4
The graphs on this page illustrate
that one 400 mg vegetarian capsule
per day of Super Bio-Curcumin
supplies the equivalent of 2,500-
2,800 mg of commercial curcumin
supplements.
A bottle containing 60
vegetarian capsules of
Super Bio-Curcumin
retails for $38. If a mem-
ber buys four bottles,
the price is reduced to
only $26.25 per bottle.
Contains rice.
References
1. Int J Pharmacol. 2009;5(6):333-45.
2. J Food Nutr Res. 2009;48(3):148-52.
3. Arch Gerontol Geriatr. 2002;34:37-46.
4. Indian J Pharm Sci. 2008 Jul-Aug;70(4):445-9.
5. Bioavailability study of BCM-95
in rats.
Orcas International Inc. 2006.
CAUTION: Do not take if you have gallbladder problems or
gallstones. If you are taking anti-coagulant or anti-platelet
medications, or have a bleeding disorder, consult your
healthcare provider before taking this product.
Bio-Curcumin
and BCM-95
s
BENEFITS?
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
3500
3000
2500
2000
1500
1000
500
0
Curcumin
Standalone Extract
Super Bio-Curcumin
(BCM-95
)
C
u
r
c
u
m
i
n
A
b
s
o
r
b
e
d
b
y
t
h
e
B
o
d
y
(
A
U
C
:
n
g
/
m
L
x
h
)
Absorption of Super Bio-Curcumin
in Humans
Compared with Conventional Curcumin
4
Chart 2. Super Bio-Curcumin
(BCM-95
) showed
6.9 times greater bioavailability (absorption and
sustainability over 8 hours) in humans compared with
conventional curcumin (as measured by the area under
the curve [AUC] in a plot of blood levels against time,
that is, the total amount of curcumin absorbed by the
body over 8 hours).
250
200
150
100
50
0
Curcumin
Standalone Extract
Super Bio-Curcumin
(BCM-95
)
P
l
a
s
m
a
C
u
r
c
u
m
i
n
C
o
n
c
e
n
t
r
a
t
i
o
n
(
n
g
/
m
L
)
Absorption of Super Bio-Curcumin
in Rats
Compared with Conventional Curcumin
5
Chart 3. Bioavailability in rats fed with BCM-95
is 7.8 times higher than conventional curcumin.
4000
3500
3000
2500
2000
1500
1000
500
0
Plant-Bound Curcumin
with Piperine
Super Bio-Curcumin
(BCM-95
)
C
u
r
c
u
m
i
n
A
b
s
o
r
b
e
d
b
y
t
h
e
B
o
d
y
(
A
U
C
:
n
g
/
m
L
x
h
)
Absorption of Super Bio-Curcumin
in Humans
Compared with Plant-Bound Curcumin with Piperine
4
Chart 1. Super Bio-Curcumin
(BCM-95
) showed 6.3
times greater bioavailability (absorption and sustain-
ability over 8 hours) in humans compared with plant-
bound curcumin with piperine (as measured by the area
under the curve [AUC] in a plot of blood levels against
time, that is, the total amount of curcumin absorbed by
the body over 8 hours).
How Much Curcumin
Are You Absorbing?
Item # 00407
To order Super Bio-Curcumin
call 1-800-544-4440
or visit www.LifeExtension.com
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Numerous garlic products can be found in health food
stores. Each garlic manufacturer claims that its products are
of the best quality and provide optimal health benefts.
Garlic supplements, however, are not that simple.
When garlic is aged, its harsh and highly odorous
compounds are converted into more benefcial and much
less odorous compounds. Numerous studies have suggested
that supplementing ones diet with aged garlic extract may be
benefcial. Published data about aged garlic extract shows that it:
1. Helps maintain healthy endothelial function and structure.*
1,2
2. Helps maintain healthy immune function.*
3,4
3. Helps maintain healthy cellular DNA structure.*
5,6
Why Life Extension Recommends
Kyolic Aged Garlic Extract
The Life Extension Foundation recommends dietary supplements
based on the published, peer-reviewed scientifc literature. There are more
published studies substantiating the multiple benefts of Kyolic Aged
Garlic Extract than any other brand.
While some other garlic preparations may work as well as Kyolic, we
do not want our members risking their precious health on a supplement that
has not been specifcally documented to work. We therefore recommend
Kyolic over all other brands.
Easy-To-Swallow Kyolic Garlic Capsules
When Kyolic introduced a high-potency tablet two years ago, we at
Life Extension were very pleased. Previous Kyolic supplements required
many capsules to be swallowed to obtain a sufcient quantity of aged
garlic extract powder.
Some people have encountered difculty in swallowing the large Kyolic
tablets. The good news is that Kyolic has a higher-potency capsule available.
Each one of these easy-to-swallow capsules provides 600-mg
of standardized aged garlic extract. The suggested dose for healthy
people is two capsules per day with meals.
The retail price for a bottle containing 120 600-mg capsules of Kyolic
Reserve is $27.95. If a member buys four bottles, the price is reduced to only
$18.75 per bottle.
WHAT IS THE IDEAL
GARLIC
SUPPLEMENT?
Item # 00789
References
1. Planta Med. 1989 Dec;55(6):506-8.
2. Zasshi. 1997 Oct;110 Suppl 1:138P-41P.
3. Cancer Immunol Immunother. 1993
Oct;37(5):316-22.
4. Mol Biother. 1991 Jun;3(2):103-7.
5. Carcinogenesis. 1993 Aug;14(8):1627-31.
6. Carcinogenesis. 1992 Oct;13(10):1847-51.
To order Kyolic Reserve 600-mg capsules,
call 1-800-544-4440 or visit www.LifeExtension.com
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Remarkable Weight Reduction with
CoffeeGenic
Green Coffee Bean Extract (GCA
)
In a placebo-controlled, human study, subjects
took 350 mg of green cofee extract three times daily
(before meals).
Study subjects were not asked to change their
calorie intake or exercise level, but people participating
in weight loss trials often do make lifestyle changes in
order to increase their odds of shedding body fat.
The impressive fndings, published in January 2012,
noted that men and women lost an average of 17.6
poundsover 10% of body weightafter 12 weeks of
green cofee extract supplementation! There was also
an average 4.44% reduction in body fat percentage!
1
The conclusion is that green cofee extract supports
the ability to lose weight.
1
The form of green cofee
bean extract used in this successful weight loss study
is CofeeGenic Green Cofee Extract (GCA).
How CofeeGenic Works
The active ingredient in green cofee bean extract
is chlorogenic acid.
Published studies on chlorogenic acid demonstrate
a wide range of supportive properties related to insulin
sensitivity
2
and to glucose formation
3,4
and absorption.
5
Clinical research has shown that chlorogenic acid
helps limit after-meal glucose surges, supporting
healthy blood sugar levels for those already within the
normal range.
6
CofeeGenic Green Cofee Extract (GCA).
provides a standardized dose of chlorogenic acid
extracted from green cofee beans.
Comprehensive Formula
The standardized green cofee extract in the
CofeeGenic Weight Management with Green
Cofee Extract (GCA) formula has been enhanced
with the following nutrients to reinforce the ability
to support weight-loss:
1. Green Tea Decafeinated Extract
Green tea contains health-promoting polyphenols,
including epigallocatechin-3-gallate (EGCG).
7
A
number of studies suggest it helps support healthy
metabolic rate and weight loss.
8-13
2. Iodine
This trace element is involved in the production of
thyroid hormones that regulate the basal metabolic
ratewhich afects the bodys rate of calorie burn.
14
3. Chromium
Chromium plays an important role in glucose utili-
zation and is required for the release of energy from
glucose. It is now generally recognized as helping
maintain healthy blood sugar levels for those already
in the normal range.
15-17
4. Integra-Lean African Mango IGOB-131
Fat cells secrete leptin, a hormone that signals
our brain that weve eaten enough.
18
But some
individuals have become resistant to leptin, resulting
in added pounds. An extract from an African mango
called Irvingia gabonensis has been shown to
support leptin sensitivityfollowed by weight loss
and a slimming of the waistline.
19,20
African mango
also helps the body control the rate of carbohydrate
absorption from the intestines, and therefore, the
caloric impact of starchy and sugary foods. And this
extract supports healthy levels of adiponectin, a
hormone that regulates metabolism of lipids and
glucose. Research indicates it has the ability to
promote weight loss.
20
Based on the latest research, CofeeGenic
Weight Management with Green Cofee
Extract (GCA) provides in each capsule:
CofeeGenic Green Cofee Bean Extract 350 mg
[Standardized to 50% chlorogenic acid]
Integra-Lean African Mango 100 mg
(Irvingia gabonensis) proprietary extract (seed)
Chromium 150 mcg
[as Crominex 3+ chromium stabilized with Capros
(Phyllanthus emblica) extract (fruit) and PrimaVie Shilajit]
Iodine (as potassium iodide) 100 mcg
Green Tea decafeinated extract 50 mg
[ 98% polyphenols, 45% EGCG)]
The suggested dose is just one
capsule before each meal.
A bottle of 90 vegetarian
capsules of CofeeGenic Weight
Management with Green Cofee
Extract (GCA) retails for $48.
If a member buys four bottles, the
price is reduced to $31.50 per
bottle.
References
1. Diabetes Metab Syndr Obes. 2012;5:21-7.
2. J Nutr Biochem. 2006 Jan;17(1):63-71.
3. J Agric Food Chem. 2010 Apr 14;58(7):4141-4.
4. Ethnopharmacol. 2010 Jul 6;130(1):93-7.
5. J Nutr Sci Vitaminol (Tokyo). 2007
Apr;53(2):166-73.
6. Nagendran MV. Efect of Green Cofee Bean
Extract (GCE), High in Chlorogenic Acids, on
Glucose Metabolism. Poster presentation
number: 45-LB-P. Obesity 2011,
the 29th Annual Scientifc Meeting of the
Obesity Society. Orlando, Florida. October
1-5, 2011.
7. J Environ Pathol Toxicol Oncol. 1999;18(3):
147-58.
8. Int J Vitam Nutr Res. 2008 Dec;78(6):275-81.
9. Obesity. 2007 Jun;15(6):1473-83.
10. In Vivo. 2004 Jan-Feb;18(1):55-62.
11. Br J Nutr. 2005 Sep;94(3):432-6.
12. Obesity. 2009 Feb;17(2):310-7.
13. J Nutr Biochem. 2011 Jan;22(1):1-7.
14. Available at: http://ods.od.nih.gov/fact-
sheets/Iodine-HealthProfessional/.
Accessed September 24, 2012.
15. Altern Med Rev. 2002 Jun;7(3):218-35.
16. Saudi Med J. 2000 Jan;21(1):45-50.
17. Endocr Pract. 2012 May-Jun;18(3):394-8.
18. Prog Histochem Cytochem. 2010
Sep;45(3):143-200.
19. Lipids Health Dis. 2008 Nov 13;7:44.
20. Lipids Health Dis. 2009 Mar 2;8:7.
Item # 01707
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To order CofeeGenic Weight Management
with Green Cofee Extract (GCA),
call 1-800-544-4440 or visit www.LifeExtension.com
Caution: This product may lower blood glucose; consult your
healthcare provider before taking this product if you are taking
blood glucose-lowering medication.
This supplement should be taken in conjunction with
a healthy diet and regular exercise program. Results
may vary.
Integra-Lean
) and azelastin
(Astelin
).
32
A subsequent study showed that com-
bining these compounds with the drugs resulted in
improved antihistamine activity.
33
Preventing Cancer at Every Stage
Epidemiological studies reveal that dietary intake
of astaxanthin along with other carotenoids is associ-
ated with the reduced risk of many different types of
cancer. Increased intake of carotenoids such as astax-
anthin typically lowers cancer risk.
34
Unlike many pharmaceuticals, astaxanthin shows
benecial effects against cancer at each stage of its
development.
1. It prevents cancer initiation by protecting
DNA from ultraviolet and oxidant damage.
4,35
2. It promotes early detection and destruction
of cells that have undergone malignant trans-
formation by boosting immune surveillance.
7
3. It prevents cancerous growth in cells that
evade immune detection by reducing inam-
matory changes such as those that appear in
aging.
12,36
4. It blocks the rapid cell replication of tumors
in their growth phase by stopping the cancer
cell reproductive cycle and restoring cancer
cells ability to die off by apoptosis.
37-40
5. It prevents tumors from spreading by
reducing tumor production of tissue-melting
proteins.
36
Animal studies show that these properties of astax-
anthin contribute to a reduced number of precancer-
ous lesions in the colon, and to fewer and smaller
tumors when they do develop in the colon and
breast.
27,41
Reducing Diabesity and Its Consequences
Diabetes and obesity are so closely intertwined that
scientists now speak of them together as one entity,
diabesity. Diabesity is a major component of meta-
bolic syndrome. Astaxanthin holds multiple benets
in managing diabesity, with its resulting oxidant stress,
high levels of chronic inammation, and extensive
tissue damage from protein and lipid glycation.
42
What You Need to Know
Diverse Health Benefits
of Astaxanthin
Super Booster.
If you take the Super Booster, you do not need additional Super K with
Advanced K2 Complex softgels.)
Warning to Coumadin
members
use supplements, hormones, and drugs to improve
their insulin sensitivity, which facilitates the more
efficient removal of glucose from the blood.
6-12
Less well-known, however, is the fact that there
are certain foods proven to decrease blood sugar
levels!
7,13-16
Specifically, barley and black beans
have been extensively studied for their ability to
maintain glycemic control.
In this article, you will learn how these two foods
have been shown to lower blood sugar and inhibit
diabetes and other glycemic-stress-related prob-
lems such as cardiovascular disease and obesity.
Including these two glucose-lowering foods as
part of your normal diet can help maintain better
blood sugar levels. >
Foods That
Safely Reduce
BLOOD
GLUCOSE
BY MICHAEL DOWNEY
APRIL 2013 | LIFE EXTENSION | 37
Barley Lowers Blood Sugar
and Insulin Levels
Excessive dietary carbohydrates, such
as white rice and potatoes, trigger surges
in blood glucose, a key factor in the world-
wide epidemic of type II diabetes.
17,18
Aging
increases this effectbeginning as early as
age 20.
17
National Institutes of Health data indi-
cate that 35% of Americans aged 20 or
older have abnormally high blood glucose
levelsknown as prediabetesas do 50%
of those aged 65 years or older!
17
Fortunately, research has established
that consumption of insoluble dietary
berwhich is found in certain whole
grains, including barley
19
is associated
with a reduced risk of type II diabetes.
20
Barley is also a rich source of soluble
ber.
19
In fact, one study conducted on over-
weight women found signicantly lower
insulin and glucose responses following
barley ingestion, compared to ingestion of
oats.
15
The researchers concluded that par-
ticle sizeour versus akesmade little
difference. The reduced glucose effect was
determined to be the result of the higher
content of the soluble ber in the barley.
15
FOODS THAT SAFELY REDUCE BLOOD GLUCOSE
38 | LIFE EXTENSION | APRIL 2013
Barley Effects Beyond Blood Sugar
Barley improves risk factors for cardiovascular
disease and stroke.
Barley ber increases the excretion of bile acids
into the intestines. Since these acids are comprised
of oxidized cholesterol, this lowers total serum cho-
lesterol.
29
Studies have conrmed that barley lowers
cholesterol,
30
low-density lipoprotein (LDL),
31,32
and
blood pressure.
33
Barley is a rich source of soluble and insoluble
berboth of which benet gastrointestinal health.
The soluble ber in barley binds with water, add-
ing bulk to stools and promoting regular bowel
movements.
34
Some of the insoluble ber in barley is
digested by colonic bacteria to produce short-chain
fatty acids, which may promote bowel health
35
and
accelerate repair of colonic mucosa in those with
ulcerative colitis.
35
Like other ber-rich foods, barley is associated
with weight control.
Some trials have suggested that greater dietary ber
consumption increases satiety and decreases caloric
intake.
36-38
A diet high in protein and berboth found
in barleyhas been shown to minimize overall daily
calorie ingestion.
39,40
Another study found that, by suppressing free fatty
acid levels in the blood, whole barley regulates blood
sugar better than other grainsand for up to 10
hours after consumption!
21
Our bodies cannot digest the viscous soluble ber
in barley, which binds with water to slow food passage
through the digestive system. This tempers the bodys
glucose and insulin responses after a meal.
22,23
Substantial research has demonstrated that the
soluble ber in barley lowers postprandial glucose and
insulin.
15,23-27
This has been demonstrated not only in
the more common single-meal test studies of limited
duration, but also in a 12-week study that pinpointed
the longer-term effects of barley consumption on non-
diabetic individuals on a weight-neutral diet.
28
This prospective, randomized, placebo controlled,
double blind trial evaluated 50 healthy subjects with-
out prior diagnosis of diabetes. After 12 weeks, the
scientists found that daily ingestion of soluble barley
ber signicantly reduced fasting serum insulin val-
ues and, during oral glucose tolerance tests, signi-
cantly lowered blood glucose responses.
28
The team concluded that soluble barley ber may
slow the deterioration of insulin sensitivity for indi-
viduals at increased risk for diabetes mellitus.
28
FOODS THAT SAFELY REDUCE BLOOD GLUCOSE
APRIL 2013 | LIFE EXTENSION | 39
Black Beans Also Target Blood Sugar!
Epidemiological studies showed a strong associa-
tion between increased consumption of the common
bean (Phaseolus vulgaris)which includes black
beans, pintos, and othersand a reduced risk of
chronic diseases, including type II diabetes.
41-44
In 2012, this was conrmed in two separate, ran-
domized trials in which beans were demonstrated
to signicantly lower glycemic response in type II
diabetics.
16,45
Scientists believe that the compounds in beans may
slow activity of the alpha-amylase enzymes that help
break down starch into sugar. This would reduce or
slow sugar release.
Also, beans have a low GI (glycemic index), which
by denition means they produce a relatively low rise
in blood glucose after a meal
46-48
compared to high-
glycemic index items such as white rice, which sharply
elevate postprandial glucose and increase oxidative
stress.
49-51
The glucose-lowering effects of beans consumed
alone has been well documented, although at least
one study had measured this effect when beans
were eaten as part of a meal.
16,41,48,52
However, a large
study recently published in the British Journal of
Nutrition found that beans signicantly reduce glyce-
mic response even when combined with othereven
higher glycemic indexfoods.
41
Also, a review and meta-analysis that examined
41 studies found that bean consumptionalone, or
as part of a low-glycemic index or a high-ber diet
improves markers of longer-term glycemic control
in humans.
46
Specically, this review found that beans produced
improvements in HbA1c (glycated hemoglobin) and
fructosamine (glycated serum protein).
46
Both are
markers for longer-term plasma glucose concentra-
tion. These observed improvements indicate that
beans deliver signicant diabetic control over a pro-
longed period.
46
These ndings clearly demonstrate that aging
individualsboth those with, and those at risk for,
type II diabetescan restore glycemic control with
simple diet changes that increase intake of black
beans and barley.
Black Beans Help Prevent
Devastating DNA Damage
A study was designed to evaluate the toxicogenic
(toxin-producing) versus protective effect of cooked
and dehydrated black beans on bone marrow and
peripheral blood cells of mice.
What You Need to Know
Reduce Blood Glucose
Health Advisor at 1-866-864-3027.
FOODS THAT SAFELY REDUCE BLOOD GLUCOSE
APRIL 2013 | LIFE EXTENSION | 41
References
1. Laukkanen JA, Mkikallio TH, Ronkainen K, Karppi J, Kurl S.
Impaired fasting plasma glucose and type 2 diabetes are related
to the risk of out-of-hospital sudden cardiac death and all-cause
mortality. Diabetes Care. 2012 Dec 17. [Epub ahead of print]
2. Capaldo B, Di Bonito P, Iaccarino M, et al. Cardiovascular char-
acteristics in subjects with increasing levels of abnormal glucose
regulation: The Strong Heart Study. Diabetes Care. 2012 Dec 5.
[Epub ahead of print]
3. Lindkvist B, Almquist M, Bjrge T, et al. Prospective cohort study
of metabolic risk factors and gastric adenocarcinoma risk in
the Metabolic Syndrome and Cancer Project (Me-Can). Cancer
Causes Control. 2013 Jan;24(1):107-16.
4. Hirakawa Y, Ninomiya T, Mukai N, et al. Association between
glucose tolerance level and cancer death in a general Japanese
population: the hisayama study. Am J Epidemiol. 2012 Nov
15;176(10):856-64.
5. Savill P. Identifying patients at risk of type 2 diabetes. Practitioner.
2012 Jul-Aug;256(1753):25-7, 3.
6. Kandeil MA, Amin KA, Hassanin KA, Ali KM, Mohammed
ET. Role of lipoic acid on insulin resistance and leptin in
experimentally diabetic rats. J Diabetes Complications. 2011 Jan-
Feb;25(1):31-8.
7. Medjakovic S, Jungbauer A. Pomegranate: a fruit that ameliorates
metabolic syndrome. Food Funct. 2013 Jan 19;4(1):19-39.
8. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cin-
namon extract prevents the insulin resistance induced by a high-
fructose diet. Horm Metab Res. 2004 Feb;36(2):119-25.
9. Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and
insulin action in elderly women and men: a randomized con-
trolled trial. JAMA. 2004 Nov 10;292(18):2243-8.
10. Maneschi E, Morelli A, Filippi S, et al. v Testosterone treatment
improves metabolic syndrome-induced adipose tissue derange-
ments. J Endocrinol. 2012 Dec;215(3):347-362. Epub 2012 Oct 8.
11. Bayrak A, Terbell H, Urwitz-Lane R, Mor E, Stanczyk FZ, Paulson
RJ. Acute effects of metformin therapy include improvement
of insulin resistance and ovarian morphology. Fertil Steril. 2007
Apr;87(4):870-5. Epub 2007 Jan 16.
12. Basturk T, Unsal A, Ulas T, et al. Effects of rosiglitazone treatment
on insulin resistance and TNF-alpha levels in patients with chron-
ic kidney disease: a prospective study. Eur Rev Med Pharmacol Sci.
2012 Nov;16(11):1519-24.
13. Roopchand DE, Kuhn P, Rojo LE, Lila MA, Raskin I. Blueberry
polyphenol-enriched soybean our reduces hyperglycemia, body
weight gain and serum cholesterol in mice. Pharmacol Res. 2012
Dec 4;68(1):59-67.
14. Taniguchi A, Yamanaka-Okumura H, Nishida Y, Yamamoto H,
Taketani Y, Takeda E. Natto and viscous vegetables in a Japanese
style meal suppress postprandial glucose and insulin responses.
Asia Pac J Clin Nutr. 2008;17(4):663-8.
15. Behall KM, Scholeld DJ, Hallfrisch J. Comparison of hormone
and glucose responses of overweight women to barley and oats. J
Am Coll Nutr. 2005 Jun;24(3):182-8.
16. Thompson SV, Winham DM, Hutchins AM. Bean and rice meals
reduce postprandial glycemic response in adults with type 2
diabetes: a cross-over study. Nutr J. 2012;11:23.
17. Wylie-Rosett J, Segal-Isaacson CJ, Segal-Isaacson A. Carbohy-
drates and increases in obesity: Does the type of carbohydrate
make a difference? Obesity Research. 2004 Nov;12(S):124S-9S.
18. Available at: http://diabetes.niddk.nih.gov/DM/PUBS/
statistics/#youngpeople. Accessed December 1, 2012.
19. Available at: http://barleyworld.org/sites/default/les/what_bar-
ley_foods_can_do_you.pdf. Accessed December 28, 2012.
20. Weickert MO, Pfeiffer AFH. Metabolic effects of dietary
ber consumption and prevention of diabetes. J Nutr. 2008
Mar;138(3):439-42.
21. Nilsson A, Granfeldt Y, Ostman E, Preston T, Bjrck I. Effects
of GI and content of indigestible carbohydrates of cereal-based
evening meals on glucose tolerance at a subsequent standardised
breakfast. Eur J Clin Nutr. 2006 Sep;60(9):1092-9.
22. Granfeldt Y, Liljeberg H, Drews A, Newman R, Bjrck I. Glu-
cose and insulin responses to barley products: inuence of food
structure and amylose-amylopectin ratio. Am J Clin Nutr. 1994
May;59(5):1075-82.
23. Anderson JW, Baird P, Davis RH, et al. Health benets of dietary
ber. Nutr Rev. 2009;67(4):188-205.
24. Alminger M, Eklund-Jonsson C. Whole-grain cereal products
based on a high-bre barley or oat genotype lower post-prandial
glucose and insulin responses in healthy humans. Eur J Nutr.
2008;47(6):294-300.
25. Casiraghi MC, Garsetti M, Testolin G, Brighenti F. Post-prandial
responses to cereal products enriched with barley beta-glucan. J
Am Coll Nutr. 2006;25(4):313-20.
26. Keogh JB, Lau CW, Noakes M, Bowen J, Clifton PM. Effects of
meals with high soluble bre, high amylose barley variant on
glucose, insulin, satiety and thermic effect of food in healthy lean
women. Eur J Clin Nutr. 2007;61(5):597-604.
27. Kim H, Stote KS, Behall KM, Spears K, Vinyard B, Conway JM.
Glucose and insulin responses to whole grain breakfasts vary-
ing in soluble ber, beta-glucan: a dose response study in obese
women with increased risk for insulin resistance. Eur J Nutr.
2009;48(3):170-5.
28. Bays H, Frestedt JL, Bell M. Reduced viscosity Barley beta-glucan
versus placebo: a randomized controlled trial of the effects on in-
sulin sensitivity for individuals at risk for diabetes mellitus. Nutr
Metab (Lond). 2011;8:58.
29. Pedersen JI. Peroxisomal oxidation of the steroid side chain in
bile acid formation. Biochimie. 1993;75(3-4):159-65.
30. Behall KM, Hallfrisch JG. Effects of barley consumption in CVD
risk factors. Cereal Food World. 2006;51:12-5.
31. AbuMweis SS, Jew S, Ames NP. -glucan from barley and its lipid-
lowering capacity: a meta-analysis of randomized, controlled
trials. Eur J Clin Nutr. 2010 Dec;64(12):1472-80
32. Keenan JM, Goulson M, Shamliyan T, et al. The effects of
concentrated barley beta-glucan on blood lipids in a popula-
tion of hypercholesterolaemic men and women. Br J Nutr. 2007
Jun;97(6):1162-8.
33. Hallfrisch JG, Scholeld DJ, Behall KM. Blood pressure re-
duced by whole grain diet containing barley or whole wheat and
brown rice in moderately hypercholesterolemic men. Nutr Res.
2003;23:1631-42.
FOODS THAT SAFELY REDUCE BLOOD GLUCOSE
42 | LIFE EXTENSION | APRIL 2013
53. Azevedo L, Gomes JC, Stringheta PC, et al. Black bean (Phaseolus
vulgaris L.) as a protective agent against DNA damage in mice.
Food Chem Toxicol. 2003 Dec;41(12):1671-6.
54. Winham DM, Hutchins AM. Baked bean consumption reduces
total cholesterol in mildly hypercholesterolemic men and women.
Nutr Res. 2007;27:380-6.
55. Winham DM, Hutchins AM, Johnston CS. Pinto bean consump-
tion reduces biomarkers for heart disease risk. J Am Coll Nutr.
2007;26:243-9.
56. Anderson JW, Gustafson NJ, Spencer DB, et al. Serum lipid
response of hypercholesterolemic men to single and divided doses
of canned beans. Am J Clin Nutr. 1990;51:1013-9.
57. Davignon J, Ganz P. Role of endothelial dysfunction in atheroscle-
rosis. Circulation. 2004;109:III-27-32.
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69. Immerseel FV, Ducatelle R, De Vos M, et al. Butyric acid-produ-
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2009 Jul 23.
38. Vitaglione P, Lumaga RB, Montagnese C, Messia MC, Marconi E,
Scal L. Satiating effects of a barley beta-glucan-enriched snack. J
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39. Samra RA, Anderson GH. Insoluble cereal ber reduces appe-
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40. Weigle DS, Breen PA, Matthys CC, et al. A high-protein diet
induces sustained reductions in appetite, ad libitum caloric
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Jul;82(1):41-8.
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and their postprandial effect in type 2 diabetics. J Sci Food Agric.
2012 Aug 30. doi: 10.1002/jsfa.5852. [Epub ahead of print] Barley
Vitamin D3 1,000 IU
250 softgels
Retail: $12.50
Four-bottle
Member Price: $8.44 ea.
Commercial companies oered only 400 IU
vitamin D products when Life Extension long
ago introduced a 1,000 IU version. For most
people, this 1,000 IU potency is insucient
to attain optimal vitamin D blood levels. For
smaller individuals who obtain 2,000-3,000
IU in their multi-nutrient formulas (and
children), this potency of vitamin D may be
suitable.
Item # 01751
To order any of these high-potency
vitamin D3 supplements,
call 1-800-544-4440
or visit www.LifeExtension.com
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
CAUTION: Individuals consuming more than 2,000 IU/day of vitamin D (from diet and
supplements) should periodically obtain a serum 25-hydroxyvitamin D measurement. Do not
exceed 10,000 IU per day unless recommended by your doctor. Vitamin D supplementation
is not recommended for individuals with high blood calcium levels.
* If you have a thyroid condition or are taking antithyroid medications, do not use without
consulting your healthcare practitioner.
Vitamin D3 5,000 IU
with Sea-Iodine*
60 capsules (non-softgel)
Retail: $14
Four-bottle
Member Price: $9.38 ea.
Most people do not ingest enough vitamin
D and iodine, especially those seeking to
reduce their salt intake. Combining 5,000
IU of vitamin D3 and 1,000 mcg of iodine
into one capsule makes taking these two
nutrients economical and convenient.
Item # 01573
D
3
New Vitamin D3 Softgels
For Superior Absorption
Study after study conrms the vital
importance of maintaining optimal
levels of vitamin D. Research
often indicates that a blood
level between 5080 ng/mL of
25-hydroxyvitamin D is ideal. Because
people have individual requirements, Life
Extension
Health Advisor at 1-866-864-3027.
FRAN DRESCHER: DEFEATING CANCER
Women today face a growing number of health issues, including
the need to support DNA gene structure in the breast. Detrimental
factors such as the aging process, along with the daily bombardment
of environmental estrogen-like compounds, demonstrate the need to
support a womans breast cellular structure.
A wealth of research shows that specic botanical extracts can
positively inuence cellular status and remove some of the anxiety
women face about maintaining a healthy balance of estrogens.
Two important metabolites that estrogen is broken down
to in the body are: the good 2-hydroxyestrone and the bad
16 alpha-hydroxyestrone. Scientists have identied nutrients like
indole-3-carbinol (I3C) that can tip the delicate balance of
estrogens in favor of the good form.
Women seeking to proactively restore their youthful hormonal
balance can now take a new, phytonutrient-based formula that
helps support healthy estrogen activity and detoxication. Some of
the active ingredients in the Breast Health Formula are:
Phytoestrogens that function as selective estrogen receptor
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cells, thus preventing bad estrogen from exerting its
harmful effects
PIant Iignans that boost benecial enterolactone levels and
favorably alter estrogen metabolism
Cruci!erous VegetabIe Extracts (such as I3C) that effectively
increase 2-hydroxyestrone while reducing undesirable 16
alpha-hydroxyestrone
CaIcium D-GIucarate to safely facilitate the removal of
harmful estrogen from the body
Vitamin D to promote healthy genetic regulatory switching
to aging cells
reast HeaIth formuIa provides nutrients that have
demonstrated broad-spectrum support for preserving optimal
breast health.
The retail price for 60 vegetarian capsules of reast HeaIth
formuIa is $34. If a member buys four bottles, the price is reduced
to only $22.50 per bottle. Contains soybeans.
ActiFlax is a trademark of Pharma Science Nutrients, Inc., all rights reserved;
SoySelect
Comprehensive Pomegranate Protection!
Few nutritional sources have gained as much scientic
validation as pomegranate.
1
The vast majority of research has focused on extracts
from the fruit. Only recently have scientists identied the
synergistic action of compounds specic to other parts of
the pomegranatemost notably its seeds and owers.
To order Full-Spectrum Pomegranate,
call 1-800-544-4440
or visit www.LifeExtension.com
POMELLA
extract is covered under U.S. Patent 7,638,640 and POMELLA
DHEA
These supplements should be taken in conjunction with
a healthy diet and exercise program. Results may vary.
Note: Those with hormone-sensitive cancers should avoid regular
DHEA, but this caution does not apply to 7-Keto DHEA. Unlike
regular DHEA, 7-Keto
Health Advisor at 1-866-864-3027.
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tion of HDACs and c-Myc. Int J Oncol. 2008 Aug;33(2):375-80.
81. Hofmann T, Kuhnert A, Schubert A, et al. Modulation of
detoxication enzymes by watercress: in vitro and in vivo
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Dec;48(8):483-91.
82. Hecht SS, Chung FL, Richie JP, Jr., et al. Effects of water-
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83. Hecht SS. Approaches to chemoprevention of lung cancer
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spect. 1997 Jun;105 Suppl 4:955-63.
84. Chung FL, Morse MA, Eklind KI, Xu Y. Inhibition of tobacco-
specic nitrosamine-induced lung tumorigenesis by compounds
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Acad Sci. 1993 May 28;686:186-201; discussion 01-2.
85. Chung FL, Conaway CC, Rao CV, Reddy BS. Chemoprevention of
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86. Chiao JW, Wu H, Ramaswamy G, et al. Ingestion of an isothio-
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87. Khor TO, Cheung WK, Prawan A, Reddy BS, Kong AN. Chemo-
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88. Rose P, Won YK, Ong CN, Whiteman M. Beta-phenylethyl and
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91. Rungapamestry V, Duncan AJ, Fuller Z, Ratcliffe B. Changes in
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92. Rouzaud G, Young SA, Duncan AJ. Hydrolysis of glucosinolates
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93. Verkerk R, Schreiner M, Krumbein A, et al. Glucosinolates in
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95. Smith S, Sepkovic D, Bradlow HL, Auborn KJ. 3,3-Diindolyl-
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96. Smith S, Sepkovic D, Bradlow HL, Auborn KJ. 3,3-Diindolyl-
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97. Ramirez MC, Singletary K. Regulation of estrogen receptor alpha
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98. Marconett CN, Sundar SN, Tseng M, et al. Indole-3-carbinol
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99. Rajoria S, Suriano R, George A, et al. Estrogen induced meta-
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101. Marconett CN, Singhal AK, Sundar SN, Firestone GL. Indole-
3-carbinol disrupts estrogen receptor-alpha dependent expres-
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Cell Endocrinol. 2012 Nov 5;363(1-2):74-84.
SHIELD YOURSELF FROM ENVIRONMENTAL CANCER RISKS
64 | LIFE EXTENSION | APRIL 2013
122. Valdes A, Garcia-Canas V, Rocamora-Reverte L, Gomez-Martinez
A, Ferragut JA, Cifuentes A. Effect of rosemary polyphenols on
human colon cancer cells: transcriptomic proling and functional
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124. Shabtay A, Sharabani H, Barvish Z, et al. Synergistic antileuke-
mic activity of carnosic acid-rich rosemary extract and the 19-nor
Gemini vitamin D analogue in a mouse model of systemic acute
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125. Singletary KW, Rokusek JT. Tissue-specic enhancement of xeno-
biotic detoxication enzymes in mice by dietary rosemary extract.
Plant Foods Hum Nutr. 1997;50(1):47-53.
126. Tsai CW, Lin CY, Wang YJ. Carnosic acid induces the NAD(P)H:
quinone oxidoreductase 1 expression in rat clone 9 cells through
the p38/nuclear factor erythroid-2 related factor 2 pathway. J Nutr.
2011 Dec;141(12):2119-25.
127. Jindal A, Soyal D, Sancheti G, Goyal PK. Radioprotective poten-
tial of Rosemarinus ofcinalis against lethal effects of gamma
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128. Sancheti G, Goyal PK. Prevention of radiation induced hemato-
logical alterations by medicinal plant Rosmarinus ofcinalis, in
mice. Afr J Tradit Complement Altern Med. 2006;4(2):165-72.
129. Soyal D, Jindal A, Singh I, Goyal PK. Modulation of radiation-in-
duced biochemical alterations in mice by rosemary (Rosemarinus
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130. Jindal A, Agrawal A, Goyal PK. Inuence of Rosemarinus of-
cinalis extract on radiation-induced intestinal injury in mice. J
Environ Pathol Toxicol Oncol. 2010;29(3):169-79.
131. Slamenova D, Kuboskova K, Horvathova E, Robichova S. Rose-
mary-stimulated reduction of DNA strand breaks and FPG-sensi-
tive sites in mammalian cells treated with H2O2 or visible light-
excited Methylene Blue. Cancer Lett. 2002 Mar 28;177(2):145-53.
132. Kar S, Palit S, Ball WB, Das PK. Carnosic acid modulates Akt/
IKK/NF-gB signaling by PP2A and induces intrinsic and extrinsic
pathway mediated apoptosis in human prostate carcinoma PC-3
cells. Apoptosis. 2012 Jul;17(7):735-47.
133. Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F. Inhibitory
effects of rosemary extracts, carnosic acid and rosmarinic acid on
the growth of various human cancer cell lines. Plant Foods Hum
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134. Sharabani H, Izumchenko E, Wang Q, et al. Cooperative antitu-
mor effects of vitamin D3 derivatives and rosemary preparations
in a mouse model of myeloid leukemia. Int J Cancer. 2006 Jun
15;118(12):3012-21.
102. Budhraja A, Gao N, Zhang Z, et al. Apigenin induces apoptosis in
human leukemia cells and exhibits anti-leukemic activity in vivo.
Mol Cancer Ther. 2012 Jan;11(1):132-42.
103. He J, Xu Q, Wang M, et al. Oral Administration of api-
genin inhibits metastasis through AKT/P70S6K1/MMP-9
pathway in orthotopic ovarian tumor model. Int J Mol Sci.
2012;13(6):7271-82.
104. King JC, Lu QY, Li G, et al. Evidence for activation of mutated
p53 by apigenin in human pancreatic cancer. Biochim Biophys
Acta. 2012 Feb;1823(2):593-604.
105. Mafuvadze B, Liang Y, Besch-Williford C, Zhang X, Hyder SM.
Apigenin induces apoptosis and blocks growth of medroxyproges-
terone acetate-dependent BT-474 xenograft tumors. Horm Cancer.
2012 Aug;3(4):160-71.
106. Hoensch H, Groh B, Edler L, Kirch W. Prospective cohort com-
parison of avonoid treatment in patients with resected colorectal
cancer to prevent recurrence. World J Gastroenterol. 2008 Apr
14;14(14):2187-93.
107. Silvan S, Manoharan S, Baskaran N, Anusuya C, Karthikeyan
S, Prabhakar MM. Chemopreventive potential of apigenin in
7,12-dimethylbenz(a)anthracene induced experimental oral carci-
nogenesis. Eur J Pharmacol. 2011 Nov 30;670(2-3):571-7.
108. Byun S, Park J, Lee E, et al. Src kinase is a direct target of api-
genin against UVB-induced skin inammation. Carcinogenesis.
2012 Nov 17.
109. Gomez-Garcia F, Lopez-Jornet M, Alvarez-Sanchez N, Castillo-
Sanchez J, Benavente-Garcia O, Vicente Ortega V. Effect of the
phenolic compounds apigenin and carnosic acid on oral carcino-
genesis in hamster induced by DMBA. Oral Dis. 2012 Jul 16.
110. Bacher N, Tiefenthaler M, Sturm S, et al. Oxindole alkaloids from
Uncaria tomentosa induce apoptosis in proliferating, G0/G1-
arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
Br J Haematol. 2006 Mar;132(5):615-22.
111. Rinner B, Li ZX, Haas H, et al. Antiproliferative and pro-apop-
totic effects of Uncaria tomentosa in human medullary thyroid
carcinoma cells. Anticancer Res. 2009 Nov;29(11):4519-28.
112. Pilarski R, Filip B, Wietrzyk J, Kuras M, Gulewicz K. Anticancer
activity of the Uncaria tomentosa (Willd.) DC. preparations with
different oxindole alkaloid composition. Phytomedicine. 2010 Dec
1;17(14):1133-9.
113. Emanuel P, Scheinfeld N. A review of DNA repair and possible
DNA-repair adjuvants and selected natural anti-oxidants. Derma-
tol Online J. 2007;13(3):10.
114. Anter J, Romero-Jimenez M, Fernandez-Bedmar Z, et al.
Antigenotoxicity, cytotoxicity, and apoptosis induction by
apigenin, bisabolol, and protocatechuic acid. J Med Food. 2011
Mar;14(3):276-83.
115. Farias I, do Carmo Araujo M, Zimmermann ES, et al. Uncaria
tomentosa stimulates the proliferation of myeloid progenitor cells.
J Ethnopharmacol. 2011 Sep 1;137(1):856-63.
116. Santos Arajo Mdo C, Farias IL, Gutierres J, et al. Uncaria
tomentosa-adjuvant treatment for breast cancer: Clinical trial.
Evid Based Complement Alternat Med. 2012;2012:676984.
117. Cheng AC, Jian CB, Huang YT, Lai CS, Hsu PC, Pan MH. In-
duction of apoptosis by Uncaria tomentosa through reactive
oxygen species production, cytochrome c release, and caspases
activation in human leukemia cells. Food Chem Toxicol. 2007
Nov;45(11):2206-18.
118. Huang SC, Ho CT, Lin-Shiau SY, Lin JK. Carnosol inhibits the
invasion of B16/F10 mouse melanoma cells by suppressing metal-
loproteinase-9 through down-regulating nuclear factor-kappa B
and c-Jun. Biochem Pharmacol. 2005 Jan 15;69(2):221-32.
119. Moran AE, Carothers AM, Weyant MJ, Redston M, Bertagnolli
MM. Carnosol inhibits beta-catenin tyrosine phosphorylation
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mouse. Cancer Res. 2005 Feb 1;65(3):1097-104.
120. Sancheti G, Goyal PK. Effect of Rosmarinus ofcinalis in modu-
lating 7,12-dimethylbenz(a)anthracene induced skin tumorigen-
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121. Ngo SN, Williams DB, Head RJ. Rosemary and cancer preven-
tion: preclinical perspectives. Crit Rev Food Sci Nutr. 2011
Dec;51(10):946-54.
Experience
Item # 00987
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To order Natural Stress Relief
with Lemon Balm and L-Theanine,
call 1-800-544-4440 or visit
www.LifeExtension.com
It Item emm###
T d N t l S
Overstressed? Losing sleep?
Left unchecked, the inner turmoil created by
these issues can lead to heart palpitations,
muscle weakness, headaches, and even
increased blood pressure. You need to take
action to halt these symptoms immediately.
Fortunately, Life Extension
has created
Natural Stress Relief, a calming formula
made with lemon balm and L-theanine, two
ingredients clinically proven to help promote
sleep and relaxation.
1-3
The Cyracos
L-Theanine
Note that the amount of L-theanine in this product is
double that of most L-theanine stand-alone supplements.
The reason for this potency increase is reports of greater
benet when at least 200 mg of L-theanine are taken.
The retail price of a 30-count bottle of Natural Stress
Relief is $28. If a member buys four bottles, the price of
this potent stress-relieving formula is reduced to just
$18 per bottle.
BEWARE OF IMITATIONS The L-theanine used in the new Natural Stress Relief is Suntheanine
, the only
pure form of L-theanine available worldwide and the only form protected by 40 internationally recognized
patents and scientically proven in clinical studies to be safe and ecacious. Independent laboratory
analysis has veried that certain other products on the market claiming to contain L-theanine are only
half L-theanine, the other half being a dierent form of theanine known as D-theanine that has not been
scientically evaluated in published studies. Suntheanine
is a registered
trademark of Naturex, Inc.
References:
1. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.
2. J Herb Pharmacother. 2006;6(2):21-30.
3. Biochem Biophys Res Commun. 2004 Jul 16;320(1):116-22.
References:
1. Am J Clin Nutr. 1987;45:1305-12.
2. Clinica Chimica Acta. 2000;294:1-26.
According to the National Institutes of Health,
magnesium is required for more than 300
biochemical reactions in the body. Magnesium
helps maintain normal muscle and nerve
function, keeps heart rhythm steady, supports a
healthy immune system, and keeps bones strong.
Magnesium also helps maintain blood sugar levels
already within normal range, promotes normal
blood pressure, and is known to be involved in
energy metabolism and protein synthesis.
1,2
With so many of our bodys critical functions
dependent upon magnesium, supplementation
can help ensure that you obtain healthy levels
of this vital mineral. The recommended intake
of magnesium to maintain vascular health is
500 mg or more a day. With Life Extension
s
Magnesium Capsules you can easily obtain
500 mg of elemental magnesium in each
vegetarian capsule.
The retail price of a bottle containing 100
500 mg Magnesium Capsules is $10. If a member
buys four bottles, the price is reduced to just
$6.75 per bottle.
MOST AMERICANS DO NOT OBTAIN
SUFFICIENT MAGNESIUM FROM THEIR DIET.
To order Magnesium Capsules,
call 1-800-544-4440 or
visit www.LifeExtension.com
Item #01369
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Caution: If taken in high doses, magnesium may have a laxative eect. If this
occurs, divide dosing, reduce intake, or discontinue product.
Scientists have identied specic extracts from cruciferous
vegetablessuch as broccoli, cauliower, cabbage and Brus-
sels sproutsthat help maintain healthy hormone metabolite
balance. Triple Action Cruciferous Vegetable Extract com-
bines some of these plant extracts into a comprehensive
formula for optimal DNA protection.
I3C (indole-3-carbinol) and DIM (di-indolyl-methane)
favorably modulate estrogen metabolism and induce liver
detoxication enzymes to help neutralize potentially harmful
estrogen metabolites and xenoestrogens (estrogen-like
environmental chemicals).
1-4
Extracts of broccoli, watercress, and rosemary provide
glucosinolates, isothiocyanates, carnosic acid, and carnosol
bioactive compounds that have a multitude of favorable
eects on estrogen metabolism and cell division.
5-8
Apigenin,
a powerful plant avonoid found in plants such as parsley
and celery, is also added to the formula to boost cell protec-
tion,
9
while 25 mg of a natural source of benzyl isothiocyanate
(BITC), are included to maintain cell health.
10
Consumers should be aware that while consumption of cruci-
ferous vegetables is highly recommended, the cooking process
depletes many of the benecial compounds such as I3C.
For those weighing less than 160 pounds, just one capsule
a day provides optimal potencies. Those weighing over 160
pounds should consider taking two capsules a day. A 60 vege-
tarian capsules bottle of Triple Action Cruciferous Vegetable
Extract retails for $24. If a member buys four bottles, the
price is reduced to $16.50 per bottle.
To order Triple Action Cruciferous
Vegetable Extract, call 1-800-544-4440
or visit www.LifeExtension.com
Item # 01468 Item # 01469
REFERENCES
1. Biochem Pharm. 2002, 64;393-404.
2. Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52.
3. J Natl Cancer Inst. 1997 May 21;89(10):718-23.
4. Cancer Detect Prevent. 2004;28:72-9.
5. Carcinogenesis. 2002 Apr;23(4):581-6.
6. Mol Cancer Ther. 2003 Oct;2(10):1045-52.
7. Carcinogenesis. 1998 Oct;19(10):1821-7.
8. Carcinogenesis. 1995 Sep;16(9):2057-62.
9. J Clin Biochem Nutr. 2009 May;44(3):260-5.
10. Food Chem Toxicol. 2008 Jul;46(7):2358-64.
CRUCIFEROUS
Vegetable Extract with Apigenin
TRIPLE ACTION
Triple Action Cruciferous Vegetable Extract provides the
following concentrates in just one vegetarian capsule:
Broccoli Extract 400 mg
[standardized to 4% glucosinolates (16 mg)]
Watercress 4:1 extract 50 mg
Indole-3-Carbinol (I3C) 80 mg
Rosemary Extract 50 mg
Cats Claw Extract 50 mg
Cabbage Extract 25 mg
DIM (di-indolyl-methane) 14 mg
Apigenin 25 mg
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Those who want to obtain the benets of trans-resveratrol
can order Triple Action Cruciferous Vegetable Extract with
Resveratrol. Each capsule provides 20 mg of trans-resveratrol
in addition to the vegetable extracts and retails for $32 per
60-capsule bottle. When a member buys four bottles, the price
is reduced to $22.20 per bottle.
Contains corn.
68 | LIFE EXTENSION | APRIL 2013
Misconceptions
About
ATHERO-
SCLEROSIS
Atherosclerosis is the underlying cause of most heart attacks
and strokes, yet doctors remain confused as to how this artery-blocking
process occurs.
Most cardiologists overlook specific mechanisms that inflict arterial
wall damage and the ensuing progression to occlusive atherosclerotic
disease. The result is that only a few of the factors that accelerate
arterial blockage (such as elevated LDL) are addressed in todays
clinical setting.
Doctors think of an atherosclerotic lesion as a clog consisting
of fat, cholesterol, and platelets that have accumulated on an inner
arterial wall. As a result, they tell their patients to eat less fat, take a
statin drug (if cholesterol levels are high), and use a baby aspirin to
prevent arterial platelet aggregation. The problem with these
approaches is that while they may postpone a heart attack or stroke,
they fail to correct the underlying pathologies that cause athero-
sclerotic lesions to form and progress.
If people are to live long lives free of the ravages of athero-
sclerosis, these lethal misconceptions must be cleared up. Otherwise,
there will be an epidemic of aging people receiving coronary stents,
undergoing bypass surgeries, and dropping dead from sudden heart
attacks. >
BY WILLIAM FALOON
A
T
H
E
R
O
S
C
L
E
R
O
S
I
S
APRIL 2013 | LIFE EXTENSION | 69
Why Arteries Clog as We Age
The aging process damages blood vessels, even when conventional risk
factors such as cholesterol and blood pressure are within normal ranges.
For over 40 years, the standard treatment for coronary atherosclerosis
has been to bypass the blocked arteries. Recuperation from this procedure
can take months, and some patients are aficted with lifetime impairments
such as chronic inammation, memory loss, and depression.
1-11
Stenting open narrowed coronary arteries has become prevalent over the
past decade, but this procedure is not a cure for underlying systemic endo-
thelial dysfunction and atherosclerosis.
MISCONCEPTIONS ABOUT ATHEROSCLEROSIS
70 | LIFE EXTENSION | APRIL 2013
endothelial cells whose integrity is crucial if athero-
sclerosis is to be prevented.
Poor health habits and normal aging result in
endothelial dysfunction, a process in which the
endothelium boundary is broken, arterial exibility
is diminished, abnormal platelet aggregation occurs,
and atherosclerotic lesions form in response to arte-
rial wall (endothelium) injuries.
How Do Most Heart Attacks
and Strokes Occur?
The two prime factors involved in occlusive arte-
rial disease are abnormal platelet aggregation and
endothelial dysfunction. When the endothelium is
not functioning properly, our platelets (blood-clotting
cells) become dangerously over-activated. This can
cause a sudden arterial blood clot, or contribute to
progression of atherosclerosis by stimulating inam-
mation.
A primary mechanism involved in endothelial
dysfunction is the depletion of nitric oxide, often
caused from the oxidation of LDL and other blood
components. Nitric oxide is produced by endothelial
cells. It regulates vascular elasticity, maintains cardiac
contraction, prevents vessel injury, and helps protect
against atherosclerosis.
59-62
As humans age, endothelial function becomes
altered. Due to a variety of insults, a depletion of nitric
oxide occurs in the endothelium. One consequence of
nitric oxide depletion is the inability of arteries to
expand and contract with youthful elasticity. The con-
tinual stiffening and occlusion of aged arteries is the
number one health risk that people in Western soci-
eties face.
63-68
In order to maintain healthy arterial
dilation, the endothelium has to manufacture enough
nitric oxide. Impairment in nitric oxide release by the
aging endothelium causes arterial dysfunction.
69,70
Therapies used by todays mainstream cardiologists
(aspirin, statin, and certain anti-hypertensive drugs)
have a benecial effect on the endothelium, but they
may only postpone a serious vascular event. If a per-
son lives long enough, the chronic depletion of endo-
thelial nitric oxide results in impairment of arterial
function and progressive restriction of blood ow to
vital parts of the body.
Summary
Endothelial cells line the arteries, veins, arterioles,
and capillaries of the vascular system. Doctors used
to view the endothelium as a relatively inert struc-
ture that played no active role in vascular function.
Starting around 20 years ago, research has shown that
A review of the scientic literature reveals that
atherosclerosis is associated with high blood levels
of homocysteine,
12-14
brinogen,
15-18
C-reactive pro-
tein,
12,15,19-26
glucose,
27,28
cholesterol,
29-32
insulin,
33-36
iron,
37-40
LDL,
41-44
and triglycerides,
45-48
along with
low levels of HDL
49-52
and testosterone (in men).
53-58
Optimizing blood levels of these substances can dra-
matically reduce heart attack and stroke risk.
Despite thousands of studies validating that ath-
erosclerosis is a multifactorial process, todays doctors
often prescribe a statin drug as the sole therapy to pre-
vent and treat coronary atherosclerosis. Mainstream
cardiologists fail to appreciate that coronary athero-
sclerosis is a sign of systemic arterial dysfunction
requiring aggressive therapy to correct.
Anatomy of the Artery
Arteries are the blood vessels that bear the full
force of each heartbeat. Most people think of arteries
as exible tubes whose only function is to carry blood
that ows continuously throughout the body. In fact,
arteries are dynamic, functioning muscular structures
that, when healthy, expand and contract to facilitate
circulation and maintain optimal blood pressure.
The outer layer of the artery comprises mostly con-
nective tissue and provides structural containment for
the two layers beneath. The middle area comprises
elastic smooth muscle that provides the contractile
strength to make possible the arterys expansion and
contraction with each heartbeat. The inner layer,
known as the endothelium, comprises a thin area of
Cross-section of an artery demonstarting plaque.
Endothelium
Smooth muscle cell
infiltration into
the endothelium
Atherosclerotic
plaque
MISCONCEPTIONS ABOUT ATHEROSCLEROSIS
APRIL 2013 | LIFE EXTENSION | 71
the endothelium is dynamic and participates in vital
aspects of arterial structure and function.
74
Over the years, Life Extension
has reported
on advances related to protecting the endothelium
against age-related deterioration, such as the remark-
able ability of pomegranate to reverse clinical mea-
surements of systemic atherosclerosis (in both carotid
and coronary arteries).
75-81
A typical 50-year-old human can postpone a major
cardiovascular event by following relatively simple
steps, such as eating healthy and taking a low-dose
statin drug if LDL is over 100 mg/dL. As that same
person ages, however, multiple processes involved in
endothelial dysfunction too often manifest in the
form of a vascular-related disorder.
Endothelial cells that line blood vessels are crucial
to maintaining vascular integrity. Endothelial dys-
function is a critical factor in the initiation and pro-
gression of cardiovascular disease,
82-84
yet mainstream
doctors continue to ignore this dominant underlying
cause of arterial occlusion. Pomegranate extracts
protect against endothelial dysfunction via several
well-dened mechanisms, including protection of
vital endothelial nitric oxide.
85-87
Atherosclerosis remains the number-one cause of
death and disability in the United States.
88
The graphic
on the next page shows 17 independent risk factors
of atherosclerosis, with low EPA/DHA blood levels
being only one of the elements that must be controlled
if heart attack and ischemic stroke are to be averted.
Annual blood testing is critical to identifying ones
individual risk factors. Modest-dose sh oil alone will
not reverse the endothelial dysfunction that exists in
aging humans with preexisting atherosclerosis.
To read specically how atherosclerosis initiates
and progresses, refer to the next article.
P
H
O
T
O
T
A
K
E
U
S
A
.
C
O
M
HOW ATHEROSCLEROSIS DEVELOPS IN HUMANS
APRIL 2013 | LIFE EXTENSION | 81
Homocysteine can induce the initial atheroscle-
rotic injury to the endothelium, then facilitate the oxi-
dation of the fat and LDL that accumulate beneath the
damaged endothelium, and nally contribute to the
abnormal accumulation of blood components around
the atherosclerotic plaque.
Fibrinogen is a clotting factor that accumulates at
the site of the endothelial lesion. Fibrinogen contrib-
utes to plaque buildup and can participate in the arte-
rial blockage after an unstable atherosclerotic plaque
ruptures.
Glucose at high-normal levels may accelerate the
glycation process that causes arterial stiffening, while
high-normal fasting glucose and insulin inicts direct
damage to the endothelium. High levels of iron pro-
mote oxidation of LDL in the damaged endothelium,
while low levels of testosterone (in men) appear to
interfere with normal endothelial function.
C-reactive protein is an inammatory marker and
directly damages the endothelium. Chronic inam-
mation, as evidenced by persistent high levels of
C-reactive protein, not only creates initial injuries to
the endothelium, but also accelerates the progression
of existing atherosclerotic lesions.
In response to a large number of published studies,
enlightened people are taking charge of the health of
their arteries. They are eating better, exercising regu-
larly, and undergoing regular blood testing to identify
the specic drugs, hormones, and dietary supplements
they need to reduce their atherosclerotic risk factors.
The emphasis in treating aging humans with pre-
existing arterial disease is that all risk factors should be
controlled if there is to be an opportunity to reverse the
occlusion of vital arteries. When only a few atherogenic
factors like elevated LDL are lowered, disease progres-
sion is virtually inevitable, albeit at a slower rate.
Summary
At least one of every two Americans over the age of
65 has atherosclerosis.
1
A number of biochemical fac-
tors in the blood can affect the development of athero-
sclerosis such as elevated LDL cholesterol, low HDL
cholesterol, and elevated glucose, homocysteine or
brinogen to name a few. Atherosclerosis begins with
changes in endothelial cell function that cause white
blood cells moving through the blood to stick to the
endothelium (inner arterial wall) instead of owing
by normally. The endothelium then becomes weak-
ened. This allows blood cells and toxic substances
circulating in the blood to pass through the endothe-
lium and enter the arterys sub-endothelial compart-
ment. Lipid or fat-like substances such as LDL and
triglycerides in the blood then accumulate in this area.
What You Need to Know
Pathway to the
Development of
Deadly Arterial Plaque
standalone or any other PQQ-containing
formula call 1-800-544-4440 or visit
www.LifeExtension.com
References
1. Mitochondrion. 2007 Jun;7 Suppl:S103-11.
2. Mech Ageing Dev. 1978 Mar;7(3):189-97.
3. Arch Biochem Biophys. 1992 Jun;295(2):230-4.
4. Lipids. 1989 Jul;24(7):579-84.
5. Biogerontology. 2002;3(1-2):37-40.
6. Exp Gerontol. 2004 Feb;39(2):189-94.
7. J Biol Chem. 2010 Jan 1;285:142-52.
8. Biochimie. 1999 Dec;81(12):1131-2.
9. Lancet. 1989 Mar 25;1(8639):642-5.
10. Curr Opin Clin Nutr Metab Care. 2010 Jul 7.
11. Age (Dordr). 2010 Mar 20.
12. Ageing Res Rev. 2010 Jun 25.
13. Cell Mol Life Sci. 2010 Jun 25.
14. Zhonghua Yi Xue Za Zhi (Taipei). 2001
May;64(5):259-70.
15. J Nutr. 2000 Apr;130(4):719-27.
16. Entrez Gene: PARGC1A peroxisome proliferator-
activated receptor gamma, coactivator 1 alpha
[Homo sapiens] GeneID: 10891.
17. Cardiovasc Drugs Ther. 2004 Nov;18(6):421-31.
18. J Cardiovasc Pharmacol Ther. 2006 Jun;11(2):119-28.
19. Biochem Biophys Res Commun. 2007 Nov
16;363(2):257-62.
20. FOOD Style. 2009;21:13(7)50-3. [Tokyo].
A
G
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BY GARY GOLDFADEN, MD, AND ROBERT GOLDFADEN
Revitalize Your
Aging Neck
Most skin care regimens are formulated only for fighting the fine
lines and wrinkles on the face. Your neck, however, is a dead give-
away of age.
The thin skin on your neck is especially prone to sagging and
wrinklesand often well before your face shows your age. Youve
seen many women on TV who have had face lifts but take one look
at their neck and you see the visible effects of aging.
In fact, your neck and upper chest/shoulder/torso area (collec-
tively referred to as the dcollet) may be one of the most underap-
preciated features of a youthful appearance.
For years, maturing individuals seeking to rejuvenate their necks
resorted to potentially dangerous cosmetic procedures such as
peels, laser resurfacing, Botox injections, and surgery.
1
But there are safer, effective, more natural approaches to fight-
ing the visible signs of an aging neck. Advances in research have
led to the discovery of compounds that offer novel approachs to
reversing the visible signs of aging. These compounds have been
shown to act as chemical messengers between the dermal layers
of the skin, thus allowing efficient communication to protect, repair,
and strengthen the skin from the inside out.
In this article, you will learn about agents that help restore and
retain a youthful-appearing neck and dcollet. >
86 | LIFE EXTENSION | APRIL 2013
APRIL 2013 | LIFE EXTENSION | 87 APR APR APPR PR R APR RRIL IL IL IIII 201 2013 3 | LLLLIFE FE IFEE IFE IFE FEE EX EXTEN TENNNNSI SIO SI SIO IOOO I NNNNNNN ||||| 8888888888888888888777777777
REVITALIZE YOUR AGING NECK
88 | LIFE EXTENSION | APRIL 2013
Maintaining Skin Cohesion
The dermo-epidermal junction is an area that
connects the epidermal skin layer with the dermal layer
beneath it. Acting as a communication center between
the two skin layers, it maintains skin cohesion and
distributes essential nutrients to the epidermis for
healthy skin.
2
As we age, the dermo-epidermal junction of the
skin begins to atten out, diminishing the contact
between the epidermis and dermis.
3
As a result, the
skin begins to lose its elasticity and rmness. This is
reected in the skin of the neck with the development
of wrinkles and sagging.
Fortunately, there is a way to rebuild this vital con-
nection between the layers of aging skin. The pep-
tide compound hexapeptide-10 has been shown to
stimulate the formation of laminin-5, _6-integrin, and
hemidesmosomes,
4
vital building blocks of the dermo-
epidermal junction that allow it to reconstruct con-
nectivity between epidermal and dermal cells. This
reinforces the skins tightness and promotes more
elasticity.
In one study, scientists tested the effects of hexa-
peptide-10 on several skin parameters in healthy vol-
unteers for 60 days. The results revealed a 9% boost
in elasticity and a 53% improvement in skin compact-
ness. Skin tone was also enhanced by 46%.
4
Support Vital Skin Structures
Your skin has a network of bers that work to
keep it rm and taut. Collagen type I provides
mechanical strength to the structure, while elastin is
responsible for skins resilience and its ability to recoil
back into position. These elements are continuously
breaking down and being regenerated. However, fac-
tors such as excessive sun exposure, smoking, inam-
mation, and air pollution cause collagen type I and
elastin to break down at a faster pace than theyre
being regenerated.
5
Over time, this accelerates aging,
which manifests itself as wrinkles and loose skin.
Theres one notable ingredient that has been shown
to both slow the breakdown and increase the formation
of these vital skin structures. An in vitro study showed
that the compound acetyl-dipeptide-13 diphenylgly-
cine protected elastin from destruction by decreasing
the activity of elastase by 23%.
6
Additionally, when the
cells that make collagen were exposed to acetyl-dipep-
tide-13 diphenylglycine, they experienced an astonish-
ing 99% increase in collagen type I formation.
6
In a human study, participants who used a topi-
cal application of acetyl-dipeptide-13 for eight weeks
improved their overall skin elasticity by 14% and
tightness by 16%.
6
Fight Free Radical Damage
Free radicals wreak havoc on the skins integrity
and structure, especially in the thin skin of the neck.
Thats why a broad spectrum antioxidant defense is
a cornerstone of any skin care regimen. And when it
comes to antioxidant power, you cant beat the goji
berry.
Goji berries boast an extremely high rating on
the ORAC scale, an indicator of antioxidant potency.
7
Theyve been shown to boost human blood antioxi-
dant activity by up to 57%.
8
A 2004 study showed that
goji berries inhibited the formation of free radicals by
an incredible 82%, further conrming their outstand-
ing antioxidant properties.
9
Goji berries have a tremendous amount of nutri-
ents that nurture and protect the skin. They contain
more collagen-building vitamin C than an orange,
along with vitamin E to reduce wrinkles and seal in
moisture.
10
Goji berries also contain bioactive polysaccharides,
complex carbohydrates that repair and rejuvenate
the skin of the neck by suppressing the elevation of
enzymes involved in collagen destruction.
11
Goji berries
REVITALIZE YOUR AGING NECK
APRIL 2013 | LIFE EXTENSION | 89
Halt Collage Destruction
The Indian gooseberry (Phyllanthus emblica)
has been celebrated for centuries in India for its high
antioxidant capacity and potent anti-inammatory
effects.
12
These attributes have sparked interest in the
fruits potential as a topical ingredient in skin care
preparations. And as it turns out, Indian gooseberry
has the potential to protect against one of the chief
causes of premature aging: ultraviolet (UV) damage.
Sun damaged skin causes an internal breakdown
of collagen that contributes to ne lines, wrinkles,
age spots, and uneven skin tone. When scientists
investigated the impact of the Indian gooseberry on
UV radiated human skin broblasts, they found that
the fruit extract was effective in protecting against
UV damage by inhibiting the expression of matrix
metalloproteinases in the specialized skin cells.
13
The powerful berry has been found to offer other
benets to the aging skin, including boosting the
synthesis of collagen type I,
14
halting the collagen-
destructive ability of collagenase,
17
and promoting
dermal wound healing.
15
Keep Skin Hydrated
In order for skin to stay healthy and young look-
ing, it must be properly hydrated and nourished.
Hyaluronic acid plays a vital role in creating an
environment in which skin cells obtain proper hydra-
tion and nourishment. Along with water and protein
complexes, hyaluronic acid acts as a ller in between
the spaces of a ber network consisting mostly of col-
lagen and elastin beneath the surface of your skin.
16
The compounds main function is to attract and
retain water, leading the skin to hold moisture and in
return lessens the visibility of ne lines. Whats more,
hyaluronic acid is responsible for transporting essen-
tial nutrients to the skin cells, supplying them with
the weapons required to rejuvenate themselves.
17
What You Need to Know
Restoring a Youthful-
Appearing Neck and
Dcollet
Health Advisor at 1-866-864-3027.
References
1. Caplin DA, Perlyn CA. Rejuvenation of the aging neck: current
principles, techniques, and newer modications. Facial Plast Surg
Clin North Am. 2009 Nov;17(4):589-601.
2. Le Varlet B, Chaudagne C, Saunois A, et al. Age-related functional
and structural changes in human dermo-epidermal junction com-
ponents. J Investig Dermatol Symp Proc. 1998 Aug;3(2):172-9.
3. Lavker RM, Zheng PS, Dong G. Morphology of aged skin. Clin
Geriatr Med. 1989 Feb;5(1):53-67.
4. Available at: http://www.lotioncrafter.com/reference/tech_data_ser-
ilesine_solution.pdf. Accessed August 17, 2012.
5. Gogly B, Ferre FC, Cheri H, Naveau A, Fournier BP. Inhibition
of elastin and collagen networks degradation in human skin by
gingival broblast. In vitro, ex vivo and in vivo studies. Journal
of Cosmetics, Dermatological Sciences and Applications. 2011
March;1(1):4-14.
6. Available at: http://www.lotioncrafter.com/reference/tech_data_
relistase.pdf. Accessed August 17, 2012.
7. Available at: http://www.oracvalues.com/. Accessed December 18,
2013.
8. Bucheli P, Vidal K, Shen L, et al. Goji berry effects on macular
characteristics and plasma antioxidant levels. Optom Vis Sci. 2011
Feb;88(2):257-62.
9. Wu SJ, Ng LT, Lin CC. Antioxidant activities of some common in-
gredients of traditional chinese medicine, Angelica sinensis, Lycium
barbarum and Poria cocos. Phytother Res. 2004 Dec;18(12):1008-12.
10. Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemis-
try, pharmacology and safety in the perspective of traditional uses
and recent popularity. Planta Med. 2010 Jan;76(1):7-19.
11. H. Zhaoa, A. Alexeeva, E. Changa,b, G. Greenburgc, K.
Bojanowskia, Lycium barbarum glycoconjugates: effect on
human skin and cultured dermal broblasts. Phytomedicine. 2005
Jan;12(1-2):131-7.
12. Krishnaveni M, Mirunalini S. Therapeutic potential of Phyllanthus
emblica (amla): the ayurvedic wonder. J Basic Clin Physiol Pharma-
col. 2010;21(1):93-105.
13. Adil MD, Kaiser P, Satti NK, et al. Effect of Emblica offcinalis (fruit)
against UVB-induced photo-aging in human skin broblasts. J Eth-
nopharmacol. 2010 Oct 28;132(1):109-14.
14. Chanvorachote P, Pongrakhananon V, Luanpitpong S, et al. Type
1 pro-collagen promoting and anti-collagenase activites of Phyl-
lanthus emblica extract in mouse broblasts. J Cosmet Sci. 2009
Jul-Aug;60(4):395-403.
15. Sumitra M, Manikandan P, Gayathri VS, Mahendran P, Suguna L.
Emblica ofcinalis exerts wound healing action through up-regula-
tion of collagen and extracellular signal-regulated kinases (ERK1/2).
Wound Repair Regen. 2009 Jan-Feb;17(1):99-107.
16. Tzellos TG, Klagas I, Vahtsevanos K. Extrinsic ageing in the
human skin is associated with alterations in the expression of
hyaluronic acid and its metabolizing enzymes. Exp Dermatol. 2009
Dec;18(12):1028-35.
17. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair.
Wound Repair Regen. 1999 Mar-Apr;7(2):79-89.
18. Dai G, Freudenberger T, Zipper P, et al. Chronic ultraviolet B irradia-
tion causes loss of hyaluronic acid from mouse dermis because of
down-regulation of hyaluronic acid synthases. Am J Pathol. 2007
Nov;171(5):1451-61.
5 Ingredients for Firmer,
Younger Skin
Hexapeptide-10 reconstructs the connectivity
of the dermo-epidermal junction, thereby rein-
forcing the skins elasticity and firmness.
AcetyI-dipeptide-13 diphenyIgIycine
improves skins tightness by halting the break-
down of elastin and stimulating the synthesis of
collagen type I synthesis.
Goji berries have unparalleled antioxidant
power that protects the skins integrity and
internal structure from free radical damage.
Indian gooseberry defends against UV dam-
age that leads to an early loss of elasticity.
HyaIuronic acid provides increased skin
hydration and firmer skin tone.
Indian gooseberry
The Moisturizing Pill the Japanese
Have Enjoyed for a Decade!
Lipowheat
ceramides have been available to
Japanese women as a functional food since 2000.
5
The hydrating action of Lipowheat
ceramides have
proven efective in clinical trials.
To take one example, after just three months ingesting
200 mg per day of Lipowheat, a group of people
reported dramatic improvement in the look and feel of
their skin. These results were verifed by electrochemical
analysis showing that 95% of participants exhibited
improved skin hydration. Even better, all subjects who at
the onset of the study experienced chronic itching
reported sharply decreased itching or complete elimina-
tion of the problem by the end of the study!
5
Aging Americans can now ofset the visible impact
of the gradual decline in their ability to produce enough
ceramides by using Skin Restoring Phytoceramides
with Lipowheat.
One bottle containing 30 350 mg vegetarian liquid
capsules of Skin Restoring Phytoceramides with
Lipowheat
retails for $25. If a member buys four
bottles, the price is reduced to $17.25.
Contains wheat.
Lipowheat
If youre not targeting the thin skin of your neck area, then
youre overlooking one of the most obvious signs of aging.
Your neck and upper chest/shoulder/torso area is a dead
giveaway of your age because its thin skin is especially prone
to sagging and wrinkles.
But it doesnt have to be.
Advances in research have led to the discovery of compounds
that ofer a novel approach to supporting the delicate skin
of your neck and dcollet. Scientists have discovered that these
compounds act as key regulators of the biochemical environment
within the dermal layers of the skin.
1-7
This facilitates the communi-
cation necessary to protect, repair, and strengthen your skin
from the inside out.
ULTIMATE NECK-CHEST SKIN SUPPORT
Cosmesis Skin Care combines these compounds in one
high-potency formula that targets multiple factors involved in
skin aging. It contains 5 intensive ingredients that work to help
restore and retain youthful-looking skin:
r )FYBQFQUJEF helps improve the connectivity
of the dermo-epidermal junction, reinforcing the skins
elasticity and frmness.
1
r "DFUZMEJQFQUJEFEJQIFOZMHMZDJOF improves skins
tightness by halting the breakdown of elastin and
stimulating the synthesis of collagen type I.
2
r (PKJCFSSJFT have unparalleled antioxidant power that
protects the skins internal structure from free radical
damage.
3,4
r *OEJBOHPPTFCFSSZ helps protect against UV damage
that leads to collagen breakdown and an early loss of
elasticity.
5
r )ZBMVSPOJDBDJE increases skin hydration and facilitates
communiction between skin layers.
6,7
Together, these 5 ingredients provide you with ultimate
support for the delicate skin of the neck to help defend against
the visible signs of aging.
A 2 oz jar of Cosmesis Skin Care Tightening & Firming Neck
Cream retails for $39. If a member buys two jars, the price is
reduced to $26.25 per jar.
Is Your ANTI-AGING
PROGRAM
Missing Something?
References
1. Available at: http://www.lotioncrafter.com/reference/
tech_data_serilesine_solution.pdf.
2. Available at: http://www.lotioncrafter.com/reference/
tech_data_relistase.pdf.
3. J Ethnopharmacol. 2007 May 22;111(3):504-11.
4. Phytother Res. 2004 Dec;18(12):1008-12.
5. J Ethnopharmacol. 2010 Oct 28;132(1):109-14.
6. Am J Pathol. 2007 Nov;171(5):1451-61.
7. Wound Repair Regen. 1999 Mar-Apr;7(2):79-89.
To order Cosmesis Skin Care
Tightening & Firming Neck
Cream, call 1-800-544-4440 or
visit www.LifeExtension.com
Item # 80148 Ite Ite Ite t m# m# m## 88888014 014 014 0148888
NEW
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Human studies suggest that supplementary enzymes may
improve digestion and help minimize post-meal glucose
surges.
1,2
Since proteins, plant fbers, and fats are broken down
diferently, one needs the proper spectrum of enzymes for
optimal digestion.
A new multi-enzyme formula facilitates both optimal
nutrient absorption and broad relief from digestive discom-
forts without promoting after-meal glucose surges.
2,3
TWELVE PREMIUM ENZYMES
Extraordinary Enzymes provides a potent array of
protease, cellulase, and lipase enzymes specially formulated
to adapt to a variety of stomach acid pH conditions and
powerfully support digestion.
With a total of twelve diferent enzymes, this unique
formula supports the digestion of just about any food that
may pose a problem for youwhether a protein, fber, or fat.
Extraordinary Enzymes provides a blend of powerful
enzymes to help your system convert a variety of foods to
energy and readily absorb the nutrients in the foods you
consume. This formulation may enhance protein content in
your body and allow for better fat utilization.
4,5
Together, these enzymes work by an all-natural, synergistic
process to help provide nutritional support for a healthy
digestive system.
The twelve enzymes in value-priced Extraordinary
Enzymes are:
Protease SP (Bacillus sp., Aspergillus oryzae) 97,000 HUT
Protease S (Aspergillus melleus) 10,500 PC
Acid Protease (Aspergillus niger) 10 SAPU
Lipase (Candida rugosa, Rhizopus oryzae, Aspergillus niger) 4,000 FIP
Cellulase (Trichoderma longibrachiatum) 2,400 CU
Trypsin (Porcine) 20,000 USP
Chymotrypsin (Porcine) 3,336 USP
Phytase (Aspergillus niger) 20 FTU
Beta-Glucanase (Trichoderma longibrachiatum) 30 BGU
Hemicellulase (Aspergillus niger) 4,000 HCU
Pectinase (Aspergillus niger) 50 endo-PGU
Xylanase (Trichoderma longibrachiatum) 600 XU
Total Nutrient Absorption Blend 200 mg
Extraordinary
Enzymes
Digestive Support That Does Not
Promote Glucose Spikes
WHATS NOT IN EXTRAORDINARY ENZYMES?
Unlike commercial digestive enzyme supplements,
amylase is intentionally left out of Extraordinary Enzymes.
The reason is that amylase breaks down starches into
glucose that is rapidly absorbed into the bloodstream.
2
Extraordinary Enzymes facilitates the healthy break-
down of plant fbers that cause people to avoid healthy
vegetables because of digestive discomforts.
Most people will take one capsule before the two
heaviest meals, which provides 400 mg of natural digestive
enzymes each day.
A bottle of 60 capsules of
Extraordinary Enzymes retails
for $26. If a member buys four
bottles, the price is reduced to
$18 per bottle.
Contains milk, soybeans, tree nuts (coconut), and wheat.
References
1. Paper: Making Sense of Digestive Enzymes: ProThera, Inc.;2008.
2. Altern Med Rev. 2004 Mar;9(1):63-9.
3. Available at: http://www.us.elsevierhealth.com/media/us/
samplechapters/9781437709599/Sample-Chapter-04.pdf.
Accessed October 3, 2012.
4. J Int Soc Sports Nutr. 2008 Jul 24;5:10.
5. Available at: http://chemistry-today.teknoscienze.com/pdf/
MU%20OMEGA3-08.pdf. Accessed October 3, 2012.
I
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7
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To order Extraordinary Enzymes, call 1-800-544-4440 or visit www.LifeExtension.com
AUTHOR INTERVIEW
APRIL 2013 | LIFE EXTENSION | 95
Power Foods
for the Brain
An Effective 3-Step Plan to
Protect Your Mind and
Strengthen Your Memory
AUTHOR INTERVIEW
Losing memory and brainpower is not
just a part of life that everyone must
endure as part of the aging process. Just
as diet, environment, and lifestyle play
an integral role in the health of the body,
the same goes for the brain. Research-
ers from around the world have uncovered
specific nutrients that either endanger or
offer protection to the brain. New imag-
ing techniques have been developed that
allow scientists to study the brain as a liv-
ing systemto learn how it functions and
how the brain is affected by time, nutri-
tion, and lifestyle. Cutting edge test-
ing has begun to offer clues as to who is
most at risk for cognitive disease as time
passes. As this body of research has
amassed, it has become clear that spe-
cific foods, eating behaviors, lifestyle, and
environmental factors can have a pow-
erful effect on the function of the brain.
The following is an exclusive Life Exten-
sion
Health Advisor
at 1-866-864-3027.
Dr. Neal Barnard is president of the
Physicians Committee for Responsible
Medicine, a faculty member of
the George Washington School of
Medicine, and the founding member
of the Whole Foods Medical Advisory
Board. He is a New York Times best-
selling author and a monthly columnist
for the Vegetarian Times. He is featured
in the new, nationally released docu-
mentary, Forks Over Knives, and has
previously appeared on Today, Good
Morning America, Ellen, and Dr. Oz.
For more information visit:
http://www.nealbarnard.org/.
To order Power Foods for the Brain,
call 1-800-544-4440 or visit
www.LifeExtension.com
Item#33855 Petal| prlce $26.99
Member prlce $20.24
avoid natural sugars or starches
the usual nave approach that has
gotten a lot of attention. Rather,
the answer is to avoid animal prod-
ucts and other fatty foods. As fat
enters the cells, it interferes with
insulins ability to work. So it pays
to emphasize vegetables, beans,
whole grains, and fruit, and skip
animal products and greasy foods
in general. Avoiding fats is a much
more powerful step than avoiding
healthful carbohydrates.
LE: How important is exercise to
maintaining a healthy brain? What
have studies shown?
NB: It protects the brain, just
as it protects the heart. At the
University of Illinois, researchers
asked 120 adults to take a brisk
walk for 10 minutes, 3 times a
week. And then they increased
the length of each walk to 15 min-
utes the next week, then to 20
minutes the following week, and
so on, until they got to about 40
minutes, three times a week. Over
time, this simple exercise program
actually reversed the age-related
shrinking of the brain that occurs
in most sedentary people. Memory
improved as well.
LE: Aside from supplements,
what are a few ways that people
can actually strengthen their
brains?
NB: These are the key steps:
1. Avoid bad fats. That means
saturated fat and trans fats.
2. Emphasize vegetables, fruits,
whole grains, and beans.
3. Take a vitamin B12 supplement
daily.
4. Be on the lookout for excess
iron, copper, and aluminum.
5. Get plenty of exercisephysical
and mental.
6. Get plenty of rest and sleep.
Three B-vitamins play key roles,
too. At the University of Oxford,
researchers tested folate, B6, and
B12 in a research study. Half the
participants got these vitamins,
while the other half got a dummy
pilla placebo. The people who
received the placebo had the usual
problems with memory as the years
went by. But those who got the three
B-vitamins did much better; they
generally preserved their memories
as the years went by. The research-
ers also did an MRI scan to actually
measure the brain, and found that
those who were getting a dummy
pill had continuing brain atrophy,
something that is often seen in
older people. They lost about 2.5%
of their brain volume per year. But
in the B-vitamin group, atrophy
was reduced to just 0.5% per year.
The vitamins work, we believe,
by knocking out a toxic chemical
called homocysteine, which can be
very rough on the brain. Your doc-
tor can check your homocysteine
level, and if youre high, these vita-
mins can remove it and that can
make a big difference. Folate is in
green leafy vegetables. Vitamin B6
is in beans and bananas, and many
other foods. Vitamin B12 is sup-
plemented in many foods such as
cereals. It is also in vitamin supple-
ments. These vitamins protect you.
LE: Since our diets inuence
more than one part of our bodies,
how does something as common
as excess blood sugar affect the
brain? And how important is man-
aging blood sugar for brain health
and what would be a solid blood
glucose management strategy?
NB: Some researchers have
begun to speak of a role of insu-
lin in memory problems, includ-
ing Alzheimers disease. While that
research is underway, it certainly
makes sense to control blood sugar.
But the way to do this is not to
# P l| l $$
The Healthy Gourmet Choice
Not all cofee provides the same powerful protection.
1-13
When it comes to obtaining cofees full range of health benefts, most
people arent getting their moneys worth!
The reason? Most of the cofee beans polyphenol content is destroyed
during the roasting process.
Among the most benefcial of these polyphenols is chlorogenic acid, a
potent inhibitor of the glucose-6-phosphatase enzyme that stimulates
excess gluconeogenesis.
A Patented Organic Roast
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Roast are made using a patented, 100% natural process called Healthy-
Roast.
*
It delivers a more complete nutritional profle of the cofee bean,
yielding chlorogenic acid levels far greater than other premium brands.
Handpicked deep in the rainforests of Central America, Rich Rewards
consists exclusively of 100% USDA certifed organic arabica cofee beans,
gently roasted in small batches and ground for easy brewing.
Savory Taste Without Stomach Upset
Have you given up cofee because it upsets your stomach? With Rich
Rewards, you can enjoy cofee again. The HealthyRoast process also
preserves special, naturally occurring compounds in cofee that soothe
your stomach.
Concerned about cafeine but dont like the weak taste of decafeinated
cofee? With Rich Rewards Decafeinated Roast, you can limit your
cafeine intake without compromising on favor. The cafeine is removed
through a completely chemical-free Water Process, which relies solely on
water and carbon flters. It delivers the full favor, aroma, and body of the
arabica bean.
Life Extensions Rich Rewards cofees give you a uniquely benefcial
brew with superior favor. The Rich Rewards Breakfast Blend contains up
to 87% more chlorogenic acid than conventional cafeinated cofees.
Rich Rewards Decafeinated Roast contains up to 187% more chloro-
genic acid than conventional decafeinated cofees.
References
1. Vinson J. The potential health benefts of
antioxidants. American Chemical Society
symposium. Aug 28, 2005. Washington, DC.
2. Am J Clin Nutr. 2006 May;83(5)1039-46.
3. Int J Cardiol. 2009; 137:216-25.
4. Am Heart J. 2009 Mar;157(3):495-501.
5. Arch Intern Med. 2009;169:2053-63.
6. J Intern Med. 2004;255(1):89-95.
7. JAMA. 2004;291:1213-9.
8. J Natl Cancer Inst. 2011 Jun 8;103(11):876-84.
9. Breast Cancer Res. 2011 May 14;13(3):R49.
10. JNCI Journal of the National Cancer Institute.
2005 Feb;97(4):293-300.
11. Eur J Neurol. 2002 Jul;9(4):377-82.
12. J Alzheimers Dis. 2011;25(2):323-35.
13. J Alzheimers Dis. 2010;20 Suppl 1:S117-26.
This chart shows Life Extensions Rich Rewards Breakfast Blend contains up to 87% more chlorogenic
acid than conventional cafeinated cofees and the Rich Rewards Decafeinated Roast contains up to
187% more chlorogenic acid than conventional decafeinated cofees. This enables one to obtain the
benefts of heavy cofee drinking in about half the number of cups.
* US Patent 6,723,368.
Chlorogenic Acid Chlorogenic Acid
Conventional Cofee 92 mg Rich Rewards Cofee Blend 172 mg
(Cafeinated) (Cafeinated)
Conventional Cofee 46 mg Rich Rewards Cofee Blend 132 mg
(Decafeinated) (Decafeinated)
Comparison of Conventional Coffee to Life Extensions Rich Rewards
Blend
To order either of the
Rich Rewards
Antioxidant
Coffees call 1-800-544-4440 or
visit www.LifeExtension.com
A 12 oz bag of Life Extension Rich
Rewards Breakfast Blend retails
for $13. Members pay $9.75 per bag.
Item # 01609
A 12 oz bag of Life Extension Rich
Rewards Decafeinated Roast
retails for $14. Members pay $10.50
per bag. Item # 01610
Rich Rewards
Polyphenol-Retained Coffee
A bottle containing 60 vegetarian
capsules of Olive Leaf Vascular Support
retails for $22. If a member buys four bottles,
the price is reduced to $15 per bottle.
References
1. Anal Chim Acta. 2007 Feb 5;583(2):402-10.
2. J Agric Food Chem. 2007 Sep 5;55(18):7609-14.
3. Lipids. 2001 Nov;36(11):1195-202.
4. Eur J Cancer. 2000 Jun;36(10):1235-47.
5. Phytother Res. 2008;22:1239-42.
6. Benolea
offers
this innovative and convenient service
at a very affordable price. Not only is
comprehensive blood testing an important
step in safeguarding your health, it is a
simple process from virtually anywhere in
the United States.
Five Easy Steps:
1. Call 1-800-208-3444 to discuss
and place your order with one of our
knowledgeable health advisors.
(This order form can also be faxed
to 1-866-728-1050 or mailed).
Online orders can also be placed at
www.lifeextension.com.
2. After your order is placed, you will be
mailed either a requisition form to take
to your local LabCorp Patient Service
Center or a Blood Draw Kit; whichever is
applicable (Please note: If a blood draw
kit is used, an additional local draw fee
may be incurred.)
3. Have your blood drawn.
4. Your blood test results will be sent directly
to you by Life Extension.
5. Take the opportunity to discuss the results
with one of our knowledgeable health
advisors by calling 1-800-226-2370;
or review the results with your personal
physician.
Its that simple! Dont delaycall today!
For Our Local Members:
For those residing in the Ft. Lauderdale,
Florida area, blood-draws are also
performed at the Life Extension Nutrition
Center from 9:00 am to 2:00 pm Monday
through Saturday. Simply purchase the blood
test and have it drawn with no wait!
Our address is 5990 North Federal Highway,
Ft. Lauderdale, FL, 33308-2633.
MOST POPULAR PANELS
Life Extension Member Pricing
THE CBC/CHEMISTRY PROFILE (LC381822) $35
OVER 40 PARAMETERS TESTED
CARDIOVASCULAR RISK PROFILE
Total Cholesterol Cholesterol/HDL Ratio
HDL Cholesterol Estimated CHD Risk
LDL Cholesterol Glucose
Triglycerides Iron
LIVER FUNCTION PANEL
AST (SGOT) Total Bilirubin
ALT (SGPT) Alkaline Phosphatase
LDH
KIDNEY FUNCTION PANEL
BUN BUN/Creatinine Ratio
Creatinine Uric Acid
BLOOD PROTEIN LEVELS
Total Protein Globulin
Albumin Albumin/Globulin Ratio
BLOOD COUNT/RED AND WHITE BLOOD
CELL PROFILE
Red Blood Cell Count Monocytes
White Blood Cell Count Lymphocytes
Eosinophils Platelet Count
Basophils Hemoglobin
Polys (Absolute) Hematocrit
Lymphs (Absolute) MCV
Monocytes (Absolute) MCH
Eos (Absolute) MCHC
Baso (Absolute) Polynucleated Cells
RDW
BLOOD MINERAL PANEL
Calcium Sodium
Potassium Chloride
Phosphorus Iron
NOTE: CBC/Chemistry prole is included in the Male
and Female Life Extension panels and Weight Loss Panels.
GENERAL HEALTH
HEMOGLOBIN A1C (HBA1C) (LC001453) $31
Hemoglobin A1C evaluates long-term blood
sugar control. Serum glucose sometimes reacts
with important proteins in the body rendering
them nonfunctional. Since this process, known
as glycation is one of the leading theories of
aging, Life Extension
believes everyone
should check their A1C level.
VITAMIN D (250H) (LC081950) $47
This test is used to rule out vitamin D
deciency as a cause of bone disease.
It can also be used to identify hypercalcemia.
FOOD SAFE ALLERGY TEST** (LCM73001) $198
This test measures delayed (IgG) food
allergies for 95 common foods.
ASPIRINWORKS* (LC501620) $149
Taking aspirin to prevent heart attack?
Is it working? This is a random urine test
used to measure your resistance to aspirin.
OMEGA SCORE
** (LCOMEGA) $131.25
Provides valuable information on your risk
of developing heart disease, sudden heart
attack, and cardiac death. The Omega
Score also includes your AA:EPA ratio,
allowing you to determine and track a major
factor in total body inammation.
COQ10* (COENZYME Q10) (LC120251) $145
This test is used to check the blood level
of CoQ10 and will enable more precise
dosing for anyone seeking to achieve and
maintain high levels of this critical antioxidant.
The Ultimate Information
* This test requires samples to be shipped to the lab on dry ice for customers using a Blood Draw Kit and will incur an
additional $35 charge. If the customer is having blood drawn at a LabCorp facility, this extra charge does not apply.
** This test is packaged as a kit, requiring a nger stick performed at home.
COMPREHENSIVE PANELS
MALE LIFE EXTENSION PANEL (LC322582) $269
Chemistry Prole includes glucose, cholesterol,
LDL, HDL, triglycerides, liver and-kidney function
tests PLUS 20 additional tests. CBC includes immune
(white) cell count, red blood cell count and platelet
count. Also includes: C-Reactive Protein
DHEA-S Homocysteine
TSH for thyroid function Free Testosterone
Estradiol Total Testosterone
Vitamin D 25- hydroxy PSA (prostate-specic antigen)
LIMITED TIME OFFER (February 1-March 25, 2013)
now includes: Fibrinogen and HbA1C
FEMALE LIFE EXTENSION PANEL (LC322535) $269
Chemistry Prole includes glucose, cholesterol,
LDL, HDL, triglycerides, liver and-kidney function
tests PLUS 20 additional tests. CBC includes immune
(white) cell count, red blood cell count and platelet
count. Also includes: C-Reactive Protein
DHEA-S Homocysteine
TSH for thyroid function Free Testosterone
Estradiol Total Testosterone
Progesterone Vitamin D 25- hydroxy
LIMITED TIME OFFER (February 1-March 25, 2013)
now includes: Fibrinogen and HbA1C
MALE WEIGHT LOSS PANEL (LCWLM) $299
Chemistry Prole includes glucose, cholesterol,
LDL, HDL, triglycerides, liver and-kidney function
tests PLUS 20 additional tests. CBC includes immune
(white) cell count, red blood cell count and platelet
count. Also includes: C-Reactive Protein
DHEA-S Insulin
SHBG Free Testosterone
Estradiol Total Testosterone
Free T3 Free T4
TSH for thyroid function PSA (prostate-specic antigen)
FEMALE WEIGHT LOSS PANEL (LCWLF) $299
Chemistry Prole includes glucose, cholesterol,
LDL, HDL, triglycerides, liver and-kidney function
tests PLUS 20 additional tests. CBC includes immune
(white) cell count, red blood cell count and platelet
count. Also includes: C-Reactive Protein
DHEA-S Insulin
Progesterone Free Testosterone
Estradiol Total Testosterone
Free T3 Free T4
TSH for thyroid function SHBG
MALE HORMONE ADD-ON PANEL (LCADDM)* $155
Pregnenolone and Dihydrotestosterone (DHT)
To provide an even more in-depth analysis of a mans
hormone status, Life Extension has created this panel
as an addition to the Male Life Extension Panel.
This panel provides valuable information about a
testosterone metabolite that can affect the prostate,
and the mother hormone that acts as a precursor
to all other hormones.
FEMALE HORMONE ADD-ON PANEL (LCADDF)* $125
Pregnenolone and Total Estrogens
To provide an even more in-depth analysis of a womans
hormone status, Life Extension has created this panel
as an addition to the Female Life Extension Panel.
This panel provides valuable information about total
estrogen status, and the mother hormone that
acts as a precursor to all other hormones.
LIFE EXTENSION THYROID PANEL (LC304131) $75
TSH, T4, Free T3, Free T4.
FEMALE COMPREHENSIVE HORMONE PANEL* $299
(LC100011) CBC/Chemistry Prole
(see description above), DHEA-S, Estradiol,
Total Estrogens, Progesterone, Pregnenolone,
Total and Free Testosterone, SHBG, TSH, Free T3.
MALE COMPREHENSIVE HORMONE PANEL* $299
(LC100010) CBC/Chemistry Prole
(see description above), DHEA-S, Estradiol,
DHT, PSA, Pregnenolone, Total and
Free Testosterone, SHBG, TSH, Free T3.
TERMS AND CONDITIONS
This blood test service is for informational
purposes only and no specic medical
advice will be provided. National Diagnostics,
Inc., and the Life Extension Foundation
contract with a physician who will order
your test(s), but will not diagnose or treat
you. Both the physician and the testing
laboratory are independent contractors and
neither National Diagnostics, Inc., nor the
Life Extension Foundation
will be liable
for their acts or omissions. Always seek the
advice of a trained health professional for
medical advice, diagnosis, or treatment.
When you purchase a blood test from Life
Extension/National Diagnostics, Inc., you
are doing so with the understanding that
you are privately paying for these tests.
There will be absolutely no billing to
Medicare, Medicaid, or private insurance.
I have read the above Terms and Conditions
and understand and agree to them.
Signature of Life Extension Member
X
Life Extension Foundation Members only
MEMBER NO.
Male Female
Mail your order form to:
3600 West Commercial Boulevard
Fort Lauderdale, FL 33309
Phone your order to: 1-800-208-3444
Fax your order to: 1-866-728-1050
NATIONAL DIAGNOSTICS, INC.
ORDER LIFE-SAVING
BLOOD TESTS
FROM VIRTUALLY
ANYWHERE IN THE US!
Name
Date of Birth
/ /
Address
City
State Zip
Phone
Credit Card No.
Expiration Date /
(required)
ENERGY PROFILE (LC100005) $375
CBC/Chemistry Prole (see description),
Epstein Barr Virus antibodies (IgG and IgM),
Cytomegalovirus Antibodies (IgG and IgM), Ferritin,
Total and Free Testosterone, DHEA-S, Free T3, Free T4,
Cortisol, C-Reactive Protein (high sensitivity),
Vitamin B12, Folate, Insulin.
ANEMIA PANEL (LC100006) $86
CBC/Chemistry Prole (see description),
Ferritin, Total Iron Binding Capacity (TIBC),
Vitamin B12, Folate, Reticulocyte Count.
INFLAMMATION PANEL (LC100007) $135
CBC/Chemistry Prole (see description above),
C-Reactive Protein (high sensitivity),
Sedimentation Rate, Rheumatoid (RA) Factor,
Antinuclear Antibodies (ANA) Screen.
THYROID ANTIBODY PROFILE (LC100004) $99
Thyroid Antithyroglobulin Antibody (ATA) and
Thyroid Peroxidase Antibody (TPO).
Popular Single Tests
HORMONES
CORTISOL (LC004051) $39
This test is to measure adrenal function.
DHEA-SULFATE (LC004020) $61
This test shows if you are taking the proper
amount of DHEA. This test normally costs $100
or more at commercial laboratories.
DIHYDROTESTOSTERONE (DHT)* (LC500142) $99
Measures serum concentrations of DHT.
ESTRADIOL (LC004515) $33
For men and women. Determines the proper
amount in the body.
INSULIN FASTING (LC004333) $42
Can predict those at risk of diabetes,
obesity, and heart and other diseases.
PREGNENOLONE* (LC140707) $116
Used to determine ovarian failure, hirsutism,
adrenal carcinoma, and Cushings syndrome.
PROGESTERONE (LC004317) $55
Primarily for women. Determines the proper
amount in the body.
SEX HORMONE BINDING GLOBULIN (SHBG) $33
(LC082016)
This test is used to monitor SHBG levels which
are under the positive control of estrogens and
thyroid hormones, and suppressed by androgens.
SOMATOMEDIN C (IGF-1) (LC010363) $75
Indicates growth hormone secretion levels. Low
levels have been associated with atherosclerosis
as well as all-cause mortality.
Other Popular Panels
Life Extension Member Pricing
For non-member prices
call 1-800-208-3444
This is NOT a complete listing of
LE blood test services. Call 1-800-208-3444
for additional information.
CARDIAC RISK
Lp-PLA2 (PLAC TEST)* (LC123240) $125
This test is used to aid in predicting risk for
coronary heart disease, and ischemic stroke
associated with atherosclerosis. Lp-PLA2 is a
cardiovascular risk factor that provides unique
information about the stability of the plaque
inside your arteries.
C-REACTIVE PROTEIN (HIGH-SENSITIVITY) $42
(LC120766)
Measures inammation factors in arteries.
Recent studies indicate that C-reactive protein
may be the most accurate risk factor for predicting
heart attack and stroke.
CARDIAC PLUS
(LC100008) $145
CBC/Chemistry prole (see description),
Vitamin D 25-hydroxy, C-Reactive Protein
(high sensitivity), Fibrinogen, Homocysteine.
VAP PLUS* (LC100009) $330
VAP, C-Reactive Protein (high sensitivity),
Homocysteine, Fibrinogen, PLAC
Test (Lp-PLA2),
Vitamin D 25-hydroxy.
FIBRINOGEN* (LC001610) $31
High levels of this blood-clotting factor
increase the risk of heart attack and stroke.
HOMOCYSTEINE (LC706994) $64
Can indicate if you are likely to have a heart attack
or stroke. Even if you take folic acid, you still may
have dangerously high levels of this artery-clotting
metabolic debris that can be lowered with high
doses of TMG, vitamin B6, and vitamin B12.
VAP TEST* (LC804500) $90
The VAP cholesterol test provides a more
comprehensive coronary heart disease (CHD) risk
assessment than the conventional lipid prole.
Direct measurements, not estimations, are
provided for total cholesterol, LDL, HDL, VLDL,
and cholesterol subclasses.
MALE HEALTH
PSA (PROSTATE-SPECIFIC ANTIGEN) $31
(LC010322)
Can provide an early warning sign for prostate
disorders and possible cancer.
FREE-PSA (INCLUDES TOTAL PSA)* (LC480780) $61
Recommended to determine if an elevated PSA
is indicative of prostate cancer.
BONE HEALTH
OSTEOCALCIN* (LC010249) $91
Osteocalcin is often used as a biochemical
marker, or biomarker, for the bone formation
process. It has been routinely observed that
higher serum osteocalcin levels are relatively
well correlated with bone diseases characterized
by increased bone turnover, especially osteoporosis.
DPD CROSS LINK URINE TEST (LC511105) $79
The deoxypyridinoline (DPD) urine test can be
used to measure bone re-absorption rates in
healthy individuals and in those with enhanced
risk of developing metabolic bone diseases.
Deoxypyridinoline can be used to monitor
therapies (which may include bisphosphonate
drugs) in people diagnosed with osteoporosis.
Blood tests available only in
the continental United States.
Not avaiable in Maryland.
AMINO ACIDS
Acetyl-L-Carnitine
Acetyl-L-Carnitine-Arginate
Branched Chain Amino Acids
D, L-Phenylalanine Capsules
Glycine Capsules
L-Arginine Capsules
Arginine/L-Ornithine Capsules
L-Carnitine Capsules
L-Carnitine Powder Natural Lemon Flavor
L-Glutathione, L-Cysteine & C
L-Glutamine Capsules
L-Glutamine Powder
L-Lysine Capsules
L-Tyrosine Tablets
Mega L-Glutathione Capsules
N-Acetyl-L-Cysteine Capsules
Optimized Carnitine with GlycoCarn
PharmaGABA
Super Carnosine Capsules
Taurine Capsules
BONE & JOINT HEALTH
ArthroMax with Theaavins and AprsFlex
ArthroMax Advanced with UC-II
and
AprsFlex
Bone-Up
Bone Restore
Bone Restore w/Vitamin K2
Bone Strength Formula w/KoAct
Chondrox
Fast Acting Joint Formula
Glucosamine Chondroitin Capsules
BRAIN HEALTH
Acetyl-L-Carnitine
Acetyl-L-Carnitine-Arginate
CDP Choline Capsules
Cognitex
Basics
DMAE
Ginkgo Biloba Certied Extract
Huperzine A
Lecithin with B5 and BHA
Lecithin Granules
Methylcobalamin Lozenges
Neuro-Mag Magnesium L-Threonate
Optimized Ashwagandha Extract
Phosphatidylserine Capsules
Rhodiola Extract
Super Ginkgo Extract
Vinpocetine
DIGESTIVE
Bido GI Balance
Carnosoothe w/PicroProtect
Digest RC
Enhanced Super Digestive Enzymes
Extraordinary Enzymes
Life Flora
Natural EsophaGuard
Pancreatin
Probiotic All-Flora
Probiotic Anti-Aging
Regimint
Theralac Probiotics
DURK AND SANDY PRODUCTS
Blast
Dual-C
Inner Power
Memory Upgrade
EYE CARE
Bilberry Extract
Brite Eyes III
Eye Pressure Support with Mirtogenol
Nutri-Flax
TruFiber
WellBetX PGX
with GlycoCarn
PhosphOmega
Policosanol
Pycnogenol
Reserve
Mega Green Tea Extract
Mega Green Tea Extract (Decaffeinated)
(also w/ CoffeeGenic Green Coffee Extract)
Mega Lycopene Extract
Nutrim
Optimized Ashwagandha Extract
Optimized Garlic
Pomegranate Extract
Pomegranate Juice Concentrate
ProGreens
Pure-Gar
Pycnogenol
Optimized Quercetin
Resveratrol with Synergistic Grape-Berry Actives
Rhodiola Extract
Rosmarinic Acid Extract
Silymarin
SODzyme with GliSODin
Stevia Extract
Super Bio-Curcumin
DHEA
DHEA
DHEA Complete
GH Pituitary Support Day Formula
GH Pituitary Support Night Formula
Melatonin
Melatonin Timed Release
Natural Estrogen with Pomegranate Extract
Pregnenolone
ProgestaCare for Women
Pure IGF
Super Miraforte with Standarized Lignans
IMMUNE ENHANCEMENT
AHCC
Lactoferrin
Norwegian Shark Liver Oil
Optimized Fucoidan w/Maritech
926
Primal Defense
ProBoost Thymic Protein A
Pure Gar
Reishi Extract Mushroom Complex
Vitamin C with Dihydroquercetin
Zinc Lozenges with Vitamin C
INFLAMMATORY REACTIONS
Arthro-Immune Joint Support
ArthroMax with Theaavins
Boswella
Boswella Topical Cream
Bromelain (Specially-coated)
DHA (Vegetarian Sourced)
Fast Acting Joint Formula
Ginger Force
Krill Oil
5-LOX
Inhibitor w/AprsFlex
Mega EPA/DHA
Mega GLA with Sesame Lignans
MSM
Natural Relief 1222 Cream
Omega-3 Whirl
Serraazyme
SODzyme with GliSODin
and Wolfberry
Super Omega-3 EPA/DHA with Sesame
Lignans & Olive Fruit Extract
Tart Cherry
Zyamend
Whole Body
LIVER HEALTH
Branch Chain Amino Acids
N-Acetyl Cysteine
Liver Efciency Formula
Certied European Milk Thistle
Hepatopro
SAMe
Silymarin
PRODUCTS
MINERALS
Biosil
Bone Restore
Bone Strength Formula w/KoAct
Bone-Up
Boron Capsules
Calcium Citrate with D3
Chromium Ultra
Copper
Iodoral
Iron Protein Plus
Magnesium
Magnesium Citrate
Only Trace Minerals
Optimized Chromium w/Crominex
3+
OptiZinc
Sea-Iodine
Selenium
Se-Methyl L-Selenocysteine
Strontium
Vanadyl Sulfate
Zinc/Vitamin C Lozenges
MISCELLANEOUS
Blender
Blood Pressure Monitor Arm Cuff Medium
Cell Sensor Gauss Meter
CR Way Edition Advanced Dietary Software
The Capsule Filler Machine
MITOCHONDRIAL SUPPORT
Acetyl-L-Carnitine
Acetyl-L-Carnitine-Arginate
Mitochondrial Basics w/BioPQQ
Mitochondrial Energy Optimizer w/BioPQQ
Optimized Carnitine with GlycoCarn
w/ Melatonin
Enhanced Natural Sleep
w/o Melatonin
Natural Stress Relief
Stabilium
200
SAMe
St. Johns Wort Extract
MOUTH CARE
Advanced Oral Hygiene
Mist Oral III with CoQ10
Mouthwash w/Pomegranate
Toothpaste
MULTIVITAMIN
Childrens Formula Life Extension Mix
Comprehensive Nutrient Packs Basic
Comprehensive Nutrient Packs Advanced
Life Extension Booster
Life Extension Mix Capsules
Life Extension Mix Powder
Life Extension Mix Tablets
Life Extension Mix w/o Copper Capsules
Life Extension Mix w/o Copper Tablets
Life Extension Mix w/Extra Niacin
Life Extension Mix w/Extra Niacin w/o Copper
Life Extension Mix w/Stevia Powder
Life Extension Mix w/Stevia w/o Copper Powder
Life Extension One-Per-Day
Life Extension Two-Per-Day
Super Booster Softgels w/Advanced K2 Complex
PET CARE
Cat Mix
Dog Mix
PROSTATE & URINARY HEALTH
BetterWOMAN
Optimized Cran-Max
with UTIRose
5-LOXIN
Bioavonoid Cream
Broccoli Sprout
Corrective Clearing Mask
DermaWhey
DNA Repair Cream
Dual-Action MicroDermAbrasion
Essential Plant Lipids Reparative Serum
Face Master
Platinum
Face Rejuvenating Antioxidant Cream
Enhanced FernBlock
with Sendara
Fine Line-Less
Hair Suppress Formula
Healing Formula All-in-One Cream
Healing Mask
Hyaluronic Facial Moisturizer
Hydrating Anti-oxidant Face Mist
Hydroderm
Rejuvenex
Body Lotion
RejuveneX
Factor
RejuveneX
Ultra RejuveNight
w/o Progesterone
Ultra Lip Plumper
Ultra Wrinkle Relaxer
Under Eye Rening Serum
Under Eye Rescue Cream
Vitamin C Serum
Vitamin D Lotion
Vitamin E-ssential Cream
Vitamin K Healing Cream
SOY
Natural Estrogen w/Pomegranate
Super Absorbable Soy Isoavones
SPECIAL PURPOSE FORMULA
Anti-Alcohol Antioxidants w/HepatoProtection
Complex
Benfotiamine w/Thiamine
Breast Health Formula
Butterbur Extract w/Standardized
Rosmarinic Acid
Chlorella
Chlorophyllin w/Zinc
Green Coffee Extract CoffeeGenic
(also w/Glucose control)
Coriolus Super Strength
CR Mimetic Longevity Formula
Cinsulin
w/InSea
2
and Crominex
3+
European Leg Solution Diosmin 95
Fem Dophilus
Femmenessence MacaPause
Potassium Iodide
PQQ Caps with BioPQQ
PteroPure
Prelox
Natural Sex for Men
Pyridoxal 5 - Phosphate
Rosmarinic Acid Extract
Ultra Natural Prostate w/AprsFlex
and Standardized Lignans
SPORTS PERFORMANCE
Creatine Capsules
Enhanced Life Extension Protein
DMG (N, N-dimethylglycine)
L-Glutamine Capsules
L-Glutamine Powder
VITAMINS
Ascorbyl Palmitate Capsules
B2
B12
Beta-Carotene
Biotin Capsules
Buffered Vitamin C Powder
Complete B Complex
Folic Acid + B12
Gamma E Tocopherol w/Sesame Lignans
Gamma E Tocopherol/Tocotrienols
Inositol Capsules
Mega Lycopene Extract
Methylcobalamin
MK-7
No-Flush Niacin
Optimized Folate
Super Ascorbate C Capsules
Super Ascorbate C Powder
Super K w/Advanced K2 Complex
Tocotrienols w/Sesame Lignans
Vitamin A Nutrisorb
Vitamin B3 (Niacin) Capsules
Vitamin B6
Vitamin B12 Tablets
Vitamin C
Vitamin D
Vitamin D3
Vitamin D3 w/Sea-Iodine
Vitamins D and K w/Sea-Iodine
Vitamin E
Vitamin K1
WEIGHT MANAGEMENT
Alli
Rell Pack
Advanced Anti-Adipocyte Formula
w/AdipoStat & Integra Lean
Complete
Fucoxanthin Slim
HCA
Integra-Lean
Irvingia
LuraLean
& APRESFLEX
TM
- 60 caps 36.00 27.00
Buy 4 bottles, price each 32.00 24.00
01404 ARTHRO-IMMUNE JOINT SUPPORT - 60 veg. caps 32.00 24.00
Buy 4 bottles, price each 28.00 21.00
00919 ARTICHOKE LEAF EXTRACT - 500 mg, 180 veg. caps 28.00 21.00
Buy 4 bottles, price each 25.38 19.04
01533 ASCORBYL PALMITATE - 500 mg, 100 veg. caps 22.50 16.88
Buy 4 bottles, price each 20.00 15.00
00888 ASHWAGANDHA EXTRACT (OPTIMIZED) - 60 veg. caps 10.00 7.50
Buy 4 bottles, price each 9.00 6.75
01066 ASPIRIN - 81 mg, 300 enteric coated tablets 6.00 4.50
Buy 4 bottles, price each 5.33 4.00
00708 ASTAXANTHIN - 2 mg, 30 softgels 10.25 7.69
01720 ASTAXANTHIN WITH PHOSPHOLIPIDS (BIO-ENHANCED) - 4 mg, 30 softgels 16.00 12.00
Buy 4 bottles, price each 14.00 10.50
B
00920 BENFOTIAMINE W/ THIAMINE - 100 mg, 120 veg. caps $19.95 $14.96
Buy 4 bottles, price each 18.60 13.95
00925 BENFOTIAMINE (MEGA) - 250 mg, 120 veg. caps 30.00 22.50
Buy 4 bottles, price each 27.00 20.25
`
`
Buyers Club Order Form
LIFE EXTENSION MEMBERS RECEIVE 25% OFF THE RETAIL PRICE OF ALL PRODUCTS APRIL 2013
SUB-TOTAL OF COLUMN 1 SUB-TOTAL OF COLUMN 3
To order online visit: www.LifeExtension.com
No. Retail Member Qty Total
Each Each
No. Retail Member Qty Total
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SUB-TOTAL OF COLUMN 4
01477 CHROMIUM ULTRA - 100 veg. caps $24.00 $18.00
Buy 4 bottles, price each 21.00 15.75
01504 CHROMIUM W/CROMINEX
W/INSEA
2
AND CROMINEX
with UTIROSE
TM
(OPTIMIZED) - 60 veg. caps 18.00 13.50
Buy 4 bottles, price each 16.00 12.00
01529 CREATINE CAPSULES - 120 veg. caps 10.95 8.21
Buy 4 bottles, price each 9.25 6.94
01646 CREATINE WHEY GLUTAMINE POWDER - 454 grams (vanilla) 30.00 22.50
Buy 4 bottles, price each 27.00 20.25
01429 CR MIMETIC LONGEVITY FORMULA - 60 veg. caps 39.00 29.25
Buy 4 bottles, price each 36.00 27.00
*33840 CRWAY GREAT GLUCOSE CONTROL CD 98.00 82.00
**CRWAY CR WAY OPTIMAL HEALTH PROGRAM SOFTWARE 195.00 195.00
Buyers Club Order Form
LIFE EXTENSION MEMBERS RECEIVE 25% OFF THE RETAIL PRICE OF ALL PRODUCTS APRIL 2013
SUB-TOTAL OF COLUMN 1 SUB-TOTAL OF COLUMN 1
To order online visit: www.LifeExtension.com
No. Retail Member Qty Total
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SUB-TOTAL OF COLUMN 8 SUB-TOTAL OF COLUMN 7
00407 CURCUMIN
w/SENDARA
NUTRI-FLAX
- 1 oz 79.95 59.96
Buy 2 bottles, price each 65.33 49.00
I
*01060 i26
WITH GLYCOCARN
FRENCH MARITIME PINE BARK EXTRACT-100 mg, 60 veg. caps 64.00 48.00
Buy 4 bottles, price each 60.00 45.00
01217 PYRIDOXAL 5-PHOSPHATE - 100 mg, 60 veg. caps 22.00 16.50
Buy 4 bottles, price each 19.80 14.85
Q, R
01309 QUERCETIN (OPTIMIZED) - 250 mg, 60 veg. caps $22.00 $16.50
Buy 4 bottles, price each 20.00 15.00
01030 RED YEAST RICE (Bluebonnet)- 600 mg, 60 veg. caps 17.50 13.13
00979 RED YEAST RICE (Natures Plus)- 600 mg, 60 veg. caps 23.95 17.96
00060 RED YEAST RICE EXTENDED RELEASE - 30 veg. tablets 21.50 16.13
00605 REGIMINT - 60 enteric-coated caps 19.95 14.96
Buy 4 bottles, price each 18.67 14.00
01708 REISHI EXTRACT MUSHROOM COMPLEX - 60 veg. caps 30.00 22.50
Buy 4 bottles, price each 27.00 20.25
01448 REJUVENEX
w/GLISODIN
)
R Charge my cc:
Card # Exp.
MEMBERSHI P APPLICATION
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Buyers Club Order Form
Retail Member Qty Total
Price
LIFE EXTENSION MEDIA
33855 POWER FOODS FOR THE BRAIN |] |e+l . B+||+|, | 2O1J $26.99 $2O.24
JJ854 THE GREAT CHOLESTEROL MYTH |] 1u||] BuWe|, ||, C|S +| S|e(|e| Si|+||+, | 2O12 $19.99 $14.99
33853 SMART, STRONG AND SEXY AT 100 |] +.i |e|ic| 2O12 $1I.95 $1J.46
JJ852 THE MAGIC OF CHOLESTEROL NUMBERS |] |. Se|e] u+| 2O12 $29.95 $22.46
JJ848 YOUR BEST INVESTMENT SECRETS TO A HEALTHY BODY AND MIND |] |Wi| |ee, | 2O12 $24.95 $18.I1
JJ84I THE FATIGUE SOLUTION |] |. |.+ CW]|+| 2O12 $24.95 $18.I1
JJ844 ABUNDANCE: THE FUTURE IS BETTER THAN YOU THINK |] S|e.e| |u|le| +| |e|e|e i+|+|i: 2O12 $26.99 $2O.24
JJ84J BOMBSHELL |] Su+||e Su|e|: 2O12 $26.OO $19.5O
JJ845 DRUG MUGGERS |] R.||. Su:] Cu|e| 2O12 $21.99 $16.49
JJ842 HEART ATTACK PROOF |] |ic|+el 0|e|, | 2O12 $19.95 $14.96
33835 PHARMOCRACY |] willi+| |+luu| 2O11 $24.OO $9.6O
Bu] 4 |uu|:, (|ice e+c| $8.OO
JJ8J9 THE GOLDEN RATIO LIFESTYLE DIET |] Ru|e|| ||ie|+|, |, +| |+|||eW C|u:: 2O12 $19.95 $14.96
33838 YOUR GUIDE TO HEALTHY SKIN THE NATURAL WAY |] +|] ull+e|, | 2O12 $26.OO $15.OO
JJ8JI WHEAT BELLY |] willi+| +.i:, | 2O11 $25.99 $19.49
33833 THE LIFE PLAN |] 1ell|] S. |ile, |, || 2O11 $26.OO $19.5O
JJ8J2 YOUR BONES |] |+|+ |iu||u, |A, ||! 2O11 $12.OO $9.OO
JJ829 THE IMMORTALITY EDGE |] |ic|+el |u::el, |, ||, |e|+ Bl+c||u||, +.i wu]|+|uW:|i, | 2O11 $25.95 $18.1I
JJ825 THE EMPOWERED PATIENT |] |li+|e|| Cu|e| 2O1O $15.OO $1O.5O
JJ824 VITAMIN D SOLUTION |] |ic|+el |. |ulic|, ||, | 2O1O $25.95 $18.1I
JJ822 BREAKTHROUGH: EIGHT STEPS TO WELLNESS |] Su+||e Su|e|: ((+(e||+c|) 2O1O $15.OO $1O.5O
JJ8J6 WEIGHT LOSS GUIDE |] S|e.e| V. 1u]+l, | +| willi+| |+luu| (|+|cu.e|) (J| |i|iu|) 2O1O $29.95 $8.99
JJ816 FDA: FAILURE, DECEPTION, ABUSE |] |ile |/|e|:iu| |uu|+|iu| 2O1O $2O.OO $15.OO
JJ818 STAY YOUNG & SEXY WITH BIO-IDENTICAL HORMONE REPLACEMENT |] 1u|+||+| w|i||, | 2O1O $19.95 $14.96
JJ815 KNOCKOUT |] Su+||e Su|e|: 2OO9 $25.99 $1I.OO
JJ814 CHEATING DEATH |] S+||+] u(|+, | 2OO9 $24.99 $1I.49
JJ812 LIFE OVER CANCER |] |ei|| Bluc|, | (|+|cu.e|) 2OO9 $25.OO $1I.5O
JJ811 THE GREAT AMERICAN HEART HOAX |] |ic|+el 0|e|, |, |ACC, |A|A 2OO9 $24.95 $1I.4I
JJ8O9 TESTOSTERONE FOR LIFE |] A||+|+| |u|e||+le|, | 2OO8 $16.95 $11.8I
JJ8O8 BREAKTHROUGH: EIGHT STEPS TO WELLNESS |] Su+||e Su|e|: 2OO8 $25.95 $18.1I
JJ599 YOUNGER YOU |] ||ic B|+.e||+|, | $24.95 $15.I5
JJ6OO DISEASE PREVENTION AND TREATMENT, EXPANDED FOURTH EDITION (|+|cu.e|) 2OOJ $49.95 $JI.46
||ice (e| |uu| W|e| 4 |uu|: (u|c|+:e $44.OO $JJ.OO
JJ696 LIFE EXTENSION REVOLUTION |] ||ili( |ee |ille|, | ((+(e||+c|) $16.OO $12.OO
JJ8O5 MIAMI MEDITERRANEAN DIET WITH 300 RECIPES |] |ic|+el . 0|e|, |, |ACC, |A|A (|+|cu.e|) 2OO8 $24.95 $16.25
JJ9O6 THE MIGRAINE CURE |] Se|e] u+|, |, || 2OO6 $24.OO $15.6O
JJ68O PRESCRIPTION FOR DISASTER DVD |] +|] |ull 2OO5 $18.OO $12.OO
JJ6IO A PRIMER ON PROSTATE CANCER (2| ei|iu|) |] S|e(|e| B. S||u|, |, +| u||+ |uli+|u 2OO5 $28.95 $21.I1
JJ262 SAVE YOUR SIGHT |] |+|c Ru:e, |/|ic|+el Ru:e, | $1J.99 $8.J5
JJ8O6 THE CR WAY |] |+ul |clu||i| +| |e|ei|| A.e|ill $15.95 $11.25
JJ828 THE SEXY YEARS |] Su+||e Su|e|: ((+(e||+c|) 2OO4 $15.OO $1O.5O
JJ695 WE BECOME SILENT V |] |e.i| |ille| $24.98 $18.I4
JJ8OJ WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT DIABETES |] S|e.e| V. 1u]+l, | 2OO8 $14.99 $1O.49
JJIOJ JOHN ABDOS NO EXCUSES WORKOUT DVD 2OO8 $1J.JO $9.98
JJ8O4 YOU: STAYING YOUNG: THE OWNERS MANUAL FOR EXTENDING YOUR WARRANTY |] |e||e| 0, | 2OO8 $26.OO $18.2O
AprsFlex is a trademark of Laila Nutraceuticals exclusively licensed to PL ThomasLaila Nutra LLC.
International patents pending.
ActiFlax is a trademark of Pharma Science Nutrients, Inc., all rights reserved. HMRlignan is a trademark
used under sublicense from Linnea S.A. USPlus and DeepExtract are trademarks of Valensa International
and are used under license. US Patents 6,319,524 & 6,669,968. Not available for export.
Ultra Natural Prostate with AprsFlex and
Standardized Lignans softgels combines cutting-edge
ingredients that have been scientifcally substantiated
to protect the prostate gland and maintain its healthy
function.*
The latest addition to this formula is AprsFlex, an
extract of Boswellia serrata that has been shown in studies
to have two times the bioavailability of the leading
boswellia extract. AprsFlex inhibits the enzyme 5-lipoxy-
genase. Boron is included because of studies showing it
may help slow elevation of prostate-specifc antigen (PSA).
The formula provides saw palmetto extract and
Graminex Flower Pollen Extract to interfere with DHT
activity and help regulate infammatory reactions in
the prostate.* Lycopene is a carotenoid that is included in
the formula to help maintain healthy DNA gene function
in prostate cells.
In order to boost its anti-estrogen capabilities, Ultra
Natural Prostate Formula incorporates HMRLignan,
derived from Norway spruce, fax lignans, and nettle
root extract.
Since normal aging can lead to potentially unsafe levels
of prostaglandins in the prostate, Pygeum africanum
extract is included to help suppress prostaglandins and
thereby promote prostate comfort.* Beta-sitosterol has
been added because it is the most biologically active
component of pygeum and enhances its protective efects.
The retail price for one bottle of Ultra Natural
Prostate Formula with AprsFlex and
Standardized Lignans is $38. If a member
buys four, the price is reduced to $26.25 per
bottle. If a member buys 12 bottles, the price
is reduced to $24 per bottle.
Contains soybeans and corn.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To order Ultra Natural Prostate
Formula with AprsFlex,
call 1-800-544-4440
or visit www.LifeExtension.com
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The daily dose of two softgels of
Ultra Natural Prostate Formula with AprsFlex
and Standardized Lignans Formula provides:
USPlus Saw Palmetto (C0
2
DeepExtract) 320 mg
(std to 85%-95% total fatty acids and sterols)
Graminex Flower Pollen Extract 252 mg
AprsFlex (Boswellia serrata) extract 70 mg
Pumpkin seed oil (Cucurbita pepo) extract 200 mg
(standardized to 85% total fatty acids)
Stinging nettle root extract (Urtica dioica) 240 mg
Pygeum extract 100 mg
Lycopene 10 mg
Phytosterol complex 678 mg
(standardized to 26.6% free beta-sitosterol)
Proprietary blend of HMRlignan 20.15 mg
Norway Spruce and ActiFlax Flax Lignan extracts
Boron 3 mg
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THE NEXT
GENERATION OF
PROSTATE
PROTECTION:
ULTRA NATURAL PROSTATE WITH
APRSFLEX
and MZ
LifeExtension
Magazine
WHATS INSIDE
Visit us at www.LifeExtension.com
36 FOODS THAT SAFELY
REDUCE BLOOD GLUCOSE
Certain foodsnotably barley and
black beanscan lower blood
glucose levels and help prevent
glycemic-related disorders.
54 SHIELD YOURSELF FROM
ENVIRONMENTAL CANCER RISKS
A huge body of research shows how
cruciferous vegetables neutralize
environmental toxins and can slash
cancer risk by up to 54%.
7 REBUTTAL TO ATTACK
AGAINST FISH OIL
The American Medical Association
questioned if vascular disease
patients should take sh oil. Read
Life Extensions scathing rebuttal to
this fatally awed report.
46 FRAN DRESCHERS
CRUSADE TO END CANCER
TV star Fran Drescher is a cancer
survivor and activist. Drescher founded
an organization to educate Americans
about preventing cancer and to enable
patients to be diagnosed no later than
stage one.
24 ENHANCED ASTAXANTHIN
FOR BETTER ABSORPTION
Astaxanthin traps huge numbers
of free radicals compared to most
other nutrients. A new compound
has been shown to increase the
bio-availability of carotenoids like
astaxanthin nearly 12-fold.
86 REJUVENATE YOUR
AGING NECK
We pay so much attention to our
aging face, but often neglect to
protect our necks delicate tissues
against the damaging effects
of time.