Professional Documents
Culture Documents
1. Introduction 2. Baby Care Products 3. Quality Control of Cosmetics 1. General Evaluation 2. Qualitative Analysis 3. Microbiological Evaluation 4. Dermatotoxicological Studies 1. Safety Evaluation 2. Efficacy Evaluation 5. Conclusion
1. Introduction
Cosmetic Greek word Kosmein = to adron Def. Articles intended to be rubbed, poured, sprinkled, or sprayed on, introduced into, or otherwise applied to the human body or any part thereof for cleansing, beautifying, promoting attractiveness, or altering the appearance Cosmeceutical popularized by Albert Kligman to bridge the gap between Cosmetics and Pharmaceuticals Make Up used to connote Cosmetics poet Richard Cranshaw
Emulsifier
Chelating Agent Buffering Agent
%w/w 11.00 5.00 1.00 3.50 q.s. q.s. q.s. q.s. 100.00
Vehicle Humectant Prevents water loss Emulsifiers Prevents rancidity Gives silky feel
Wt % 30.00 2.00 1.20 1.00 0.70 0.65 1.00 63.45 q.s.
High Moisturizing effect Clogs the pores prevents natural release of toxins If accidentally ingested vitamin deficiencies
Isopropyl myristate
Cyclomethicone Perfumes, solubilisers, antioxidants, etc.
10.00
15.00 q.s.
Centrifugation Test 5000 rpm, 10 min (200C) = effect of gravity for 1 yr. 24 hr, 7, 14, 21, 28 days no phase separation
Determination of fineness
10g in 150 sieve running tap water residue dried & weighed
Pressure Testing
Penetrometer Penetration of a sharp metal point into pressed powder
Breakage Testing
Godet dropped onto a wooden board from 8-10 in. height chip or break
Aloins
Alkanol Amines Carbocysteine Quaternary Ammonium Compounds
Skin Care
Shampoos Shampoos Hair Care
GC-MS
LC UV/Visible LC
N-Nitrosodiethanol amine
LC & GC
Glycolic Acid
LC
LC LC
Antimony
Selenium Lead
Shampoos
Shampoos Talcum Powder Shampoos
Zinc Pyrithione
Shampoos
Coco Betaine
Different Cosmetics
Creams
Homogenization with MeOH or 0.1M HCl acidified MeOH, centrifuged and submitted to a cation exchange catridge. Eluate is evaporated and redissolved in MeOH for running TLC
TLC-UV/V
Different Cosmetics
Compounds
Technique
1,4 dioxane
Ethoxylated Alcohols and GC Ethoxylated Alkyl Amines GC-MS LC Reaction between amines with nitrating agents Ethoxylation process Betane Cocoamidoporpyl betaine Betane Cocoamidoporpyl betaine Chemiluminiscence detector TEA coupled with GC/LC LC-UV LC-UV
N-Nitrosamines
Dicholoroacetic acid
GC
Establishment of microbial limits i. Products of baby, eye, mucus membrane 100 cfu/g in 0.5g of product ii. Other products 1000 cfu/g in 0.1 g of product iii. Pathogenic microorganisms Pseudomonas aeruginosa, Staphylococcus aureus and C. albaicans must not be detected in above two products
Escherichia coli
1ml + 100ml Mac Conkey broth 43-450C for 18-24 hrs. Subcultured - Mac Conkey agar 43-450C for 18-24 hrs. Lactose fermenting gm ve detected
Pseudonomas aeruginosa
1ml + 100ml TSB - 35-370C for 24-48 hrs. Subcultured - Cetrimide agar - 35-370C for 24-48 hrs. Detection
Molecular Diagnosis
Very rapid (27 hrs.) ATP bioluminiscence PCR Assay
4. DERMATOTOXICOLOGICAL STUDIES
Safety Evaluation Acute systemic toxicity Skin corrosion/irritation Eye irritation Skin absorption Miscellaneous Efficacy Evaluation Stratum Corenum Moisture TEWL
5. Conclusion
Baby Cosmetic ingredients mild Non irritant Non allergent Less concentration of preservatives, perfumes Quality is an essential aspect in baby cosmetic products as it effects safety and efficacy