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Drug Dev Ind Pharm. 2004 Jul ;30 (6):609-17 15285334 (P,S,G,E,B) c
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[Cited?]
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Evaluation of selected polysaccharide excipients in buccoadhesive tablets for sustained release of nicotine. w
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Calum R Park, Dale L Munday S
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School of Pharmacy, The Robert Gordon University, Aberdeen, Scotland, UK.
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Some naturally occurring biocompatible materials were evaluated as mucoadhesive controlled release excipients for buccal drug e
delivery. A range of tablets were prepared containing -50% w/w xanthan gum, karaya gum, guar gum, and glycol chitosan and were tested
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for swelling, drug release, and mucoadhesion. Guar gum was a poor mucoadhesive and lacked sufficient physical integrity for buccal n
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delivery. Karaya gum demonstrated superior adhesion to guar gum and was able to provide zero-order drug release, but concentrations i
greater than 50% w/w may be required to provide suitable sustained release. Xanthan gum showed strong adhesion to the mucosal
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membrane and the 50% w/w formulation produced zero-order drug release over 4 hours, about the normal time interval between daily t
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meals. Glycol chitosan produced the strongest adhesion, but concentrations greater than 50% w/w are required to produce a nonerodible t
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matrix that can control drug release for over 4 hours. Swelling properties of the tablets were found to be a valuable indicator of the ability of
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the material to produce sustained release. Swelling studies also gave an indication of the adhesion values of the gum material where s
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adhesion was solely dependent upon penetration of the polymer chains into the mucus layer. h
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Mesh-terms: Karaya Gum :: chemistry; Administration, Buccal; Chemistry, Pharmaceutical; Chitin :: analogs & derivatives; Chitin :: r
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chemistry; Comparative Study; Delayed-Action Preparations :: administration & dosage; Delayed-Action Preparations :: chemistry; Drug
Carriers :: chemistry; Excipients :: chemistry; Galactans :: chemistry; Kinetics; Mannans :: chemistry; Nicotine :: administration & dosage;
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Nicotine :: chemistry; Polysaccharides :: chemistry; Polysaccharides, Bacterial :: chemistry; Tablets; Time Factors; d
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Most cited papers: s
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Glycobiology. 1996 Mar ;6 (2):131-9 8727785 (P,S,G,E,B) Cited:4 o
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[Cited?] e
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antibodies MAC207, JIM4 and JIM13 to exudate gum antigens was an acidic trisaccharide, isolated from a partial acid hydrolysate of gum s
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karaya which has the structure: GlcA beta(1-->3) GalA alpha(1-->2)Rha, determined by a combination of FAB-MS, GC-MS and NMR i
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spectroscopy. e