Escuela profesional de Farmacia y Bioqumica Nombre: Ana Lucia Apaza Cruz ANALISIS CLINICOS

WARFARINA Y PRADAXA
COMPARE TO WARFARIN FOR AFIB NOT CAUSED BY A HEART VALVE PROBLEM PRADAXA represents progress in helping to reduce the risk of stroke due to atrial fibrillation (AFib) not caused by a heart valve problem.

Medication type: Both PRADAXA and warfarin are anticoagulants. These blood-thinning medicines help to stop clots by targeting factors your blood needs to form clots. PRADAXA and warfarin work differently to help reduce the risk of stroke due to AFib not caused by a heart valve problem.

PRADAXA is a direct thrombin inhibitor that helps to stop clots from forming by working directly on thrombin. PRADAXA is not for use in people with artificial (prosthetic) heart valves

Warfarin is a vitamin K antagonist that helps to stop clots from forming by interfering with vitamin Ka vitamin your body needs to form clots.

Stroke risk reduction: PRADAXA and warfarin help to stop clots by targeting factors your blood needs to form clots.

In a clinical trial of more than 18,000 people, PRADAXA 150 mg capsules reduced the risk of stroke 35% better than warfarin.

Warfarin has been extensively studied and prescribed by doctors to help reduce the risk of stroke in people with AFib since 1954.

How you take the medication:

PRADAXA is taken by mouth 2 times each daywith or without food.

Warfarin is taken by mouth once every day.

Dosing options:

PRADAXA comes in 75 mg and 150 mg strengths. Your doctor will decide which dose is right for you based on a simple kidney function

Warfarin comes in 1 mg, 2 mg, 2-1/2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7-1/2 mg, and 10 mg strengths.

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Your doctor will decide which dose is right for you. He or she will adjust your dose based on the results of regular blood tests. Based on these tests, your doctor will determine your dose and adjust it, if necessary.

Monitoring:

No need for regular blood tests. PRADAXA has been clinically proven to help reduce the risk of stroke in people with AFib not caused by a heart valve problem. And, unlike warfarin, there is no need for regular blood tests to see if your blood-thinning level is in the right range.

Requires regular blood test. Warfarin has also been proven to be an effective blood thinner. When you take warfarin, you need to have a regular blood test to measure International Normalized Ratio (INR) to determine the time it takes for your blood to clot.

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Dietary restrictions:

No dietary restrictions PRADAXA requires no changes to your diet.

Dietary restrictions required When you take warfarin, you need to avoid foods high in vitamin K, such as large amounts of leafy green vegetables and some vegetable oils. This is because Vitamin K can affect the way warfarin works in your body. You may also need to avoid alcohol, cranberry juice, and products containing cranberries