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Note: Performing your original search, Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent, in PubMed will retrieve 6
records.

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All: 1 Review: 0

1: Med Hypotheses. 1995 Mar;44(3):207-13. Links

Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Related Articles

Altered production of the active oxygen species is involved in enhanced cytotoxic

Riordan NH, Riordan HD, Meng X, Li Y, Jackson JA. action of acylated derivatives of ascorbate to tumor cells.
[Bi ochim Bio physActa. 1988]
Project RECNAC, Bio-Communications Research Institute, Wichita, Kansas 67219, USA. Cytotoxic effect of ascorbate and its derivatives on cultured malignant and
nonmalignant cell lines. [Anticancer Res. 1993]
Ascorbic acid and its salts (AA) are preferentially toxic to tumor cells in vitro and in vivo. Given in high enough
Antimetastatic effect of a lipophilic ascorbic acid derivative with antioxidation
doses to maintain plasma concentrations above levels that have been shown to be toxic to tumor cells in vitro,
through inhibition of tumor invasion. [Cancer Chemoth er Pha rmacol. 2006]
AA has the potential to selectively kill tumor cells in a manner similar to other tumor cytotoxic
chemotherapeutic agents. Most studies of AA and cancer to date have not utilized high enough doses of AA to Review Comparative study of the antitumor action between sodium
maintain tumor cytotoxic plasma concentrations of AA. Data are presented which demonstrate the ability to [Anticancer Res. 1997]
5,6-benzylidene-L-ascorbate and sodium ascorbate (minireview).
sustain plasma levels of AA in humans above levels which are toxic to tumor cells in vitro and suggests the Review Final report of the safety assessment of L-Ascorbic Acid, Calcium
feasibility of using AA as a cytotoxic chemotherapeutic agent. Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate,[I nt JT oxicol. 2005]
Sodium

PMID: 7609676 [PubMed - indexed for MEDLINE]

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Cited by PubMed Central articles

Ascorbate in pharmacologic concentrations selectively generates ascorbate

[P roc Natl Acad Sci U SA. 2007]
radical and hydrogen peroxide in extracellular fluid in vivo.

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as

a pro-drug to deliver hydrogen peroxide to tissues. [P roc Natl Acad Sci U SA. 2005]

Nutrition and cancer: a review of the evidence for an anti-cancer diet.

[NutrJ. 2004]

» See all (5)...

Patient Drug Information

Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used
to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.

Source: AHFS Consumer Medication Information

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Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent.

Innovation vs. quality control: an 'unpublishable' clinical trial of supplemental

ascorbat...

Indomethacin and ascorbate inhibit desmoid tumors.

Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C.

Preventive action of vitamin C on nitrosamine formation.

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