NETWORK MONTHLY UPDATE Agustus 2010

Untuk status terkini studi Network, silakan klik: https://sp.seaclinicalresearch.org/networkstudies/default.aspx

(SEPTEMBER 2008)

SEA034: Monthly Update on Enrollment, Discontinuation and Completion Across all Study Sites* SEA008 Enrollment Update July 2010
Diagnosis H5N1 H1N1 1
Enrolled Completed Discontinued due to an AE Discontinued due to Other Reason(s) Number of Operator AE(s)

Site Number
11

12 -

13 34 34 -

14 63 63 -

15 54 54 -

Total

Number of Subjects: Group (pax) Adult (1) 1

63 63 -

214 214 -

Code 21

Site Sulianti Suroso Total

Note: SEA008 includes enrollment of H5N1/H1N1 survivors from outside Jakarta which involves participation non-partner/other hospital. Adult enrollment since March has also included Psychology Questionnaire.

*Only clean status of BASE, SCOL, and ADE CRFs were counted. Data was accumulated until 4 August 2010. Create Date: August 5, 2010

Catatan untuk SEA032 Studi SEA032 resmi menutup enrollment per 9 Juli 2010 Analisa laboratorium dan CRF sedang berjalan. SEA032: Monthly Update on Screening and Enrollment Status as of July 2010
Site Code 11 12 13 14 15 33 34 Site Name NIITD NHP HTD CH1 CH2 QSNICH Siriraj Total Total Screen Received* 50 10 104 1 5 3 8 181 Total Enroll Received* 50 10 104 1 5 3 8 181 Cumulative Enrolled** Children 1 10 11 1 5 3 6 37 Adult 49 0 93 0 0 0 2 144 Total 50 10 104 1 5 3 8 181

Note: Children is below 18 years old, Adult is more than or equal 18 years old *Only clean status of IEC was counted , **Only clean status of IEC & ENRHIST1 were counted Data was accumulated until August 4, 2010 Create Date: August 5, 2010

NETWORK MONTHLY UPDATE Agustus 2010

SEA032: Monthly Update of PK Sampling as of July 2010 Site Code 11 12 13 14 15 33 34 Site name NIITD, Hanoi NHP, Hanoi Hospital Trop Dis, HCMC Children1, HCMC Children2, HCMC Queen Sirikit Siriraj Total Age <= 2 yrs* Intensive PK** 0 0 0 0 3 0 0 3 1PK sampling 0 4 0 0 0 0 1 5 Age >2 - <18 yrs* Intensive PK** 0 0 11 0 2 0 1 14 1 PK sampling 1 6 0 1 0 3 4 15

(SEPTEMBER 2008)
Age >=18 yrs* Intensive PK** 4 0 93 0 0 0 0 97 1 PK sampling 36 0 0 0 0 0 1 37

*Only clean status of ENRHIST1 & OSLM were counted ** Intensive PK means intention to use full intensive PK regimen including 2-8 PK sampling. Data was accumulated until August 4, 2010 Create Date: August 5, 2010

Highlights Sebuah makalah ilmiah dengan judul Community incidence of pandemic influenza in Vietnam and the effect of social contact patterns on the probability of infection: a prospective cohort study yang ditulis oleh mitra SEAICRN di Hanoi telah terpilih sebagai salah satu presentasi oral dalam Konferensi Options for the Control of Influenza VII di Hong Kong, 3-7 September, 2010. Selain makalah ini, tujuh makalah anggota Network lainnya juga telah terpilih sebagai presentasi poster dalam salah satu pertemuan internasional terbesar dan terlengkap seputar influenza ini. Beragamnya topik presentasi para anggota Network serta kedalaman analisa masing-masing makalah menunjukan kontribusi signifikan Network kepada dunia penelitian influenza. Setelah berkolaborasi selama lima tahun dengan mitra-mitra penelitian lokal yang berdedikasi tinggi serta memiliki visi yang maju, SEAICRN merasa terhormat untuk dapat berbagi pengalaman dalam penelitian-penelitian influenza secara global, ujar Direktur SEAICRN, Prof Jeremy Farrar. Konferensi Options juga menjadi sebuah forum bagi para kolega Network untuk menunjukan pencapaian penelitian klinis yang telah mereka lakukan serta menjalin berbagai kemungkinan kerjasama di masa mendatang. Para anggota Network akan menghadiri Konferensi Options setelah mengikuti pertemuan Network Investigator bersama SEAICRN pada tanggal 2 September.

NETWORK MONTHLY UPDATE Agustus 2010

(SEPTEMBER 2008)
No 1 Judul Community incidence of pandemic influenza in Vietnam and the effect of social contact patterns on the probability of infection: a prospective cohort study. The Southeast Asia Infectious Disease Clinical Research Network: responding to pandemic challenges Characterizations of the Human Carboxylesterase 1 (CES1) mutation(s) which may be responsible for markedly reduced conversion of oseltamivir phosphate to oseltamivir carboxylate, and determination of its frequency in SE Asian populations Clinical Picture and Epidemiology of Avian Influenza in Indonesia The Neuraminidase Inhibitors: A review of assay development and pharmacokinetic studies undertaken by the Southeast Asia Infectious Disease Clinical Research Network Changes in lung function among severe H5N1 and pandemic H1N1 influenza survivors in Indonesia Laboratory Capacity Building in Asia for Infectious Disease Research: Experiences from the South East Asia Infectious Disease Clinical Research Network (SEAICRN) Early Pandemic Influenza (2009 H1N1) in Ho Chi Minh City, Vietnam: A Clinical Virological and Epidemiological Analysis Household and community transmission parameters for pandemic influenza A/H1N1 2009 in Vietnam. Monitoring antiviral - resistance of influenza viruses in Vietnam SEA001: High-Dose versus Standard-Dose Oseltamivir for the Treatment of Severe Influenza Penulis Peter Horby Catatan Oral Presentation Poster Presentation

Tawee Chotpitayasunondh

Nicholas Day

Poster Presentation Poster Presentation Poster Presentation Poster Presentation Poster Presentation Poster Presentation Oral Presentation -

4 5 6 7

Sardikin Giriputro

Niklas Lindegardh Erlina Burhan Heiman Wertheim

8 9 10 11

Rogier van Doorn Pham Quang Thai Hoang Vu Mai Phuong Tran Tinh Hien

Petunjuk dari Pustakawan Network oleh Dini Wikartaadmadja (dwikartaadmadja@eocru.org)

Petunjuk dari Pustakawan.doc