Dr.
Frank Shallenberger’s
Vol. 7, No. 4
Slam the Brakes on Aging, Part 2
In last month’s issue, I showed you how
decreased cellular energy production is the
cause of all aging and degenerative diseases.
I told you about an innovative test that
measures your biological age by measuring
how well the cells of your body produce ener-
gy. And I told you about all the things that
can damage your cells’ mitochondria, affect-
ing your energy production and causing you
to age.
One of the things we talked about last
month is the effect of free radicals. As you
know, free radicals are highly reactive mole-
cules that can damage the cells. Because of
In this Issue
Q How men can dramatically decrease
their risk for cancer, heart disease,
diabetes, and memory loss ........ p. 4
Q A powerful extract that can stop
diabetes and cancer — and when
you should never take it ............ p. 6
Q If you have shoulder pain, here’s
how to stop the inflammation
and reduce your pain ................ p. 8
Coming Next Month
• Suffering from stomach pains, gas,
bloating, or any other digestion problem?
I’ll show you how to get permanent relief
once and for all.
• If dust, mold, or a number of other irritants
bother your eyes, you have to avoid this
drug. Instead, try this simple, over-the-
counter remedy.
April 2008
this, many doctors believe that free radical
molecules cause aging.
Well, I’d like to take it a step further.
Yes, free radicals can cause cell damage. And
yes, this cell damage can cause your cells to
produce less energy. But here’s something
even more important: lower cell energy caus-
es free radicals!
When your mitochondria work efficient-
ly, they don’t produce very many free radi-
cals. But when the mitochondria are dam-
aged, they produce a lot of free radicals. It’s
very similar to a car engine. As the car
engine works less efficiently, you get more
pollution coming from the exhaust.
So when you have mitochondrial damage
you get more free radicals … which cause
more mitochondrial damage … which causes
still more free radicals. It’s a vicious circle.
How to Stop Free Radicals in
Their Tracks
For years, you’ve been told that the best
way to quench free radicals is by taking
antioxidants like selenium, vitamins C and
E, beta-carotene, and alpha lipoic acid. It’s
good advice, except for one problem: antioxi-
dants don’t stop the aging process!
In fact, dozens of animal studies have
been done on antioxidants. And not one sin-
gle study has ever found that taking them
can stop or even slow down aging.
Why? Because antioxidants don’t directly
attack free radicals; antioxidant enzymes do.
These enzymes include catylase, glu-
tathione peroxidase, and SOD (superoxide
dismutase). When these antioxidant
enzymes come into contact with a free radi-
cal molecule, they neutralize it so that it
doesn’t cause damage to your cells.
Unfortunately, every time an antioxidant
enzyme comes in touch with a free radical, it
becomes weakened or even de-activated. That
means it can’t quench another free radical
until something re-activates it. And that
something is the antioxidant nutrients. These
include antioxidants like vitamins C and E,
beta-carotene, selenium, and lipoic acid.
The bottom line: taking antioxidants is
not enough. You also have to increase the
level of antioxidant enzymes.
Now here’s the problem: Antioxidant
enzymes are produced by the mitochondria.
So when your mitochondria are not working
efficiently, they make fewer antioxidant
enzymes. At the same time, they’re making
more free radicals. Thus, decreased energy
production leads to a deadly combination –
increased free radical formation with
decreased antioxidant enzyme production.
So the answer to the problem is to
increase energy production. The answer
once again is energy. The more energy your
mitochondria produce, the more antioxidant
enzymes your body makes!
It’s a self-perpetuating cycle. Your cells
make more energy …which creates fewer
free radicals and more antioxidant enzymes
… this protects you from the long-term
effects of free radical damage, which leads to
youthful energy production even as you
grow much older … and so on.
Real Cures (ISSN 1062-4163) is published monthly by
Soundview Publishing, LLC. Publisher: Wallis W. Wood;
Editor: Frank Shallenberger, MD. Subscriptions $49 per
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eral comments on health, nutrition, and medicine. Readers
are advised to consult with their own physician before
implementing any health idea they read about, whether
here or in any other publication. Copyright © 2008 by
Soundview Publishing, LLC. All rights reserved.
Unauthorized reproduction of this newsletter or its con-
tents by xerography, facsimile, or any other means is illegal.
—2—
But that still doesn’t answer the big
question, which is: How can we make more
energy? The answer is:
Fuel (carbs and/or fats) +
Oxygen = Energy
We’ll talk about fats and carbs in a
moment, but let’s talk about oxygen first.
Why? Because you can have the best nutri-
tion in the world, and you’ll still age if your
body isn’t processing oxygen properly. In
fact, an article in the New England Journal
of Medicine concluded that the biggest dif-
ference between a 25-year-old and a 75-year-
old is in how their bodies use oxygen.
So How Do You Get
the Cells Oxygenated?
One way to get more oxygen into your
cells is through oxygen therapies, like ozone
therapy or intravenous hydrogen peroxide.
But the cheapest, easiest, and most practical
way is through moderate aerobic exercise.
I’ve showed you in past issues how
many people don’t get enough exercise and
how others get too much exercise. Both
cases will have a negative effect on your
ability to produce energy. This is why some
people who exercise a lot are tired all the
time. And it’s also why people who don’t
exercise feel sluggish. They simply don’t
produce enough energy.
However, if you can get the right
amount of exercise, you will greatly optimize
your energy production. And greater energy
production results in less aging. In fact,
hundreds of studies show that exercise can
slow or even stop most diseases. People who
exercise properly have lower rates of heart
disease, cancer, diabetes, you name it.
So how do you know how much exer-
cise to get? I gave you all the details in my
article, but let me briefly sum it up for you.
It’s all about interval training.
Interval training means that you exer-
cise at different levels for different rates of
time. The program I tell my patients to fol-
low is very simple. The first level is simply
exercising at a low level for three to five
minutes. The level of exertion should be low
enough that you could easily have a conver-
sation without having to hesitate from
breathlessness. Then exercise for one to two
minutes at the point where you’re on the
verge of being out of breath. (This is called
the aerobic zone.)
After you’ve gone for one or two min-
utes at this rate, then go for 30 seconds as
hard as you can. (This is called the anaero-
bic zone.)
After 30 seconds, go back to the low
level for three to five minutes. This is the
recovery zone. It can be a simple walking
pace or, maybe, a little faster. Then repeat
this cycle as many times as you like, up to
40 minutes. That’s all there is to it. Any
harder or longer and you begin to negatively
affect your energy production.
The Rest of the Plan
Moderate exercise is the best anti-aging
treatment available. But it’s not the only
thing you can do to stop the aging process
and avoid disease. There are three other
areas you need to look at in order to achieve
your optimum energy production. They are:
diet, supplements, and stress management.
Let’s talk about each of these…
Diet: I’ve told you in other articles
about the importance of having a metabo-
lism that burns fat, not glucose. Burning
fat is the cleanest, most efficient way for
your body to make energy.
The best way to have a fat-burning
metabolism is to avoid carbohydrates, espe-
cially grains and sugars. There’s no secret
formula to follow. No tricky diet plan. Just
stop eating the high-carb foods, especially
refined carbs!
What should you eat? As far as I’m
concerned, you can eat as much good meat
(i.e., grass-fed beef, fish, free-range chicken,
etc.) and organic vegetables as you want.
You should make the bulk of your diet con-
sist of the non-starchy vegetables and
legumes. You can also eat a minimal amount
—3—
of fruit (especially berries), as long as you
don’t overdo it. In general, I tell patients to
avoid fruits altogether for the first three
weeks on the plan. After that they can have
as many berries as they want, and one or
two pieces of whole fruit per week. Be sure to
avoid fruit juice — it is way too high in sugar.
Stress Management: Believe it or
not, you can have a great exercise and diet
program and still kill your energy produc-
tion by living a stressful life.
I have a patient who’s a great illustra-
tion of this. She’s 63 years old, and for sev-
eral years she had the biological age of a 42-
year-old. Then, one day she came into my
clinic and her Bio-Energy scores had
dropped by 40%! We were shocked.
I asked her about her diet and exercise.
Everything was perfect. Then I asked her
if she had made any changes in her life.
She told me her mother was dying of
Alzheimer’s and had moved in with her. The
stress of caring for her mom was affecting
her ability to produce energy in a negative
way. It was wearing her out and ultimately
aging her.
Situations like this are almost impossi-
ble to avoid. So you have to develop stress
management techniques, such as making
sure you get enough sleep, proper exercise,
and limiting your intake of coffee and alco-
hol. You also have to develop other ways
to handle stress, which I outlined in detail
the October 2007 issue. I urge you to read
that issue.
Supplements: By supplements, I’m
referring to vitamins, minerals, amino acids,
herbs, and other nutrients. But I’m also
referring to certain hormones. You see, one
of the things that happens as you age is that
your glands don’t produce as many hor-
mones as they used to.
These can be sex hormones, like testos-
terone or estrogen. Or they could be other
hormones like cortisol, thyroid hormone,
melatonin, or DHEA.
The only way to know for sure if you’re
deficient in any of these is to be evaluated
 One Test Every Man Must Get to
Help Prevent Cancer, Heart
Disease, and Diabetes
I’ve written about metabolic syndrome for
years. And yet, many people still don’t know
how dangerous it is. Metabolic syndrome
destroys more lives than any other single imbal-
ance. It causes diabetes, cancer, heart disease,
senility, weakness, and hypertension.
The easiest way to diagnose metabolic syn-
drome is to stand in front of the mirror. If you
have metabolic syndrome, you’ll have fat gain
that’s limited to the abdominal area. People
with this problem typically have minimal fat
accumulation in other areas.
Any man who is overweight either has
metabolic syndrome or is on the way to getting
it. The same is true for 70% of overweight
women. In most cases, simply losing the excess
weight by exercising regularly and limiting car-
bohydrate intake will eliminate this terrible
problem.
But what if you’re not overweight? In this
case the mirror doesn’t help, and the only way
to identify it is by examining laboratory tests,
such as fasting insulin, glucose, and blood fat
levels.
So how can you prevent metabolic syn-
drome from occurring in a man who is not over-
weight? In this case, weight loss is not an
option. Recent research is helping solve this
problem.
In a recent study researchers followed 950
men who did not have metabolic syndrome.
They took blood tests to determine the partici-
pants’ SHBG (sex hormone binding globulin)
and testosterone (male sex hormone) levels.
They also questioned the patients regarding
signs of decreased testosterone. This might
include depression, decreased sex drive, forget-
fulness, and musculo-skeletal aches. They then
followed these men over the next 20 years to see

by a doctor who is familiar with anti-aging Does It Really Work?

medicine and natural hormone replacement
therapy. You can find one near you by going
to www.acam.org.
Apart from hormones and vitamins, I
suggest you take a good full-spectrum multi-
vitamin/mineral. My favorite is a product I
developed myself called QuickStart.
QuickStart contains 11 vitamins and
11 minerals … plus green superfoods, high-
quality whey protein, concentrated fiber,
and several herbs that support detoxifica-
tion and a strong immune system. In fact,
one scoop of QuickStart powder provides as
many nutrients as you would find in 30
large tablets!
But you don’t have to choke down any
tablets; all you have to do is mix a scoop into
a glass of water and drink it. I take
QuickStart every morning, and so do most
of my patients. And they rave about it. (If
you’re interested in trying QuickStart, call
1-800-728-2288.)
So there you have it — the greatest
strategy for stopping the aging and disease
process. It can help you add years to your
life. But, more importantly, it can help you
live those years with vibrancy.
I told you earlier how well it worked
for me. But I’m not alone. Thousands of my
patients have gone through the protocol. We
give them a Bio-Energy test, put them on
the protocol, and then test them again six
months later. And time after time, those
people who follow the protocol see an im-
provement. Their bodies actually grow younger.
Will It Work for You?
The answer is yes. Obviously, not
everyone will respond in the same way.
We’ve seen the numbers vary from patient
to patient. Much of it depends on your
genetics. I’ve had patients with great genes
who increase their mitochondrial efficiency
by 100% in just three months. I’ve also had

—4—
whether or not they developed metabolic syn-
drome.
They found that the lower the partici-
pant’s level of SHBG and testosterone, the
greater their likelihood for developing metabolic
syndrome. This was definitely true for over-
weight men, but it was even truer for non-obese
men. The lower the levels of SHBG and testos-
terone, and the higher the occurrence of low
testosterone symptoms, the more likely a man
is to develop metabolic syndrome.
More importantly, the researchers con-
cluded, “Low SHBG and/or AD [androgen defi-
ciency = symptoms of decreased testosterone
levels] may provide early warning signs for car-
diovascular risk and an opportunity for early
intervention in non-obese men.”
So men, do yourself a favor. Here’s what
you need to do even if you’re not overweight:
Instead of just looking at your cholesterol each
year, have your doctor also check your fasting
insulin levels, SHBG, and testosterone levels. If
people with terrible genetics who see
increases of 10%, 20%, or 30% in that same
three-month period.
Chronological age also comes into play.
If you start the program before age 50, like I
did, you can see a dramatic turnaround. But
if you start after the age of 70, you may
already have some permanent damage to
organs and tissues that cannot be fixed. But
even then, you will most likely see some
improvement.
This Powerful Extract Lowers Blood
Sugar and Fights Cancer
In the past, I’ve told you the best way
to avoid getting cancer – make sure that
your cells are burning fat for energy instead
of carbohydrates (sugar/glucose). Although
all cells can burn either fat or carbohydrates
for energy, healthy cells prefer to burn fat.
your insulin levels are over 10 mU/I, you are on
your way to metabolic syndrome.
The same is true if your SHBG and/or
testosterone levels are in the bottom 25% of the
normal range. Even if you’re not in this bottom
range, any of the symptoms of testosterone defi-
ciency, such as depression, decreased sex drive,
forgetfulness, and musculoskeletal aches, could
mean you’re on your way to metabolic syn-
drome. By preventing metabolic syndrome, you
will dramatically decrease your risk for every
disease of aging, including cancer, heart disease,
diabetes, weakness, and senility.
If you are headed toward metabolic syn-
drome and you’re not obese, make sure you’re
getting plenty of exercise and eating lots of veg-
etables and proteins.
Reference: Kupelian V., S.T. Page, et al. “Low sex hormone-bind-
ing globulin, total testosterone, and symptomatic androgen defi-
ciency are associated with development of the metabolic syn-
drome in nonobese men.” J Clin Endocrinol Metab 2006
March;91(3):843-50.
So regardless of your condition, get
started now. You can find doctors trained in
Bio-Energy Testing by visiting my website
(www.bioenergytesting.com) or by
calling 866-376-0610. Q
References:
Speakman JR, Talbot DA, et al. “Uncoupled and surviving: indi-
vidual mice with high metabolism have greater mitochondrial
uncoupling and live longer.” Aging Cell. 2004 Jun;3(3):87-95.
Trifunovic A, Wredenberg A, et al. “Premature aging in mice
expressing defective mitochondrial DNA polymerase.” Nature.
2004 May 27;429(6990):417.
Cancer cells, on the other hand, burn
sugar. This is a major reason cancer is such
a problem today – everyone eats too many
carbohydrates and sugars.
The best way to prevent cancer or to
stop cancer from growing is to greatly
—5—
reduce your carbohydrate intake, eliminate
your sugar intake, exercise properly, get
plenty of sleep, take the right supplements
and hormones, and don’t stress out. All of
these activities force your cells – even cancer
cells – to burn fat instead of glucose.
But that’s not all you can do. One of
the most intriguing, new ways to shift the
body into a fat-burning mode comes from
one of my favorite foods.
Way back in 1995, researchers from the
Department of Biochemistry at Oxford
University in Britain discovered the cancer-
fighting abilities of the avocado. First, they
added an extract from the avocado plant
(Persea americana) to tumor cells in a test
tube. They found that the extract inhibited
the tumors cells’ ability to burn carbohy-
drates by as much as 75%. This forced the
Mark These Dates:
Fighting Disease and Pain in Reno
Dr. Shallenberger will be presenting his
seminar for doctors and interested scientists
and lay people on the use of ozone in medi-
cine on April 11-13, in Reno, NV. He will be
teaching doctors how to use ozone therapy
to combat chronic disease, and will also be
offering a full day's training on how to use
Prolozone Therapy®. Prolozone Therapy®
is a revolutionary new way to cure chronic
back, neck, shoulder, and joint diseases that
Dr. Shallenberger has invented and pio-
neered. You can learn more about this
course at www.ozonecourse.com.
Fighting Aging In Orlando
Dr. Shallenberger has been invited to be a
guest speaker at the 16th Annual American
Academy of Anti-Aging Medicine
International Congress in Orlando, FL on
April 25-27, 2008. Dr. Shallenberger will be
reporting on his research using a method he
has developed to evaluate mitochondrial
function in his patients, and to determine
their biological age. The title of his talk is,
“Mitochondrial Functional Analysis — A
New Method For Assessing Anti-Aging
Strategies.”
—6—
cancer cells into a fat-burning mode.
The result? As expected, the avocado
extract stopped the growth rate of the can-
cer cells.
Next, the researchers gave the same
extract to lab animals with cancer. They
used a dose of 1.7 mg of extract for every
gram of body weight, and they gave it to
the animals for only five days. To their
delight, they found that the growth rate of
the tumors was reduced by at least 65%,
and as much as 79%. This is a truly remark-
able finding!
The purified extract that they used
contained a substance found in high levels
in the avocado called d-mannoheptulose.
Researchers at the University of
California at Los Angeles tried using d-
mannoheptulose on a line of prostate cancer
cells. These cancer cells were “androgen-
independent.” That means that they grow
independently of whether or not they are
exposed to the hormone testosterone. These
are the most difficult kind of prostate can-
cers to treat. The researchers found that the
avocado extract caused the cancer cells to
stop growing.
Based on these studies, there’s good
reason to believe that regularly taking avo-
cado extract is a great way to prevent can-
cer. It can help prevent the shift from fat to
carbohydrate metabolism. And it works even
better is you use it with the other treatments
I mentioned earlier. But there’s more….
It’s Not Just a Preventive As
Good As It Is, Never Take It
When…
It also looks like taking the extract is
an excellent idea for people who have had
cancer in the past or are currently battling
cancer. However, this comes with one
caveat: Don’t take this extract if you’re get-
ting chemotherapy!
Ironically, arresting the growth of
cancer cells is about the last thing you want
to do if you’re on chemo. With chemo you
want the cancer cells’ growth rate to
increase, not decrease. Let me explain. same is also true for people getting radiation
All cells including cancer cells go therapy.
through a life cycle. The final part of this Helps Control Blood Sugar Too
cycle, which we call mitosis, is where the
cell divides into two daughter cells. And the One other potential problem to consid-
only time the cancer cell is vulnerable to er is that since d-mannoheptulose alters
chemotherapy is during mitosis — when the carbohydrate metabolism, it might also
cell is actually dividing. alter blood sugar levels in diabetics. So any-
So to make the tumor one with diabetes should be
most vulnerable to the sure to let their physician
chemo, you need to have They found that the know that they intend to
as many cells dividing at take the supplement. They
extract inhibited the may very likely find that
the time of the treatment. tumors cells’ ability
Anything that slows down their need for medication
the cells’ cycle (decreasing
to burn carbohydrates will decrease – a good prob-
the growth rate of the by as much as 75%. lem to have.
cancer) will cause a lower This forced the Currently, d-mannohep-
percentage of the cells cancer cells into tulose is available in two
to be in this vulnerable a fat-burning mode. different products. You can
stage. The result? As expect- easily find it in supplements.
That’s why taking a ed, the avocado extract However, these often will
substance like avocado contain other nutrients that
stopped the growth rate
extract, which slows down are designed for fat loss.
of the cancer cells. This makes complete sense.
cell growth, will make a
cancer more resistant to Since the effect of d-manno-
chemotherapy and radia- heptulose is to increase fat
tion. So be sure not to take anything that metabolism, this is great for those who need
slows down cancer growth while you’re to drop some weight.
actively getting cancer treatment. It will If you don’t need to lose weight, look
interfere with it. for an avocado extract powder. These prod-
Of course, once the course of treat- ucts will work for most people. My only
ment is over, then it makes complete sense complaint with them is that they don’t
to take d-mannopheptulose both as a pre- always list exactly how much d-mannohep-
ventive, and just in case some cancer tulose is contained in the powder. If you buy
remains. It just might slow the growth some that doesn’t have the amount listed,
rate down to the point that it stops growing contact the manufacturer and ask. You
altogether. should be able to find their contact informa-
tion on the Internet. Q
One final note on chemotherapy treat-
ments: While the avocado extract will slow References:
down tumor growth, there is an easy way to Board, Mary, Alison Colquhoun and Eric A. Newsholme, “High
make a tumor grow. All you need to do is Km Glucose-phosphorylating (Glucokinase) Activities in a
Range of Tumor Cell Lines and Inhibition of Rates of Tumor
take antioxidants. They speed up the growth Growth by the Specific Enzyme Inhibitor Mannoheptulose.”
rate of cancers. And by doing this, they Cancer Research, 55, 3278-3285, August 1, 1995.
make them much more sensitive to the Lu, Q.Y., et al. “Inhibition of prostate cancer cell growth by an
killing effects of chemotherapy. avocado extract: role of lipid-soluble bioactive substances.”
Journal of Nutritional Biochemistry, 2005;16(1):23-30.
So patients who are getting chemother-
apy are well advised to take a healthy dose of
antioxidants during their treatment. The

—7—
 LETTERS TO THE
Q. I have heard about the success of
Goji Juice. What is your opinion? —
Wes V.K., via e-mail
Dear Wes,
Gogi juice is another one of the “Super
Juices” that are so widely promoted these
days by multi-level marketing companies. I
would like to believe that these juices were
more than just a very nutritional form of
snake oil. But, unfortunately, they have no
nutritional value over just eating healthy
foods. And they’re much more expensive.
Additionally, there are no reputable
clinical trials proving that they do what the
sellers say they can do. That being said, I
will tell you what I tell all my patients when
asked this sort of question. Try it out, and
let me know what happens. If it works,
email me and let me know. So far I have not
had one patient get back to me.
Q. I have a slight neuropathy in my
feet from too much sugar. I’m control-
ling the sugar content in my diet. What
supplements are good for helping the
sugar levels in my blood? What can
help to regenerate the nerves to
reverse the neuropathy? — Dave W., via
e-mail
Dear Dave,
The one nutrient that immediately
comes to my mind is alpha lipoic acid (ALA).
ALA is very effective at controlling blood
sugar, as well as preventing and even revers-
ing neuropathy.
Make sure that your glycohemoglobin
(also known as hemoglobin-A1c) is below
5.8%. To do this, make sure your diet is
perfect, and take 300 mg of ALA every eight
hours. Please read my book, The Type 2
Diabetes Breakthrough, which you can buy
at all the major bookstores. Everything you
need to know about controlling blood sugar
naturally is in that book.
Finally, you should consider taking the
synthetic, fat-soluble form of vitamin B1
—8—
EDITOR
called benfotiamine. You can buy it a
www.benfotiamine.net. I recommend you
take 150 mg every eight hours.
Q. I recently fell on my shoulder and
it continues to hurt. I would appreci-
ate your thoughts on how to overcome
the inflammation that just does not
end. — Greg O., via e-mail
Dear Greg,
The best way to treat these problems is
to have the shoulder joint and/or the
inflamed ligaments or tendons injected with
a combination of vitamin B12, folic acid,
procaine, a homeopathic mixture called
Traumeel, and ozone. You can find a list of
doctors I have trained to do this at
www.oxygenhealingtherapies.com.
If your doctor is interested in learning
this marvelous technique, have him/her
check out my next course at
www.ozonecourse.com.
Other than that, the best thing you can
do on your own besides rest and physical
therapy is to try taking an extract of the
herb boswellia. Boswellia reduces inflamma-
tion in both osteoarthritis and rheumatoid
arthritis, inflammatory bowel disease, and
other autoimmune conditions. It does this
by blocking the pro-inflammatory enzyme 5-
lipoxygenase, also known as 5-LOX. It's sim-
ilar to some anti-inflammatory drugs in this
way, although it has none of the side effects.
Start off with 200 mg every eight hours.
Then increase your dosage up to a maxi-
mum of 400 mg as needed.
Got a Question?
Do you have a question for Dr.
Shallenberger? If so, please send it (typed
only) to him c/o Soundview Publications,
P.O. Box 467939, Atlanta, GA 31146-7939 or
feedback@RealCuresLetter.com. While he
won’t be able to respond personally, he’ll try
to answer as many questions as he can in
these pages.