Pediatric drugs info

Acetaminophen

Elixir(oral solution) 10-15 mg/kg/dose

120mg=5cc

drop:100mg/ml 10kg=5cc qid drop;2.5drop/kg

Pain or fever: Oral, rectal Children <12 years: 10-15 mg/kg/dose every 4-6 hours as needed; do not exceed 5 doses (2.6 g) in 24 hours Limit dose to <4 g/day Activated charcoal Antidiarrheal Antidote, Adsorbent Antiflatulent 5-10 [intoxicated drug] 30-100mg/250cc water

Single dose: Charcoal in water (a cathartic such as sorbitol should be added in appropriate doses): Infants <1 year: 1 g/kg Children 1-12 years: 1-2 g/kg or 25-50 g Adolescents and Adults: 30-100 g or 1-2 g/kg Adult cold Acetaminophen 325+Phenylephrine HCL 5mg+Chlorpheniramine 2mg

Amoxiciline

susp 125 & 250=5cc 20-40 mg/kg/24hrs 10 kg =5cc tds

cap 250 & 500 mg

DOSING: PEDIATRIC Susceptible infections: Oral: Children 3 months: 20-30 mg/kg/day divided every 12 hours Children: >3 months and <40 kg: Dosing range: 20-50 mg/kg/day in divided doses every 8-12 hours

Ear, nose, throat, genitourinary tract, or skin/skin structure infections: Oral: Children: >3 months and <40 kg: Mild-to-moderate: 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours Severe: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours

Acute otitis media: Oral: Children: >3 months and <40 kg: 80-90 mg/kg/day divided every 12 hours

Lower respiratory tract infections: Oral: Children: >3 months and <40 kg: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours

Subacute bacterial endocarditis prophylaxis: Oral: Children: >3 months and <40 kg: 50 mg/kg 1 hour before procedure

Anthrax exposure (unlabeled use): Oral: Note: Postexposure prophylaxis only with documented susceptible organisms: <40 kg: 15 mg/kg every 8 hours 40 kg: 500 mg every 8 hours Co-amoxyclav tab 375mg Susp 312mg : 250mg Amoxy/5cc tds

Ampiciline

susp 125 & 250=5cc 50-100 mg/kg/24 hrs

cap 250 & 500 mg 10kg=5cc qid

DOSING: PEDIATRIC Mild-to-moderate infections: Infants and Children: I.M., I.V.: 100-150 mg/kg/day in divided doses every 6 hours (maximum: 2-4 g/day) Oral: 50-100 mg/kg/day in doses divided every 6 hours (maximum: 2-4 g/day)

Severe infections/meningitis: Infants and Children: I.M., I.V.: 200-400 mg/kg/day in divided doses every 6 hours (maximum: 6-12 g/day)

Endocarditis prophylaxis: Infants and Children: I.M., I.V.: Dental, oral, respiratory tract, or esophageal procedures: 50 mg/kg within 30 minutes prior to procedure in patients unable to take oral amoxicillin Genitourinary and gastrointestinal tract (except esophageal) procedures: High-risk patients: 50 mg/kg (maximum: 2 g) within 30 minutes prior to procedure, followed by ampicillin 25 mg/kg (or amoxicillin 25 mg/kg orally) 6 hours later; must be used in combination with gentamicin. Moderate-risk patients: 50 mg/kg within 30 minutes prior to procedure. AL-MG-S AL(OH)3 225mg/5cc syr 1-2 cc/kg/24hrs

MG(OH)2 200mg/5cc Simethicone(Gas-X) 25mg/5cc Atrovent(ipratropium bromide) DOSING: PEDIATRIC Bronchospasm: Nebulization: Infants and Children 12 years: 125-250 mcg 3 times/day Children >12 years: Refer to adult dosing. Metered dose inhaler: Children 3-12 years: 1-2 inhalations 3 times/day, up to 6 inhalations/24 hours

Children >12 years: Refer to adult dosing.

Colds (symptomatic relief of rhinorrhea): Intranasal: Safety and efficacy of use beyond 4 days in patients with the common cold have not been established: Children 5-11 years: 0.06%: 2 sprays in each nostril 3 times/day Children 5 years and Adults: 0.06%: 2 sprays in each nostril 3-4 times/day

Allergic/nonallergic rhinitis: Intranasal: Children 6 years: Refer to adult dosing. USE Anticholinergic bronchodilator used in bronchospasm associated with COPD, bronchitis, and emphysema; symptomatic relief of rhinorrhea associated with the common cold and allergic and nonallergic rhinitis Azithromycine (Zithromax) tab 250 mg susp 100,250mg/5cc children2 y-old 12mg/kg/daily

Bacterial sinusitis: Oral: Children 6 months: 10 mg/kg once daily for 3 days (maximum: 500 mg/day) Pharyngitis, tonsillitis: Oral: Children 2 years: 12 mg/kg/day once daily for 5 days (maximum: 500 mg/day) Cardiac glycosides: Macrolides may increase the serum concentrations of cardiac glycosides; monitor. Warfarin: Azithromycin and other macrolides may decrease metabolism, via CYP isoenzymes, of warfarin. Monitor for increased effects.

Belladonna Pb Bisacodyl

Atropine+Hyosine+Hyocyamine+Phenobarbital

0.1 cc/kg

ped Supp 5mg-----------1 +adult supp 10 mg------------------1-2 DOSING: PEDIATRIC Relief of constipation: Oral: Children >6 years: 5-10 mg (0.3 mg/kg) at bedtime or before breakfast Rectal (suppository): Children: <2 years: 5 mg as a single dose >2 years: 10 mg

Bromhexine hcl elixir

Mucolytic Agent

syr 5cc=4mg

Oral: Children <2 years: 1 mg 3 times/day Children 2-6 years: 4 mg(5cc) twice daily or 2 mg 3 times/day Children 6-12 years: 4 mg(5cc) 3 times/day Children >12 years and Adults: 8 mg(10cc) 3 times/day Cefixime tab 200&400 mg susp 100mg/5cc---------------8mg/kg/daily---bd-------------- 0.5cc/kg/daily---bd

USE Treatment of urinary tract infections, otitis media, respiratory infections due to susceptible organisms including S. pneumoniae and S. pyogenes, H. influenzae and many Enterobacteriaceae; uncomplicated cervical/urethral gonorrhea due to N. gonorrhoeae DOSING: ADULTS Susceptible infections: Oral: 400 mg/day divided every 12-24 hours Uncomplicated cervical/urethral gonorrhea due to N. gonorrhoeae: Oral: 400 mg as a single dose Note: For S. pyogenes infections, treat for 10 days DOSING: PEDIATRIC Susceptible infections: Oral: Children 6 months: 8 mg/kg/day divided every 12-24 hours Children >50 kg or >12 years: Refer to adult dosing. Note: For S. pyogenes infections, treat for 10 days

Cotrimoxasole

Susp 40 mgTMP=5cc 8-10 mg/kg/24hrs TMP

pediatric tab=20 mgTMP/Adult tab=80mgTMP 10 kg= 5cc BD

Shigellosis: Oral: 8 mg TMP/kg/day in divided doses every 12 hours for 5 days I.V.: 8-10 mg TMP/kg/day in divided doses every 6, 8, or 12 hours for up to 5 days Acute otitis media: Oral: 8 mg TMP/kg/day in divided doses every 12 hours for 10 days Urinary tract infection:

Treatment: Oral: 6-12 mg TMP/kg/day in divided doses every 12 hours I.V.: 8-10 mg TMP/kg/day in divided doses every 6, 8, or 12 hours for up to 4 days with serious infections Prophylaxis: Oral: 2 mg TMP/kg/dose daily or 5 mg TMP/kg/dose twice weekly CONTRAINDICATIONS Hypersensitivity to any sulfa drug, trimethoprim, or any component of the formulation; porphyria; megaloblastic anemia due to folate deficiency; infants <2 months of age; marked hepatic damage; severe renal disease; pregnancy (at term)

Diazepam DOSING: PEDIATRIC Conscious sedation for procedures: Oral: Children: 0.2-0.3 mg/kg (maximum dose: 10 mg) 45-60 minutes prior to procedure Adolescents: 10 mg I.V.: Adolescents: 5 mg; may repeat with 2.5 mg if needed

Febrile seizure prophylaxis: Oral: Children: 1 mg/kg/day divided every 8 hours; initiate therapy at first sign of fever and continue for 24 hours after fever is gone

Sedation or muscle relaxation or anxiety: Oral: Children: 0.12-0.8 mg/kg/day in divided doses every 6-8 hours I.M., I.V.: Children: 0.04-0.3 mg/kg/dose every 2-4 hours to a maximum of 0.6 mg/kg within an 8-hour period if needed

Status epilepticus: I.V.: Infants >30 days and Children <5 years: 0.05-0.3 mg/kg/dose given over 3-5 minutes, every 15-30 minutes to a maximum total dose of 5 mg or 0.2-0.5 mg/dose every 2-5 minutes to a maximum total dose of 5 mg; repeat in 2-4 hours as needed Children 5 years: 0.05-0.3 mg/kg/dose given over 3-5 minutes, every 15-30 minutes to a maximum total dose of 10 mg or 1 mg/dose every 2-5 minutes to a maximum of 10 mg; repeat in 2-4 hours as needed Rectal: 0.5 mg/kg/dose then 0.25 mg/kg/dose in 10 minutes if needed

Anticonvulsant (acute treatment): Rectal gel: Infants <6 months: Not recommended Children <2 years: Safety and efficacy have not been studied Children 2-5 years: 0.5 mg/kg Children 6-11 years: 0.3 mg/kg Children 12 years: Refer to adult dosing. Note: Dosage should be rounded upward to the next available dose, 2.5, 5, 10, 12.5, 15, 17.5, and 20 mg/dose; dose may be repeated in 4-12 hours if needed; do not use for more than 5 episodes per month or more than one episode every 5 days.

Muscle spasm associated with tetanus: I.V., I.M.: Infants >30 days: 1-2 mg/dose every 3-4 hours as needed Children 5 years: 5-10 mg/dose every 3-4 hours as needed In children, do not exceed 1-2 mg/minute IVP; adults 5 mg/minute

Diphenhydramine

HCL Elixir 12.5mg=5cc 5mg/kg/24hrs 10 kg =5cc tds-qid

tab 25 mg

DOSING: PEDIATRIC Treatment of dystonic reactions and moderate to severe allergic reactions: Oral, I.M., I.V.: 5 mg/kg/day or 150 mg/m2/day in divided doses every 6-8 hours, not to exceed 300 mg/day

Minor allergic rhinitis or motion sickness: Oral, I.M., I.V.: 2 to <6 years: 6.25 mg every 4-6 hours; maximum: 37.5 mg/day 6 to <12 years: 12.5-25 mg every 4-6 hours; maximum: 150 mg/day 12 years: 25-50 mg every 4-6 hours; maximum: 300 mg/day

Night-time sleep aid: 30 minutes before bedtime: Oral, I.M., I.V.: 2 to <12 years: 1 mg/kg/dose; maximum: 50 mg/dose 12 years: 50 mg

Antitussive: Oral, I.M., I.V.: 2 to <6 years: 6.25 mg every 4 hours; maximum 37.5 mg/day 6 to <12 years: 12.5 mg every 4 hours; maximum 75 mg/day 12 years: 25 mg every 4 hours; maximum 150 mg/day Diphenhydramine compound=Diphenhydramine+Sodium citrate+Ammonium chloride+Menthol Dexa methasone Dicyclomine in Croup 0.6 mg/kg/IM/stat

Gastrointestinal motility disorders/irritable bowel Amp 20 mg child=10 mg DOSING: PEDIATRIC Oral: Infants >6 months: 5 mg/dose 3-4 times/day Children: 10 mg/dose 3-4 times/day syr 5cc=10 mg

Dimethicone(activated simethicone)

drop 1cc=40 mg Child max 20 drop tds

inf max=15 drop tds

DOSING: PEDIATRIC Flatulence/bloating: Oral: Infants: 20 mg 4 times/day Children <12 years: 40 mg 4 times/day Children >12 years: Refer to adult dosing.

DOSING: ADULTS Flatulence/bloating: Oral: 40-120 mg after meals and at bedtime as needed, not to exceed 500 mg/day

Domperidone Motilium PHARMACOLOGIC CATEGORY Dopamine Antagonist Gastrointestinal Agent, Prokinetic

DOSING: ADULTS GI motility disorders: Oral: 10 mg 3-4 times/day, 15-30 minutes before meals Severe/resistant cases: 20 mg 3-4 times/day, 15-30 minutes before meals Nausea/vomiting associated with dopamine-agonist anti-Parkinson agents: Oral: 20 mg 3-4 times/day

Erythromycine

susp 200 mg=5cc

tab 200 & 400 mg

30-50 mg /kg/24 hrs------ qid

DOSING: ADULTS Usual dosage range: Oral: (Note: Due to differences in absorption, 400 mg erythromycin ethylsuccinate produces the same serum levels as 250 mg erythromycin base, sterate or estolate) Base: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 2 g/day Estolate: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 2 g/day Ethylsuccinate: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 3.2 g/day Stearate: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 2 g/day I.V.: Lactobionate: 15-20 mg/kg/day divided every 6 hours or 500 mg to 1 g every 6 hours, or given as a continuous infusion over 24 hours (maximum: 4 g/24 hours)

Ophthalmic infection: Ophthalmic: Instill 1/2" (1.25 cm) 2-6 times/day depending on the severity of the infection

Dermatologic infection: Topical: Apply over the affected area twice daily after the skin has been thoroughly washed and patted dry

Indication-specific dosing: Cervicitis: Oral: 500 mg 4 times/day for 7 days Chancroid (unlabeled use; not a preferred agent): Oral: 500 mg 4 times/day for 7 days Community-acquired pneumonia, bronchitis: Oral, I.V.: 500-1000 mg 4 times/day for 10-14 days. If Legionella is suspected/confirmed, 750-1000 mg 4 times/day for 21 days or more may be recommended. Note: Other macrolides and/or fluoroquinolones may be preferred and better tolerated. Lymphogranuloma venereum: Oral: 500 mg 4 times/day for 21 days Nongonococcal urethritis (recurrent): Oral: CDC Guidelines for the Treatment of Sexually Transmitted Diseases recommendation: Metronidazole (2 g as a single dose) plus 7 days of erythromycin base (500 mg 4 times/day) or erythromycin ethylsuccinate (800 mg 4 times/day) Pertussis: Oral: 250-500 mg every 6 hour; standard treatment course is 14 days, but there is evidence to support a shorter (7-day) course Preop bowel preparation (unlabeled use): Oral: 1 g erythromycin base at 1, 2, and 11 PM on the day before surgery combined with mechanical cleansing of the large intestine and oral neomycin Gastrointestinal prokinetic (unlabeled use): Oral: Erythromycin has been used as a prokinetic agent to improve gastric emptying time and intestinal motility. In adults, 200 mg was infused I.V. initially followed by 250 mg orally 3 times/day 30 minutes before meals. Lower dosages have been used in some trials. DOSING: PEDIATRIC Prophylaxis of neonatal gonococcal or chlamydial conjunctivitis: Neonates: Ophthalmic: 0.5-1 cm ribbon of ointment should be instilled into each conjunctival sac

Usual dosage range: Infants and Children: Oral:Note: Due to differences in absorption, 400 mg erythromycin ethylsuccinate produces the same serum levels as 250 mg erythromycin base, stearate or estolate). Base: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 2 g/day Estolate: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 2 g/day Ethylsuccinate: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 3.2 g/day Stearate: 30-50 mg/kg/day in 2-4 divided doses; do not exceed 2 g/day I.V. (as lactobionate): 15-50 mg/kg/day divided every 6 hours, not to exceed 4 g/day

Indication-specific dosing: Acne vulgaris (unlabeled use): Adolescents: Oral: 250-1500 mg/day in 2 divided doses; therapy may be continued for 4-6 weeks at lowest possible dose Pharyngitis: Oral: 40 mg/kg/day in 2 doses; maximum: 1600 mg/day; short-course therapy for 5 days may be considered Pertussis: Oral: 40-50 mg/kg/day in divided doses; standard treatment course is 14 days, but there is evidence to support a shorter (7-day) course Preop bowel preparation: Oral: 20 mg/kg erythromycin base at 1, 2, and 11 PM on the day before surgery combined with mechanical cleansing of the large intestine and oral neomycin Ophthalmic infection: Ophthalmic: Refer to adult dosing. Topical: Refer to adult dosing.

Guaifenesine(Expectorant )

syr 100 mg =5cc Cough (expectorant): Oral: Children: 6 months to 2 years: 25-50 mg every 4 hours, not to exceed 300 mg/day 2-5 years: 50-100 mg every 4 hours, not to exceed 600 mg/day 6-11 years: 100-200 mg every 4 hours, not to exceed 1.2 g/day >12 years: Refer to adult dosing. WARNINGS / PRECAUTIONS Not for persistent cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema or cough accompanied by excessive secretions. When used for self-medication (OTC), contact healthcare provider if needed for >7 days or for a cough with a fever, rash, or persistent headache.

Ferrous sulfate DOSING: ADULTS Dose expressed in terms of ferrous sulfate: Treatment of iron deficiency anemia: Oral: 300 mg twice daily up to 300 mg 4 times/day or 250 mg (extended release) 1-2 times/day Prophylaxis of iron deficiency: Oral: 300 mg/day

DOSING: PEDIATRIC Dosage expressed in terms of elemental iron: Treatment of severe iron-deficiency anemia: Oral: 4-6 mg Fe/kg/day in 3 divided doses

Treatment of mild-to-moderate iron-deficiency anemia: Oral: 3 mg Fe/kg/day in 1-2 divided doses

Prophylaxis: Oral: 1-2 mg Fe/kg/day up to a maximum of 15 mg/day ADMINISTRATION Administer ferrous sulfate 2 hours prior to, or 4 hours after antacids ADVERSE REACTIONS SIGNIFICANT >10%: Gastrointestinal: GI irritation, epigastric pain, nausea, dark stools, vomiting, stomach cramping, constipation

1% to 10%: Gastrointestinal: Heartburn, diarrhea Genitourinary: Discoloration of urine Miscellaneous: Liquid preparations may temporarily stain the teeth

<1% (Limited to important or life-threatening): Contact irritation

CONTRAINDICATIONS Hypersensitivity to iron salts or any component of the formulation; hemochromatosis, hemolytic anemia

Furazolidone

susp 50mg=15cc

tab 100 mg

max 8mg/kg/24hrs

DOSING: PEDIATRIC Diarrhea/enteritis: Oral: Children >1 month: 5-8 mg/kg/day in 4 divided doses for 7 days, not to exceed 400 mg/day or 8.8 mg/kg/day

ADVERSE REACTIONS SIGNIFICANT >10%: Genitourinary: Discoloration of urine (dark yellow to brown)

1% to 10%: Central nervous system: Headache Gastrointestinal: Abdominal pain, diarrhea, nausea, vomiting

<1% (Limited to important or life-threatening): Agranulocytosis, disulfiramlike reaction after ethanol ingestion, hemolysis in patients with G6PD deficiency, hypoglycemia, leukopenia, orthostatic hypotension

CONTRAINDICATIONS Hypersensitivity to furazolidone or any component of the formulation; concurrent use of ethanol; infants <1 month of age because of the possibility of producing hemolytic anemia; foods high in tyramine content

WARNINGS / PRECAUTIONS Use caution in patients with G6PD deficiency when administering large doses for prolonged periods; furazolidone inhibits monoamine oxidase

Hydroxyzine

syr 10 mg=5cc 2mg/kg/24hrs

tab 10,25 mg 10kg=2.5cc tds-qid

amp 100 mg=2cc

Metronidasole

susp 125 mg=5cc

tab 250mg 10kg=5cc 10 kg=2cc Drop 0.6 cc daily

Amebiasis 35-50 mg/kg/24hrs Giardiasis 15 mg/kg/24hrs Multivitamine MOM (mg(oh)2) Metoclopramide Syr 5cc daily 0.5-1 cc/kg +200cc water

drop 60mg=15cc 1cc=15 drop=4mg 0.1 mg/kg/dose

amp 10mg=2cc

5kg=2drop qid tab500000 iu

Nystatine

term more than 2500gr = 30drops Less than 2500 gr = 15 drops Children 400000-600000 iu or tab/qid

Mebandasole Promethasine

chewable tab 100 mg syr 5.65 mg=5cc tab 25mg amp 25,50 mg

1mg/kg/24hrs Phenobarbital tab 15,30,60,100

10kg=2.5cc amp 100, 200 mg amp 5mg/kg/24hrs/bd/Im 4-8 mg/kg24hrs/bd

Amp 10 mg/kg/IM/stat Phenytoine Pyrantel pamoate

amp 15/mg/kg/stat slowly IV tab 125 mg 11mg/kg/dose

syr 250mg=5cc single dose syr 2mg=5cc 20kg=5cc 0.15 mg/kg/dose 0.375cc/kg

Salbutamole (ventoline)