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Dr. Sidney Schnoll
(Expert in Pharmacology, Neurology, Psychiatry; Addiction Medicine Specialist)
Plaintiffs' Expert Witness.
Direct examination by Michael Koskoff:
Q. Dr. Schnoll, can you tell us where it is that you reside?
A. I reside? Westport, Connecticut.
Q. And where were you born?
A. Newark, New Jersey.
Q. Now, following your undergraduate education -- by the way, where did you go to college?
A. Well, you have to -- you have to write a grant that you submit to the n.I.H. It is reviewed by
a committee of peers who then decide whether or not it should be funded. And so it's not
something that you just get automatically.
Q. So you had to apply for it and you got special funding to do this -- this program and
fellowship, special fellowship?
A. Yes. That was for my Ph.D. work.
Q. That was for your Ph.D. And then after that, did you get -- have any further fellowships?
A. Yes. I had what's called a career teacher fellowship, also from n.I.H. That was from
national institute on alcoholism and alcohol abuse, and that career teacher fellowship was to
study addiction further. The purpose of that particular fellowship was to try and get a faculty
member in every medical school in the country who had expertise in addiction.
Q. Why was it that the -- they were trying to get faculty members in every university to have
specialization in addiction?
A. Well, the feeling was that there weren't enough people who understood the problems of
addiction and how to treat it, how to diagnose it. And by getting a faculty member into the
medical school, then it was possible to teach medical students how to do this. But without a
trained faculty member, it would be very difficult to teach the medical students.
Q. Then after that second fellowship was completed, you had your m.D., you had your ph.D.,
you had two fellowships, time to get a job?
A. Well, yes. Those fellowships did not pay very well.
Q. And did you then go on to -- what did you do after completing those fellowships?
A. I became medical director at a hospital that specialized in the treatment of addictive
diseases.
Q. And what was that hospital?
A. Eagleville hospital and rehabilitation center.
Q. And what -- what kinds of patients did you -- you said you became medical director of the
hospital?
A. Yes.
Q. And what kinds of patients did they take at Eagleville?
A. Eagleville took all kinds of patients. A -- a large number of the patients we treated were
people who came directly from the prison or were placed there by the courts.
Q. And are these people who had addiction disorders?
A. Yes.
Q. And what kinds of drugs did they have addiction -- were they addicted to?
A. I guess probably 40 to 50 percent of the people had alcohol problems. There was -- the
rest had various drugs; cocaine, heroin, benzodiazepines. I mean, just about everything, we
saw there.
Q. We've heard a little bit about benzodiazepines in the trial so far, and I think the jury
probably all knows now about lorazepam and midazolam and diazepam and all those. But
what, generally, do these drugs do?
A. The benzodiazepines are sedatives, they calm down the central nervous system. Also,
they treat seizure disorders. They're used to help people to sleep. Those are the main -- main
uses of the benzodiazepines.
Q. And are these drugs that are in common usage throughout society?
A. Yes, yes, they're very --
Q one of the most commonly used kind of pharmaceuticals?
A. They're very widely prescribed drugs, yes.
Q. And can people become addicted to them?
A. Yes.
Q. And can people become dependent on them?
A. Yes.
Q. We're going to talk about these two words in a few minutes, but -- now, in addition -- after
eagle --
A. Eagleville.
Q. -- Eagleville -- how long did you remain at Eagleville, approximately?
A. I was there for four years.
Q. And then what did you do?
A. Then I accepted a faculty position at Northwestern University Medical School.
Q. And so -- and what was that faculty position you took at northwestern at that time?
A. I was an associate professor of Psychiatry, and later got a joint appointment in the
department of Pharmacology.
Q. Okay. Now, you are not a psychiatrist; is that correct?
A. That is correct.
Q. But you can teach in -- in the school of Psychiatry?
A. In the department. It's a department within the medical school.
Q. And, also, by the way, did you work as a medical director in the health free clinic in
philadelphia?
A. Yes. That was before I went to Chicago.
Q. Okay. And you were medical director there?
A. Yes.
Q. What was the health -- what is the health free clinic?
A. It was a free medical clinic in the central part of Philadelphia that treated people with drug
and alcohol problems. But it -- the whole purpose was to provide free care.
Q. Did you get paid for that position?
A. No.
Q. And were you there for 11 years as Medical Director?
A. Yes.
Q. Did you also work with the -- at the Wilmington Veterans Administration Hospital?
A. Yes.
Q. What did you do there?
A. I was one of the Neurology attendings there, and also ran their drug abuse program.
Q. And did the -- did you also have a teaching appointment at the University of
Pennsylvania?
A. Yes, when I was in my career teacher fellowship, the one I mentioned after the first
fellowship, that's when I had an appointment assistant professor at the university of
pennsylvania medical school.
Q. And was that in the field of Pharmacology?
Q. And you also had an appointment, you said, in Psychiatry. Did you teach psychiatrists
about --
A. Yes.
Q. -- drug abuse, as well?
A. Yes.
Q. And did you remain at the University of Virginia Medical College?
A. As the faculty there would say, it's not the University of Virginia, it's Virginia commonwealth
university. We're the ones who went to the basketball semifinals a couple of years ago. So
differentiate.
Q. Important point.
A. Yes.
Q. And did you remain there for some period of time?
A. Yes. I was there almost 15 years.
Q. And then after that, where did you go?
A. After that, I took a position at Purdue Pharma.
Q. And that's what brought you to Connecticut, is Purdue Pharma of Connecticut
corporation?
A. Purdue Pharma is in Stanford, Connecticut; and that's what brought me to Connecticut.
Q. And at Purdue Pharma, what was your position there?
A. My job there was to develop the risk management program for one of their drugs because
of problems of abuse with the drug.
Q. Had there been problems related to one of their drugs that they asked you to come in and
work on?
A. Yes. They asked me to come in and develop the program to try to understand more the
problems with abuse, how to address them. That's what a risk management program does.
Q. And then did there come a time when you left there?
A. Yes. I was there four years, and then I left Purdue Pharma.
Q. And where did you go after Purdue Pharma?
Q. And can you say approximately how many patients' lives you intersected with over those
34 --
A. Over that time, probably tens of thousands of patients I've seen.
Q. Did you become familiar with the methods in treating drug addiction?
A. Yes.
Q. And with the diagnosis of drug addiction?
A. Yes.
Q. Now, in addition to the various faculty positions and educational backgrounds that you
have, do you -- have you also had occasion to consult for various entities, private entities,
outside of the university setting?
A. Yes.
Q. Okay. The -- have you served as a consultant to the national football league association?
A. Yes.
Q. Have you served -- now, there's a -- there's a --
A. It's the national football players Association.
Q. National Football Players Association?
A. Yes.
Q. They're the ones who hired you?
A. Yes.
Q. Okay. And have you also -- I'm going to ask you a little bit more about this later, but
worked with a group called -- let me see if I can get the title right -- the Chicago National
League Franchise? Is that the right title for the group I'm referring to?
A. That's the right title, but it's more commonly known as the Chicago Cubs.
Q. The Chicago Cubs?
A yes. But that's not its official name.
Q. Its official name is Chicago National Franchise whatever?
A. Yeah.
Q. I'm going to ask you a little bit more about that a little later. And have you also had
occasion to publish in the learned journals concerning addiction over the years?
A. Yes.
Q. And I'm certainly not going to read all your publications, but have you served on editorial
boards for many publications?
A. Yes.
Q. Have you had -- have you served as an editor for the Journal of Addiction Medicine?
A. Yes.
Q. The Journal of Maintenance in Addiction?
A. Yes.
Q. The American Journal of Drug and Alcohol Abuse?
A. Yes.
Q. The Addiction Medicine Education Series?
A. Yes.
Q. The Journal of Addicted Diseases?
A. Yes.
Q. The Journal of Psychoactive Drugs?
A. Yes.
Q. Substance abuse -- a journal called "Substance Abuse"?
A. Yes.
Q. And "Medical Monograph Series and Contemporary Drug Problems." Are those all
publications that you have been -- served as an editor for?
A. Those are all publications for which I've served on the editorial board, yes.
Q. And have you also published 116 articles now in various learned journals?
A. Yes, those are the articles I've published in peer-reviewed journals.
Q. Peer-reviewed journals. And do those include the Journal of the American Medical
Association?
A. Yes.
Q. And Archives of Internal Medicine?
A. Yes.
Q. And the New England Journal of Medicine?
A. Yes.
Q. And have you also written chapters in textbooks?
A. Yes.
Q. Do you know approximately how many?
A. About 40 some odd chapters at this point.
Q. And is that all in the field of addiction?
A. Not all, but the overwhelming majority is in the field of addiction.
Q. What other areas do you go into where it's not completely addiction? Is it Pharmacology?
A. Well, the first few publications I had while I was a medical student were in immunology. I
was studying with a very famous biochemist who discovered the Rheumatoid factor, so --
Q. Discovered the Rheumatoid factor?
A. Yes.
Q. And so you thought you might go into that area, and then you decided to go into addiction
medicine?
A. Yes.
Q. Have you -- and you have chapters now that are waiting for publication?
A. Yes, there are two chapters that are waiting for publication.
Q. And are these in the field of addiction medicine?
A. Yes.
Q. Now, in the course of your work -- by the way, and you stopped seeing patients when?
Approximately when?
A. 2001.
testify?
A. That's correct.
Q. Now, one of the things that we discussed a little bit earlier is that you did have an occasion
to work for this national league franchise the chicago cubs. And tell me a little bit about why it
is, what brought you to work for the chicago cubs. What -- and when was it, approximately?
A. That, I think started in 1982. And that was at a time when major league baseball was
becoming quite concerned about drug use in baseball players, and they sent out a memo to
every team requesting that each team have somebody on board to address issues of drug
abuse in the baseball players.
Q. And when you got to the Chicago Cubs, can you tell us in terms of drug abuse what kind
of a condition was it that you saw there?
A. Well, I was -- I was actually quite concerned my first day that I arrived there. I went into the
training room where the players go to get rubdowns, take care of any problems they have,
and right on the counter in the training room was a bottle of amphetamine pills which the
ballplayers called greenies because they were green in color. And it was right there for the
players to take at any time they wanted it. And, also, they had a beer tap right in the
clubhouse, so the players could just go in and pull the lever and get their beer.
Q. I can swear I just saw Mr. Panish signal that what's wrong with that, but I'm sure he didn't
say that. So was there something that concerned you when you arrived as an addiction
specialist?
Ms. Cahan: Objection; relevance.
Judge: Overruled.
A I was -- I was quite concerned and said that if I'm going to be an addiction specialist with
you and treat these problems, that was inappropriate to have available.
Q. And did a drug-monitoring -- did you start a drug-monitoring and testing program at that
point?
A. Yes.
Q. And can you tell me what was the -- what happened with that drug-monitoring and testing
program? Was that later --
A. Well, that was --
Q. What was the destiny of that program?
A. Well, that became the model program for Major League Baseball at that time.
Dr. Earley?
A. Dr. Hurly? That name is not familiar.
Q. Paul Earley?
A. Oh, Earley. I thought you said hurly. I'm sorry.
Q. No, no. Earley.
A. I misunderstood you. I'm sorry.
Q. Yes.
A. No. I -- yes, I -- I reviewed Dr. Earley's, but that -- I didn't know a Dr. Hurly. I'm sorry.
Q. Okay. And you know -- you know who Dr. Earley is, as well, right?
A. Yes, I know him.
Q. You've served on committees with him?
A. Yes.
Q. And did you review testimony by a Dr. Levounis?
A. Yes.
Q. And did you also review all of the documents that they reviewed?
A. Yes.
Ms. Cahan: Objection; calls for speculation.
Mr. Koskoff: It's not speculation. They have been listed, the documents were attached
to the deposition.
Ms. Cahan: The documents that they relied upon were identified at their depositions;
but not everything they reviewed, your honor, so this necessarily calls for speculation.
Mr. Koskoff: I will amend the question.
Q. Did you review all of the documents they relied upon as stated in the list attached to their
deposition?
A yes.
Q. And do you -- now, we have been -- I think we've used the term "addiction" in sort of a
broad sense to refer to people who have drug problems. Can you tell me what -- from a point
of view of a -- of a specialist in the field of addiction medicine, is there any distinction between
the words "addiction" and "dependence"?
A. Yes.
Q. Okay. So first let's talk about what is drug dependence?
A. Drug dependence is the pharmacologic effect of a drug to the point where if you take it
continuously and suddenly stop taking it, you will go through a withdrawal syndrome. And in
addition, if you continue to take it, you will develop tolerance to some of the effects of the
drug.
Q. So let me first ask you about the word "tolerance." what is tolerance to a drug?
A. Tolerance is the need to take more of the drug in order to get the desired effect of the
drug.
Q. And when you said -- and so is tolerance, then, one of the factors that enters into drug
dependence?
A. Yes. Tolerance and withdrawal are the two key factors in drug dependence.
Q. And what is withdrawal? What does that refer to?
A. Withdrawal, when you take certain drugs, if you suddenly stop the drug, you go through a
characteristic withdrawal syndrome, which is some symptoms that usually are opposite of the
effect of the drug. So an example. Opioids normally cause constipation; so when somebody
goes into withdrawal, they'll have diarrhea. So that's an example.
Q. So the withdrawal tends to be the opposite of the effect that the drug has, then?
A. That's -- that's typically. It's not 100 percent, but that's typically what happens.
Q. And for how long -- question withdrawn. Can you tell me whether or not people who are
undergoing treatment, proper treatment, can become drug dependent?
A. Yes.
Q. And is that something that has -- that you have -- that is commonly experienced?
A. Yes.
Q. For how long can a person remain drug-dependent under the care of a physician and
function normally?
A. They could maintain that for the remainder of their life if they needed the medication and it
was properly prescribed to them.
Q. And on some occasions, do people become drug-dependent and not function normally?
A. Yes.
Q. And what -- what causes that?
A. Well, that can be prescribing too much to the individual. Sometimes prescribing too little
can cause that, also.
Q. And even -- we're still talking just about dependence, not addiction. But even if a person is
not a drug addict, can withdrawal from drugs sometimes be difficult?
A. Yes.
Q. Can it -- does it require any special expertise to -- to manage that?
A. Yes.
Q. And does it require any particular work on behalf of the person undergoing withdrawal to
get out of the dependence sometimes?
Ms. Cahan: Objection; vague.
Judge: It is a little vague. What do you mean, "work"?
Mr. Koskoff: Yeah.
Q. What is required, if anything, about the person who is undergoing withdrawal? What kind
of a commitment do they have to make?
Judge: To what?
Mr. Koskoff: To get through a withdrawal.
The witness: They have to be willing to come off of the drug in order to go through the
withdrawal.
Q. And can that -- is that something that happens in a very short time or can it take a long
time?
A. It depends on the drug, it depends on the amount of time the person has taken the drug,
and it depends on the individual characteristics of that person. So there are a number of
factors that are involved in doing this, so I -- it's not everybody does it in three days or five
days. It's a very individualized kind of thing.
Q. And are there people who have a specialty in helping people through withdrawal?
A. Well, addiction specialists, the people in addiction medicine, are hopefully all trained in
doing that properly.
Q. Now, we've talked a little bit about dependency. Now, what is addiction?
A. Addiction is a chronic disease that's characterized by craving, compulsive use of a drug,
continued use despite evidence of harm.
Q. And what is the -- do the people who are addicted take a drug for a purpose other than
relief of their symptoms?
A. Well, they might take the drug for relief of withdrawal; but they're not taking the drug for,
say, relief of pain or relief of some other underlying disorder that is being appropriately treated
by that drug.
Q. And is there often -- what types of behaviors are associated with addiction?
Ms. Cahan: Objection; vague.
Judge: What kind of behaviors?
Mr. Koskoff: Yes.
Judge: Overruled.
A. Well, people will display what we call drug-seeking behavior. They will try to get the drug at
any cost, so they may go to people on the street to buy the drug, they may commit crimes in
order to get the money to purchase the drug. They will -- as I mentioned, the continued use of
the drug leads to problems so that they may ignore family, jobs, schoolwork, things of that sort
in order to continue to take and use the drugs.
Q. And is there a stigma associated with this sort of behavior?
A. Unfortunately, society has created stigma for that, yes.
Q. And can you tell me whether or not addiction is considered a disease?
A. Yes, it is.
Q. If it's a disease, what is the primary factor that causes the disease, or that leads to the
disease?
A. Well, the primary factor is usually genetics.
person's behaviors around the use of that drug, how do they deal with the drug. For instance,
if you reviewed the drug -- using pain as an example, if you prescribe the drug for pain,
usually what we do is look at a zero to ten scale, zero being the absence of pain, ten being
the most severe pain the person can imagine. So what you do is you titrate the drug to the
level that that person says, "I'm now getting relief."
Q. What's the word titrate mean?
A. Titrate means adjust the dose of the drug to get the appropriate level needed for that
person.
Q. Okay. Now, that -- that -- now, how do you -- so that's -- now you're talking about what you
do to treat a patient; is that right?
A. Well, but this is -- say a person comes to me and they are -- somebody says, well, this
person is in pain, I think they're abusing their drugs, they're an addict. Let me, maybe, step
back and give a simpler example. This is actually a case that I had of a young woman who
was sent to me who had severe headaches. And she kept on asking her physicians for more
and more pain medication; and they said, "This is too much. She's an addict, she's abusing
these medications." well, when she came to me, I took her off of all of her medication and I
had her fill out a pain diary where she kept track of every day exactly when she felt the pain,
when she didn't feel the pain. Also, what she was doing. Was she working? Was she eating?
Was she sleeping? All of the things she was doing. And when I looked at her pain diary,
something jumped right out at me. And what jumped out at me was, one, she always had her
headaches at about 4:00 o'clock every day, except weekends. The other thing I noticed when
I carefully looked at her pain diary, she never ate lunch when she was at work during the
week, but she ate lunch on weekends. And so I said to her, "I think your headaches are due to
hypoglycemia, low blood sugar, that's causing your headache." and she said, "No, that's --
that can't be it." and so I said, "Let's do a glucose tolerance test; and I want you, as the test is
going on, to say whether or not you have a headache." and in a glucose tolerance test, the
blood sugar goes up, and then it goes down, and her headaches came on as the blood sugar
went down. The solution to her headaches was to eat three meals a day, and she had no
more headaches and didn't need any more drugs.
Q. She didn't ask for narcotic drugs any more?
A. No, no. She needed no more narcotics after that. Her pain was appropriately treated. And
so that's what I'm saying. You -- often it takes time and effort to determine what the underlying
cause of a person's pain mror whatever symptoms they're having, sleep disorders or
whatever, in order to get the proper treatment for that person.
Judge: Why don't we stop right here. Okay. I'm going to ask the ladies and gentlemen of the
jury to return at 10:00 o'clock tomorrow morning. Okay. Thank you. Goodnight. And you, too.
10:00 o'clock for you.
The witness: I'll be here.
(the following proceedings were held in open court, outside the presence of the
jurors):
Judge: Okay. Is Dr. Schnoll going all day tomorrow, or do you have somebody else?
Mr. Panish: I would think it's a safe assumption that he'll be for the day, he'll take up the day.
Mr. Koskoff: We are going to try to finish him tomorrow.
Judge: Is that right?
Ms. Cahan: Probably.
Judge: I just want to know so if there's somebody else, I can -- then I'll be prepared. All right.
See you tomorrow at 10:00.
Ms. Cahan: Thank you, your honor.
Court adjourned