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Cited by since 1996

This article has been cited 594 times in Scopus:
(Showing the 2 most recent)

Volume 4, Issue 6, November 2007, Pages 807-818

Bioavailability of curcumin: Problems and promises

Anand, P.a, Kunnumakkara, A.B.a, Newman, R.A.b, Aggarwal, B.B.ac
a

( Review )

Sun, J. , Bi, C. , Chan, H.M.

Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability
(2013) Colloids and Surfaces B: Biointerfaces Nambiar, D. , Singh, R.P.

Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, United

States
b

Pharmaceutical Development Center, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030,

United States
c

Advances in prostate cancer chemoprevention: A translational perspective

(2013) Nutrition and Cancer

Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Box 143, 1515 Holcombe Blvd, Houston, TX 77030, United

States View references (85)

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Abstract

Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, antiproliferative and antiangiogenic activities. Phase I clinical trials have shown that curcumin is safe even at high doses (12 g/day) in humans but exhibit poor bioavailability. Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve, first, the use of adjuvant like pipeline that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipid complex; and fifth, the use of structural analogues of curcumin (e.g., EF-24). The latter has been reported to have a rapid absorption with a peak plasma half-life. Despite the lower bioavailability, therapeutic efficacy of curcumin against various human diseases, including cancer, cardiovascular diseases, diabetes, arthritis, neurological diseases and Crohn's disease, has been documented. Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease. 2007 American Chemical Society.
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Author keywords
Absorption; Adjuvants; Bioavailability; Biocurcumax; Curcumin; Formulations; Metabolism; Nanoparticles

Indexed keywords
EMTREE drug terms: antineoplastic agent; biocurcumax; boron; cadmium; copper; curcumin; curcumin glucuronide derivative; dihydrocurcumin; ef 24; epigallocatechin gallate; eugenol; gallium; genistein; glucuronide; hexahydrocurcumin; indium; liposome; manganese; nanoparticle; oxaliplatin; phospholipid; piperine; placebo; quercetin; terpene derivative; terpeneol; tetrahydrocurcumin; unclassified drug; vanadyl derivative EMTREE medical terms: adenomatous polyp; adjuvant therapy; area under the curve; arthritis; carcinoma cell; cardiovascular disease; clinical trial; colorectal cancer; combination chemotherapy; complex formation; Crohn disease; diabetes mellitus; drug absorption; drug bioavailability; drug blood level; drug dosage form comparison; drug efficacy; drug elimination; drug half life; drug megadose; drug metabolism; drug potentiation; drug structure; drug tissue level; glucuronidation; human; micelle; monotherapy; neoplasm; neurologic disease; nonhuman; priority journal; review; single drug dose; unspecified side effect MeSH: Animals; Biological Availability; Curcumin; Drug Delivery Systems; Humans; Tissue Distribution Medline is the source for the MeSH terms of this document. Chemicals and CAS Registry Numbers: boron, 7440-42-8; cadmium, 22537-48-0, 7440-43-9; copper, 15158-11-9, 7440-50-8; curcumin, 458-37-7; epigallocatechin gallate, 989-51-5; eugenol, 97-53-0; gallium, 7440-55-3; genistein, 446-72-0; indium, 7440-746; manganese, 16397-91-4, 7439-96-5; oxaliplatin, 61825-94-3; piperine, 94-62-2; quercetin, 117-39-5;Curcumin, 458-37-7 Drug tradename: ef 24.
ISSN: 15438384 Source Type: Journal Original language: English Document Type: Review View in table layout

DOI: 10.1021/mp700113r

PubMed ID: 17999464

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Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers
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(2007) Cancer Investigation, 25 (3), pp. 172-181. Cited 5 times. doi: 10.1080/07357900701209053
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Synthesis and biolgical analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer
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First 80 references displayed (View all references) Aggarwal, B.B.; Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Box 143, 1515 Holcombe Blvd, Houston, TX 77030, United States; email:aggarwal@mdanderson.org Copyright 2009 Elsevier B.V., All rights reserved. MEDLINE is the source for the MeSH terms of this document.
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