Updated 04/09

Edward E. Cable, Ph.D.

17239 Grandee Place (858) 603-0855 (c)
San Diego, CA 92128 ed.cable@san.rr.com

SUMMARY

Highly experienced, creative scientist and emerging leader, with a demonstrated record
of sustained success in drug discovery and academic science. A collaborative
investigator who enjoys the challenge of identifying and implementing novel and
challenging research projects with the potential to address unmet medical needs. An
engaging communicator, equally comfortable interacting with academic and
pharmaceutical scientists, other functional specialists – including physicians – and
executives.

• Evaluation, selection and • Due diligence and evaluation of

implementation of internally
identified research opportunities
• Established multiple academic and
business partnerships
• Preclinical team leadership and
clinical development team
participation
external projects for in-licensing
opportunities
• Successful in acquiring funding
from NIH and other sources
• Published author of more than 30
peer-reviewed manuscripts, and
numerous reports and
presentations

QUALIFICATION HIGHLIGHTS

Strategic Communication Experience

• As the MB07811 project leader, authored or co-authored internal document in
support of the development of MB07811 for the treatment of elevated LDL
cholesterol. Document package included scientific rationale, preclinical efficacy
and safety pharmacology data, regulatory strategy and hurdles, projected
patient populations and market analyses including marketed and potential
treatments currently in development
• Represented MB07811 in peer reviewed manuscripts, national meetings and
internal consultant and Key Opinion Leader (KOL) meetings
• Developed numerous non-confidential summaries for potential out-licensing
efforts
• Served as advisor on in-licensing opportunities and competitor analyses
• Authored numerous white papers and Strength, Weakness, Opportunities and
Threats (SWOT) analyses for different therapeutic areas

Therapeutic/Scientific Area Experience

• Extensive background in metabolic diseases and integrative physiology
• Systems biology approach to research and eagerness to implement the use of
new technology to gain fundamental insights
Edward Cable Resume

• Broad-based understanding of pharmacokinetic and pharmacodynamic

principles for small molecules and macromolecular therapeutics
• Designed an implemented various technologically challenging assays including
enzyme, protein/RNA interaction, cell based transporter and in vitro
pharmacology assays

Management Experience
• Developmentally-oriented project manager
• Matrix team and cross-functional, permissive democratic leader who seeks the
best possible solution
• Experience in developing effective and efficient research programs to generate
go/no-go decisions

BD/IP Experience
• Identified and recruited KOL’s and CRO’s to contribute to projects
• Analyzed market opportunities and commercial viability of metabolic disease
targets including different therapeutic intervention strategies and IP space
• Evaluated and identified key IP spaces with freedom to operate for nuclear
receptor agonists, treatment of hepatic steatosis and novel peripheral
treatments for obesity
• Due diligence evaluating in-licensing opportunities and potential collaborations

EMPLOYMENT HISTORY
Scientific Investigator 2002 - 2009
Metabasis Therapeutics
Project Leader, Liver-targeted thyroid hormone receptor agonist for the treatment
of elevated LDL cholesterol
Designed and implemented of sub-chronic safety studies, pharmacokinetic (PK)
and pharmacodynamic (PD) studies in both small and large animals
Performed complex statistical analyses of continuous, non-continuous and
categorical data using JMP software (SAS Corporation), Sigma Plot, Basic
pharmacokinetic analysis (WinNonLin-Pharsight, Inc.), and lipomic data
analysis
Designed and implemented a company-wide wellness program to encourage
non-athletes to start and continue a voluntary wellness program. Program
achieved more than 75% voluntary participation.
Co-authored 5 published peer-reviewed manuscripts and 6 meeting
presentations disclosing MB07811 for the treatment of elevated LDL
cholesterol, obesity and hepatic steatosis
Authored key portions of the pre-clinical Animal Pharmacology and Toxicology
Studies section of the MB07811 IND

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Edward Cable Resume

Postdoctoral Fellow through Assistant Professor 1994 –2002

Penn State College of Medicine
Authored/co-authored 10 published peer-reviewed manuscripts and 3 funded
grant applications as PI, co-authored several other grant applications
Successfully secured and maintained external funding for academic position at
>80% for the full duration of tenure
Developed and implemented tissue culture methods for both primary cells and
immortalized and transformed cell lines and engineered cell lines and
microscopy methods including transmission electron microscopy and
immuno-EM, scanning laser confocal and deconvolution microscopy
Designed novel RNA gel shift , characterization of HBV antivirals in an ovel in
vitro pharmacology HBV assay, used viral gene transfer vectors and methods
in primary hepatocytes and cell lines
Designed experiments and analyzed genomic data from cells and tissues
Established collaborative academic efforts among PI’s from three different
departments leading to the receipt of Program Project funding
(5P01DK053430) >$1M/4 years: Harriet Isom, Michael Chorney, James
Conner, and Mel Billingsley

Graduate Student to Postdoctoral Research Associate 1990- 1994

University of Massachusetts Medical Center
Authored/co-authored 17 peer reviewed publications

Education and Professional Development

University of Massachusetts Medical Center Ph.D. Biochemistry
Emory University Graduate Program Biochemistry
Grove City College B.S. Chemistry

Awards
Metabasis, First in Human MB07811
Biology Project Leader
American Liver Foundation Liver Scholar Award November,
American Gastroenterology Association Student Research Award Runner-up
Senior Research Award, Grove City College

Publications
32 published peer-reviewed papers
36 abstracts
1 patent/patent application

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