PRACTICAL-13 Aim: To prepare stable oral suspension of given API using different structured

vehicles and to study the effect on stability of suspension.

Formula: each 5ml contains Barium sulphate(calcium carbonate).1.56g

Base . q.s.

Batch size: 50 ml. Packaging: Narrow mouth glass bottle with metal screw cap. Formula:
Ingredients Dummy drug (CaCO3) Kollidon 90 F(PVP) Quantity given 31.25 gm 1.56 gm Quantity for 50 ml 15.62 ml 0.78 ml 0.062 ml 0.062 ml 0.1 ml 0.01 ml 50 ml Role of each ingredients Drug Suspending agent Flocculating agent Antioxidant Preservative Preservative Vehicle

Sodium carboxy methyl 0.125 gm cellulose Sodium bisulfite Methylparaben Propylparaben Water 0.125 gm 0.02 ml 0.02 ml 100 ml (up to)

Procedure:

1. Method of preparation:
All the ingredients were weighed accurately. Calcium carbonate, sodium bisulfite and kollidon 90 F (PVP) were passed through sieve no. 20 and mixed thoroughly in a mortar.

Observation table: 1) Organoleptic properties:

Structured vehicle Color Odor

2) PH:
excipients PH

3) Sedimentation parameter:
excipient Time (min) Initial height(cm) H0 Final height (cm)Hu Ratio (Hu/H0)

Sucrose

 Both the preservatives were dissolved in water. Small quantity of aqueous phase was added gradually in the mortar with continuous trituration until a smooth paste was formed. Then the solution of structured vehicle (sodium carboxy methyl cellulose, methyl cellulose) or syrup of sucrose, fructose, and dextrose was added and mixed thoroughly in particular concentration. Now the remaining amount of water was added with mixed thoroughly and volume was made up to 100 ml. The suspension was then evaluated. Following ingredients were used to prepare structured vehicle: Sucrose syrup, dextrose syrup, fructose syrup, Sodium carboxy methyl cellulose (1% - 2% W/W) Methyl cellulose (1% - 2% W/W)

Evaluation parameters:
1. 2. 3. 4. Organoleptic properties pH Density Sedimentation parameters a. Sedimentation volume ratio b. Sedimentation rate c. Redispersibility study

Dextrose

Fructose

Sodium carboxy methyl cellulose

Conclusion:
In oral suspension formulation uniformity of solid or dispersed phase in dispersed medium ensured by addition of proper viscosity enhancers throughout its shelf life. Dispersed phase can be kept in well distributed form by addition of various structured vehicles but the viscosity of the formulation should not affect the pourability of the dosage form. In oral suspension formulation solid should have minimum sedimentation and this can be achieved by addition of structured vehicles. In the present study, attempt is made to prepare stable and pourable oral suspension with various synthetic and syrup base structured vehicles. The observation shows that syrup base structured vehicle gives flocculated suspension which is desirable; it does not form a hard cake and can be easily redispersed. Methyl cellulose also gives easily redispersed suspension while Sodium carboxymethyl cellulose form hard cake and it cannot be easily redispersed.

Methyl cellulose

1) Redispersibility:
excipients No of inversion

2) Density:
Structured vehicle Density (gm/L)