Suez Canal University Faculty of Veterinary Medicine Pharmacology Department.

2nd semester (2012-2013)

Name: Time allowed: 1 hour Date: 24/2/2013

I. N o 1

Complete the following tables with suitable answer Drug Action Endocitocidal Broad spectrum anthelmentic Mechanism of action GABA agonist GABA : "inhibitory neuro chemical transmmitor" bind to chloride channles in parasite nerve and muscle fiber .cause paralysis Neuro muscular blocker -curare like action -:block ach at myoneural junction cause paralysis

Ivermectin

Piprazine citrate

Antiascaris

Live worm expelled by peistalsis 2-GABA agoinst GABA : "inhibitory neuro chemical transmmitor" bind to chloride channles in parasite nerve and muscle fiber .cause 3 paralysis inhibit mitochondrial reaction: inhibit fumerate reductase inhibit transformation of

Albendazole

Anti adult trematode -Broad spectrum anthlemintic.

fumerate to succinate inhibit tubulin polymerization Inhibit egg and 4

Levamisole HCl

Nematocidal against GIT and lung worm.

larva production Choleinergic agonist stimulate adult nervous system cause

Anti ascaridia galli paralysis of the worm. 5

Pyrental tartarate

Antinematodal against GIT worm.

Ganglionic stimulant :Mimice action of ACH stimulate nicotonic raceptor at neuromuscular junction of

Praziquantel

Anticestodal, antischistosomal

,cause paralysis. increase permeability to Ca. - damage to tegument lead to paralysis of the

Mebendazole

worm. Anti adult Fasciola 1-inhibit glucose -Broad spectrum anthlemintic transport and utilization by the worm . 2-inhibit microtubulin formation. Inhibit egg and

Niclosamise

Anticestodal antischistosomal

larva Uncoupling of oxidative phosphorylaton

Nitroxinil

Antinematodal

Uncoupling of oxidative phosphorylaton

1 0

Clorsulon

Anti adult trematode

Inhibit enzymes of glycolytic path way

1 1

Thiabendazol e

Antinematodal

Inhibit egg and larva production 2-inhibit tubulin polymerization to microtubule 3-inhibit mitochondrial reaction.

1 2

Closantel

Fasciolicidal Anti adult trematode Uncoupling of oxidative phosphorylaton

1 3

Dichlorofos

Antinematodal Endocitocidal

Inhibit cholinestrase activity causing ACH to remain ne in neuro

muscular junction of parasite cause paralysis. 1 4

Diamphenati de

Fasciolicidal for young Fasciola

increase permeability to Ca. - damage to tegument lead to paralysis of the worm. inhibit mitochondrial reaction: inhibit fumerate reductase inhibit transformation of fumerate to succinate inhibit tubulin polymerization

1 5

Triclabendaz ole

Fasciolicidal ( 1 day youngadult )

Inhibit egg and 1 6

Rafoxanide

Fasciolicidal Anti trematode

larva Uncoupling of oxidative phosphorylaton

1 7

Fenbendazol e

Anti adult trematode Broad spectrum anthlemintic

inhibit mitochondrial reaction: inhibit fumerate reductase inhibit transformation of fumerate to succinate inhibit tubulin polymerization Inhibit egg and larva

1 8

Aricholine HCl

anticestodal

Choleinergic agonist stimulate adult nervous system cause paralysis of the worm. GABA agonist GABA : "inhibitory neuro chemical transmmitor" bind to chloride channles in parasite nerve and muscle fiber .cause paralysis Uncoupling of oxidative phosphorylaton

1 9

Doramectin

Endocitocidal antinematodal

2 0

Clioxanide

Anti trematodal

N o 1

Drug

Adverse effects Embryotoxic in animal. Teratogenic effect not used during pregnancy Increase active ach neurotoxicity in host Narrow range of safety Not used in heart worm positive dogs

Albendazol e Fenchlorof os

Ivermectin Nitroxinil Pyrental

Infertiltiy in rabbit (male) abortion in female.

4 5

Hyperthermia in host Cataract-. Diarrhea- headach-weakness-GIT distress.

tartarate
II.

Write only 1 word for each of the following sentence Simple heterocyclic compound of choice for treatment of Parascaris equarum in donkey. (Piperazine

citrate)

Injestable endocticide could be given by IM route. (ivermectine)

Parasympathomimetic cesticide.

(Arecholine

HCL)

Faciolicide could be combined with ivermectin in order to broaden its spectrum. (clorsulon) (GABA)

Site of action of abamectin in the tick. Immunostimulant imidazothiazole

(Levamezol)

Route of administration of morantel tartarate (orally)

Highly active metabolite of mebendazole (Mebendazol

sulfoxide)

III. How to use subject index to search about albendazole in Veterinary Drug Therapy

Look at index at the back of the book Search for albendazole : for example: anti nematodal >page:300 anti cestodal > page :500