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Poster number 1 (paper 70) 2 (paper 71) Poster Topic Spray zone demarcation in top-spray fluidised bed granulation by droplet detection methods Transfer of batch fluid bed granulation to a continuous process Case study Presenters M. Brner E. Tsotsas K. Germer1 M. Jacob2 M. Zenker2 G. Eckardt3 B. Wolf4 F.G. Melchiades1 L.R. Santos1,2 S. Nastri1 A.O. Boschi1,2 D. Smrka M. Schngut F. tpnek M. Khalilitehrani P.J. Abrahamsson A. Rasmuson I. Klimova1 V. Mikli2 T. Kaljuvee1 Z.M. Mirza1 C. Mangwandi1 G.M. Walker1,2 V. Oehl S. Wltje H. Falck D. Barling1,2 T. Leadbeater3 A. Ingram4 D.A.V. Morton2 J.P.K. Seville5 K. Hapgood1 Group
Otto-von-Guericke University, Magdeburg, Germany
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3 (paper 72)
Comparison between granules produced by spray drying and dry granulation for the fabrication of ceramic porcelain tiles
Use of reactive wetting as a tool for realtime monitoring of binder distribution during granulation The rheology of dense granular flows in a disc impeller high shear granulator Upgrading the crush strength of ammonium nitrate prills by coating with limestone or dolomite powder
Salutas Pharma GmbH, Germany 2 Glatt Ingenieurtechnik GmbH, Germany 3 Parsum GmbH, Germany 4 Anhalt University of Applied Sciences, Bernburg, Germany 1 Dept. de Eng. de Materiais, Universidade Federal de So Carlos, Brazil 2 Programa de Ps-Graduao em Cincia e Engenharia de Materiais, Universidade Federal de So Carlos, Brazil Institute of Chemical Technology Prague, Czech Republic Chalmers University of Technology, Gothenburg, Sweden
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Effect of impeller design on product homogeniety in high shear wet granulation Fluidized bed micro-encapsulation of probiotic microorganisms for animal feeding Analysis of the effect of impeller type and speed on the rate and quality of mixing in a high shear mixer
Tallinn University of Technology, Laboratory of Inorganic Materials, Estonia 2 Tallinn University of Technology, Centre of Materials Research, Estonia 1 Queen's University Belfast, Northern Ireland, UK 2 University of Limerick, Ireland
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Influence of viscous forces on collision dynamics in a fluidised bed granulator: A DEM-CFD study
Monash University, Australia Monash Institute of Pharmaceutical Sciences, Australia 3 School of Physics and Astronomy, University of Birmingham,U.K. 4 Department of Chemical Engineering, University of Birmingham, U.K. 5 University of Surrey, U.K. 1 Nestl Research Center Lausanne, Switzerland 2 Hamburg University of Technology, Germany
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University of Sheffield, UK Nestl Product Technology Center York, UK 3 Nestl Research Center, Lausanne Switzerland 4 Nestl SA Headquarters, Vevey, Switzerland
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Experimental and numerical investigations of a spout fluidized bed with draft plates
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Granulation of indomethacin and hydrophilic carrier by fluidized hot melt method: The drug solubility enhancement Continuum modeling of particle flows in high shear granulation
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A.P.M. Oliveira1 T.A. Cunha1 R.C. Serpa1 S.F. Taveira1 E.M. Lima1 L.A.P. Freitas2 R.N. Marreto1 Effect of type of lactose and J. Langridge microcrystalline cellulose combination E. Camelot-Nijman on recompaction R. Shegokar H. van Duinen M. Lindner Wettability study of glass beads bed by M. Benali capillary rise with pressure increase K. Saleh Measuring caking degree in cocoa E. Chvez Montes powders: A material science approach V. Girard J-C Gumy Comparison of the effect of ultrasound W.N. Al Nasser1 and an electronic anti fouling system on K. Pitt2 the aggregation and scaling behaviour of F.H. Al Salhi1 calcium carbonate by an inline technique A.M. Al Mofleh1 M.J. Hounslow2 A.D. Salman2 Improvement of enalapril maleate chemical stability by high shear melting granulation Blade - granule bed stress in a cylindrical high shear granulator: Further characterisation with DEM E.L. Chan1 G.K. Reynolds2 B. Gururajan3 M.J. Hounslow1 A.D. Salman1
Department of Chemical Engineering, Chalmers University of Technology, Gteborg, Sweden 2 Department of Applied Mechanics: Division of Fluid Dynamics, Chalmers University of Technology, Gteborg, Sweden 1 Federal University of Gois, Goinia, Brazil 2 University of So Paulo, Brazil
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University of Campinas - SP, Brazil 1 Institute of Chemical Technology, Prague, Czech Republic 2 Zentiva k.s. (a Sanofi company), Prague, Czech Republic
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Centre for Research in Metallurgy, Lige, Belgium 2 ArcelorMittal Ironmaking, Global R&D | Maizires Process, France 3 Institute of Chemical Technology Prague, Czech Republic 4 University of Lige, Belgium University of Sheffield, UK
Twin screw granulator: Effect of primary particle size Evaluating the solid surface free energy of amorphous maltodextrin A unit cell approach for extracting macroscopic coalescence and breakage kernels from DEM simulations
University of Sheffield, UK
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Investigation of the effect of Mg silicate addition on the powder physical properties of compacted metformin-HCl
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Envisioning the factory of the future: Case study on continuous granulation and tableting
I.S. Rashid1 K.A. Alkhamis2 H.A. Hassan1 T.H. Altalafha1 A.A. Badwan1 S. Kozhar1 S. Antonyuk1 S. Heinrich1 L. Gilson2 U. Brckel2 K. Schoeters
Department of Chemical Engineering, Purdue University, USA 2 Department of Mechanical Engineering, Purdue University, USA 3 Department of Industrial and Physical Pharmacy, Purdue University, USA 1 The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan 2 Jordan University of Science and Technology, Irbid, 22110, Jordan
Hamburg University of Technology, Germany 2 Institute for Micro-ProcessEngineering and Particle Technology, Birkenfeld, Germany GEA Pharma Systems, Wommelgem, Belgium
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L. Benelli C.R.F. Souza W.P. Oliveira Roller compaction/ comparison of C.S. Omar1 ribbon and granule properties using J.D. Osborne1 different types of lactose T. Althaus 2 S. Palzer2 M.J. Hounslow1 A.D. Salman1 A quality by design approach to N. Souihi1, 2 investigate the effect of mannitol and M. Dumarey1 dicalcium phosphate qualities on roll H. Wikstrm3 compaction P. Tajarobi3 M. Fransson3 O. Svensson3 M. Josefson3 J. Trygg1 Powder flow characterisation of N. Sandler1 pharmaceutical excipients: evaluation of B. Gururajan2 different techniques H. Ehlers1 M. Fransson2 L. Johnson2 P. Tajarobi2 In-line measurement of the agglomerate C. Aviles-Aviles1,2,3 size distribution in fluidized bed M. Terray4 agglomeration E. Dumoulin1,2,3 C. Turchiuli1,2,3 A combined experimental and modelling C.A. Kastner investigation of the impact of powder G.P.E. Brownbridge properties S. Mosbach M. Kraft A validated flowsheeting tool for the I.M. Cotabarren study of industrial granulation processes D.E. Bertn V. Bucal J. Pia Discrete Element Modelling of elastic M.F.H. Wolff 1 bending of ceramic-polymer beams V. Salikov1 generated by spouted bed spray S. Antonyuk1 granulation S. Heinrich1 G.A. Schneider2 Movement of secondary immiscible S.F. Islam1 liquid into a suspension of hydrophilic S. Whitehouse2 particles in a continuous hydrophobic R. Sundara2 phase T.O. Althaus2 S. Palzer3 M.J. Hounslow1 A.D. Salman1 A novel non-intrusive particle tracking J. Neuwirth1 measurement technique for dense S. Heinrich1 granular flows M. Jacob2
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Department of Chemistry, Ume University, Sweden 2 Industrial Doctoral School, Ume University, Sweden 3 AstraZeneca R&D Mlndal, Sweden
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AgroParisTech, Massy, France INRA, Massy, France 3 CNAM, Massy, France 4 Malvern Instruments SA, France University of Cambridge, United Kingdom
Institute of Solids Process Engineering and Particle Technology, Hamburg, Germany 2 Institute of Advanced Ceramics, Hamburg, Germany
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University of Sheffield, UK Nestl Product Technology Centre, York, UK 3 Nestl SA Headquarters, Vevey, Switzerland
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Dept. of Pharmaceutical and Pharmacological Sciences, Padova, Italy 2 Dept. of Industrial Engineering, Padova, Italy
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A combined experimental and computational analysis of the effect of powder and granule properties on tablet compaction characterisitics
Rutgers, The State University of New Jersey, USA 2 Institute of Chemical Technology, Prague, Czech Republic
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Development and evaluation of a novel pharmaceutical excipient by coprocessing of microcrystalline cellulose and magnesium silicate by roller compaction Agglomeration of particles in oilcontinuous suspensions driven by liquid bridges
University of Jordan, Amman, Jordan 2 The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan
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University Paris-Sud, Chtenay Malabry, France 2 Sanofi, Carbon Blanc Cedex, France
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Experimental and numerical investigation on the compression behaviour of tetrahedral agglomerates Stochastic Modelling of fluidised bed spray agglomeration tracking particle structure Influence of internal structure parameters and additives on the mechanical properties of spray dried granules Granulation of ultra-fine powders: tracking changes in granular microstructure using XRCT
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Otto-von-Guericke University, NaWiTec, Magdeburg, Germany 2 IPT Pergande GmbH, Germany 3 Otto-von-Guericke University, Magdeburg, Germany Fraunhofer Institute for Ceramic Technologies and Systems IKTS, Dresden, Germany
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Evaluation of compacted preparations comprising binary mixtures of starch and magnesium silicate with model low strength water soluble drugs Dynamic image analysis offers new applications in production and quality control Effect of process parameters during high-shear granulation on the content uniformity of resulting low dose tablets
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F.T. Al- Akayleh1 Z.K. Al-Qaysi1 M.S. Shubair1 I.S. Rashid2 A.A. Badwan2 G. Beckmann1 J. Ayar2 S. Kindgen1 M. Knoell2 U. Schmidt2 J. Mller2 P. Langguth1 P.A. Trusty
Department of Chemical Engineering, Purdue University, USA 2 Department of Industrial and Physical Pharmacy, Purdue University, USA 3 School of Mechanical Engineering, Purdue University, USA 1 Petra University, Jordan 2 The Jordanian Pharmaceutical Manufacturing Co. Naor, Jordan
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Johannes Gutenberg-University of Mainz, Germany 2 Httlin GmbH A Bosch Packing Technology Company, Schopfheim, Germany
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The application of a materials sciencebased approach for drug product design and understanding Investigation of the particle surface in fluidized bed spray granulation
GlaxoSmithKline, Global Manufacturing & Supply, Ware, UK NaWiTec, Otto von Guericke University Magdeburg, Germany
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U.M.R. IATE Montpellier France 2 U.M.R. IATE Universit Montpellier France 1 King's College London, UK 2 Eli Lilly and Company, Indianapolis, USA Southeast University, Nanjing, P.R.China
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One dimensional model for the prediction of residence time distribution granulation in a twin-screw granulator
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A comparison of granule properties between impeller slash in high shear mixer and screw rotation in twin screw extruder Designing fix-bed reactor for esterification using ion-exchange resin as catalyst Adsorption of nanoparticles on sugars using fluid bed drying Agglomeration of wet granular material during dense flow
Z. Wang M.J. Hounslow A.D. Salman S. Ralebhat, S. Boite S.B. Shinde R. Shegokar1,2 K.K. Singh1 N. Berger1, 2 E. Azema1 F. Radjai1 J-F. Douce2 J.R. Brown X. Dai A.B. Dennis J.W. Jones P.J. Reddy W.E. Sinclair P. Timmins M. Fonteyne1 J. Arruabarrena2 J. Vercruysse3 C. Vervaet3 J.P. Remon3 T. De Beer1
Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Belgium 2 Laboratory of Pharmaceutical Technology, Ghent University, Belgium 1 Dept. of Mathematical Modelling, Statistics and Bioinformatics, Ghent University, Belgium 2 Dept. of Pharmaceutical Analysis, Ghent University, Belgium 3 Technical University of Denmark, Kongens Lyngby, Denmark University of Sheffield, UK
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Drug form kinetics as a function of high shear wet granulation captured using online Raman spectroscopy
Freie Universitt Berlin, Germany 2 C.U. Shah College of Pharmacy, SNDT University, Mumbai, India 1 Laboratoire de Universit Montpellier II, France 2 ArcelorMittal Maizires Research, Maizires-ls-Metz, France Bristol Myers Squibb Research & Development, Moreton, UK
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Comparison of two different fiber optic probes for the in-line NIR based granule moisture assessment in the drying unit of a continuous pharmaceutical tabletting process
Laboratory of Pharmaceutical PAT, Ghent University, Belgium 2 Universitat Autnoma de Barcelona, Spain 3 Laboratory of Pharmaceutical Technology, Ghent University, Belgium
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AstraZeneca R&D, Mlndal, Sweden 2 AstraZeneca R&D, Macclesfield, United Kingdom GlaxoSmithKline R&D, Harlow, UK,
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Universit de Technologie de Compigne, France 2 PLAPIQUI (UNS CONICET, Baha Blanca, Argentina
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Universit de Lorraine, France Bionov, France 3 Universit de Toulouse, France. 4 INRA, UR638, PIHM, France 5 Agrocampus Ouest, INRA, UMR1253, STLO, Rennes, France
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Development of appropriate granulation techniques for a novel agrochemical granule formulation with built-in adjuvant
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Study on the influence of granulation process parameters on tablet properties using transmission and backscattering Raman and transmission NIR
Laboratory of Pharmaceutical Technology, Ghent University, Belgium 2 VTT Technical Research Centre of Finland, Kuopio/Oulu, Finland 3 Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Belgium
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Investigation into the granulation of nanoparticles using scanning electron microscopy and focussed ion beam techniques Electrostatics effect on bed pressure fluctuation during fluidization of pharmaceutical particles Optimisation of granule size in pulsed spray fluidised bed granulation using the box-behnken experimental design
Department of Physics, Durham University, UK 2 Durham Microscopy Facility, Durham University, UK University of So Paulo, Brazil
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Foam as a new binder for powder granulation: Rheology approach, granules properties and effect of gelling products Melt granulation: Effects of operating variables on particles growth mechanisms
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Process parameters selection for end-use products and scale-up of fluid bed wet granulation and drying
G. Lefebvre D. Oulahna A. de Ryck A. Michrafy S. Veliz, I. Cotabarren, D. Bertn, J. Pia, M. Pedernera V. Bucal S. Martin1 C. Gabaude-Renou2 M. Berger3 J-R. Authelin4
Institute for Material Science and Technologies, Technische Universitt Berlin, Germany 2 Chair of Process Dynamics and Operation, Technische Universitt Berlin, Germany 3 Department of Chemistry, Technische Universitt Berlin, Germany Universit de Toulouse, France
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N. Souihi1,2 M. Josefson3 P. Tajarobi3 B. Gururajan3 J. Trygg1 M. Dosta S. Heinrich I.S. Rashid1 K.A. Alkhamis2 T.H. Altalafha1 H.A. Hassan1 A.A. Badwan1 C.I. Haider1 T.O. Althaus2 G. Niederreiter3 S. Palzer3 M.J. Hounslow1 A.D. Salman1
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Architecture of the multiscale simulation environment for modelling of fluidized bed granulation The development of a controlled release preparation comprising metronidazole and compacted hydrophilic binary polymer matrix of chitosan and xanthan gum Assessment of single particle contact mechanisms and cohesion under controlled temperature and humidity
SCoPT consulting, Trevoux, France 2 Sanofi, Pharmaceutical Sciences Department, Montpellier, France 3 Sanofi, Clinical & Scientific Operations, Montpellier, France 4 Sanofi, Pharmaceutical Sciences Department, Vitry-Sur-Seine, France 1 Department of Chemistry, Ume University, Sweden 2 Industrial Doctoral School, Ume University, Sweden 3 Pharmaceutical Development, AstraZeneca R&D Mlndal, Sweden Hamburg University of Technology, Germany
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The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan 2 Jordan University of Science and Technology, Irbid, Jordan
1 University of Sheffield, UK 2 Nestl Product Technology Centre, UK 3 Nestl SA Headquarters, Vevey, Switzerland
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J. Mosig P. Kleinebudde
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School of Chemical Engineering, Purdue University, USA 2 Innopharma Labs, Sandyford, Ireland 3 Department of Industrial and Physical Pharmacy, Purdue University, USA 1 University of Sheffield, UK 2 Procter and Gamble, Beijing Innovation Centre, China
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