Brand

Amikin Pediatric Abilify, Abilify Discmelt

Name
Amikacin sulfate Aripiprazole

Indications
aminoglycoside antibiotic bipolar, Schizophrenia

Ototoxicity
Ototoxicity: auditory & vestibular tinnitus

Brand
Allegra, Allegra ODT

Name

Indications

Ototoxicity
otitis media (2-4%) potential ototoxicity

Fexofenadine hydrochloride allergies edema management, hypertension

Lasix

Furosemide

Ecotrin, Bayer, Ascriptin, Aspergum, Aspirtab, Easprin, Ecpirin, Entercote Aspirin AzaSite, Zithromax, Zmax

general pain, fever, rheumatoid arthritis

tinnitus

Azithromycin antibiotic edema manageBumetanide ment, hypertension

Ototoxicity, tinnitus Ototoxicity (with rapid I.V. administration)

Garamycin, Genoptic, Genoptic S.O.P., Gentacidin, Gentafair, Gentak, Gentasol, Gentamicin Ocu-mycin sulfate

aminoglycoside antibiotic

Ototoxicity: auditory & vestibular (>10%)

Bumex Zyrtec, Children's Allergy

Certirizine

Tinnitus, perennial & seasonal ototoxicity, allergy relief earaches (<2%)

Advil, Motrin, A-G Profen, Addaprin, Bufen, Genpril, Haltran, I-Prin Ibuprofen

general pain, fever, rheumatoid arthritis tinnitus (3-9%)

OTOTOXIC MEDICATION GUIDE FOR AUDIOLOGIST ADULT/ PEDIATRIC

Neosporin Ototoxicity (1030%) - pediatric cancer treament for population more pediatrics suseptible

Neomycin and Polymycin B topical antibiotic

Ototoxicity

Platinol-AQ

Cisplatin

Neo-Fradin

Neomycin sulfate

infection of skin, minor cuts, scrapes, and burns Ototoxicity

Depakote, Depakote ER, Depakote Sprinkles, Divalproex Depakote DR Sodium Taxotere Docetaxel

seizures

tinnitus (1-7%), ear pain (>1-5%), deafness (>1<5%), otitis media (>1-<5%)

cancer treament for pediatrics Ototoxicity

Neomycin, (Bacitracin) Polymyxin B, Cortisporin Otic, & HydrocortiPediOtic sone otic antibiotic Humatin aminoglycoside Paromomycin antibiotic Streptomycin aminoglycoside sulfate antibiotic

Ototoxicity Ototoxicity

Akne-Mycin, Ery-Tab, Eryc, Eryderm, Erygel, EryPed, Erythro-RX, Erythrocin, PCE, Romycin Erythromycin antibiotic Edecrin, Sodium Edecrin Ethacrynic Acid edema management, hypertension heartburn, acid indegestion, & GERD relief

Kathleen Masterson Purdue University AuD Program 2009 Resources: Micromedex Healthcare Series, Lexi-Comp Online, Online Facts and Comparison DISCLAIMER: THIS IS NOT AN OFFICIAL PDR. THIS REFERENCE HAS NO ASSOCIATION WITH THE FDA.

tinnitus (3%) tinnitus (3% when inhaled)

Ototoxicity (after I.V. use), tinnitus Ototoxicity, tinnitus Ototoxicity, tinnitus

AKTob, Tobi, Tobrasol, Tobrex Tobramycin

aminoglycoside antibiotic edema management, hypertension

Demadex

Torsemide

Ototoxicity Ototoxicity, assoc. w/ conc. >40 mcg/mL

Pepcid, Pepcid AC Famotidine

Vancocin

Vancomycin

aminoglycoside antibiotic

Brand

Name
Amikacin sulfate

Indications

Ototoxicity Brand
Taxotere Cymbalta Vasotec

Amikin Abilify, Abilify Discmelt Ecotrin, Bayer, Ascriptin, Aspergum, Aspirtab, Easprin, Ecpirin, Entercote

Ototoxicity: auditory aminoglycoside & vestibular (1antibiotic 10%) Ototoxicity: auditory & vestibular (110%)

Name
Docetaxel

Indications

Ototoxicity

Brand

Name

Indications

Ototoxicity

cancer treatment Ototoxicity (<1%) tinnitus (<1%) Ototoxicity (<1%) Ototoxicity Cortisporin Otic, PediOtic Neomycin, Polymyxin B, & Hydrocortisone otic antibiotic

Duloxetine hydrochloride antidepressant Enalapril Escitalopram oxalate hypertension antidepressant

Aripiprazole

antipsychotic

Lexapro

Ototoxicity: increased risk for patients with extended use or tympanic membrane perforation, therapy should be limited to 10 days

Aspirin

general pain, fever, rheumatoid arthritis

hearing loss, tinnitus (dose related)

Allegra, Alle- Fexofenadine gra ODT hydrochloride

allergies

otitis media (2-4%)

Onxol, Taxol Paclitaxel

cancer treatment Ototoxicity (<1%) treatment of gastrointestinal infections

Lasix prevention & treatment of Bacitracin, infammatory Neomycin, conditions if Polymycin B, bacterial infecand tion is at risk or Hydrocortisone present Ototoxicity edema management, hypertension

Furosemide

edema manage- Ototoxicity with ment, I.V. or I.M. hypertension administration Humatin Paromomycin Streptomycin sulfate

Ototoxicity (<1%)

Cortisporin Ointment (topical)

Garamycin, Genoptic, Genoptic S.O.P., Gentacidin, Gentafair, Gentak, Gentasol, Gentamicin Ocu-mycin sulfate Advil, Motrin, A-G Profen, Addaprin, Bufen, Genpril, Haltran, I-Prin Ibuprofen

aminoglycoside antibiotic tinnitus (3%)

Ototoxicity: audiaminoglycoside tory & vestibular antibiotic (>10%)

Bumex Budeprion SR, Budeprion XL, Wellbutrin XL

Bumetadine

Ototoxicity (1%)

Cialis AKTob, Tobi, Tobrasol, Tobrex

Tadalafil

erectile dysfunction

sudden onset (<2%), sudden hearing loss (<2%)

Bupropion Hydrochloride antidepressant

tinnitus & auditory disturbance Ototoxicity (subclinical hearing loss: 11%, clinical loss: 3%)

general pain, fever, rheumatoid arthritis

Tobramycin

aminoglycoside tinnitus (3% when antibiotic inhaled) hearing decreased (12%), tinnitus (12%) Ototoxicity (<1%)

tinnitus (3-9%) Topamax Vancocin Topiramate Vancomycin anticonvulsant aminoglycoside antibiotic

Capastat ParaplatinAQ

Capreomycin

antibiotic treatment of ovarian cancer

Kantrex

Kanamycin Neomycin and Polymycin B

Ototoxicity aminoglycoside (auditory & vestibular) antibiotic

Neosporin Ototoxicity (1%) Neo-Fradin

topical antibiotic Ototoxicity

Carboplatin

Zyrtec

Certirizine

perennial & seasonal allergy relief Ototoxcity (<2%) cancer treatment antibiotic Ototoxicity (1030%) tinnitus

Ototoxicity: aminoglycoside auditory & vestibular (<1%) Neomycin sulfate antibiotic

Effexor, Effexor XR Navelbine

Venlafaxine hydrochloride Vinorelbine

antidepressant

deafness (1-<5%)

cancer treatment Ototoxicity (<1%)

Platinol-AQ Cisplatin Aczone Depakote, Depakote ER, Depakote Sprinkles, Depakote DR Dapsone

Divalproex Sodium

antipsychotic

tinnitus (1-7%), ear pain (>1-5%), deafness (>1-<5%), otitis media (>1<5%)

Coly-Mycin S, Cortisporin

Neomycin, Colistin, Hydrocortisone, and Thonzonium

antibiotic/ corticosteroid

Ototoxicity: increased risk for patients with longstanding otitis media or tympanic membrane perforation Ambien, Zolpidem Ambien CR tartrate

Ototoxicity (tinnitus, hearing loss) In most cases it is reversible, however, insomnia, short- permanent damterm treatment age can occur.