BIO ZOOLOGY CHATPER 4 MODERN GENETICS OBJECTIVE TYPE QUESTIONS

1. Colchicine stops mitosis at a. prophase b. metaphase c. anaphase d. telophase

2. For Karyotyping cells are subjected to ----------- solution a. isotonic b. hypertonic c. hypotonic d. concentrated

3. In karyotyping of human chromosome, many groups are classified based on the centromere position a. 5 b. 6 c. 7 d. 10

4. In karyotyping of human chromosome, which group exclusively contain metacentric a. Group A b. Group B c. Group C d. Group D

5. In karyotyping of human chromosome, which one of the following group is considered as largest group a. Group A b. Group B c. Group C d. Group D

6. In karyotyping of human chromosome, which group contain x chromosome a. Group A b. Group B c. Group C d. Group D

7. In karyotyping of human chromosome, x chromosome resemble ----- chromosome a. 5 b. 6 c. Y d. 3

8. In karyotyping of human chromosome, which group contain only 2 chromosome of submetacentric a. B b. C c. D d. E

9. In karyotyping of human chromosome, which group contain only 2 chromosome of shorter metacentric a. F b. E c. D d. C

10. In karyotyping of human chromosome, which group contain only short acrocentric chromosome a. Group E b. Group F c. Group G d. Group C

11. Y chromosome belongs to the group a. Group E b. Group F c. Group G d. Group C

12. The existence of mobile genetic elements were visualized by a. Waldeyer 13. Vehicle DNA is b. Johanson c. Barbara Meclintock d. Bridges

a. Vectors

b. endonucleases

c. foreign DNA

d. restriction endonucleases

14. Palindrome sequences recognized by a. ligase 15. EcoR1 is a a. ligase b. exo nucleases c. endo nucleases d. restriction endonucleases b. exo nucleases c. endo nucleases d. restriction endonucleases

16. The recombination of foreign DNA with plasmid DNA done by a. ligase b. exo nucleases c. endo nucleases d. restriction endonucleases

17. The first gene was cloned in a. 1980 b. 1973 c. 1999 d. 1978

18. The first gene was cloned by a. Watson and Crik b. Johanson c. Barbara Meclintock d. Hebert Bayer and Stanely cohen

19. In human beings, more than ----------- hereditary diseases have been indentified a. 200 b 300 c. 100 d. 400 20. Which one of the following genotype suffer from a fatal haemolytic anaemia a. Hba Hba b Hbs Hbs c. Hba Hbs d. Hbs Hba 21. Which one of the following hereditary disease cause damaged heart, kidney, spleen and brain.
a. Sickle

cell anaemia b. Thalassemia

c. Agammaglobulinemia

d. Albinism

22. In Sickle cell anaemia , genotype of carrier is a. Hba Hba b Hbs Hbs c. Hba Hbs 23. Erythroblastic anaemia is
a. Sickle

d. Hbx Hby

cell anaemia

b. Thalassemia

c. Agammaglobulinemia

d. Albinism

24. Peripheral haemolysis is the charateristic symptom of

a. Sickle

cell anaemia

b. Thalassemia

c. Agammaglobulinemia

d. Albinism

25. Splenomegaly and hepatomegaly is the charateristic symptom of

a. Sickle

cell anaemia

b. Thalassemia

c. Agammaglobulinemia

d. Albinism

26. Which one of the following is recessive gene disease

a. Sickle

cell anaemia

b. Thalassemia

c. Agammaglobulinemia

d. Albinism

27. Agammaglobulinemia mostly affects,

a. Boys

b. Womens

c. Elders

d. Babies

28. Failure in r-globulin synthesis resulting,

a. Sickle

cell anaemia

b. Thalassemia

c. Agammaglobulinemia

d. Albinism

29. The incidence of albinism in human is a. 1:5000 to 1:2500 b. 1:500 to 1:25000 c. 1:1000 to 1: 5000 d. 1:2000 to 1:2500

30. Disease caused by an autosomal dominant gene is

a. SCID b. Thalassemia c. Huntingtons

chorea

d. Albinism

31. Onset of Huntingtons chorea is between ------------ years a. 35-40 b. 12-15 c. 18-25 d. above 60

32. In Huntingtons chorea the affected gene located in ----------- chromosome a. 5 b. 4 c. Y d. 3

33. Which one of the following disease characterized by uncontrolled jerking of the body
a. SCID b. Thalassemia c. Huntingtons

chorea

d. Albinism

34. ADA gene located in ----------- chromosome a. 7 b. 20 c. X d. Y

35. Which one of the following hereditary disease is called extremely rare
a. SCID b. Thalassemia c. Huntingtons

chorea d. Albinism

36. Bubble Boy Syndrome,

a. SCID b. Thalassemia c. Huntingtons

chorea d. Albinism

37. Huntingtons chorea is the a. Incurable disease b. cured by bone marrow transplant c. prevented by vaccine d.cured by WBC transplant 38. In HGP total number of genes identified by sequencing the genome are, a. 25000 b.30000 c.50000 d. 5000

39. Total number of different m-RNA identified so far is, a. 25000 b.60000 c.50000 d. 75000

40. Nuclear transplantation developed by, a. R.Briggs and T.King b. Dr. Ian Wilmut c.Bridges d.Anand Mohan chakrabarty

BIO ZOOLOGY CHATPER 4 MODERN GENETICS OBJECTIVE TYPE QUESTIONS

1. Colchicine stops mitosis at b. prophase b. metaphase c. anaphase d. telophase

2. For Karyotyping cells are subjected to ----------- solution b. isotonic b. hypertonic c. hypotonic d. concentrated

3. In karyotyping of human chromosome, many groups are classified based on the centromere position b. 5 b. 6 c. 7 d. 10

4. In karyotyping of human chromosome, which group exclusively contain metacentric b. Group A b. Group B c. Group C d. Group D

5. In karyotyping of human chromosome, which one of the following group is considered as largest group b. Group A b. Group B c. Group C d. Group D

6. In karyotyping of human chromosome, which group contain x chromosome a. Group A b. Group B c. Group C d. Group D

7. In karyotyping of human chromosome, x chromosome resemble ----- chromosome a. 5 b. 6 c. Y d. 3

8. In karyotyping of human chromosome, which group contain only 2 chromosome of submetacentric a. B b. C c. D d. E

9. In karyotyping of human chromosome, which group contain only 2 chromosome of shorter metacentric a. F b. E c. D d. C

10. In karyotyping of human chromosome, which group contain only short acrocentric chromosome a. Group E b. Group F c. Group G d. Group C

11. Y chromosome belongs to the group a. Group E b. Group F c. Group G d. Group C

12. The existence of mobile genetic elements were visualized by a. Waldeyer 13. Vehicle DNA is a. Vectors b. endonucleases c. foreign DNA d. restriction endonucleases b. Johanson c. Barbara Meclintock d. Bridges

14. Palindrome sequences recognized by a. ligase 15. EcoR1 is a a. ligase b. exo nucleases c. endo nucleases d. restriction endonucleases b. exo nucleases c. endo nucleases d. restriction endonucleases

16. The recombination of foreign DNA with plasmid DNA done by a. ligase b. exo nucleases c. endo nucleases d. restriction endonucleases

17. The first gene was cloned in a. 1980 b. 1973 c. 1999 d. 1978

18. The first gene was cloned by a. Watson and Crik b. Johanson c. Barbara Meclintock d. Hebert Bayer and Stanely cohen

19. In human beings, more than ----------- hereditary diseases have been indentified a. 200 b 300 c. 100 d. 400 20. Which one of the following genotype suffer from a fatal haemolytic anaemia a. Hba Hba b Hbs Hbs c. Hba Hbs d. Hbs Hba 21. Which one of the following hereditary disease cause damaged heart, kidney, spleen and brain.
a. Sickle

cell anaemia

b. Thalassemia c. Agammaglobulinemia

d. Albinism

22. In Sickle cell anaemia , genotype of carrier is a. Hba Hba b Hbs Hbs c. Hba Hbs

d. Hbx Hby

23. Erythroblastic anaemia is

a. Sickle

cell anaemia

b. Thalassemia c. Agammaglobulinemia

d. Albinism

24. Peripheral haemolysis is the charateristic symptom of

a. Sickle

cell anaemia

b. Thalassemia c. Agammaglobulinemia

d. Albinism

25. Splenomegaly and hepatomegaly is the charateristic symptom of

a. Sickle

cell anaemia

b. Thalassemia c. Agammaglobulinemia

d. Albinism

26. Which one of the following is recessive gene disease

a. Sickle

cell anaemia

b. Thalassemia

c. Agammaglobulinemia

d. Albinism

27. Agammaglobulinemia mostly affects, a. Boys b. Womens c. Elders d. Babies

28. Failure in r-globulin synthesis resulting,

a. Sickle

cell anaemia

b. Thalassemia

c. Agammaglobulinemia

d. Albinism

29. The incidence of albinism in human is a. 1:5000 to 1:2500 b. 1:500 to 1:25000 c. 1:1000 to 1: 5000 d. 1:2000 to 1:2500

30. Disease caused by an autosomal dominant gene is

a. SCID b. Thalassemia c. Huntingtons

chorea d. Albinism

31. Onset of Huntingtons chorea is between ------------ years a. 35-40 b. 12-15 c. 18-25 d. above 60

32. In Huntingtons chorea the affected gene located in ----------- chromosome a. 5 b. 4 c. Y d. 3

33. Which one of the following disease characterized by uncontrolled jerking of the body
a. SCID b. Thalassemia c. Huntingtons

chorea d. Albinism

34. ADA gene located in ----------- chromosome a. 7 b. 20 c. X d. Y

35. Which one of the following hereditary disease is called extremely rare
a. SCID b. Thalassemia c. Huntingtons

chorea d. Albinism

36. Bubble Boy Syndrome,

a. SCID

b. Thalassemia

c. Huntingtons

chorea d. Albinism

37. Huntingtons chorea is the a. Incurable disease b. cured by bone marrow transplant c. prevented by vaccine d.cured by WBC transplant 38. In HGP total number of genes identified by sequencing the genome are, a. 25000 b.30000 c.50000 d. 5000

39. Total number of different m-RNA identified so far is, a. 25000 b.60000 c.50000 d. 75000

40. Nuclear transplantation developed by, a. R.Briggs and T.King b. Dr. Ian Wilmut c.Bridges d.Anand Mohan chakrabarty