Science News. Magazine of the Society for Science & the Public.

Print Edition: November 17, 2012; Vol. 182 #10

Cancer cells executed by magnet Metal nanoparticles trigger cell's own death machinery
By Rachel Ehrenberg Evil geniuses, commence drooling. Scientists have figured out how to remotely control a cells self-destruction. Magnets that guide the behavior of tiny metal beads can be used to flip on a cells death switch, kick-starting the cells demolition. The approach might one day be us ed to kill cancer cells or orchestrate other cellular events without drugs or incisions. In the past, scientists have explored killing cancer using tiny ironcontaining nanoparticles that latch onto malignant cells and heat up when exposed to a magnetic field. In the new work, a bit of protein guides each nanoparticle to death receptor 4, an aptly named handle on the outside of a cell that acts as a molecular doomsday switch. Exposing the cells to a magnetic field makes the nanoparticles clump together. This clumping pulls together the three molecular prongs that make up the switch, activating it and triggering a process that leads to the cells demise. The scientists from Yonsei University in South Korea tried the approach with a dish of colon cancer cells. Within 24 hours, more than half of the cells exposed to the magnetic field were dead, the team reports online October 7 in Nature Materials. Theyve identified a major opportunity for magnetic nanoparticles, says bioengineer Andrew MacKay of the University of Southern California. This might be a new way to do really targeted therapeutics. Figuring out how to target only particular cells is an ongoing problem, though. Death receptor 4 sits on normal cells too, which can also be destroyed via remote-controlled magnetism. When the researchers tested their approach on developing zebra fish, the tails of the exposed fish developed a kink where cells were killed off in a particular area. not yet clear whether the magnetic field could be directed with such finesse and specificity that it would kill only tumor cells and not

nearby healthy cells. Many cancer cells become resistant and responding to the protein that normally hits the death switch; such also might not respond to the magnetic nanoparticle version, Courtney Broaddus, a doctor at the University of California, Francisco who investigates resistance in cancer cells.

stop cells says San

But its very intriguing, the potential applications of this technology for remote controlling activities at the cell membrane, she says. The researchers are now working on extending the concept to switches on other cells, such as those that stimulate blood vessel growth, says chemist and team member Jinwoo Cheon. Pgina: http://www.sciencenews.org Link:http://www.sciencenews.org/view/generic/id/345663/description/C ancer_cells_executed_by_magnet Justificacin:
Esta noticia trata sobre una nueva forma de eliminar clulas cancergenas, como sabemos mltiples organizaciones estn intentando encontrar una manera de disminuir la prevalencia del cncer y eliminarlo. Los tratamientos ms utilizados son las radioterapias y quimioterapias (ya sea con productos sintticos o productos fitoqumicos).

Ah escrbele otra cosa de patologa as que suene pro, yo ya no s que escribirle...tu leela y ya relacinalo. Te amo cielo, quisiera que leyers ms cosas as, porque es muy importante para tu crecimiento profesional, no te quejes de tareas as, porque tienen mucho sentido.