Information Sheet Reconstitution Procedure

OPADRY II film coating systems are quick and easy to prepare. Simply add OPADRY II film coating system powder to water and mix for 45 minutes with a propeller stirrer.* The coating suspension can be made with up to 20% solids. Your Area Technical Manager can recommend the ideal solids for your specific Opadry II system and your equipment. Materials Opadry II film coating system. Water, deionized or distilled preferred, ambient temperature (maximum 30 C) Equipment Variable-speed mixer capable of producing and maintaining a vortex. Propeller stirrer. For optimum mixing, utilize a propeller with a diameter equivalent to 1/4 - 1/3 of the diameter of the mixing vessel. (see Figure 1.) Mixing vessel large enough to contain a liquid volume 15% to 25% greater than the total suspension being prepared. The liquid height and vessel diameter should be equal. *Mixing Procedure 1. Weigh necessary quantity of Opadry II film coating system. 2. Weigh necessary quantity of water into the mixing vessel. 3. With the propeller in the center and as close to the bottom of the vessel as possible, stir the water to form a vortex without drawing air into the liquid. 4. Steadily add the Opadry II system powder to the vortex, avoiding powder flotation on the liquid surface. If required, increase the stirrer speed in order to maintain the vortex . 5. After all the Opadry II system has been added, reduce the mixer speed to nearly eliminate the vortex. Mix for 45 minutes. Suspension Handling The prepared Opadry II dispersion can be pumped directly from the preparation vessel if desired. We recommend that the Opadry II dispersion be gently agitated during the coating process.

Figure 1.

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The information contained herein, to the best of our knowledge is true and accurate. Any recommendations or suggestions are made without warranty or guarantee, since the conditions of use are beyond our control. Any information contained herein is intended as a recommendation for use of our products so as not to infringe on any patent. 2003 Colorcon. The information contained in this document is proprietary to Colorcon and may not be used or disseminated inappropriately.

Opadry II is a trademark of BPSI Holding, Inc. FC/OPADRYIIRECON/06/99 REV.2_0703